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Collection of Czechoslovak Chemical Communications最新文献

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Towards the de novo design of DNA based catalytic sites using a combined NMR and in silico approach 采用核磁共振和硅相结合的方法重新设计基于DNA的催化位点
Collection of Czechoslovak Chemical Communications Pub Date : 2014-01-01 DOI: 10.1135/CSS201414151
Dieter Buyst, Vicky Gheerardijn, J. Begin, A. Madder, José C. Martins
{"title":"Towards the de novo design of DNA based catalytic sites using a combined NMR and in silico approach","authors":"Dieter Buyst, Vicky Gheerardijn, J. Begin, A. Madder, José C. Martins","doi":"10.1135/CSS201414151","DOIUrl":"https://doi.org/10.1135/CSS201414151","url":null,"abstract":"","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"14 1","pages":"151-154"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63712840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Orientation-dependent FRET between the intercalated donor and acceptor fluorophores 插入的供体和受体荧光团之间的定向依赖FRET
Collection of Czechoslovak Chemical Communications Pub Date : 2014-01-01 DOI: 10.1135/CSS201414186
H. Kashida, Ayako Kurihara, Tomohiro Kato, H. Asanuma
{"title":"Orientation-dependent FRET between the intercalated donor and acceptor fluorophores","authors":"H. Kashida, Ayako Kurihara, Tomohiro Kato, H. Asanuma","doi":"10.1135/CSS201414186","DOIUrl":"https://doi.org/10.1135/CSS201414186","url":null,"abstract":"","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"14 1","pages":"186-189"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63713187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Further improvements in disaccharide synthesis: synthesis of 2’-O-α-D-ribofuranosyladenosine and its derivatives 二糖合成的进一步改进:2 ' -O-α- d -核糖呋喃基腺苷及其衍生物的合成
Collection of Czechoslovak Chemical Communications Pub Date : 2014-01-01 DOI: 10.1135/CSS201414255
M. Drenichev, V. Oslovsky, S. Mikhailov
{"title":"Further improvements in disaccharide synthesis: synthesis of 2’-O-α-D-ribofuranosyladenosine and its derivatives","authors":"M. Drenichev, V. Oslovsky, S. Mikhailov","doi":"10.1135/CSS201414255","DOIUrl":"https://doi.org/10.1135/CSS201414255","url":null,"abstract":"","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"55 1","pages":"255-256"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63713319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Enzymatic decomposition of a locked nucleoside phosphoramidate monitored by 31 P NMR spectroscopy 用31p核磁共振波谱法监测一个锁定的核苷磷酸酯的酶解
Collection of Czechoslovak Chemical Communications Pub Date : 2014-01-01 DOI: 10.1135/CSS201414356
E. Procházková, H. Hřebabecký, Radim Nencka, M. Dračínský
{"title":"Enzymatic decomposition of a locked nucleoside phosphoramidate monitored by 31 P NMR spectroscopy","authors":"E. Procházková, H. Hřebabecký, Radim Nencka, M. Dračínský","doi":"10.1135/CSS201414356","DOIUrl":"https://doi.org/10.1135/CSS201414356","url":null,"abstract":"","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"14 1","pages":"356-357"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63713404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Syntheses and characterizations of DNA duplexes having metal ion mediated base pairs 具有金属离子介导碱基对的DNA双链的合成和表征
Collection of Czechoslovak Chemical Communications Pub Date : 2014-01-01 DOI: 10.1135/CSS201414014
A. Ono, I. Okamoto, Hideo Urata, Hidetake Torigoe, Hisao Saneyoshia, J. Kondo, Yoshiyuki Tanaka
{"title":"Syntheses and characterizations of DNA duplexes having metal ion mediated base pairs","authors":"A. Ono, I. Okamoto, Hideo Urata, Hidetake Torigoe, Hisao Saneyoshia, J. Kondo, Yoshiyuki Tanaka","doi":"10.1135/CSS201414014","DOIUrl":"https://doi.org/10.1135/CSS201414014","url":null,"abstract":"","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"14 1","pages":"14-19"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63712363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA bases beyond Watson and Crick 沃森和克里克之外的DNA碱基
Collection of Czechoslovak Chemical Communications Pub Date : 2014-01-01 DOI: 10.1135/css201414175
T. Carell
{"title":"DNA bases beyond Watson and Crick","authors":"T. Carell","doi":"10.1135/css201414175","DOIUrl":"https://doi.org/10.1135/css201414175","url":null,"abstract":"I am going to discuss the latest results related to the function and distribution of the new nucleobases 5-hydroxymethylcytosine (hmC), 5-formylcytosine (fC), 5-carboxycytosine (caC) and 5-hydroxymethyluracil. These nucleobases seem to play an important role in epigenetic reprogramming of stem cells and some of these bases are also detected at relatively high levels in brain tissues. I will present new synthetic routes that enable preparation of these compounds and of the corresponding phosphoramidites using modern metal organic chemistry. Finally I will discuss how chemistry leads to new insights into the biology of stem cell development processes. In particular mass spectroscopy in combination with the availability of isotopically labeled material allows investigation of the distribution of these novel bases in various tissues and during stem cell development. The recently discovered base formylcytosine for example, is present at relatively high levels in stem cells and its distribution varies during development in a wave like fashion. I am going to describe the distribution of carboxylcytosine in somatic tissues and in stem cells and will provide new quantitative data derived from a detailed mass spectrometric analysis. In order to elucidate the function of the nucleobases we devised a new isotope tracing experiment that enables us to unravel the biochemistry of the bases with high precision and accuracy. I will discuss the synthesis of double [N]-labeled hmC, fC and caC and the preparation of DNA containing these isotopologes. The DNA strands are subsequently added to stem cell nuclear extracts and the formation of the novel nucleobases is followed by high sensitive mass spectrometry.","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"14 1","pages":"175-175"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63713076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluorescent nucleotides: a powerful toolbox for labeling of biological macromolecules 荧光核苷酸:一个强大的工具箱标记生物大分子
Collection of Czechoslovak Chemical Communications Pub Date : 2014-01-01 DOI: 10.1135/CSS201414180
Thomas A. Waldbach, F. Bieber, B. Schaefer, T. Billert, M. Gruen
{"title":"Fluorescent nucleotides: a powerful toolbox for labeling of biological macromolecules","authors":"Thomas A. Waldbach, F. Bieber, B. Schaefer, T. Billert, M. Gruen","doi":"10.1135/CSS201414180","DOIUrl":"https://doi.org/10.1135/CSS201414180","url":null,"abstract":"","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"14 1","pages":"180-182"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63713135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilisation of enzymatic labelling with 4-aminophtalimide and 4-hydroxybenzylideneimidazolinone fluorescent derivates for monitoring of DNA-protein interaction 利用酶标记与4-氨基苯胺和4-羟基苄基氨基咪唑啉酮荧光衍生物监测dna -蛋白质相互作用
Collection of Czechoslovak Chemical Communications Pub Date : 2014-01-01 DOI: 10.1135/CSS201414340
P. Orság, Hana Pivoňková, Jan Riedl, Michal Hocek, M. Fojta
{"title":"Utilisation of enzymatic labelling with 4-aminophtalimide and 4-hydroxybenzylideneimidazolinone fluorescent derivates for monitoring of DNA-protein interaction","authors":"P. Orság, Hana Pivoňková, Jan Riedl, Michal Hocek, M. Fojta","doi":"10.1135/CSS201414340","DOIUrl":"https://doi.org/10.1135/CSS201414340","url":null,"abstract":"","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"14 1","pages":"340-341"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63713328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
5’- C -Alkylated analogs of gemcitabine: antiviral and anticancer properties 吉西他滨的5′- C -烷基化类似物:抗病毒和抗癌特性
Collection of Czechoslovak Chemical Communications Pub Date : 2014-01-01 DOI: 10.1135/CSS201414259
N. Dyatkina, Guangyi Wang, V. Rajwanshi, Hua Tan, Jin Hong, Qingling Zhang, J. Deval, J. Symons, L. Blatt, L. Beigelman
{"title":"5’- C -Alkylated analogs of gemcitabine: antiviral and anticancer properties","authors":"N. Dyatkina, Guangyi Wang, V. Rajwanshi, Hua Tan, Jin Hong, Qingling Zhang, J. Deval, J. Symons, L. Blatt, L. Beigelman","doi":"10.1135/CSS201414259","DOIUrl":"https://doi.org/10.1135/CSS201414259","url":null,"abstract":"","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"14 1","pages":"259-261"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63713365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural basis of the binding of Actinomycin D to CGG triplet repeats 放线菌素D与CGG三重重复序列结合的结构基础
Collection of Czechoslovak Chemical Communications Pub Date : 2014-01-01 DOI: 10.1135/CSS201414278
Y. Lo, W. Tseng, C. Chuang, M. Hou
{"title":"Structural basis of the binding of Actinomycin D to CGG triplet repeats","authors":"Y. Lo, W. Tseng, C. Chuang, M. Hou","doi":"10.1135/CSS201414278","DOIUrl":"https://doi.org/10.1135/CSS201414278","url":null,"abstract":"","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"14 1","pages":"278-280"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63713420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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