Current drug targets最新文献_第9页

Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials 葡萄产品的摄入量是否会影响成年人的体重？随机对照试验的系统回顾和元分析

IF 3.2 4区医学

Current drug targets Pub Date : 2023-12-23 DOI: 10.2174/0113894501272740231219072525

Mohammad Ali Goudarzi, Zahra Sohrabi, Mohammad Hashem Hashempur, Saeed Nosratabadi, Zahra Namkhah, Cain C. T. Clark, Neda Haghighat

{"title":"Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials","authors":"Mohammad Ali Goudarzi, Zahra Sohrabi, Mohammad Hashem Hashempur, Saeed Nosratabadi, Zahra Namkhah, Cain C. T. Clark, Neda Haghighat","doi":"10.2174/0113894501272740231219072525","DOIUrl":"https://doi.org/10.2174/0113894501272740231219072525","url":null,"abstract":"Introduction:: There is a growing interest in the considerable benefits of grape products intake, as some studies have indicated that they may improve cardiometabolic risk factors. However, the widespread impact of grape products on the anthropometric indices is not fully resolved. Method:: The purpose of this systematic review and meta-analysis was to examine the effects of grape products intake on anthropometric indices in adults. Randomized controlled trials (RCT) examining the effects of grape products intake on anthropometric indices, published up to December 2021, were identified through PubMed, SCOPUS, and ISI Web of Science databases. 30 studies with 35 effect sizes, including 1284 participants (708 cases and 576 controls), were included and analyzed using a random-effects model to calculate weighted mean differences (WMDs) with 95% confidence interval (CI). Result:: The outcomes have revealed grape products intake to significantly decrease body weight (p = 0.001) and body mass index (p = 0.004) in obese participants, and also, a greater effect was observed when grape seed extract was used. Conclusion:: Our study suggests that grape products intake may help to decrease body weight in obese participants. Future large RCTs with longer duration and obese populations are needed to expand our findings.","PeriodicalId":10805,"journal":{"name":"Current drug targets","volume":"3 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139024043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcription Factors in Brain Regeneration: A Potential Novel Therapeutic Target 脑再生中的转录因子：潜在的新治疗靶点

IF 3.2 4区医学

Current drug targets Pub Date : 2023-12-15 DOI: 10.2174/0113894501279977231210170231

Basheer Abdullah Marzoog

引用次数: 0

An Update on the Emerging Role of Wnt/β-catenin, SYK, PI3K/AKT, and GM-CSF Signaling Pathways in Rheumatoid Arthritis 类风湿关节炎中 Wnt/β-catenin、SYK、PI3K/AKT 和 GM-CSF 信号通路新作用的最新进展

IF 3.2 4区医学

Current drug targets Pub Date : 2023-12-12 DOI: 10.2174/0113894501276093231206064243

Pradyuman Prajapati, Gaurav Doshi

{"title":"An Update on the Emerging Role of Wnt/β-catenin, SYK, PI3K/AKT, and GM-CSF Signaling Pathways in Rheumatoid Arthritis","authors":"Pradyuman Prajapati, Gaurav Doshi","doi":"10.2174/0113894501276093231206064243","DOIUrl":"https://doi.org/10.2174/0113894501276093231206064243","url":null,"abstract":": Rheumatoid arthritis is an untreatable autoimmune disorder. The disease is accompanied by joint impairment and anomalies, which negatively affect the patient’s quality of life and contribute to a decline in manpower. To diagnose and treat rheumatoid arthritis, it is crucial to understand the abnormal signaling pathways that contribute to the disease. This understanding will help develop new rheumatoid arthritis-related intervention targets. Over the last few decades, researchers have given more attention to rheumatoid arthritis. The current review seeks to provide a detailed summary of rheumatoid arthritis, highlighting the basic description of the disease, past occurrences, the study of epidemiology, risk elements, and the process of disease progression, as well as the key scientific development of the disease condition and multiple signaling pathways and enumerating the most current advancements in discovering new rheumatoid arthritis signaling pathways and rheumatoid arthritis inhibitors. This review emphasizes the anti-rheumatoid effects of these inhibitors [for the Wnt/β-catenin, Phosphoinositide 3-Kinases (PI3K/AKT), Spleen Tyrosine Kinase (SYK), and Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) signaling pathways], illustrating their mechanism of action through a literature search, current therapies, and novel drugs under pre-clinical and clinical trials.","PeriodicalId":10805,"journal":{"name":"Current drug targets","volume":"54 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138581866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering the Role of Pyroptosis Impact on Cardiovascular Diseases 解读焦亡对心血管疾病的影响

IF 3.2 4区医学

Current drug targets Pub Date : 2023-11-29 DOI: 10.2174/0113894501267496231102114410

Poonam Patil, Gaurav Doshi

{"title":"Deciphering the Role of Pyroptosis Impact on Cardiovascular Diseases","authors":"Poonam Patil, Gaurav Doshi","doi":"10.2174/0113894501267496231102114410","DOIUrl":"https://doi.org/10.2174/0113894501267496231102114410","url":null,"abstract":": Pyroptosis has become a noteworthy area of focus in recent years due to its association with inflammatory diseases. Pyroptosis is a type of programmed cell death accompanied by an inflammatory response, and the discovery of the gasdermin family has expanded the study of pyroptosis. The primary characteristics of pyroptosis include cell expansion, membrane penetration, and the ejection of cell contents. In healthy physiology, pyroptosis is an essential part of the host's defence against pathogen infection. Excessive Pyroptosis, however, can lead to unchecked and persistent inflammatory responses, including the emergence of inflammatory diseases. More precisely, gasdermin family members have a role in the creation of membrane holes during pyroptosis, which leads to cell lysis. It is also related to how pro-inflammatory intracellular substances, including IL-1, IL-18, and High mobility group box 1 (HMGB1), are used. Two different signalling pathways, one of which is regulated by caspase-1 and the other by caspase-4/5/11, are the primary causes of pyroptosis. Cardiovascular diseases are often associated with cell death and acute or chronic inflammation, making this area of research particularly relevant. In this review, we first systematically summarize recent findings related to Pyroptosis, exploring its characteristics and the signalling pathway mechanisms, as well as various treatment strategies based on its modulation that has emerged from the studies. Some of these strategies are currently undergoing clinical trials. Additionally, the article elaborates on the scientific evidence indicating the role of Pyroptosis in various cardiovascular diseases. As a whole, this should shed insight into future paths and present innovative ideas for employing Pyroptosis as a strong disease-fighting weapon.","PeriodicalId":10805,"journal":{"name":"Current drug targets","volume":"46 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138503882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomarkers and Treatment Strategies for Breast Cancer Recurrence 乳腺癌复发的生物标志物和治疗策略

IF 3.2 4区医学

Current drug targets Pub Date : 2023-11-29 DOI: 10.2174/0113894501258059231103072025

Shivam Rajput, Pramod Kumar Sharma, Rishabha Malviya

{"title":"Biomarkers and Treatment Strategies for Breast Cancer Recurrence","authors":"Shivam Rajput, Pramod Kumar Sharma, Rishabha Malviya","doi":"10.2174/0113894501258059231103072025","DOIUrl":"https://doi.org/10.2174/0113894501258059231103072025","url":null,"abstract":": Despite recent treatment advancements, breast cancer remains a life-threatening disease. Although treatment is successful in the early stages, a significant proportion of individuals with breast cancer eventually experience a recurrence of the disease. Breast tumour recurrence poses a significant medical issue. Despite tumours being a primary cause of mortality, there remains a limited understanding of the fundamental mechanisms underlying tumour recurrence. The majority of the time, after surgery or medical treatment, this metastatic disease manifests itself after the disease is undiagnosed for a considerable amount of time. This phenomenon is commonly referred to as a relapse or recurrence. Metastatic breast cancer has the potential to recur at varying intervals, ranging from a few months to several decades following the initial diagnosis and treatment. This article aimed to summarise the primary causes of breast cancer recurrence and highlight the key issues that need to be addressed in order to effectively decrease the mortality rate among breast cancer patients. This article discusses various therapeutic approaches currently employed and emerging treatment strategies that hold the potential for the complete cure of cancer.","PeriodicalId":10805,"journal":{"name":"Current drug targets","volume":"46 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138503881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Synthesis of BODIPY-TKI Conjugates and Investigation of Their Ability to Target the Epidermal Growth Factor Receptor BODIPY-TKI偶联物的合成及其靶向表皮生长因子受体能力的研究

IF 3.2 4区医学

Current drug targets Pub Date : 2023-08-30 DOI: 10.3390/targets1010005

S. Dhingra, Prajesh Shrestha, Arpan Chowdhury, Zehua Zhou, S. Jois, M. G. H. Vicente

{"title":"The Synthesis of BODIPY-TKI Conjugates and Investigation of Their Ability to Target the Epidermal Growth Factor Receptor","authors":"S. Dhingra, Prajesh Shrestha, Arpan Chowdhury, Zehua Zhou, S. Jois, M. G. H. Vicente","doi":"10.3390/targets1010005","DOIUrl":"https://doi.org/10.3390/targets1010005","url":null,"abstract":"A near-IR BODIPY was covalently conjugated via its isothiocyanate groups to one or two Erlotinib molecules, a known tyrosine kinase inhibitor (TKI), via triethylene glycol spacers, to produce two novel BODIPY-monoTKI and BODIPY-diTKI conjugates. The ability of these conjugates to target the intracellular domain of the epidermal growth factor receptor (EGFR) was investigated using molecular modeling, surface plasma resonance (SPR), EGFR kinase binding assay, time-dependent cellular uptake, and fluorescence microscopy. While both the BODIPY-monoTKI and the BODIPY-diTKI conjugates were shown to bind to the EGFR kinase by SPR and accumulated more efficiently within human HEp2 cells that over-express EGFR than BODIPY alone, only the BODIPY-monoTKI exhibited kinase inhibition activity. This is due to the high hydrophobic character and aggregation behavior of the BODIPY-diTKI in aqueous solutions, as shown by fluorescence quenching. Furthermore, the competition of the two Erlotinibs in the diTKI conjugate for the active site of the kinase, as suggested by computational modeling, might lead to a decrease in binding relative to the monoTKI conjugate. Nevertheless, the efficient cellular uptake and intracellular localization of both conjugates with no observed cytotoxicity suggest that both could be used as near-IR fluorescent markers for cells that over-express EGFR.","PeriodicalId":10805,"journal":{"name":"Current drug targets","volume":"118 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86254982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Activatable Nanoscintillator Probe for Detecting Telomerase Activity and Screening Inhibitors In Vivo 用于检测端粒酶活性和筛选体内抑制剂的可活化纳米闪烁探针

IF 3.2 4区医学

Current drug targets Pub Date : 2023-06-14 DOI: 10.3390/targets1010004

Baoliu Chen, Junduan Dai, Sijie Song, Xianzhe Tang, Yu-lin Guo, Ting Wu, Meng-Han Wu, Chaojie Hao, Xiaofeng Cheng, Xucong Lin, Yijie Bian, Zhaowei Chen, Huanghao Yang

{"title":"An Activatable Nanoscintillator Probe for Detecting Telomerase Activity and Screening Inhibitors In Vivo","authors":"Baoliu Chen, Junduan Dai, Sijie Song, Xianzhe Tang, Yu-lin Guo, Ting Wu, Meng-Han Wu, Chaojie Hao, Xiaofeng Cheng, Xucong Lin, Yijie Bian, Zhaowei Chen, Huanghao Yang","doi":"10.3390/targets1010004","DOIUrl":"https://doi.org/10.3390/targets1010004","url":null,"abstract":"Telomerase represents an essential molecular machinery for tumor occurrence and progression and a potential therapeutic target for cancer treatment. Sensitive and reliable analysis of telomerase activity is of significant importance for the diagnosis and treatment of cancer. In this study, we developed a telomerase-activated nanoscintillator probe for deep-tissue and background-free imaging of telomerase activity and screening telomerase inhibitors in tumor-bearing living mice models. The probe was constructed by modifying lanthanide-doped nanoscintillators with aptamer-containing DNA anchor strands which hybridized with quencher labelled–oligonucleotide strands and telomerase primers. The X-ray-induced fluorescence of the probe was quenched originally but turned on upon telomerase-catalyzed extension of the primer. Benefiting from exceptional tissue penetrating properties and negligible autofluorescence of X-ray excitation, this probe enabled direct detection of telomerase activity in vivo via fluorescence imaging. Furthermore, with the direct, readable fluorescent signals, the probe enabled the screening of telomerase inhibitors in living cells and whole-animal models in the native states of telomerase. This strategy would inspire the development of low autofluorescence and deep tissue bioimaging probes for disease diagnosis and drug development in high-level living settings.","PeriodicalId":10805,"journal":{"name":"Current drug targets","volume":"33 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84610037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Publisher’s Note: Targets—A New Open Access Journal 出版商注:目标-一个新的开放获取期刊

IF 3.2 4区医学

Current drug targets Pub Date : 2023-05-27 DOI: 10.3390/targets1010002

I. Craciun

引用次数: 0

Meet the Editorial Board Member 与编辑委员会成员见面

4区医学

Current drug targets Pub Date : 2023-04-01 DOI: 10.2174/138945012405230508151636

L. Zhang

引用次数: 0

Meet the Regional Editor 见见地区编辑

4区医学

Current drug targets Pub Date : 2023-04-01 DOI: 10.2174/138945012406230531150048

Silvio Danese

引用次数: 0