Current Psychopharmacology最新文献

{"title":"Dermatologic Effects of Psychopharmacologic Agents in the Pediatric Population","authors":"A. Yamasaki, A. Leonov, D. Greydanus","doi":"10.2174/2211556007666180126112844","DOIUrl":"https://doi.org/10.2174/2211556007666180126112844","url":null,"abstract":"","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73969044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Adverse Effects from Atypical Antipsychotics","authors":"Ahsan Nazeer and Joseph L. Calles","doi":"10.2174/2211556007666180220162945","DOIUrl":"https://doi.org/10.2174/2211556007666180220162945","url":null,"abstract":"","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"461 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76730496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Effects of Psychopharmacologic Products in Pediatrics: Primum Non Nocere!","authors":"D. Greydanus","doi":"10.2174/221155600701180716121401","DOIUrl":"https://doi.org/10.2174/221155600701180716121401","url":null,"abstract":"","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89784659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"6-hydroxydopamine Lesion of the Mesolimbic Dopamine System Alters Morphine-Induced Conditioned Reinforcement","authors":"S. T. D. A. B. Plotkin","doi":"10.2174/2211556007666180131154111","DOIUrl":"https://doi.org/10.2174/2211556007666180131154111","url":null,"abstract":"","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80122553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Adverse Effects from Medications Used to Treat Substance Use Disorders","authors":"Joseph L. Calles","doi":"10.2174/2211556006666171124161420","DOIUrl":"https://doi.org/10.2174/2211556006666171124161420","url":null,"abstract":"","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88192710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunologic Effects of Psychotropic Pharmaco-Therapeutics","authors":"A. Leonov, D. Greydanus, Hc Athens","doi":"10.2174/2211556006666171019155320","DOIUrl":"https://doi.org/10.2174/2211556006666171019155320","url":null,"abstract":"","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75244142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intramuscular Route of Administration Increases Potency in Eliciting Cocaine-Induced Behavioral Sensitization.","authors":"Beth Ann Rice,&nbsp;Raza Tariq,&nbsp;Chana K Akins","doi":"10.2174/2211556005666160902170354","DOIUrl":"https://doi.org/10.2174/2211556005666160902170354","url":null,"abstract":"<p><strong>Background: </strong>Cocaine is the number one abused psychostimulant drug that reaches addiction criterion in the US. In animals, repeated administration of cocaine results in behavioral sensitization which is thought to represent adaptations in the mesolimbic dopamine neural circuitry, the reward pathway. Cocaine-induced behavioral sensitization is evident in rodents and quail when cocaine is administered intraperitoneally (IP).</p><p><strong>Objectives: </strong>The purpose of the current study was to investigate dose-dependent and temporal effects of acute and chronic intramuscular (IM) administration of cocaine in male quail.</p><p><strong>Methods: </strong>After habituation to the test chambers, male quail received an IM injection of saline, 3 or 10 mg/kg cocaine and were immediately placed in the chambers. Distance traveled (in meters) was recorded in 5 min time bins for 30 min. Testing was conducted once per day for ten days with each subject receiving the same treatment throughout the experiment. Other behaviors including pecking, preening, and feather fluffing were measured.</p><p><strong>Results: </strong>Cocaine-induced behavioral sensitization and tolerance were evident at relatively low doses of IM cocaine. Dose-dependent effects were evident. IM cocaine also reduced feather fluffing, a behavior that typically occurs during hypothermia.</p><p><strong>Conclusions: </strong>The findings replicated and extended previous research with pigeons and suggested that IM administration of cocaine may be a relatively potent route of administration. Potency of drugs of abuse may be related to the bioavailability of a drug and its addictive properties. Thus, studying drugs of abuse using an IM route of administration may be useful in drug addiction research.</p>","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"6 1","pages":"36-42"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665583/pdf/nihms872257.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35576945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of calcium channels in bipolar disorder.","authors":"Stasia D'Onofrio, Susan Mahaffey, Edgar Garcia-Rill","doi":"10.2174/2211556006666171024141949","DOIUrl":"10.2174/2211556006666171024141949","url":null,"abstract":"<p><p>Bipolar disorder is characterized by a host of sleep-wake abnormalities that suggests that the reticular activating system (RAS) is involved in these symptoms. One of the signs of the disease is a decrease in high frequency gamma band activity, which accounts for a number of additional deficits. Bipolar disorder has also been found to overexpress neuronal calcium sensor protein 1 (NCS-1). Recent studies showed that elements in the RAS generate gamma band activity that is mediated by high threshold calcium (Ca²⁺) channels. This mini-review provides a description of recent findings on the role of Ca²⁺ and Ca²⁺ channels in bipolar disorder, emphasizing the involvement of arousal-related systems in the manifestation of many of the disease symptoms. This will hopefully bring attention to a much-needed area of research and provide novel avenues for therapeutic development.</p>","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"6 2","pages":"122-135"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771645/pdf/nihms933220.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35755325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on the Pharmacological Treatment of Pathological Gambling.","authors":"Scott A Bullock,&nbsp;Marc N Potenza","doi":"10.2174/22115560113029990008","DOIUrl":"https://doi.org/10.2174/22115560113029990008","url":null,"abstract":"<p><p>This is an update to a previously published article discussing the neuropsychopharmacology of pathological gambling (PG) (1). In the prior manuscript, we described how cortico-limbic circuitry and neurotransmitter systems (norepinephrine, serotonin, dopamine, opioids, glutamate, and gamma-aminobutyric acid (GABA)) have been implicated in PG. These systems represent potential targets for psychopharmacological treatments for PG, with opioid antagonists arguably showing the most consistent benefit in RCTs. In the past year and half since this publication was prepared, there has been one additional randomized clinical trial (RCT) published along with a single case study. Our original manuscript did not describe in detail findings from case studies or open-label studies so in addition to the new RCT data and a new case report involving naltrexone, here we describe case and open-label findings. A PubMed search was conducted using terms such as \"pathological gambling treatment\", \"clinical trials and gambling\", and \"gambling psychopharmacology.\" Using these search terms, numerous results were obtained, necessitating further search modifiers. For example, using just \"pathological gambling treatment\" results in over 1600 hits. In order to focus in on the search modalities, we searched within the initial results for specific phrases such as \"psychopharmacology, clinical trial, medication, serotonergic, dopaminergic, etc.\" in addition to searching for specific medications. Results not directly related to the treatment of pathological gambling were not included. The study of pathological gambling is relatively new. As such, our search did not exclude any studies due to age of material, but with a few exceptions, the majority of the studies discussed were published later than 2000. This resulted in 24 case studies and/or RCTs not previously included in our original review article. These findings in conjunction with our prior publication provide a comprehensive overview of controlled investigations and exploratory reports of pharmacotherapies for PG.</p>","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"2 3","pages":"204-211"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220454/pdf/nihms565537.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32804378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene Expression Under the Influence: Transcriptional Profiling of Ethanol in the Brain.","authors":"Candice Contet","doi":"10.2174/2211556011201040301","DOIUrl":"10.2174/2211556011201040301","url":null,"abstract":"<p><p>Sensitivity to ethanol intoxication, propensity to drink ethanol and vulnerability to develop alcoholism are all influenced by genetic factors. Conversely, exposure to ethanol or subsequent withdrawal produce gene expression changes, which, in combination with environmental variables, may participate in the emergence of compulsive drinking and relapse. The present review offers an integrated perspective on brain gene expression profiling in rodent models of predisposition to differential ethanol sensitivity or consumption, in rats and mice subjected to acute or chronic ethanol exposure, as well as in human alcoholics. The functional categories over-represented among differentially expressed genes suggest that the transcriptional effects of chronic ethanol consumption contribute to the neuroplasticity and neurotoxicity characteristic of alcoholism. Importantly, ethanol produces distinct transcriptional changes within the different brain regions involved in intoxication, reinforcement and addiction. Special emphasis is put on recent profiling studies that have provided some insights into the molecular mechanisms potentially mediating genome-wide regulation of gene expression by ethanol. In particular, current evidence for a role of transcription factors, chromatin remodeling and microRNAs in coordinating the expression of large sets of genes in animals predisposed to excessive ethanol drinking or exposed to protracted abstinence, as well as in human alcoholics, is presented. Finally, studies that have compared ethanol with other drugs of abuse have highlighted common gene expression patterns that may play a central role in drug addiction. The availability of novel technologies and a focus on mechanistic approaches are shaping the future of ethanol transcriptomics.</p>","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"1 4","pages":"301-314"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783024/pdf/nihms483417.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31769346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}