{"title":"Odotopia and Intraoperative Brain Mapping: Implications for Management of Patients with Diffuse Low-grade Gliomas","authors":"F. Barone","doi":"10.15406/jnsk.2017.07.00228","DOIUrl":"https://doi.org/10.15406/jnsk.2017.07.00228","url":null,"abstract":"From a surgical point of view, last years have showed more and more satisfying results thanks to methods defining tumour’s exact location and identifying the function of the brain in the tumoral area. The aim is to optimize the removal and minimizing permanent postoperative deficits to bring the patient to the adjuvant treatment as well as possible, to guarantee of a good compliance. In fact, considering that it is still impossible to heal the patient, each treatment must aim to get the best possible result (the most durable disease control) keeping the residual quality of life at the top.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128611990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. M. Nunes, R. Joao, A. C. B. S. Motta, R. V. D. Azevedo, Marcelo Lucci Mussi, Anabelli Zanchetta Buani, J. E. Ferri-de-Barros
{"title":"An Atypical Presentation of Spinal Epidural Hematoma-Case Report and Literature Review","authors":"R. M. Nunes, R. Joao, A. C. B. S. Motta, R. V. D. Azevedo, Marcelo Lucci Mussi, Anabelli Zanchetta Buani, J. E. Ferri-de-Barros","doi":"10.15406/JNSK.2017.07.00227","DOIUrl":"https://doi.org/10.15406/JNSK.2017.07.00227","url":null,"abstract":"Spinal epidural hematoma (SEH) is a rare neurological condition with challenging clinical management [1], especially in emergency situations in which there are misleading atypical features that simulate other more common diagnoses [2]. In this article, we describe a case of SEH diagnosed in our emergency department presenting with atypical history and findings. This report will be followed by discussion and review of the relevant medical literature.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130681224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Kalatha, T. Tegos, A. Papaioannou, A. Charitanti-Kouridou, A. Orologas
{"title":"Multiple Spinal Cord Infarction due to Primary Antiphospholipid Syndrome","authors":"T. Kalatha, T. Tegos, A. Papaioannou, A. Charitanti-Kouridou, A. Orologas","doi":"10.15406/JNSK.2017.07.00226","DOIUrl":"https://doi.org/10.15406/JNSK.2017.07.00226","url":null,"abstract":"Spinal cord infarction (SCI) is considered rare in comparison with cerebral infarction but its consequences can lead to greater disability. Reliable incidence rates do not exist due to publication of case reports or cases series [1,2]. A retrospective one-center study finds spinal cord infarction accountable for 1.2% of the total admissions [3]. Etiologies of spinal infarcts include atheromas involving the aorta as the most common cause, usually after a thoraces abdominal aneurysm repair. Other causes of SCI include spinal arteriovenous malformation repair, dissecting aortic aneurysm, cardiac arrest, embolic infarction, syphilitic angiitis, and less common etiologies include collagen disease as systemic lupus or polyarteritis nodosa, pregnancy, sickle cell disease and neurotoxic effects of iodinated contrast material [4]. Syphilitic arteritis was the most frequent cause of SCI until the introduction of penicillin [5]. Neurovascular syndromes of SCI have different symptomatology depending on the level of the infarction and arteries involved, but they usually present with weakness, radicular back pain, are flexia, spin thalamic sensory loss, and autonomic dysfunction.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125181996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quantitative Equilibrium Test and Complementary Studies in Patients with Vertigo","authors":"S. Jorge","doi":"10.15406/JNSK.2017.07.00225","DOIUrl":"https://doi.org/10.15406/JNSK.2017.07.00225","url":null,"abstract":"Several useful studies have been reported in the evaluation of nystagmus that may be spontaneous and inductive, any of which have been given to study vestibular function through the vestibulospinal, retinoocular, and vestibular systems [7-8]. Through the test of the Skull-Body-Spray (CCG), Posturography (TOB) tests, and Computerized Electronystagmography (CNG) [10-16]. 1343 patients with vertigo or dizziness are investigated; 48.16% of the cases have a vascular origin, prevailing a group of pathologies secondary to the process of hydrodynamic alterations, 10,335 patients were studied and investigated under German parameters. Argentina 2,234 patients. Through the Doppler Ultrasonography of the head and neck (USD), the modern physician can help to complement his better diagnosis, correlating the clinical exploration with vestibulospinal (CCG) and (TOB), retinoocular And vestibulocular (CNG)] of the patient with vertigo or dizziness [17-23].","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131134130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cortical Alpha Oscillation During 3 kHz Steady-State Sinusoidal Electric Current Stimulation","authors":"L. Volpi, C. Tierra-Criollo","doi":"10.15406/JNSK.2017.07.00224","DOIUrl":"https://doi.org/10.15406/JNSK.2017.07.00224","url":null,"abstract":"Little is known about the changes in ongoing cortical rhythms due to application of the steady-state sinusoidal electrical stimuli of 3 kHz, although it has been shown to elicit tactile sensations. In addition, it is known that somatosensory stimulation attenuates ongoing alpha rhythm in centroparietal cortex. Thus, the present work aimed to evaluate alpha rhythm alterations in sensorimotor area and sensations perceived with application of 3 kHz sinusoidal stimulus. Sensory perception threshold (ST) was measured in ten healthy volunteers for posterior stimulation in three distinct stimulus intensities (1.1xST, 2xST and 3xST). Cognitive evaluation of perceived sensations was obtained through questionnaires and cortical alpha rhythm blockade profile was evaluated through the classical event-related synchronization/ desynchronization method. Results showed alpha attenuation in the central cortex bilaterally, in the ipsilateral pre-frontal cortex and contralateral parietal cortex during stimulation. Moreover, there was a tendency of bilateral centroparietal alpha rhythm desynchronization increase with stimulus intensity. In conclusion, sinusoidal electrical stimulation may be useful for disease diagnostics and treatment as well as neurofeedback for brain-machine interface (BMI) applications. Patients may benefit from the novel objective method proposed for assessment of tactile perception, mainly, who might not have their cognition preserved (e.g., stroke).","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125856616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Course of Depression Following Myocardial Infarction and the Impact of the Social Neglect on the Recovery of the Patient","authors":"M. Hasanovi, Amila izmi, M. Jašarevi","doi":"10.15406/JNSK.2017.06.00223","DOIUrl":"https://doi.org/10.15406/JNSK.2017.06.00223","url":null,"abstract":"Depression and low perceived social support (LPSS) after myocardial infarction (MI) are associated with higher morbidity and mortality. In the original AHRQ EPC report, prevalence varied by type of measure used. For example, use of the Structured Clinical Interview for the Diagnostic and Statistical Manual (SCID) yielded prevalence ranging from 17% to 27%. Including the ENRICHD trial at 20% and validated depression scales, such as the Beck Depression Inventory (BDI), yielded prevalence ranging from 10% to 47%, depending on the cut points used. The updated evidence review continued to show a wide range of prevalence (7.2% to 41.2%) depending on the method used to assess depression. Structured interviews tended to produce lower prevalence estimates, and ratings scales, such as the BDI, produced higher prevalence estimates. In general, across the studies, about 1 of every 5 patients with an MI has depression during an initial hospitalization [1].","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132029041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Primary Pilocytic Astrocytoma with Malign Transformation","authors":"S. Fındık, H. Esen, Fatih Erdi, Pembe Oltulu","doi":"10.15406/JNSK.2017.06.00222","DOIUrl":"https://doi.org/10.15406/JNSK.2017.06.00222","url":null,"abstract":"Pilocytic astrocytoma is a slow-growing brain tumor that occurs more often in children with a benign course and long clinical history compared to diffuse astrocytomas. Pilocytic astrocytomas may rarely show malignant transformation and radiotherapy plays a key role in the treatment of malignant transformation. In this study, we present a pilocytic astrocytoma case with no radiotherapy history and showing malignant characteristics histologically on a 3 year old girl.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131341153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"NF1 Gene Mutations are the Major Molecular Event in Neurofibromatosis-Noonan Syndrome","authors":"P. Sharafi, B. Anlar, Ş. Ayter","doi":"10.15406/JNSK.2017.06.00220","DOIUrl":"https://doi.org/10.15406/JNSK.2017.06.00220","url":null,"abstract":"Neurofibromatosis–Noonan syndrome is a rare autosomal dominant disorder which combines neurofibromatosis type 1 (NF1) features with Noonan syndrome. Noonan syndrome (NS) and the clinically overlapping disorders and Neurofibromatosis-Noonan syndrome (NFNS) share the some common clinical features. It is now known that all these disorders are caused by mutations in components of the RAS-MAPK signaling pathway which is important in tumorigenesis. NF1 gene mutations are reported in the majority of these patients. There are some data in the literature about the NF1 mutant allele which can lead to manifestations of Noonan syndrome. We have studied four NFNS cases which all fit the NFNS criteria. We evaluated these patients one with Watson syndrome (WS) and the other one with Rhabdomyosarcoma. Although WS and NFNS were described as distinct disorders, detailed clinical examination of these families revealed that not only pulmonic stenosis, borderline intelligence, and multiple cafe ́-au-lait spots, but also multiple Lisch nodules, neurofibromas in one third of patients, and short stature were present. The only distinction between WS and NFNS would be that NFNS patients show a more classical phenotype of both NS and NF, whereas WS patients show only a mild expression of NF. Recently, there is increasing evidence for WS and NFNS being allelic to NF1 in the majority of patients. We analyzed 4 NFNS patients by PCR based techniques. Genomic DNA was extracted from peripheral blood samples. PCR was performed with intronic primers for all exons of the NF1. DNA samples were sequenced to detect variations in each exon. This study supports that the major gene causing NFNS is NF1. Therefore inclusion of NF1 in the genetic screening of patients with clinically suspected NS, preferentially when café-au-lait spots are present. As a result, the present study provides the molecular evidence of the role of NF1 mutations in NFNS.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115537538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Familial Colloid Cyst of the Third Ventricle in Monozygotic Twins","authors":"Mohsen Yaish, L. Török, B. Zanotti, A. Alfieri","doi":"10.15406/JNSK.2017.06.00219","DOIUrl":"https://doi.org/10.15406/JNSK.2017.06.00219","url":null,"abstract":"J Neurol Stroke 2017, 6(6): 00219 mm versus 8 mm), 3) ventricular dilation (83% versus 31%),and 4) increased signal on T2-weighted magnetic resonance images (44% versus 8%) [1]. More than half of cases were discovered incidentally. In five patients with incidental cysts (8.8%) an enlargement of the cyst was documented and a surgical procedure was done. Nearly half of symptomatic patients present hydrocephalus, more than 10% present an acute symptom, and 1% of patients decease due to obstructive hydrocephalus and herniation [1].","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132875353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Benefit of Botulinum Toxin A in the Management of Central Post Stroke Pain: A Case Report","authors":"C. Shippen, G. Bavikatte, David Mackarel","doi":"10.15406/JNSK.2017.06.00218","DOIUrl":"https://doi.org/10.15406/JNSK.2017.06.00218","url":null,"abstract":"Results: This case report demonstrates the benefit of Botulinum Toxin A in the management of central post-stroke pain with elbow flexor spasticity. The clinical characteristics of the pain were neuropathic and the severity was greater than expected given the degree of spasticity. The pain responded to Botulinum Toxin treatment within a few days, independently of the improvement in spasticity and the effect was continued over six cycles of treatment.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122101561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}