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Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology最新文献

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T-type calcium channel in mammalian CNS neurones. 哺乳动物中枢神经系统神经元中的t型钙通道。
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Pub Date : 1991-01-01
N Akaike
{"title":"T-type calcium channel in mammalian CNS neurones.","authors":"N Akaike","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>1. In all neurones freshly isolated from various brain regions of newborn, adult and aged rats, the T-type Ca2+ currents were elicited by step depolarizations to potentials more positive than -60 mV from a holding potential of -100 mV, and reached a peak in the current-voltage relationship around -30 mV. 2. The activation and inactivation processes were highly potential-dependent, and the latter was fitted by a single exponential function. 3. It was concluded that mammalian brain neurones possess a definite class of T-type Ca2+ channel characterized by both current kinetics and ion selectivity for Ca2+, Ba2+ and Sr2+. However, the pharmacological nature of the T-type Ca2+ channel differed from that in other tissues such as cardiac and smooth muscle cells, peripheral neurones, and cultured cells.</p>","PeriodicalId":10579,"journal":{"name":"Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology","volume":"98 1","pages":"31-40"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12838670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative neuroscience in Japan. 日本的比较神经科学。
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Pub Date : 1991-01-01
{"title":"Comparative neuroscience in Japan.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10579,"journal":{"name":"Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology","volume":"98 1","pages":"1-270"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12838699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Grafting of catecholaminergic cells in the mammalian brain and reconstruction of disturbed function: basic problems to be solved. 哺乳动物脑内儿茶酚胺能细胞的移植及紊乱功能的重建:亟待解决的基本问题。
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Pub Date : 1991-01-01
H Nishino, T Hashitani, M Kumazaki
{"title":"Grafting of catecholaminergic cells in the mammalian brain and reconstruction of disturbed function: basic problems to be solved.","authors":"H Nishino,&nbsp;T Hashitani,&nbsp;M Kumazaki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>1. Catecholaminergic cells were grafted in the caudate nucleus of hemi-Parkinsonian model rats, and the following problems were discussed. 2. Phenotypic plasticity and development of catecholamine-producing cells. 3. Mechanism of motor recovery. 4. Trophic factor. 5. Regulation of immunological responses. 6. Long-term survival and security.</p>","PeriodicalId":10579,"journal":{"name":"Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology","volume":"98 1","pages":"211-20"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12838664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurotransmitters and neuromodulators controlling the anterior byssus retractor muscle of Mytilus edulis. 控制贻贝前足牵开肌的神经递质和神经调节剂。
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Pub Date : 1991-01-01
Y Muneoka, Y Fujisawa, M Matsuura, T Ikeda
{"title":"Neurotransmitters and neuromodulators controlling the anterior byssus retractor muscle of Mytilus edulis.","authors":"Y Muneoka,&nbsp;Y Fujisawa,&nbsp;M Matsuura,&nbsp;T Ikeda","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>1. The anterior byssus retractor muscle (ABRM) of Mytilus edulis is innervated by at least two kinds of nerves, excitatory and relaxing nerves. The principal neurotransmitters released from these nerves have been shown to be acetylcholine and serotonin, respectively. 2. Some other monoamines, such as dopamine and octopamine, and various peptides, such as FMRFamide-related peptides, Mytilus inhibitory peptides, SCP-related peptides and a catch-relaxing peptide, may also be involved in the regulation of the muscle as neurotransmitters or neuromodulators. 3. The ABRM seems to be typical of invertebrate muscles controlled by multiple neurotransmitters and neuromodulators.</p>","PeriodicalId":10579,"journal":{"name":"Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology","volume":"98 1","pages":"105-14"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12838700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Localization and regulation of mRNAs in the nervous tissue as revealed by in situ hybridization. 原位杂交显示神经组织中mrna的定位和调控。
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Pub Date : 1991-01-01
M Kawata, K Yuri, Y Sano
{"title":"Localization and regulation of mRNAs in the nervous tissue as revealed by in situ hybridization.","authors":"M Kawata,&nbsp;K Yuri,&nbsp;Y Sano","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>1. In situ hybridization histochemistry permits the study of specific mRNAs of neuropeptides, enzymes involved in the synthesis of neurotransmitters, receptors and proteins associated with glial cells in nervous tissue. 2. The central and peripheral nervous systems are composed of heterogeneous elements and specific regulatory mechanisms occur in specific cells. 3. This review will focus on the localization and regulation of different mRNAs in the nervous system from Drosophila to human, as revealed by in situ hybridization histochemistry.</p>","PeriodicalId":10579,"journal":{"name":"Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology","volume":"98 1","pages":"41-50"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12838671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple opioid receptors and GTP-binding proteins. 多种阿片受体和gtp结合蛋白。
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Pub Date : 1991-01-01
H Ueda, M Nozaki, M Satoh
{"title":"Multiple opioid receptors and GTP-binding proteins.","authors":"H Ueda,&nbsp;M Nozaki,&nbsp;M Satoh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We believed that GTP-binding protein (G-protein)-coupling receptor always transduces stimulatory signals to G-proteins. From our recent experiments using reconstitution techniques, however, it was revealed that some receptors transduce an inhibitory or no signal to G-proteins in specific tissues, despite some interaction between them. Here we discuss the molecular basis of mechanisms of such diverse modes of functional coupling between different subtypes of opioid receptors and G-proteins.</p>","PeriodicalId":10579,"journal":{"name":"Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology","volume":"98 1","pages":"157-69"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12838704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiological and biochemical approaches to the toxicological assessment of environmental pollution. 环境污染毒理学评价的生理生化方法。
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Pub Date : 1991-01-01 DOI: 10.1016/0378-4274(90)90263-l
{"title":"Physiological and biochemical approaches to the toxicological assessment of environmental pollution.","authors":"","doi":"10.1016/0378-4274(90)90263-l","DOIUrl":"https://doi.org/10.1016/0378-4274(90)90263-l","url":null,"abstract":"","PeriodicalId":10579,"journal":{"name":"Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology","volume":"78 1","pages":"1-310"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83891294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Electrophysiological analysis of structural aspects of voltage-dependent SR K+ channel. 电压依赖性SR K+通道结构的电生理分析。
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Pub Date : 1991-01-01
M Sokabe, M Kasai, K Nomura, K Naruse
{"title":"Electrophysiological analysis of structural aspects of voltage-dependent SR K+ channel.","authors":"M Sokabe,&nbsp;M Kasai,&nbsp;K Nomura,&nbsp;K Naruse","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article presents a brief review on the electrophysiological analysis of the structural aspects of the voltage-dependent SR (sarcoplasmic reticulum) K+ channel. In the first half, early attempts to determine the physical dimensions of the ion conducting mechanism such as the mouth, narrow tunnel, or ion selective filter of the channel, are reviewed. The depicted cartoon of the SR K+ channel, as an extremely short, busy district with a big mouth on each side, is quite similar to the recently-obtained reconstructed structural image of the acetylcholine receptor channel. In the latter half, we introduce our recent attempts to draw a physical image of the gating mechanism of the SR K+ channel. We examined, for example, the location of the gate and the voltage sensor, and the relationship between them. It is suggested that the gate and the sensor are connected tightly and that the sensor would be exposed to the surface of the lumen side of SR when the gate opens. Finally, the issue of substates in SR K+ channel is discussed. It is implied that the substrate-conductances reflect a partial occlusion of the pore by an intermediate-open gate.</p>","PeriodicalId":10579,"journal":{"name":"Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology","volume":"98 1","pages":"23-30"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12838667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
History of neurophysiology in Japan. 日本神经生理学的历史。
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Pub Date : 1991-01-01
Y Oomura
{"title":"History of neurophysiology in Japan.","authors":"Y Oomura","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The progress of the neurophysiological research in Japan during the past 45 years is related. Modern Japanese neurophysiology started immediately after the end of World War 2. The introduction of microelectrode techniques contributed greatly to most fields of Japanese neurophysiology. These techniques were used to study most neurophysiological phenomena: sensory physiology including vision, audition, chemical sensitivity, and other modalities; learning and memory. These techniques plus lesions, transplants, and behavioral physiology were used to study circadian rhythm, posture and motor control, and sex. These and other techniques were used to study neural plasticity, immunity, membrane excitability, pain and other psychophysiological functions. The disciplines advanced quickly into multidiscipline approaches into not only electrophysiological, but biophysical, biochemical and immunological research fields. From the past research results our neurophysiologists can be expected to advance rapidly toward further development in the future of Japanese neurophysiology.</p>","PeriodicalId":10579,"journal":{"name":"Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology","volume":"98 1","pages":"1-18"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12838698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurokinin A and B. 神经激肽A和B。
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Pub Date : 1991-01-01
E Munekata
{"title":"Neurokinin A and B.","authors":"E Munekata","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The chemical features, pharmacological and biochemical characteristics of novel mammalian tachykinin peptides, neurokinin A and neurokinin B are described and are compared with those of substance P, a representative of tachykinin family.</p>","PeriodicalId":10579,"journal":{"name":"Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology","volume":"98 1","pages":"171-9"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12872933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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