Current Rheumatology Reports最新文献_第8页

The Interplay of Biomechanical and Biological Changes Following Meniscus Injury. 半月板损伤后生物力学和生物学变化的相互作用

IF 5 2区医学

Current Rheumatology Reports Pub Date : 2023-02-01 Epub Date: 2022-12-07 DOI: 10.1007/s11926-022-01093-3

Patrick X Bradley, Karl N Thomas, Avery L Kratzer, Allison C Robinson, Jocelyn R Wittstein, Louis E DeFrate, Amy L McNulty

{"title":"The Interplay of Biomechanical and Biological Changes Following Meniscus Injury.","authors":"Patrick X Bradley, Karl N Thomas, Avery L Kratzer, Allison C Robinson, Jocelyn R Wittstein, Louis E DeFrate, Amy L McNulty","doi":"10.1007/s11926-022-01093-3","DOIUrl":"10.1007/s11926-022-01093-3","url":null,"abstract":"Purpose of review: Meniscus injury often leads to joint degeneration and post-traumatic osteoarthritis (PTOA) development. Therefore, the purpose of this review is to outline the current understanding of biomechanical and biological repercussions following meniscus injury and how these changes impact meniscus repair and PTOA development. Moreover, we identify key gaps in knowledge that must be further investigated to improve meniscus healing and prevent PTOA.Recent findings: Following meniscus injury, both biomechanical and biological alterations frequently occur in multiple tissues in the joint. Biomechanically, meniscus tears compromise the ability of the meniscus to transfer load in the joint, making the cartilage more vulnerable to increased strain. Biologically, the post-injury environment is often characterized by an increase in pro-inflammatory cytokines, catabolic enzymes, and immune cells. These multi-faceted changes have a significant interplay and result in an environment that opposes tissue repair and contributes to PTOA development. Additionally, degenerative changes associated with OA may cause a feedback cycle, negatively impacting the healing capacity of the meniscus. Strides have been made towards understanding post-injury biological and biomechanical changes in the joint, their interplay, and how they affect healing and PTOA development. However, in order to improve clinical treatments to promote meniscus healing and prevent PTOA development, there is an urgent need to understand the physiologic changes in the joint following injury. In particular, work is needed on the in vivo characterization of the temporal biomechanical and biological changes that occur in patients following meniscus injury and how these changes contribute to PTOA development.","PeriodicalId":10761,"journal":{"name":"Current Rheumatology Reports","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9626604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Has Molecular Biology Enhanced Our Undertaking of axSpA and Its Management. 分子生物学如何提高我们对 axSpA 及其管理的认识？

IF 5.7 2区医学

Current Rheumatology Reports Pub Date : 2023-01-01 Epub Date: 2022-10-29 DOI: 10.1007/s11926-022-01092-4

Mauro Fatica, Arianna D'Antonio, Lucia Novelli, Paola Triggianese, Paola Conigliaro, Elisabetta Greco, Alberto Bergamini, Carlo Perricone, Maria Sole Chimenti

{"title":"How Has Molecular Biology Enhanced Our Undertaking of axSpA and Its Management.","authors":"Mauro Fatica, Arianna D'Antonio, Lucia Novelli, Paola Triggianese, Paola Conigliaro, Elisabetta Greco, Alberto Bergamini, Carlo Perricone, Maria Sole Chimenti","doi":"10.1007/s11926-022-01092-4","DOIUrl":"10.1007/s11926-022-01092-4","url":null,"abstract":"Purpose: This review aims at investigating pathophysiological mechanisms in spondyloarthritis (SpA). Analysis of genetic factors, immunological pathways, and abnormalities of bone metabolism lay the foundations for a better understanding of development of the axial clinical manifestations in patients, allowing physician to choose the most appropriate therapeutic strategy in a more targeted manner.Recent findings: In addition to the contribution of MHC system, findings emerged about the role of non-HLA genes (as ERAP1 and 2, whose inhibition could represent a new therapeutic approach) and of epigenetic mechanisms that regulate the expression of genes involved in SpA pathogenesis. Increasing evidence of bone metabolism abnormalities secondary to the activation of immunological pathways suggests the development of various bone anomalies that are present in axSpA patients. SpA are a group of inflammatory diseases with a multifactorial origin, whose pathogenesis is linked to the genetic predisposition, the action of environmental risk factors, and the activation of immune response. It is now well known how bone metabolism leads to long-term structural damage via increased bone turnover, bone loss and osteoporosis, osteitis, erosions, osteosclerosis, and osteoproliferation. These effects can exist in the same patient over time or even simultaneously. Evidence suggests a cross relationship among innate immunity, autoimmunity, and bone remodeling in SpA, making treatment approach a challenge for rheumatologists. Specifically, treatment targets are consistently increasing as new drugs are upcoming. Both biological and targeted synthetic drugs are promising in terms of their efficacy and safety profile in patients affected by SpA.","PeriodicalId":10761,"journal":{"name":"Current Rheumatology Reports","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9568134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuromodulation as a Potential Disease-Modifying Therapy for Osteoarthritis. 将神经调节作为骨关节炎的一种潜在疾病调节疗法

IF 5.7 2区医学

Current Rheumatology Reports Pub Date : 2023-01-01 Epub Date: 2022-11-26 DOI: 10.1007/s11926-022-01094-2

Carlos J Cruz, L Savannah Dewberry, Kevin J Otto, Kyle D Allen

{"title":"Neuromodulation as a Potential Disease-Modifying Therapy for Osteoarthritis.","authors":"Carlos J Cruz, L Savannah Dewberry, Kevin J Otto, Kyle D Allen","doi":"10.1007/s11926-022-01094-2","DOIUrl":"10.1007/s11926-022-01094-2","url":null,"abstract":"Purpose of review: The following review discusses the therapeutic potential of targeting the autonomic nervous system (ANS) for osteoarthritis (OA) treatment and encourages the field to consider the candidacy of bioelectronic medicine as a novel OA treatment strategy.Recent findings: The study of OA pathogenesis has focused on changes occurring at the joint level. As such, treatments for OA have been aimed at the local joint environment, intending to resolve local inflammation and decrease pain. However, OA pathogenesis has shown to be more than joint wear and tear. Specifically, OA-related peripheral and central sensitization can prompt neuroplastic changes in the nervous system beyond the articular joint. These neuroplastic changes may alter physiologic systems, like the neuroimmune axis. In this way, OA and related comorbidities may share roots in the form of altered neuroimmune communication and autonomic dysfunction. ANS modulation may be able to modify OA pathogenesis or reduce the impact of OA comorbidities. Moreover, blocking chronic nociceptive drive from the joint may help to prevent maladaptive nervous system plasticity in OA.","PeriodicalId":10761,"journal":{"name":"Current Rheumatology Reports","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9561235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurosarcoidosis: Phenotypes, Approach to Diagnosis and Treatment. 神经结节病:表型，诊断和治疗方法。

IF 5 2区医学

Current Rheumatology Reports Pub Date : 2022-12-01 Epub Date: 2022-10-12 DOI: 10.1007/s11926-022-01089-z

Jeanne Gosselin, Chantal Roy-Hewitson, Sean S M Bullis, John C DeWitt, Bruno P Soares, Sidarth Dasari, Alana Nevares

{"title":"Neurosarcoidosis: Phenotypes, Approach to Diagnosis and Treatment.","authors":"Jeanne Gosselin, Chantal Roy-Hewitson, Sean S M Bullis, John C DeWitt, Bruno P Soares, Sidarth Dasari, Alana Nevares","doi":"10.1007/s11926-022-01089-z","DOIUrl":"https://doi.org/10.1007/s11926-022-01089-z","url":null,"abstract":"Purpose of review: The aim of this review is to provide an update of clinical presentation, diagnosis, differential diagnoses, and treatment according to recent evidence.Recent findings: Neurosarcoidosis remains a diagnosis of exclusion, with infectious and malignant etiologies recognized as important mimickers. Corticosteroids remain as first-line therapy. In recent years, however, studies have demonstrated the effectiveness of anti-tumor necrosis factor (anti-TNF) therapy in the treatment of neurosarcoidosis, leading to improved outcomes. Neurosarcoidosis is a granulomatous disease with protean manifestations that may affect any part of the central and peripheral nervous system. It has many mimickers, and potentially devastating complications necessitating long-term follow-up. Early initiation of treatment, particularly with anti-TNF therapy, may lead to better outcomes and fewer relapses. There is an unmet need for randomized controlled trials that provide robust data to guide therapy and the long-term management of neurosarcoidosis patients.","PeriodicalId":10761,"journal":{"name":"Current Rheumatology Reports","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33500885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

T cell Repertoire Profiling and the Mechanism by which HLA-B27 Causes Ankylosing Spondylitis. T细胞库谱分析和HLA-B27引起强直性脊柱炎的机制。

IF 5 2区医学

Current Rheumatology Reports Pub Date : 2022-12-01 Epub Date: 2022-10-05 DOI: 10.1007/s11926-022-01090-6

Jose Garrido-Mesa, Matthew A Brown

{"title":"T cell Repertoire Profiling and the Mechanism by which HLA-B27 Causes Ankylosing Spondylitis.","authors":"Jose Garrido-Mesa, Matthew A Brown","doi":"10.1007/s11926-022-01090-6","DOIUrl":"https://doi.org/10.1007/s11926-022-01090-6","url":null,"abstract":"Purpose of review: Ankylosing spondylitis (AS) is strongly associated with the HLA-B27 gene. The canonical function of HLA-B27 is to present antigenic peptides to CD8 lymphocytes, leading to adaptive immune responses. The 'arthritogenic peptide' theory as to the mechanism by which HLA-B27 induces ankylosing spondylitis proposes that HLA-B27 presents peptides derived from exogenous sources such as bacteria to CD8 lymphocytes, which subsequently cross-react with antigens at the site of inflammation of the disease, causing inflammation. This review describes findings of studies in AS involving profiling of T cell expansions and discusses future research opportunities based on these findings.Recent findings: Consistent with this theory, there is an expanding body of data showing that expansion of a restricted pool of CD8 lymphocytes is found in most AS patients yet only in a small proportion of healthy HLA-B27 carriers. These exciting findings strongly support the theory that AS is driven by presentation of antigenic peptides to the adaptive immune system by HLA-B27. They point to new potential approaches to identify the exogenous and endogenous antigens involved and to potential therapies for the disease.","PeriodicalId":10761,"journal":{"name":"Current Rheumatology Reports","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33505092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Use of Imaging in Axial Spondyloarthritis for Diagnosis and Assessment of Disease Remission in the Year 2022. 2022年影像学在轴型脊柱炎诊断和疾病缓解评估中的应用

IF 5 2区医学

Current Rheumatology Reports Pub Date : 2022-12-01 Epub Date: 2022-10-15 DOI: 10.1007/s11926-022-01091-5

Ann-Sophie De Craemer, Zuzanna Łukasik, Philippe Carron

{"title":"Use of Imaging in Axial Spondyloarthritis for Diagnosis and Assessment of Disease Remission in the Year 2022.","authors":"Ann-Sophie De Craemer, Zuzanna Łukasik, Philippe Carron","doi":"10.1007/s11926-022-01091-5","DOIUrl":"https://doi.org/10.1007/s11926-022-01091-5","url":null,"abstract":"Medical imaging remains the cornerstone of diagnostics and follow-up of axial spondyloarthritis (axSpA) patients. With the lack of specific biomarkers allowing monitoring of disease activity and progression, clinicians refer to imaging modalities for accurate evaluation of the axSpA burden. Technological advances and increasing availability of modern imaging techniques such as MRI have enabled faster diagnosis of the disease, hence dramatically changed the diagnostic delay and improved the prognosis and functional outcomes for axSpA patients.Active sacroiliitis as visualized by MRI has been widely accepted as a diagnostic tool, and definitions of inflammatory and structural lesions within the axial skeleton have been developed. Recently, it has been acknowledged that bone marrow edema, suggestive of sacroiliitis, is a common finding among non-SpA patients, and could be attributed to mechanical loading or accumulate with age in healthy individuals. Therefore, it is crucial to distinguish between true pathological and concealing imaging findings, not only for diagnostic but also for disease remission purposes. New imaging modalities, aimed for in vivo visualization of specific molecular processes, could be employed to cross-validate findings from techniques used in daily clinical practice. This review critically evaluates the use of different imaging modalities for diagnosis and assessment of disease remission in axSpA in the year 2022.","PeriodicalId":10761,"journal":{"name":"Current Rheumatology Reports","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33513228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

At the Heart of Eosinophilic Granulomatosis with Polyangiitis: into Cardiac and Vascular Involvement. 嗜酸性肉芽肿病合并多血管炎的心脏:进入心脏和血管累及。

IF 5 2区医学

Current Rheumatology Reports Pub Date : 2022-11-01 Epub Date: 2022-10-04 DOI: 10.1007/s11926-022-01087-1

Milena Bond, Filippo Fagni, Michele Moretti, Federica Bello, Allyson Egan, Augusto Vaglio, Giacomo Emmi, Christian Dejaco

{"title":"At the Heart of Eosinophilic Granulomatosis with Polyangiitis: into Cardiac and Vascular Involvement.","authors":"Milena Bond, Filippo Fagni, Michele Moretti, Federica Bello, Allyson Egan, Augusto Vaglio, Giacomo Emmi, Christian Dejaco","doi":"10.1007/s11926-022-01087-1","DOIUrl":"https://doi.org/10.1007/s11926-022-01087-1","url":null,"abstract":"Purpose of review: To provide an overview of existing literature on pathogenetic and clinical aspects of cardiac and vascular involvement in eosinophilic granulomatosis with polyangiitis (EGPA).Recent findings: In EGPA, cardiac and vascular involvement are more common than previously thought. However, no international recommendations on the topic are available yet. Herein, we summarize the existing evidence on the topic and propose a diagnostic approach for cardiac involvement in EGPA. The prevalence of cardiovascular involvement in patients with EGPA varies greatly among published studies, ranging between 3.1-18.7% for occlusive arterial disease, 5.8-30% for venous thrombosis and 17-92% for heart involvement. Cardiac involvement in EGPA is associated with high mortality even though manifestations are heterogeneous. In principle, every anatomical structure of the heart can be involved, and EGPA-related heart disease may be completely asymptomatic at first. A careful diagnostic work-up for early detection and prompt treatment initiation is therefore required. While cardiac manifestations are more common in anti-neutrophil cytoplasmic antibodies (ANCA)-negative patients, arterial and venous thrombotic events are not linked to ANCA status but correlate closely with disease activity and accumulate at disease onset. Thrombotic events (mainly venous) are considerably more frequent in EGPA than in the general population contributing substantially to morbidity and highlighting the importance of developing specific prevention strategies for patients who are diagnosed with EGPA.","PeriodicalId":10761,"journal":{"name":"Current Rheumatology Reports","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33488087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A Spotlight on Drug-Induced Vasculitis. 药物性血管炎研究进展

IF 5 2区医学

Current Rheumatology Reports Pub Date : 2022-11-01 Epub Date: 2022-09-21 DOI: 10.1007/s11926-022-01088-0

Kinanah Yaseen, Alana Nevares, Hiromichi Tamaki

引用次数: 7

Spectrum of Large and Medium Vessel Vasculitis in Adults: Primary Vasculitides, Arthritides, Connective Tissue, and Fibroinflammatory Diseases. 成人大、中血管炎谱：原发性血管炎、关节炎、结缔组织和纤维炎症。

IF 5.7 2区医学

Current Rheumatology Reports Pub Date : 2022-11-01 Epub Date: 2022-09-27 DOI: 10.1007/s11926-022-01086-2

Luca Seitz, Pascal Seitz, Roxana Pop, Fabian Lötscher

{"title":"Spectrum of Large and Medium Vessel Vasculitis in Adults: Primary Vasculitides, Arthritides, Connective Tissue, and Fibroinflammatory Diseases.","authors":"Luca Seitz, Pascal Seitz, Roxana Pop, Fabian Lötscher","doi":"10.1007/s11926-022-01086-2","DOIUrl":"10.1007/s11926-022-01086-2","url":null,"abstract":"Purpose of review: To provide a comprehensive overview of the spectrum of large and medium vessel vasculitis in adults with primary vasculitides, arthritides, connective tissue, and fibroinflammatory diseases as well as vasculitis mimics, for an efficient differential diagnosis and initial diagnostic approach.Recent findings: Imaging has had a tremendous impact on the diagnosis of medium to large vessel vasculitis, now often replacing histopathologic confirmation and identifying new disease manifestations (e.g., intracranial disease in giant cell arteritis; vascular manifestations of IgG4-related disease). Novel diseases or syndromes involving blood vessels have been described (e.g., VEXAS-Syndrome with polychondritis). The use of the terms \"medium\" or \"large\" vessel varies considerably between medical specialties. The differential diagnosis of large and medium vessel vasculitis is becoming increasingly complex as new entities or disease manifestations of known inflammatory rheumatic diseases are regularly identified. A more precise and widely recognized definition of the vessel sizes would make future research more comparable.","PeriodicalId":10761,"journal":{"name":"Current Rheumatology Reports","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40377740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectrum of Large- and Medium-Vessel Vasculitis in Adults: Neoplastic, Infectious, Drug-Induced, Autoinflammatory, and Primary Immunodeficiency Diseases. 成人大血管和中血管炎谱：肿瘤性、感染性、药物诱发、自身炎症和原发性免疫缺陷疾病。

IF 5.7 2区医学

Current Rheumatology Reports Pub Date : 2022-10-01 Epub Date: 2022-08-03 DOI: 10.1007/s11926-022-01083-5

Fabian Lötscher, Roxana Pop, Pascal Seitz, Mike Recher, Luca Seitz

引用次数: 0