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Molecular Docking, Drug likeness Studies and ADMET prediction of Flavonoids as Platelet-Activating Factor (PAF) Receptor Binding 黄酮类化合物与血小板活化因子(PAF)受体结合的分子对接、药物相似性研究及ADMET预测
IF 1.8 3区 管理学
College & Research Libraries Pub Date : 2021-05-01 DOI: 10.22034/CRL.2021.262806.1098
M. Bouachrine, Larbi Elmchichi, A. E. Aissouq, A. Belhassan, H. Zaki, A. Ouammou, T. Lakhlifi
{"title":"Molecular Docking, Drug likeness Studies and ADMET prediction of Flavonoids as Platelet-Activating Factor (PAF) Receptor Binding","authors":"M. Bouachrine, Larbi Elmchichi, A. E. Aissouq, A. Belhassan, H. Zaki, A. Ouammou, T. Lakhlifi","doi":"10.22034/CRL.2021.262806.1098","DOIUrl":"https://doi.org/10.22034/CRL.2021.262806.1098","url":null,"abstract":"Studies and scientific research indicate that the platelet-activating factor (PAF) is a major pro-inflammatory mediator in the initiation and development of cancer. There is also evidence confirming that PAF is an integral part of suppressing the immune system and promoting the appearance of a malignant tumor. For this reason, it is useful to analyze the molecular docking data of eleven flavonoids derivatives isolated from the active leaf extracted from chromolaena odorata with their anti-PAF activity. As a result, it is evident that the natural product of flavonoids may have a positive effect in the development of both therapeutic and preventive agents for platelet activating factor (PAF) antagonist and suggests potential guidelines for the design of PAF inhibitors. Based on the docking score analysis, drug likeness study, and ADMET prediction. We found that six compounds respect all drug-likeness rules and can be used as a potent molecule for inhibition of platelet activating factor (PAF).","PeriodicalId":10686,"journal":{"name":"College & Research Libraries","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89212704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
In Silico Adsorption of Lomustin anticancer drug on the surface of Boron Nitride nanotube 氮化硼纳米管表面Lomustin抗癌药物的硅吸附
IF 1.8 3区 管理学
College & Research Libraries Pub Date : 2021-05-01 DOI: 10.22034/CRL.2021.290865.1111
M. Afshar, R. R. Khojasteh, R. Ahmadi, M. N. Moghaddam
{"title":"In Silico Adsorption of Lomustin anticancer drug on the surface of Boron Nitride nanotube","authors":"M. Afshar, R. R. Khojasteh, R. Ahmadi, M. N. Moghaddam","doi":"10.22034/CRL.2021.290865.1111","DOIUrl":"https://doi.org/10.22034/CRL.2021.290865.1111","url":null,"abstract":"The present study aimed to assess the adsorption of Lomustin on the single-walled Boron Nitride nanotube which has been examined using Density Functional Theory (DFT), agent in a solvent phase (water) at the B3LYP/6-31G (d) theoretical level. Initially, the structures of Lomustin, Boron Nitride nanotube, and Lomustin complexes with Boron Nitride nanotubes were designed in Gauss View in three different conformers and were optimized geometrically, on which IR and frontier molecular orbital computations were carried out. Adsorption energy values, Gibbs free energy changes (ΔGad), adsorption enthalpy changes (ΔHad), and equilibrium thermodynamic constants were estimated. The results showed that adsorption process was spontaneous, exothermic and non-equilibrium. The values of specific heat capacity and adsorption enthalpy indicate that this nanostructure can be used to build new thermal sensors to measure Lomustin. The results of molecule orbitals estimations showed that energy gap, after drug absorption on the nanotube surface, decreased significantly and the values of chemical hardness and dipole moment were studied after the interaction of drug with adsorbent and the results showed that drug solubility and reactivity, after adsorption on Boron Nitride nanotubes, increased significantly. According to the obtained results for adsorption of Lomustin, this nanostructure can be used as a sensing material in building new electrochemical sensors to measure this drug.","PeriodicalId":10686,"journal":{"name":"College & Research Libraries","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88729114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Efficient and environmentally sustainable domino protocol for the synthesis of diversified dispiroheterocycles using 1-Butyl-3-methylimidazolium bromide [bmim]Br 利用1-丁基-3-甲基咪唑溴[bmim]Br合成多种双杂环的高效和环境可持续多米诺骨牌方案
IF 1.8 3区 管理学
College & Research Libraries Pub Date : 2021-05-01 DOI: 10.22034/CRL.2021.278900.1107
C. Gill, Makrand V. Kulkarni, C. Jadhav, Amol S. Nipate, Bhausaheb K. Magar
{"title":"Efficient and environmentally sustainable domino protocol for the synthesis of diversified dispiroheterocycles using 1-Butyl-3-methylimidazolium bromide [bmim]Br","authors":"C. Gill, Makrand V. Kulkarni, C. Jadhav, Amol S. Nipate, Bhausaheb K. Magar","doi":"10.22034/CRL.2021.278900.1107","DOIUrl":"https://doi.org/10.22034/CRL.2021.278900.1107","url":null,"abstract":"An environmentally benign, simple, and efficient procedure has been developed for the construct of some symmetrical dispiroheterocycles derivatives by the reaction of the variety of 6-amino-2-thiouracil/6-aminouracil /2-amino-1,3,4-thiadiazole, isatins and p-toluidine in the presence of 1-Butyl-3-methylimidazolium bromide ([bmim]Br) as a solvent as well as catalyst at room temperature. In this study, a variety of bis-spiro-indoline-chromenes, pyranopyranes, imidazo-pyridines, pyrido-pyrimidines and pyridines were obtained with excellent yields within short reaction time and without chromatographic separation. Furthermore, the green catalytic system can be recycled specific times with no decreases in yields and reaction rates.","PeriodicalId":10686,"journal":{"name":"College & Research Libraries","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84319323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Docking Simulations and Virtual Screening to find Novel Ligands for T3S in Yersinia pseudotuberculosis YPIII, A drug target for type III secretion (T3S) in the Gram-negative pathogen Yersinia pseudotuberculosis 伪结核耶尔森菌III型分泌(T3S)药物靶点YPIII对接模拟和虚拟筛选寻找新型T3S配体
IF 1.8 3区 管理学
College & Research Libraries Pub Date : 2021-05-01 DOI: 10.22034/CRL.2021.254804.1088
E. Edache, Uzairu Adamu, P. Mamza, Gideon Adamu Shallangwa
{"title":"Docking Simulations and Virtual Screening to find Novel Ligands for T3S in Yersinia pseudotuberculosis YPIII, A drug target for type III secretion (T3S) in the Gram-negative pathogen Yersinia pseudotuberculosis","authors":"E. Edache, Uzairu Adamu, P. Mamza, Gideon Adamu Shallangwa","doi":"10.22034/CRL.2021.254804.1088","DOIUrl":"https://doi.org/10.22034/CRL.2021.254804.1088","url":null,"abstract":"In the Gram-negative pathogen Yersinia pseudotuberculosis and Chlamydia, the aggregate use of molecular docking, molecular dynamic simulations, and ADMET was successfully used to develop salicylidene acyl hydrazides as type III secretion (T3S) inhibitors. The molecular docking analysis was carried out on CMP's simulated protein, which helped to correlate amino acid associations with the ligand. The review of molecular dynamics simulations showed that the CMP protein A-chain was stable at and above 100ps concerning temperature, total energy, and kinetic energy. Virtual screening was performed to distinguish the new inhibitors depending on pharmacophore modeling and molecular docking. Based on the Rerank score fitness feature, ten top-ranked compounds were discovered. In keeping with the reference ranges, ADME tests were carried out on compounds retrieved from simulated sampling. For our further drug design, all the findings will give us more useful evidence.","PeriodicalId":10686,"journal":{"name":"College & Research Libraries","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78183808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Pyrolysis of plastic wastes as a way of obtaining valuable chemical raw materials (n1) 塑料废弃物热解获得有价值的化工原料(n1)
IF 1.8 3区 管理学
College & Research Libraries Pub Date : 2021-04-01 DOI: 10.22034/CRL.2021.272418.1101
Krystian Leski, Gabriela Berkowicz-Płatek
{"title":"Pyrolysis of plastic wastes as a way of obtaining valuable chemical raw materials (n1)","authors":"Krystian Leski, Gabriela Berkowicz-Płatek","doi":"10.22034/CRL.2021.272418.1101","DOIUrl":"https://doi.org/10.22034/CRL.2021.272418.1101","url":null,"abstract":"This article presents a mini-review of the literature on the laboratory scale pyrolysis of selected plastic waste. Among the various types of polymer materials polyolefins (PE and PP), as well as polystyrene (PS), polyoxymethylene (POM), and polyvinyl chloride (PVC), were selected. The paper highlights valuable compounds and chemical raw materials can be obtained by pyrolyzing the waste polymers.","PeriodicalId":10686,"journal":{"name":"College & Research Libraries","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87287331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Computational techniques in designing a series of 1,3,4-trisubstituted pyrazoles as unique hepatitis C virus entry inhibitors 设计一系列1,3,4-三取代吡唑作为独特丙型肝炎病毒进入抑制剂的计算技术
IF 1.8 3区 管理学
College & Research Libraries Pub Date : 2021-04-01 DOI: 10.22034/CRL.2021.248725.1079
S. Ejeh, A. Uzairu, G. Shallangwa, S. Abechi
{"title":"Computational techniques in designing a series of 1,3,4-trisubstituted pyrazoles as unique hepatitis C virus entry inhibitors","authors":"S. Ejeh, A. Uzairu, G. Shallangwa, S. Abechi","doi":"10.22034/CRL.2021.248725.1079","DOIUrl":"https://doi.org/10.22034/CRL.2021.248725.1079","url":null,"abstract":"In this study, we developed a QSAR model for studying the antiviral activity of 1,3,4-trisubstituted pyrazoles derivatives on hepatitis C virus infected in human HuH-7 cell lines. We employed random analysis to split the data sets. Statistically robust model was generated with R2, Q2 and R2pred values of 0.777, 0.731 and 0.774 respectively. The reliability of this model was confirmed by acceptable validation parameters, and this model also fulfilled the Golbraikh and Tropsha standard model conditions. Through the evaluation of selected molecular descriptors we observed that, topological charge index of order 4 (GGI4), mean topological charge index of order 1 (JGI1), octanol water partition coefficient (XlogP), 3D topological distance based autocorrelation lag5/weighted by polarizabilities (TDB5p) and total molecular surface area (FPSA-2) are the molecular properties determining biological activities of the study compounds, which shed light on the vital features that aid in the design of unique potent hepatitis C virus entry inhibitors using computer-aided drug design tools.","PeriodicalId":10686,"journal":{"name":"College & Research Libraries","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85612973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Co-production of parabiotic metabolites by Lactobacillus acidophilus LA5 and Bifidobacterium animalis subsp. lactis BB12 in dairy effluents 嗜酸乳杆菌LA5与动物双歧杆菌亚群共生代谢物的研究。乳业废水中含有BB12
IF 1.8 3区 管理学
College & Research Libraries Pub Date : 2021-04-01 DOI: 10.22034/CRL.2021.253739.1086
S. Amiri, M. R. Bari, M. A. Khaledabad, R. Mokarram, M. S. Khiabani
{"title":"Co-production of parabiotic metabolites by Lactobacillus acidophilus LA5 and Bifidobacterium animalis subsp. lactis BB12 in dairy effluents","authors":"S. Amiri, M. R. Bari, M. A. Khaledabad, R. Mokarram, M. S. Khiabani","doi":"10.22034/CRL.2021.253739.1086","DOIUrl":"https://doi.org/10.22034/CRL.2021.253739.1086","url":null,"abstract":"In this study, the effects of initial pH (5 − 7), temperature (30 − 38 ◦C) and incubation time (12 − 48 h), as well as yeast extract and free linoleic acid concentrations, respectively (0 – 4 %) and (0 − 400 µL), on the co-production of conjugated linoleic acid (CLA), exopolysaccharides (EPSs) and bacteriocins (BACs) by Lactobacillus acidophilus LA5 and Bifidobacterium animalis subsp. lactis BB12 and their biomass in cheese whey and milk permeate were evaluated. The results showed that biomass, CLA, EPSs and BACs activity ranged Log 0.80 - Log 8.67 g.L-1, 3.08-107.95 µg.mL-1, 107.75-351.92 mg.L-1 and 9.29-14.62 mm, respectively. Yeast extract concentration was the only factor with the positive significant effect on biomass and parabiotic metabolites i.e. its increasing caused to an increase in both of them (p <0.05). The temperature significantly affected the production of biomass and CLA; its increasing resulted in increasing both (p <0.05). The initial pH had significant, but different, effects on EPSs and BACs production (p <0.05) i.e. EPSs and BACs production decreased and increased, respectively, as a result of increased initial pH. Increasing free linoleic acid concentration from 0 up to 400 µL led to increased CLA biosynthesis. Higher biomass, EPSs and BACs are produced in cheese whey, compared with milk permeate, but CLA produced in milk permeate was higher than that obtained in cheese whey. B. animalis BB12 produced more biomass, CLA and EPSs in comparison to L. acidophilus LA5. However, these probiotics had no statistical difference in terms of producing BACs. This work successfully demonstrated the co-production potential of CLA, EPSs and BACs by two commercial probiotics in dairy effluents.","PeriodicalId":10686,"journal":{"name":"College & Research Libraries","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90770625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Studies on Some Mechanical Properties of PVC-Wood Fiber Composite pvc -木纤维复合材料力学性能研究
IF 1.8 3区 管理学
College & Research Libraries Pub Date : 2021-04-01 DOI: 10.22034/CRL.2021.242652.1076
D. Arthur, J. N. Akoji, Greatman C. Okafor, K. Abdullahi, A. Samira, Abdullahi, C. Mgbemena, A. Aroh, E. Uwaiya, Danzarami Amagai, Danlami
{"title":"Studies on Some Mechanical Properties of PVC-Wood Fiber Composite","authors":"D. Arthur, J. N. Akoji, Greatman C. Okafor, K. Abdullahi, A. Samira, Abdullahi, C. Mgbemena, A. Aroh, E. Uwaiya, Danzarami Amagai, Danlami","doi":"10.22034/CRL.2021.242652.1076","DOIUrl":"https://doi.org/10.22034/CRL.2021.242652.1076","url":null,"abstract":"In this study some mechanical properties of PVC-Wood fibre composite were investigated. The wood fibre was gotten from a mahogany tree. The sample was moulded and shaped at a temperature of 150oC using a hadraulic hot press and pressure of 3bar for 5mins and the mechanical properties were studied base on varying the wood fibre contents from 0% to 50%. The hardness test carried out using the durometer hardness tester show a decrease in the hardness of the composite as the wood fibre is varied from 0%, 10%, 20%, 30% 40% and 50% and the impact strength of the composite decreases as well in that order. The tensile strength conducted using the Mensato Tensometer show a decrease at 10% wood fibre, while an increase in the wood fibre to 20% show an increase in the tensile strength on further addition of the wood fibre a decrease is noticed. This decrease in tensile strength decreases the strain of the PVC-wood fibre composite and hence increasing the modulus of elasticity of the PVC-wood fibre composite as the wood fibre is been added.","PeriodicalId":10686,"journal":{"name":"College & Research Libraries","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87306779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Plant Mediated Synthesis of CdS Nanoparticles, their characterization and application for photocatalytic degradation of toxic organic dye 植物介导合成CdS纳米颗粒及其表征及其在光催化降解有毒有机染料中的应用
IF 1.8 3区 管理学
College & Research Libraries Pub Date : 2021-04-01 DOI: 10.22034/CRL.2021.262754.1097
Amir Ullah, Sufian Rasheed, Irfan Ali, N. Ullah
{"title":"Plant Mediated Synthesis of CdS Nanoparticles, their characterization and application for photocatalytic degradation of toxic organic dye","authors":"Amir Ullah, Sufian Rasheed, Irfan Ali, N. Ullah","doi":"10.22034/CRL.2021.262754.1097","DOIUrl":"https://doi.org/10.22034/CRL.2021.262754.1097","url":null,"abstract":"In this work, environmentally friendly and cheap method for the synthesis of CdS nanoparticles for the first time using extract of Dicliptera Roxburghiana is presented. The present method is found to be reproducible and rapid. Structural analysis is carried out by UV-visible, FTIR, XRD, EDX, SEM, and TEM. XRD and TEM analysis revealed that the nanoparticles have spherical shape and size in the range of 2.5-8nm. FTIR studies showed the presence of functional groups which belong to the phytochemicals of plant extract that surrounds the nanoparticle preventing them from agglomeration. Thus the prepared CdS NPs exhibit excellent stability even after 2 months. The optical band gap was calculated using Tauc Plot i.e. 3.31 eV. Their activity as photocatalysts against an aqueous solution of methylene blue degradation under solar irradiation in a comparative manner is also reported and the particle has a % degradation of 87.12% in just 120 minutes under solar light irradiation.","PeriodicalId":10686,"journal":{"name":"College & Research Libraries","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74251949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Bulk microstructure evolution of two high Hf-containing Ni-based alloys during exposure at temperatures from 1100 to 1250°C 两种高含氢镍基合金在1100 ~ 1250℃温度下的体组织演变
IF 1.8 3区 管理学
College & Research Libraries Pub Date : 2021-01-27 DOI: 10.22034/CRL.2021.266573.1100
P. Berthod, D. A. Kane
{"title":"Bulk microstructure evolution of two high Hf-containing Ni-based alloys during exposure at temperatures from 1100 to 1250°C","authors":"P. Berthod, D. A. Kane","doi":"10.22034/CRL.2021.266573.1100","DOIUrl":"https://doi.org/10.22034/CRL.2021.266573.1100","url":null,"abstract":"Two Hf–poorest versions of a high performance chromia–forming nickel–based polycrystalline cast alloy reinforced by HfC carbides were investigated by replacing more or less hafnium by tantalum to reduce production cost. After elaboration, microstructure control, thermal analysis and exposures at temperature were carried out on samples cut in the obtained ingots. The as–cast microstructures of the two alloys are similar to the initial alloy one but their behaviors at the three considered high temperatures (1100, 1200 and 1250°C) were more or less different: more fragmentation of the MC carbides and precipitation of chromium carbides during aging. Some decreasing effects on the room temperature hardness were observed, and one can suppose that the high temperature mechanical properties of these two {(Hf,Ta)C carbides}–containing alloys derived from the HfC–strengthened initial one may be lowered.","PeriodicalId":10686,"journal":{"name":"College & Research Libraries","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2021-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82878581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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