Current topics in cellular regulation最新文献

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Eukaryotic DNA methylation and gene expression. 真核生物DNA甲基化与基因表达。
Current topics in cellular regulation Pub Date : 1989-01-01 DOI: 10.1016/b978-0-12-152830-0.50003-7
A Weissbach, C Ward, A Bolden
{"title":"Eukaryotic DNA methylation and gene expression.","authors":"A Weissbach, C Ward, A Bolden","doi":"10.1016/b978-0-12-152830-0.50003-7","DOIUrl":"https://doi.org/10.1016/b978-0-12-152830-0.50003-7","url":null,"abstract":"","PeriodicalId":10933,"journal":{"name":"Current topics in cellular regulation","volume":"30 ","pages":"1-21"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13838060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
Transducin: a signaling switch regulated by guanine nucleotides. 转导蛋白:一种由鸟嘌呤核苷酸调节的信号开关。
Current topics in cellular regulation Pub Date : 1989-01-01 DOI: 10.1016/b978-0-12-152830-0.50008-6
Y K Ho, V N Hingorani, S E Navon, B K Fung
{"title":"Transducin: a signaling switch regulated by guanine nucleotides.","authors":"Y K Ho, V N Hingorani, S E Navon, B K Fung","doi":"10.1016/b978-0-12-152830-0.50008-6","DOIUrl":"https://doi.org/10.1016/b978-0-12-152830-0.50008-6","url":null,"abstract":"","PeriodicalId":10933,"journal":{"name":"Current topics in cellular regulation","volume":"30 ","pages":"171-202"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13703695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Coordinate interactions of cyclic nucleotide and phospholipid metabolizing pathways in calcium-dependent cellular processes. 钙依赖性细胞过程中环核苷酸和磷脂代谢途径的协调相互作用。
Current topics in cellular regulation Pub Date : 1989-01-01 DOI: 10.1016/b978-0-12-152830-0.50009-8
S G Laychock
{"title":"Coordinate interactions of cyclic nucleotide and phospholipid metabolizing pathways in calcium-dependent cellular processes.","authors":"S G Laychock","doi":"10.1016/b978-0-12-152830-0.50009-8","DOIUrl":"https://doi.org/10.1016/b978-0-12-152830-0.50009-8","url":null,"abstract":"<p><p>It is hoped that his review enables the reader to appreciate the complexities implicit in the interactions among Ca2+, cyclic nucleotides, and phospholipid-metabolizing pathways in cell signal transduction. The interactions are varied and intricate, often involving several levels of cell amplification mechanisms. Upsetting the balance of fatty acids in membrane phospholipids can have detrimental effects on adenylate cyclase. Thus, n - 3 fatty acid enrichment of phospholipids suppresses adenylate cyclase activity. The effects of significant alterations in dietary fatty acids, such as might occur with the current vogue for n - 3 eicosapentaenoic acid and docosahexaenoic acid (fish oil) dietary enrichment regimens, will need to be assessed more fully with regard to stimulus-induced changes in cyclic nucleotide production in various tissues. Since the n - 3 fatty acids have not been demonstrated to affect guanylate cyclase activity, dietary changes in certain of these fatty acids would not be expected to contribute to changes in cGMP generation as much as in cAMP production. Moreover, the ingestion of large quantities of these n - 3 fatty acids can alter the profile of cyclooxygenase and lipoxygenase products produced in cells. According to the paradigm developed in this article, changes in the metabolism of fatty acids are amplified by alterations in cyclic nucleotide production and phospholipase activities, with the eventual physiological impact predicated on the tissue type and the specific stimulus response. There appears to be a rather clear distinction between the regulatory properties of eicosanoids regarding adenylate and guanylate cyclase activities. Whereas prostaglandins often stimulate adenylate cyclase activity, they have little effect on guanylate cyclase activity. On the other hand, the HETE compounds seem to play an important role in guanylate cyclase regulation in certain cells. Moreover, arachidonic acid affects adenylate cyclase activity without prior peroxidation, whereas endoperoxides and hydroperoxides are more effective than arachidonic acid with regard to guanylate cyclase stimulation. However, in the intact cell there is a strong implication that the dual stimulation of guanylate cyclase by Ca2+ and fatty acid evokes optimal enzyme activity. An advantage of multidimensional response mechanisms in cells includes the ability to recognize different stimuli and to respond with specific, coordinated responses modulated in their intensity and/or duration by messenger interaction. Few cell types respond to receptor stimulation in an all-or-none fashion, and the \"milieu interior\" depends on specific, graded responses to the autonomic nervous system and endocrine stimuli.(ABSTRACT TRUNCATED AT 400 WORDS)</p>","PeriodicalId":10933,"journal":{"name":"Current topics in cellular regulation","volume":"30 ","pages":"203-42"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13703696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
The intracellular site of action of insulin: the mitochondrial Krebs cycle. 胰岛素的细胞内作用部位:线粒体克雷布斯循环。
Current topics in cellular regulation Pub Date : 1989-01-01 DOI: 10.1016/b978-0-12-152830-0.50006-2
C Mohan, P J Geiger, S P Bessman
{"title":"The intracellular site of action of insulin: the mitochondrial Krebs cycle.","authors":"C Mohan,&nbsp;P J Geiger,&nbsp;S P Bessman","doi":"10.1016/b978-0-12-152830-0.50006-2","DOIUrl":"https://doi.org/10.1016/b978-0-12-152830-0.50006-2","url":null,"abstract":"","PeriodicalId":10933,"journal":{"name":"Current topics in cellular regulation","volume":"30 ","pages":"105-42"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13660721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
Regulation of nitrogenase activity by reversible ADP ribosylation. 可逆ADP核糖基化对氮酶活性的调节。
Current topics in cellular regulation Pub Date : 1989-01-01 DOI: 10.1016/b978-0-12-152830-0.50004-9
P W Ludden, G P Roberts
{"title":"Regulation of nitrogenase activity by reversible ADP ribosylation.","authors":"P W Ludden,&nbsp;G P Roberts","doi":"10.1016/b978-0-12-152830-0.50004-9","DOIUrl":"https://doi.org/10.1016/b978-0-12-152830-0.50004-9","url":null,"abstract":"","PeriodicalId":10933,"journal":{"name":"Current topics in cellular regulation","volume":"30 ","pages":"23-56"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13718583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 121
Recognition of DNA by type II restriction enzymes. II型限制性内切酶识别DNA。
Current topics in cellular regulation Pub Date : 1989-01-01 DOI: 10.1016/b978-0-12-152830-0.50005-0
S P Bennett, S E Halford
{"title":"Recognition of DNA by type II restriction enzymes.","authors":"S P Bennett,&nbsp;S E Halford","doi":"10.1016/b978-0-12-152830-0.50005-0","DOIUrl":"https://doi.org/10.1016/b978-0-12-152830-0.50005-0","url":null,"abstract":"","PeriodicalId":10933,"journal":{"name":"Current topics in cellular regulation","volume":"30 ","pages":"57-104"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13838061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 38
Regulation of fatty acid uptake and synthesis in mammary and adipose tissues: contrasting roles for cyclic AMP. 乳腺和脂肪组织中脂肪酸摄取和合成的调节:环AMP的对比作用。
Current topics in cellular regulation Pub Date : 1988-01-01 DOI: 10.1016/b978-0-12-152829-4.50005-7
R A Clegg
{"title":"Regulation of fatty acid uptake and synthesis in mammary and adipose tissues: contrasting roles for cyclic AMP.","authors":"R A Clegg","doi":"10.1016/b978-0-12-152829-4.50005-7","DOIUrl":"https://doi.org/10.1016/b978-0-12-152829-4.50005-7","url":null,"abstract":"","PeriodicalId":10933,"journal":{"name":"Current topics in cellular regulation","volume":"29 ","pages":"77-128"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13978229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Control of metabolism by dynamic macromolecular interactions. 通过动态大分子相互作用控制代谢。
Current topics in cellular regulation Pub Date : 1988-01-01 DOI: 10.1016/b978-0-12-152829-4.50003-3
T Keleti, J Ovádi
{"title":"Control of metabolism by dynamic macromolecular interactions.","authors":"T Keleti,&nbsp;J Ovádi","doi":"10.1016/b978-0-12-152829-4.50003-3","DOIUrl":"https://doi.org/10.1016/b978-0-12-152829-4.50003-3","url":null,"abstract":"","PeriodicalId":10933,"journal":{"name":"Current topics in cellular regulation","volume":"29 ","pages":"1-33"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14420489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 45
Function and regulation of the pentose phosphate pathway in brain. 脑内戊糖磷酸通路的功能与调控。
Current topics in cellular regulation Pub Date : 1988-01-01 DOI: 10.1016/B978-0-12-152829-4.50008-2
N. Baquer, J. Hothersall, P. Mclean
{"title":"Function and regulation of the pentose phosphate pathway in brain.","authors":"N. Baquer, J. Hothersall, P. Mclean","doi":"10.1016/B978-0-12-152829-4.50008-2","DOIUrl":"https://doi.org/10.1016/B978-0-12-152829-4.50008-2","url":null,"abstract":"","PeriodicalId":10933,"journal":{"name":"Current topics in cellular regulation","volume":"14 1","pages":"265-89"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85509087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 87
Ligand binding and multienzyme complex formation between ornithine carbamoyltransferase and arginase from Saccharomyces cerevisiae. 酿酒酵母鸟氨酸氨基甲酰转移酶与精氨酸酶的配体结合及多酶复合物的形成。
Current topics in cellular regulation Pub Date : 1988-01-01 DOI: 10.1016/b978-0-12-152829-4.50004-5
P Hensley
{"title":"Ligand binding and multienzyme complex formation between ornithine carbamoyltransferase and arginase from Saccharomyces cerevisiae.","authors":"P Hensley","doi":"10.1016/b978-0-12-152829-4.50004-5","DOIUrl":"https://doi.org/10.1016/b978-0-12-152829-4.50004-5","url":null,"abstract":"","PeriodicalId":10933,"journal":{"name":"Current topics in cellular regulation","volume":"29 ","pages":"35-75"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14422859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
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