Cogent Chemistry最新文献_第9页

Verbena officinalis a herb with promising broad spectrum antimicrobial potential 马鞭草是一种具有广谱抗菌潜力的草本植物

Cogent Chemistry Pub Date : 2017-01-01 DOI: 10.1080/23312009.2017.1363342

D. Ahmed, Kamal Ahmed Qasim, C. M. Ashraf, H. Maab

{"title":"Verbena officinalis a herb with promising broad spectrum antimicrobial potential","authors":"D. Ahmed, Kamal Ahmed Qasim, C. M. Ashraf, H. Maab","doi":"10.1080/23312009.2017.1363342","DOIUrl":"https://doi.org/10.1080/23312009.2017.1363342","url":null,"abstract":"Abstract The treatment of infectious diseases has increasingly become a serious problem as the pathogens are rapidly acquiring resistance against the current antibiotics. The herb Verbena officinalis has a great repute as ethnomedicine against infections. Keeping in view its immense medicinal scope, the present study was designed. Antimicrobial potential of its stems, leaves, and roots was evaluated against 24 strains of Gram-positive and Gram-negative bacteria. Ethanolic extracts of stems, leaves, and roots of V. officinalis and their fractions in various solvents were assessed. The stems proved to be most potent against all the strains. Its activity against Staphylococcus aureus and Pseudomonas aeruginosa was higher than the antibiotic Amoxicillin. The leaves also showed considerable activity against P. aeruginosa, Citrobacter freundii, and S. aureus. The roots turned out to be highly effective against Bacillus subtilis, S. aureus, and P. aeruginosa. The study confirmed the efficacy of V. officinalis against infectious diseases. While all the three parts of the plant were active against the test micro-organisms, stems were most powerful. The plant has great potential to provide exploitable leads for new antimicrobial drugs.","PeriodicalId":10640,"journal":{"name":"Cogent Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23312009.2017.1363342","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42832061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Design and synthesis of 1,4-benzothiazine derivatives with promising effects against colorectal cancer cells 具有抗结直肠癌癌症细胞作用的1,4-苯并噻嗪衍生物的设计与合成

Cogent Chemistry Pub Date : 2017-01-01 DOI: 10.1080/23312009.2017.1303909

A. Rai, V. Raj, Ashutosh Kumar Singh, Amit K Keshari, U. Kumar, Dinesh Kumar, S. Saha

{"title":"Design and synthesis of 1,4-benzothiazine derivatives with promising effects against colorectal cancer cells","authors":"A. Rai, V. Raj, Ashutosh Kumar Singh, Amit K Keshari, U. Kumar, Dinesh Kumar, S. Saha","doi":"10.1080/23312009.2017.1303909","DOIUrl":"https://doi.org/10.1080/23312009.2017.1303909","url":null,"abstract":"Abstract In this study, we designed and synthesized a series of 1,4-benzothiazine and evaluated them for anticancer activity toward HT-29 human colon cancer cells using SRB assay. Before the synthesis, docking studies were performed using various molecular targets of colon cancer including IL-2, IL-6, COX-2, caspase-3, and caspase-8. The molecular dynamic (MD) simulation was also executed to examine the stability of ligand-receptor complex of more stable dock conformation. Further computational study was carried out in order to predict the pharmacokinetic profile of titled compounds. Among 34 tested compounds, compounds AR13 and AR15 were found to be active against HT-29 cells (GI50 < 10 μM). Moreover, Compounds AR5, AR22, and AR34 showed the moderate activity with GI50 < 70 μM. The binding energy was found to be > −5 kcal/mol for AR13 and AR15 with all the molecular targets and the ligand-protein complex was found stable after its formation. Again, computational analysis revealed that both molecules AR13 and AR15 had good ADMET profiling. These encouraging outcomes allowed us to conclude that both AR13 and AR15 may emerge as lead compounds against colon cancer.","PeriodicalId":10640,"journal":{"name":"Cogent Chemistry","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23312009.2017.1303909","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41321849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Evaluation of phytochemical content, antioxidant, antimicrobial activity and DNA cleavage effect of endemic Linaria corifolia Desf. (Plantaginaceae) 地方特有的卷叶Linaria corifolia Desf.植物化学成分、抗氧化、抗菌活性和DNA裂解作用的评价。(车前草科)

Cogent Chemistry Pub Date : 2017-01-01 DOI: 10.1080/23312009.2017.1337293

M. Gul, Ilkay Ozturk Cali, A. Cansaran, Onder Idil, Irem Kulu, Umut Çelikoğlu

引用次数: 11

What does non-destructive analysis mean? 无损分析是什么意思?

Cogent Chemistry Pub Date : 2017-01-01 DOI: 10.1080/23312009.2017.1405767

T. Borgwardt, D. Wells

引用次数: 7

Synthesis of the 3,5-diphenyl-1H-pyrazole and cytogenetic and oxidative alterations after exposure of cultured human whole blood cells 3,5-二苯基-1H-吡唑的合成及其暴露于培养的人全血细胞后的细胞遗传学和氧化变化

Cogent Chemistry Pub Date : 2017-01-01 DOI: 10.1080/23312009.2017.1344115

E. Akbas, F. Çelikezen, H. Turkez, O. Ozdemir, Adem Ruzgar, Erdem Ergan, E. Şahin

引用次数: 3

Solvent extraction studies of rhodium(III) by using n-octylaniline from malonate media: Analysis of synthetic mixtures and alloys 丙二酸介质中正辛基苯胺溶剂萃取铑（III）的研究：合成混合物和合金的分析

Cogent Chemistry Pub Date : 2017-01-01 DOI: 10.1080/23312009.2017.1339334

A. P. Gaikwad, V. Suryavanshi, M. Anuse

引用次数: 1

Collagen-immobilized polyimide membranes for retinal pigment epithelial cell adherence and proliferation 胶原固定聚酰亚胺膜对视网膜色素上皮细胞粘附和增殖的影响

Cogent Chemistry Pub Date : 2017-01-01 DOI: 10.1080/23312009.2017.1292593

S. Teymouri, M. Calejo, M. Hiltunen, Anni Sorkio, K. Juuti-Uusitalo, H. Skottman, M. Kellomäki

{"title":"Collagen-immobilized polyimide membranes for retinal pigment epithelial cell adherence and proliferation","authors":"S. Teymouri, M. Calejo, M. Hiltunen, Anni Sorkio, K. Juuti-Uusitalo, H. Skottman, M. Kellomäki","doi":"10.1080/23312009.2017.1292593","DOIUrl":"https://doi.org/10.1080/23312009.2017.1292593","url":null,"abstract":"Abstract Degenerative retinal diseases are a leading cause of visual loss and irreversible blindness, particularly in the developed world. Retinal pigment cell (RPE) transplantation is nowadays considered the most promising therapeutic approach for certain retinal diseases, and the presence of a supportive scaffold has been considered essential to ensure the success of the implant. In this work, collagen IV was covalently immobilized to the surface of polyimide membranes, with the purpose of developing scaffold materials for RPE cell culture. The covalent modification method involved four steps: argon-plasma treatment, acrylic acid graft polymerization, surface activation, and finally immobilization of collagen type IV. Collagen-modified membranes did not become more rough but became significantly more hydrophilic than the unmodified and dip-coated controls. ARPE-19 cell morphology and attachment were studied by immunofluorescence staining and confocal microscopy. Covalently modified surfaces showed cell attachment and cell properties comparable to the uncoated and dip-coated controls. This work demonstrated the potential of collagen IV-immobilized polyimide membranes as substrates for the growth of ARPE-19 cells.","PeriodicalId":10640,"journal":{"name":"Cogent Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23312009.2017.1292593","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48669036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Comparative physicochemical, anti-inflammatory, and analgesic activity assay of synthesized chromium and nickel complexes of indomethacin 吲哚美辛铬镍复合物的理化、抗炎和镇痛活性比较测定

Cogent Chemistry Pub Date : 2017-01-01 DOI: 10.1080/23312009.2017.1302312

Abhijit Sukul, Sanjana Haque, S. Poddar, M. Hossain, K. Niloy, S. Saha

{"title":"Comparative physicochemical, anti-inflammatory, and analgesic activity assay of synthesized chromium and nickel complexes of indomethacin","authors":"Abhijit Sukul, Sanjana Haque, S. Poddar, M. Hossain, K. Niloy, S. Saha","doi":"10.1080/23312009.2017.1302312","DOIUrl":"https://doi.org/10.1080/23312009.2017.1302312","url":null,"abstract":"Abstract Objectives: Complexation of non-steroidal anti-inflammatory drugs (NSAIDs) with transition metals—chromium and nickel is a unique approach of masking the inherent side effect of gastrointestinal hemorrhage and ulceration of NSAID along with imparting beneficial pharmacological effects. Methods: Chromium and nickel complexes of indomethacin were synthesized followed by characterization of these complexes by FT-IR spectroscopy, UV–Visible spectroscopy, atomic absorption spectroscopy, calorimetric DSC analysis, and melting point analysis. For screening of biological activities to uncover potentially interesting pharmacological properties, the metal complexes were assayed for peripheral analgesic, central analgesic, and anti-inflammatory activity. Results: Nickel-indomethacin complex at dose of 20 mg/kg showed peripheral analgesia of 67.03% by inhibiting writhing and at its dose of 20 mg/kg showed potent central analgesic action at 60 min (92% elongation of tail flicking time). In anti-inflammatory study, nickel-indomethacin and chromium indomethacin complex at its 15 mg/kg dose in the 2 h showed inhibition of paw edema of 78.35 and 73.23%, respectively, which is comparable to the standard indomethacin. Conclusion: Based upon the results, it can be predicted that chromium and nickel complex of indomethacin may show promising pharmacological effects which can be revealed by extensive analysis using pharmacokinetic and pharmacodynamic test model.","PeriodicalId":10640,"journal":{"name":"Cogent Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23312009.2017.1302312","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43784600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effect of electronegativity on structural, spectrophotometric and thermo-chemical properties of fluorine and chlorine substituted isoxazoles by DFT method DFT法研究电负性对氟和氯取代异恶唑结构、分光光度和热化学性质的影响

Cogent Chemistry Pub Date : 2017-01-01 DOI: 10.1080/23312009.2017.1296342

Nilesh. U. Jadhao, A. Naik

引用次数: 9

Defining free amino acid contents of grass pea (Lathyrus sativus) genotypes in Turkey 测定土耳其草豆(Lathyrus sativus)基因型的游离氨基酸含量

Cogent Chemistry Pub Date : 2017-01-01 DOI: 10.1080/23312009.2017.1302311

M. Arslan

引用次数: 4