Current Nanomaterials最新文献_第9页

Cinacalcet HCl Loaded PLGA Nanoparticles Using the Porous Carrier 利用多孔载体负载氯化钠的PLGA纳米颗粒

Current Nanomaterials Pub Date : 2022-04-18 DOI: 10.2174/2405461507666220418113115

Dipthi Shree, C. Patra, D. Ghose, G. Jena, B. Sahoo, K. C. Panigrahi, J. Sruti

{"title":"Cinacalcet HCl Loaded PLGA Nanoparticles Using the Porous Carrier","authors":"Dipthi Shree, C. Patra, D. Ghose, G. Jena, B. Sahoo, K. C. Panigrahi, J. Sruti","doi":"10.2174/2405461507666220418113115","DOIUrl":"https://doi.org/10.2174/2405461507666220418113115","url":null,"abstract":"\u0000\u0000Cinacalcet HCl, a calcimimetic, BCS class IV drug with low oral bioavailability. Polymeric nanoparticles are widely used as biomaterials owing to their biocompatibility, biodegradability, varied structures, low toxicity, simple and easy formulation process.\u0000\u0000\u0000\u0000To enhance the oral bioavailability of poorly water soluble drug i.e., Cinacalcet HCl by using a suitable particulate nanocarrier system i.e., Polymeric Nanoparticles.\u0000\u0000\u0000\u0000A Biodegradable Cinacalcet HCl (CH) loaded Poly (Lactic-co-glycolic acid) (PLGA) nanoparticles were prepared by nano precipitation method using Poloxamer-188 as stabilizer. The experimental parameters like polymer concentration, stabilizer concentration, temperature and RPM speed were optimized. An optimized Polymeric nanoparticles (PNP F8) was solidified by adsorption to porous carrier sylysia 350.\u0000\u0000\u0000\u0000PNP F8 exhibited particle size 155 nm with low PDI (0.231) and high zeta potential (-21.3 mV). In vitro diffusion study revealed sustain release of CH for 24 h for both PNP (F8) and solidified PNP (F8). Pharmacokinetics after oral administration of PNP (F8) and solidified PNP (F8) exhibited 5 fold increases in bioavailability. Thus, both PNP (F8) and solidified PNP (F8) showed significant improvement in oral bioavailability.\u0000\u0000\u0000\u0000Adsorption to polymeric nanoparticles to porous carriers like sylysia 350 can be considered as a promising approach for its long term stability.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46632807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of multilayered Cobalt Silicide Nanostructured Thin films prepared by Ion Beam Sputtering 离子束溅射制备多层硅化钴纳米薄膜的研究

Current Nanomaterials Pub Date : 2022-04-17 DOI: 10.2174/2405461507666220417003137

Karamjit Kaur, Anil Kumar

引用次数: 0

A review of nanoparticles characterization techniques 纳米颗粒表征技术综述

Current Nanomaterials Pub Date : 2022-04-05 DOI: 10.2174/2405461507666220405113715

P. Wadhwa, Sushant Sharma, S. Sahu, A. Sharma, D. Kumar

引用次数: 2

Optimization of Nano Science Parameters for Extracting Phenolic Compounds from Ficus religiosa by Three-Phase Partitioning (TPP) Method 三相分割法提取榕中酚类化合物的纳米科学参数优化

Current Nanomaterials Pub Date : 2022-03-21 DOI: 10.2174/1573401318666220321140651

N. Rane, S. Shewale

{"title":"Optimization of Nano Science Parameters for Extracting Phenolic Compounds from Ficus religiosa by Three-Phase Partitioning (TPP) Method","authors":"N. Rane, S. Shewale","doi":"10.2174/1573401318666220321140651","DOIUrl":"https://doi.org/10.2174/1573401318666220321140651","url":null,"abstract":"\u0000\u0000The phenolic compounds are generally found in different parts of the plants such as leaves, barks, seeds, fruits, and so on. These compounds show numerous nanoscience-based bioactive properties including antioxidant characteristics. The phenolic compounds obtained from beneficial herbs and dietary plants include total phenolic compounds, flavonoids, and tannins. In recent times, nanoscience has proved to be extensively reliable in extracting bioactive components. Additionally, nanomaterials have made a considerable contribution in the development of methodical techniques to retain superiority in processing foods and medicines.\u0000\u0000\u0000\u0000Of late, extracting nano-bioactive composites from natural resources have gained high interest as these composites are used in manufacturing a wide range of products such as foods, paints, and pharmaceuticals. Therefore, there is a requirement to separate natural products and identify new nano-bioactive compounds that have the potential to improve the importance of logical and developed techniques.\u0000\u0000\u0000\u0000This research is focused on optimizing the experimental parameters to extract the phenolic compounds from Ficus religiosa (banyan leaves) by the Three-Phase Partitioning (TPP) method. TPP is an advanced method that has been used for the extraction, concentration, and purification of various nano-based bioactive compounds and enzymes.\u0000\u0000\u0000\u0000During the investigation, various experimental parameters have been studied to obtain the maximum concentration of phenolic compounds from the dried powder of the Ficus religiosa leaves. The optimised results were found as ammonium sulphate by 30%, solute to the solvent ratio in 1:20 (v/v), and slurry to t-butanol ratio in 1:1 proportions.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48337838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NANOSILVER-REINFORCED AgSn ALLOYS FOR DENTAL APPLICATIONS: MECHANICAL BEHAVIOR AND HARDNESS 牙科用纳米增强AgSn合金的力学行为和硬度

Current Nanomaterials Pub Date : 2022-03-09 DOI: 10.2174/2405461507666220309114149

L. Ortega-Arroyo, Eduardo San-Martín-Martínez, Federico H. Barceló, Jorge H. Vargas-Aparicio, Fabio A. Vengoechea-Gómez, V. Castaño

引用次数: 0

A Review on Properties, Synthesis, Surface Functionalization and Application of Nanodiamonds for Antimicrobial Activity 纳米金刚石抗菌性能、合成、表面功能化及应用研究进展

Current Nanomaterials Pub Date : 2022-03-08 DOI: 10.2174/2405461507666220308143436

V. Tyagi, A. Chandra, Neelam Dhankhar, Bhavna Tyagi

引用次数: 0

A Review on Unknown Repercussions Associated with Metallic Nanoparticles and their Rectification Techniques 金属纳米粒子的未知反应及其矫正技术综述

Current Nanomaterials Pub Date : 2022-03-04 DOI: 10.2174/2405461507666220304204152

Saman Aqeel, Aparna Gupta, L. Singh

{"title":"A Review on Unknown Repercussions Associated with Metallic Nanoparticles and their Rectification Techniques","authors":"Saman Aqeel, Aparna Gupta, L. Singh","doi":"10.2174/2405461507666220304204152","DOIUrl":"https://doi.org/10.2174/2405461507666220304204152","url":null,"abstract":"\u0000\u0000The wide use of metallic nanoparticles (MNPs) has toxic effects on the human body affecting vital organs such as brain, liver and kidney. Therefore it is necessary to develop approaches to eradicate such health issues without compromising plus the potential benefits of the respective metallic nanoparticles including silver, gold, zinc, copper, etc.\u0000\u0000\u0000\u0000This study aimed to assess methods which can mutually reduce the nanotoxicity while retaining the therapeutic benefits of metal-based nanocarriers.\u0000\u0000\u0000\u0000The implementation of certain methods, such as the addition of chelating agents, providing protective coatings and surface modification during the synthesis of metallic nanoparticles can subsequently minimize metallic toxicity.\u0000\u0000\u0000\u0000Through extensive and exhaustive literature survey it was proved that the above strategies are effective in reducing nanotoxic effects which can be further assessed by toxicity assessment tools as biochemistry, histopathology, etc.\u0000\u0000\u0000\u0000Metallic nanoparticles have emerged as a beneficial tool for treating various diseases such as cancer, hepatitis, etc. Scientists are also preserving their efficacy by escorting novel techniques for limiting its toxicity, in the world of nanotechnology.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48816969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Nanotechnology Applications in Biomedical Systems 纳米技术在生物医学系统中的应用

Current Nanomaterials Pub Date : 2022-03-01 DOI: 10.2174/2405461507666220301121135

I. Buniyamin, R. Akhir, N. Asli, Z. Khusaimi, M. F. Malek, M. Mahmood

引用次数: 5

Green synthesis of copper oxide nanoparticle using Eichhornia crassipes leaf extract, its Antibacterial and Photocatalytic Activities 绿色氧化铜纳米颗粒的合成及其抑菌和光催化活性研究

Current Nanomaterials Pub Date : 2022-03-01 DOI: 10.2174/2405461507666220301122316

Tamene S. Saligedo, Gutta G. Muleta, T. Tsega, Kirubel Teshome Tadele

{"title":"Green synthesis of copper oxide nanoparticle using Eichhornia crassipes leaf extract, its Antibacterial and Photocatalytic Activities","authors":"Tamene S. Saligedo, Gutta G. Muleta, T. Tsega, Kirubel Teshome Tadele","doi":"10.2174/2405461507666220301122316","DOIUrl":"https://doi.org/10.2174/2405461507666220301122316","url":null,"abstract":"\u0000\u0000Green approach is among the most preferable methods for metal-based nanoparticles synthesis due to its simplicity, cost effectiveness, eco-friendly reagents and broad spectrum of biological activities. The aim of this study is to synthesize copper oxide nanoparticles using Eichhornia Crassipes (Water hyacinth) leaf extract in an eco-friendly manner.\u0000\u0000\u0000\u0000Copper oxide nanoparticles were synthesized using Eichhornia Crassipes (Water hyacinth) leaf extract. The effect of different parameters such as concentration of the plant extract, time, light and pH on the formation of the nanoparticles was investigated. The synthesized nanoparticles were characterized by UV-Vis, FTIR, TEM and P-XRD spectroscopic techniques. The antibacterial and photocatalytic activities of the synthesized copper oxide nanoparticles were determined.\u0000\u0000\u0000\u0000Powder X Ray diffraction analysis (PXRD) showed that the copper oxide nanoparticles have a size of 9.1 nm. Transmission electron microscopy (TEM) images displayed that the Nps were spherical, polydispersed and well crystallized. The nanoparticles displayed good antibacterial activity against Escherichia coli, Staphylococcus, Bacillus stabtilus and Salmonella typhi with the highest activity against Salmonella typhi.\u0000\u0000\u0000\u0000Copper oxide nanoparticles were effectively synthesized and secondary metabolites such as flavonoids, alkaloids, tannins, phenols acted as both capping and stabilizing agents. The good antibacterial and photocatalytic activities of the synthesized nanoparticles indicated their potential for applications in pharmacology and environmental protections respectively. However, the product needs further investigation to enhance its antibacterial potential for efficient pharmacological application.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48700161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Effect of conditions of the pulsed plasma-chemical synthesis on physicochemical properties of the CuxOy/TiO2 nanocomposite 脉冲等离子体化学合成条件对CuxOy/TiO2纳米复合材料物理化学性能的影响

Current Nanomaterials Pub Date : 2022-02-21 DOI: 10.2174/2405461507666220221095932

R. Sazonov, G. Kholodnaya, D. Ponomarev, O. Lapteva

引用次数: 0