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Parathyroid‐Hormone‐Related Protein is a Neuroprotective Endogenous Regulator of L‐Type Calcium Channels 甲状旁腺激素相关蛋白是L型钙通道的神经保护性内源性调节剂
CNS drug reviews Pub Date : 2006-06-07 DOI: 10.1111/J.1527-3458.2000.TB00185.X
O. Chatterjee, I. Nakchbandi, W. Philbrick, L. Kaczmarek, M. Brines, A. Broadus
{"title":"Parathyroid‐Hormone‐Related Protein is a Neuroprotective Endogenous Regulator of L‐Type Calcium Channels","authors":"O. Chatterjee, I. Nakchbandi, W. Philbrick, L. Kaczmarek, M. Brines, A. Broadus","doi":"10.1111/J.1527-3458.2000.TB00185.X","DOIUrl":"https://doi.org/10.1111/J.1527-3458.2000.TB00185.X","url":null,"abstract":"","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"24 1","pages":"42-42"},"PeriodicalIF":0.0,"publicationDate":"2006-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81925407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroimaging in Alzheimer's Disease: Relevance for the Development of Therapeutic Agents 阿尔茨海默病的神经影像学:与治疗剂开发的相关性
CNS drug reviews Pub Date : 2006-06-07 DOI: 10.1111/J.1527-3458.2000.TB00172.X
C. Dyck
{"title":"Neuroimaging in Alzheimer's Disease: Relevance for the Development of Therapeutic Agents","authors":"C. Dyck","doi":"10.1111/J.1527-3458.2000.TB00172.X","DOIUrl":"https://doi.org/10.1111/J.1527-3458.2000.TB00172.X","url":null,"abstract":"","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"34 2 1","pages":"26-27"},"PeriodicalIF":0.0,"publicationDate":"2006-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77685478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alzheimer's Association International Conference on Prevention of Dementia Washington, D.C., USA June 18–21, 2005 2005年6月18日至21日在美国华盛顿特区举行的阿尔茨海默病协会预防痴呆症国际会议
CNS drug reviews Pub Date : 2006-06-07 DOI: 10.1111/J.1527-3458.2005.TB00050.X
A. Scriabine
{"title":"Alzheimer's Association International Conference on Prevention of Dementia Washington, D.C., USA June 18–21, 2005","authors":"A. Scriabine","doi":"10.1111/J.1527-3458.2005.TB00050.X","DOIUrl":"https://doi.org/10.1111/J.1527-3458.2005.TB00050.X","url":null,"abstract":"","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"28 1","pages":"335-338"},"PeriodicalIF":0.0,"publicationDate":"2006-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87059735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mapping Cortical and Hippocampal Activation with an AMPA Receptor Potentiator in the Rat Brain Using c-fos Immunocytochemistry and [14C]2-deoxyglucose Autoradiography 利用c-fos免疫细胞化学和[14C]2-脱氧葡萄糖放射自显影技术，用AMPA受体增强剂定位大鼠脑皮层和海马的激活
CNS drug reviews Pub Date : 2006-06-07 DOI: 10.1111/J.1527-3458.2004.TB00016.X
Jill H. Fowler, K. Whalley, T. Murray, M. O'Neill, J. Mcculloch
{"title":"Mapping Cortical and Hippocampal Activation with an AMPA Receptor Potentiator in the Rat Brain Using c-fos Immunocytochemistry and [14C]2-deoxyglucose Autoradiography","authors":"Jill H. Fowler, K. Whalley, T. Murray, M. O'Neill, J. Mcculloch","doi":"10.1111/J.1527-3458.2004.TB00016.X","DOIUrl":"https://doi.org/10.1111/J.1527-3458.2004.TB00016.X","url":null,"abstract":"","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"32 1","pages":"194-194"},"PeriodicalIF":0.0,"publicationDate":"2006-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90093517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence for Neuropathology in Transgenic Mice Overexpressing p25, an Activator of cdk5 过表达cdk5激活因子p25转基因小鼠的神经病理学证据
CNS drug reviews Pub Date : 2006-06-07 DOI: 10.1111/J.1527-3458.2000.TB00178.X
M. Ahlijanian
{"title":"Evidence for Neuropathology in Transgenic Mice Overexpressing p25, an Activator of cdk5","authors":"M. Ahlijanian","doi":"10.1111/J.1527-3458.2000.TB00178.X","DOIUrl":"https://doi.org/10.1111/J.1527-3458.2000.TB00178.X","url":null,"abstract":"","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"11 1","pages":"34-34"},"PeriodicalIF":0.0,"publicationDate":"2006-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91517330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunophilin Ligands and Anti‐inflammatory Drugs Regulate Amyloid Precursor Protein Synthesis and Metabolism 亲免疫蛋白配体和抗炎药物调节淀粉样蛋白前体蛋白的合成和代谢
CNS drug reviews Pub Date : 2006-06-07 DOI: 10.1111/J.1527-3458.2000.TB00169.X
Robert K. K. Lee
{"title":"Immunophilin Ligands and Anti‐inflammatory Drugs Regulate Amyloid Precursor Protein Synthesis and Metabolism","authors":"Robert K. K. Lee","doi":"10.1111/J.1527-3458.2000.TB00169.X","DOIUrl":"https://doi.org/10.1111/J.1527-3458.2000.TB00169.X","url":null,"abstract":"","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"13 1","pages":"20-21"},"PeriodicalIF":0.0,"publicationDate":"2006-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81784619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of Selective Inhibitors of Neuronal Nitric Oxide Synthase for Neuroprotection 神经元一氧化氮合酶选择性抑制剂的神经保护作用
CNS drug reviews Pub Date : 2006-06-07 DOI: 10.1111/J.1527-3458.2000.TB00182.X
D. Reif
{"title":"Discovery of Selective Inhibitors of Neuronal Nitric Oxide Synthase for Neuroprotection","authors":"D. Reif","doi":"10.1111/J.1527-3458.2000.TB00182.X","DOIUrl":"https://doi.org/10.1111/J.1527-3458.2000.TB00182.X","url":null,"abstract":"","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"6 1","pages":"39-39"},"PeriodicalIF":0.0,"publicationDate":"2006-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85898283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antiaging compounds: (-)deprenyl (selegeline) and (-)1-(benzofuran-2-yl)-2-propylaminopentane, [(-)BPAP], a selective highly potent enhancer of the impulse propagation mediated release of catecholamine and serotonin in the brain. 抗衰老化合物:(-)去戊烯基(selegeline)和(-)1-(苯并呋喃-2-基)-2-丙基氨基戊烷，[(-)BPAP]，一种选择性的高效增强剂，可促进脑内冲动传播介导的儿茶酚胺和血清素的释放。
CNS drug reviews Pub Date : 2006-06-07 DOI: 10.1111/J.1527-3458.2001.TB00202.X
J. Knoll
{"title":"Antiaging compounds: (-)deprenyl (selegeline) and (-)1-(benzofuran-2-yl)-2-propylaminopentane, [(-)BPAP], a selective highly potent enhancer of the impulse propagation mediated release of catecholamine and serotonin in the brain.","authors":"J. Knoll","doi":"10.1111/J.1527-3458.2001.TB00202.X","DOIUrl":"https://doi.org/10.1111/J.1527-3458.2001.TB00202.X","url":null,"abstract":"Hundreds of millions of people now die over the age of 80 years primarily due to twentieth century progress in hygiene, chemotherapy, and immunology. With a longer average lifespan, the need to improve quality of life during the latter decades is more compelling. \"Aging--The Epidemic of the New Millenium,\" a recent international conference (Monte Carlo, June 17-18, 2000), showed with peculiar clarity that a safe and efficient drug strategy to slow the age-related decay of brain performance is still missing. This review summarizes the physiologic and pharmacologic arguments in favor of a peculiar lifelong prophylactic medication with reasonable chances to keep in check brain aging and decrease the precipitation of age-related neurological diseases.","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"38 1","pages":"317-45"},"PeriodicalIF":0.0,"publicationDate":"2006-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85994925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
Abstracts from the Sixth International Conference on Progress in Alzheimer's and Parkinson's Diseases. May 8-12, 2003. Seville, Spain. 第六届阿尔茨海默病和帕金森病国际进展会议摘要2003年5月8日至12日。西班牙塞维利亚。
CNS drug reviews Pub Date : 2004-01-01
{"title":"Abstracts from the Sixth International Conference on Progress in Alzheimer's and Parkinson's Diseases. May 8-12, 2003. Seville, Spain.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"10 2","pages":"190-201"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24649544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Negative allosteric modulation of AMPA-preferring receptors by the selective isomer GYKI 53784 (LY303070), a specific non-competitive AMPA antagonist. 选择性异构体GYKI 53784 (LY303070)对AMPA偏好受体的负变构调节，一种特异性的非竞争性AMPA拮抗剂。
CNS drug reviews Pub Date : 2002-01-01
Jérôme Ruel, Matthieu J Guitton, Jean-Luc Puell
{"title":"Negative allosteric modulation of AMPA-preferring receptors by the selective isomer GYKI 53784 (LY303070), a specific non-competitive AMPA antagonist.","authors":"Jérôme Ruel,&nbsp;Matthieu J Guitton,&nbsp;Jean-Luc Puell","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>GYKI 53784 or LY303070 [(-)1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-4,5-dihydro-3-methylcarbamoyl-2,3-benzodiazepine] belongs to a new family of 2,3-benzodiazepine compounds (also called homophtalazines) selective and non-competitive antagonists at alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptors. These compounds include the original GYKI-52466, its more potent derivative GYKI 53655 and the active isomer of the latter, GYKI 53784. This review summarizes current knowledge of this novel AMPA antagonist: GYKI 53784. GYKI 53784 is the most potent of the compounds in the 2,3-benzodiazepine class, blocking AMPA receptor-mediated responses. In contrast to the compounds of the quinoxalinedione family, that block AMPA as well as kainate receptors, GYKI 53784 does not block the activation of kainate receptors. Furthermore, GYKI 53784 does not act at the same receptor site as positive AMPA modulators (i.e., cyclothiazide, BDP-12, 1-BCP or aniracetam). GYKI 53784 is a powerful neuroprotective agent in both in vitro and in vivo models of AMPA receptor-mediated excitotoxicity. In contrast to NMDA receptor antagonists, whose favorable clinical actions are compromised by important side effects such as the impairment of memory functions, the selective AMPA antagonist, GYKI 53784, may be of potential clinical value, both in acute (stroke and trauma) and chronic (Alzheimer's disease, epilepsy) neurological disorders.</p>","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"8 3","pages":"235-54"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741693/pdf/CNS-8-235.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22043980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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