IEEE Nuclear Science Symposium Conference Record, 2005最新文献_第5页

Initial evaluation of the Indiana small animal PET scanner 印第安纳州小动物PET扫描仪的初步评估

IEEE Nuclear Science Symposium Conference Record, 2005 Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596815

N. Rouze, V.C. Soon, J. Young, S. Siegel, G. Hutchins

{"title":"Initial evaluation of the Indiana small animal PET scanner","authors":"N. Rouze, V.C. Soon, J. Young, S. Siegel, G. Hutchins","doi":"10.1109/NSSMIC.2005.1596815","DOIUrl":"https://doi.org/10.1109/NSSMIC.2005.1596815","url":null,"abstract":"The Indiana small animal PET scanner is a new generation PET scanner with design goals of 1 microliter volumetric spatial resolution, a point source sensitivity of greater than 5 percent, and an imaging field-of-view suitable for whole body mouse imaging. The scanner design uses 12 planar detector banks each consisting of a 48 /spl times/ 108 array of 20 mm long LSO crystals with an array pitch of 0.87 mm coupled to two Hamamatsu H8500 large area, 64-anode photomultiplier tubes. The detector modules are mounted on a rotatable gantry and are offset from the center of rotation to give an increased sampling density. Eight detector banks are currently installed in the scanner, and this report presents an initial performance evaluation of the scanner for this configuration. Using a 30 gauge needle (ID=0.15 mm, OD=0.30 mm) positioned near the center of the scanner, the transaxial resolution has been measured to be 1.1 mm FWHM and the axial resolution has been measured to be 1.5 mm FWHM. The sensitivity has been measured to be 4.0% of all decays. The scatter fraction is 0.26 and the peak noise equivalent countrate is 80 kcps at an activity of 0.22 mCi. Sample images demonstrate good imaging capabilities.","PeriodicalId":105619,"journal":{"name":"IEEE Nuclear Science Symposium Conference Record, 2005","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121122585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

High resolution GSO block detectors using PMT-quadrant-sharing design for human whole body and breast/brain PET applications 采用pmt象限共享设计的高分辨率GSO块检测器，适用于人体全身和乳房/脑部PET应用

IEEE Nuclear Science Symposium Conference Record, 2005 Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596929

Soonseok Kim, W. Wong, Hongdi Li, Yuxuan Zhang, S. Xie, R. Ramirez, Yu Wang, J. Uribe, H. Baghaei, Jiguo Liu, Shitao Liu

{"title":"High resolution GSO block detectors using PMT-quadrant-sharing design for human whole body and breast/brain PET applications","authors":"Soonseok Kim, W. Wong, Hongdi Li, Yuxuan Zhang, S. Xie, R. Ramirez, Yu Wang, J. Uribe, H. Baghaei, Jiguo Liu, Shitao Liu","doi":"10.1109/NSSMIC.2005.1596929","DOIUrl":"https://doi.org/10.1109/NSSMIC.2005.1596929","url":null,"abstract":"High resolution GSO block detectors have been developed using the PMT-quadrant-sharing (PQS) design for human whole body and breast/brain PET applications. Segmented GSO (Ce 0.5 mol%) crystals of 3.02 mmtimes3.02 mmtimes20 mm (13times13 array) and 3.58 mmtimes3.58 mmtimes20 mm (11times11) were assembled together to build two prototype detectors for whole body PET imaging with 39 mm round PMTs and crystals of 2.04 mmtimes2.04 mmtimes20 mm (9times9) for breast/brain PET imaging with 19 mm round PMTs. The enhanced specular reflector (3M Co.) mirror-film windows with reflectance 98% and thickness 0.065 mm were used to control light collection and distribution. Crystal pitches are 3.1 (13times13), 3.64 (11times11), and 2.12 mm (9times9) and crystal-packing fractions are 95, 97, and 93%, respectively. List-mode measurements with Cs-137 sources were carried out to investigate crystal decoding and were analyzed to extract individual crystal spectra. All the crystals in the detectors were identified. Energy resolution for individual crystals ranges from 13.7 to 18.5% (13times13), 12.2 to 14.2% (11times11), and 20.9 to 28.9% (9times9), with overall energy resolutions of 15.6, 13.2, and 24.3%, respectively. Light collection efficiencies for the central crystals are 60 (13times13), 66 (11times11), and 72% (9times9), compared to the corner crystals. The maximum decodable crystals/PMT ratios at 511 keV are high 121-169 for the 39 mm PQS GSO detector design and 81 for the 19 mm PQS GSO detector design with crystals 20 mm deep. It is anticipated that these PQS GSO detectors will provide high resolution and sensitivity at low cost","PeriodicalId":105619,"journal":{"name":"IEEE Nuclear Science Symposium Conference Record, 2005","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125698108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Development of a fully rotational non-contact fluorescence tomographer for small animals 小动物全旋转非接触荧光层析仪的研制

IEEE Nuclear Science Symposium Conference Record, 2005 Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596814

R. Schulz, G. Echner, H. Ruhle, W. Stroh, J. Vierling, T. Vogt, J. Peter, W. Semmler

引用次数: 6

MCNP prediction of measured subcritical reactor parameters 测量的亚临界反应堆参数的MCNP预测

IEEE Nuclear Science Symposium Conference Record, 2005 Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596394

Ned Xoubi, Zhong‐Kuo Zhao, G. Maldonado

引用次数: 3

Performance characteristics of continuous miniature crystal element (cMiCE) detectors 连续微型晶元(cMiCE)探测器的性能特性

IEEE Nuclear Science Symposium Conference Record, 2005 Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596622

T. Ling, Kisung Lee, R. Miyaoka

{"title":"Performance characteristics of continuous miniature crystal element (cMiCE) detectors","authors":"T. Ling, Kisung Lee, R. Miyaoka","doi":"10.1109/NSSMIC.2005.1596622","DOIUrl":"https://doi.org/10.1109/NSSMIC.2005.1596622","url":null,"abstract":"In this work, we investigate the performance characteristics of our continuous miniature crystal element detector (cMiCE). Versions with a 25 mm by 25 mm by 4 mm thick LSO crystal and with a 50 mm by 50 mm by 8 mm thick LSYO crystal were evaluated. Both detectors utilized a 64-channel flat panel photomultiplier tube (PMT). The intrinsic spatial resolution for the detectors was evaluated using standard Anger positioning and a statistics based positioning (SBP) algorithm. We also examined the effect different reflective materials applied on the entrance surface had on the intrinsic resolution for the 8 mm LYSO crystal. The average energy resolution was 20% for the 4 mm thick LSO crystal and 16% - 21% for the 8 mm thick LYSO crystal. The average intrinsic spatial resolution for the 4 mm thick crystal was 1.8 mm full width at half maximum (FWHM) for Anger positioning to within 3 mm of the crystal's edge and 1.14 mm FWHM for SBP to within 2 mm of the edge. The average intrinsic spatial resolution for the 8 mm thick crystal was 2.2 mm FWHM for Anger positioning to within 8 mm of the crystal's edge and 1.3-1.5 mm FWHM (depending on the reflective material used) for SBP to within 2 mm of the edge. Intrinsic spatial resolution is reported without correcting for point source size. The point spot flux had a FWHM of -0.52 mm. Using the SBP algorithm showed significant improvement in spatial resolution, linearity of positioning result, and effective field of view for our cMiCE detector","PeriodicalId":105619,"journal":{"name":"IEEE Nuclear Science Symposium Conference Record, 2005","volume":"16 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123663784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SPECT-CT study of directed drug delivery using /sup 111/In-labeled liposomes in a murine mammary carcinoma model 使用/sup 111/ in标记脂质体在小鼠乳腺癌模型中定向给药的SPECT-CT研究

IEEE Nuclear Science Symposium Conference Record, 2005 Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596717

E. Izaguirre, Mingshan Sun, D. Drummond, D. Kirpotin, T. Funk, S. Thompson, J. Carver, M. Hayes, M. Wendland, M. Knudsen, B. Hasegawa

{"title":"SPECT-CT study of directed drug delivery using /sup 111/In-labeled liposomes in a murine mammary carcinoma model","authors":"E. Izaguirre, Mingshan Sun, D. Drummond, D. Kirpotin, T. Funk, S. Thompson, J. Carver, M. Hayes, M. Wendland, M. Knudsen, B. Hasegawa","doi":"10.1109/NSSMIC.2005.1596717","DOIUrl":"https://doi.org/10.1109/NSSMIC.2005.1596717","url":null,"abstract":"Liposomal drugs offer the promise of an improved therapeutic index due to improvements in the specific delivery of anti-cancer agents to tumors. The presented work concentrates on imaging the tumor uptake of /sup 111/In-labeled liposomes noninvasively as a specific tumor drug delivery carrier in a murine cancer model. The tumor uptake of liposomes has been imaged using a microSPECT/microCT small animal dedicated scanner prototype constructed at our laboratory. The imaging system consists of a high resolution SPECT (700 /spl mu/m) and high resolution CT (70 /spl mu/m). The SPECT subsystem consists in specially designed CZT gamma cameras shielded for energies up to 250 keV. The mice were injected with liposomes and scanned at the time of maximum tumor uptake (24 h). The total activity of the mouse samples was of the order of 250 uCi, and with tumor sizes of 1000-1500 mm/sup 3/. The imaging geometries in the CT and SPECT acquisitions were selected to obtain high magnification and high efficiency to image the tumor located within the torso. The SPECT and CT projections were taken sequentially. The acquired images show that necrotic tumors can de imaged with high resolution to observe liposome inhomogeneous uptake.","PeriodicalId":105619,"journal":{"name":"IEEE Nuclear Science Symposium Conference Record, 2005","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114508840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Development and initial results of a dual-modality SPECT/optical small animal imager 双模SPECT/光学小动物成像仪的开发和初步结果

IEEE Nuclear Science Symposium Conference Record, 2005 Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596718

J. Peter, H. Ruehle, V. Stamm, R. Schulz, M. Smith, B. Welch, V. Popov, B. Kross, R. Wojcik, A. Weisenberger, S. Majewski, W. Semmler

{"title":"Development and initial results of a dual-modality SPECT/optical small animal imager","authors":"J. Peter, H. Ruehle, V. Stamm, R. Schulz, M. Smith, B. Welch, V. Popov, B. Kross, R. Wojcik, A. Weisenberger, S. Majewski, W. Semmler","doi":"10.1109/NSSMIC.2005.1596718","DOIUrl":"https://doi.org/10.1109/NSSMIC.2005.1596718","url":null,"abstract":"We have developed a dual-modality single photon (SPECT)/optical (OT) small animal tomographic device to image simultaneously and from identical projection angles in vivo distributions of bioluminescent/(near-infrared) fluorescent and radiolabeled markers. For the SPECT sub-system a compact gamma detector has been developed. A custom-made pinhole (PH) collimator suitable for attachment of reflective surfaces for concurrent optical imaging has been built. The collimator's reflective surfaces filter out optical photons from the multi-energetic photon flux. These photons are directed into a system of mirrors to compose an optical projection that is aligned with the angular field of view of the PH SPECT camera. For the optical detector sub-system a high resolution cooled CCD camera is used. In addition to initial small animal imaging studies several experimental phantom studies were performed with capillary tubes filled with various isotopes and optical markers to evaluate energy/wavelength/tissue dependent spatial resolution capabilities of the sub-systems.","PeriodicalId":105619,"journal":{"name":"IEEE Nuclear Science Symposium Conference Record, 2005","volume":"349 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122755366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Initial performance of the RatCAP, a PET camera for conscious rat brain imaging RatCAP的初步表现，这是一种用于老鼠大脑成像的PET相机

IEEE Nuclear Science Symposium Conference Record, 2005 Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596971

P. Vaska, C. Woody, D. Schlyer, V. Radeka, P. O'connor, J. Pratte, S. Shokouhi, S. Stoll, S. Junnarkar, M. Purschke, S. Park, S. Southekal, V. Dzhordzhadze, W. Schiffer, J. Neill, M. Murphy, T. Aubele, R. Kristiansen, A. Villanueva, S. Boose, A. Kandasamy, B. Yu, A. Kriplani, S. Krishnamoorthy, R. Lecomte, R. Fontaine

{"title":"Initial performance of the RatCAP, a PET camera for conscious rat brain imaging","authors":"P. Vaska, C. Woody, D. Schlyer, V. Radeka, P. O'connor, J. Pratte, S. Shokouhi, S. Stoll, S. Junnarkar, M. Purschke, S. Park, S. Southekal, V. Dzhordzhadze, W. Schiffer, J. Neill, M. Murphy, T. Aubele, R. Kristiansen, A. Villanueva, S. Boose, A. Kandasamy, B. Yu, A. Kriplani, S. Krishnamoorthy, R. Lecomte, R. Fontaine","doi":"10.1109/NSSMIC.2005.1596971","DOIUrl":"https://doi.org/10.1109/NSSMIC.2005.1596971","url":null,"abstract":"The first fully functional prototype of the RatCAP (Rat conscious animal PET) scanner has been constructed and preliminary evaluations have been performed. RatCAP is a miniature, high performance PET scanner designed specifically to image the brain of a rat while directly attached to its head. The goal is to eliminate the need for anesthesia which can confound quantitative brain studies and prevent simultaneous correlations of neurochemistry and behavior. RatCAP is a fully 3D tomograph with a transaxial (axial) field-of-view of 38(18) mm, outside diameter 72 mm, and weight <200 g which is supported by a small tether. A total of 384 LSO crystals are divided among 12 independent detector blocks, each of which contains an avalanche photodiode (APD) photosensor array and a custom-designed ASIC for highly integrated front-end processing. A custom FPGA-based time-stamp module has been designed and implemented, achieving a preliminary system resolution of 13.9 ns FWHM. With a point source in the FOV center, spatial resolution is 2.1 mm FWHM, energy resolution averages 23% FWHM, and sensitivity is 0.7% at an average threshold of 150 keV. Novel offline data processing algorithms have been developed including methods for time and energy calibrations, corrections for physical effects, and a highly accurate iterative image reconstruction. Initial phantom and rat brain images have been obtained","PeriodicalId":105619,"journal":{"name":"IEEE Nuclear Science Symposium Conference Record, 2005","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117223209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Development of silica aerogel with any density 任意密度二氧化硅气凝胶的研制

IEEE Nuclear Science Symposium Conference Record, 2005 Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596380

M. Tabata, I. Adachi, T. Fukushima, H. Kawai, H. Kishimoto, A. Kuratani, H. Nakayama, S. Nishida, T. Noguchi, K. Okudaira, Y. Tajima, H. Yano, H. Yokogawa, H. Yoshida

引用次数: 19

Implementation of scatter corrected list-mode OP-EM reconstruction algorithm and a dual (histogram/list-mode) reconstruction scheme for dynamic PET imaging 实现散射校正列表模式的OP-EM重建算法和动态PET成像的双重(直方图/列表模式)重建方案

IEEE Nuclear Science Symposium Conference Record, 2005 Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596792

J. Cheng, A. Rahmim, S. Blinder, M. Camborde, V. Sossi

{"title":"Implementation of scatter corrected list-mode OP-EM reconstruction algorithm and a dual (histogram/list-mode) reconstruction scheme for dynamic PET imaging","authors":"J. Cheng, A. Rahmim, S. Blinder, M. Camborde, V. Sossi","doi":"10.1109/NSSMIC.2005.1596792","DOIUrl":"https://doi.org/10.1109/NSSMIC.2005.1596792","url":null,"abstract":"We describe an implementation of ordinary Poisson list-mode expectation maximization (OP-LMEM) algorithm for the high resolution research tomography (HRRT) with a scatter correction method based on the single scatter simulation (SSS) technique, and a random correction method based on the variance-reduced delayed-coincidence technique. A hybrid EM algorithm has also been implemented in list-mode reconstruction (H-LMEM) using delayed-coincidence event subtraction technique with the same scatter correction as in OP-LMEM. The reconstructed images of a dynamic scanning sequence of a contrast phantom have been compared with those reconstructed using the histogram-mode reconstruction, in particular, 3D ordinary Poisson ordered subset expectation maximization (3D-OP) with the same variance-reduced random and estimated scatter. The transaxial and axial profile analyses have shown excellent agreement between histogram and both list-mode reconstructions. Likewise the preliminary contrast and noise analyses have shown a close agreement between histogram-mode and both list-mode reconstructions. Based on these results, a dual reconstruction scheme can now be applied to dynamic imaging in positron emission tomography (PET) with scatter correction; i.e. histogram-mode reconstruction (3D-OP) can be applied to frames with a large number of counts, and list-mode reconstruction (OP-LMEM) will subsequently be used for low statistics frames, as an effort to obtain efficient and quantitatively accurate reconstructions applicable to state-of-the-art dynamic PET imaging using the HRRT.","PeriodicalId":105619,"journal":{"name":"IEEE Nuclear Science Symposium Conference Record, 2005","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123069678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9