Clinical Medicine最新文献

Fertility Treatments in Patients with Medical Conditions. 有疾病患者的生育治疗。

IF 3.6 4区医学

Clinical Medicine Pub Date : 2025-06-16 DOI: 10.1016/j.clinme.2025.100333

Paramjit Uppal, Edward Coats, Charlotte Frise

引用次数: 0

Palliative Sedation at the End of Life: Practical and Ethical Considerations. 临终时的姑息性镇静：实践和伦理考虑。

IF 3.6 4区医学

Clinical Medicine Pub Date : 2025-06-14 DOI: 10.1016/j.clinme.2025.100338

Dr Caroline Barry, Dr Robert Brodrick, Dr Gurpreet Gupta, Dr Imranali Panjwani

引用次数: 0

A descriptive cohort study of pregnancy and parenthood in women with cystic fibrosis. 囊性纤维化妇女妊娠和生育的描述性队列研究。

IF 3.6 4区医学

Clinical Medicine Pub Date : 2025-06-12 DOI: 10.1016/j.clinme.2025.100340

Aleksandra Duffy, Susan Parker, Simon Williams, Kenneth Hodson, Simon Doe, Carlos Echevarria, Stephen J Bourke

{"title":"A descriptive cohort study of pregnancy and parenthood in women with cystic fibrosis.","authors":"Aleksandra Duffy, Susan Parker, Simon Williams, Kenneth Hodson, Simon Doe, Carlos Echevarria, Stephen J Bourke","doi":"10.1016/j.clinme.2025.100340","DOIUrl":"https://doi.org/10.1016/j.clinme.2025.100340","url":null,"abstract":"Women with cystic fibrosis (wwCF) are increasingly undertaking pregnancy. This study assessed the current state of relationships, fertility, pregnancy and parenthood in a total cohort of 217 wwCF. Overall, 64% of wwCF were in long-term heterosexual relationships, 32% were single and 4% were in same-sex relationships; 64 wwCF had 111 children; 97 (87.4%) were conceived naturally and 10 (9%) by assisted reproduction. One woman had two children by surrogacy, one couple adopted a child and 6 had a role as a step-parent. Of the 217 wwCF 31 (14%) died at a mean age of 41.4 years; they had 18 children and 8 (44%) were less than 18 years old when the mother died. There was a marked increase in pregnancies associated with the introduction of CF modulator medications, from 3 in 2020 to 16 in 2023. There were 50 pregnancies between 2020 and 2024;17 (34%) were not planned (5 were terminated); and 15 (30%) partners did not have CF genetic tests pre-conception. There were 8 miscarriages. Exacerbations of lung disease occurred in 11 (31%) completed pregnancies, gestational diabetes in 12 (34%), one gastrointestinal bleeding, and one pre-eclampsia. Delivery was by caesarean section in 14 (40%) and 4 (11%) births were pre-mature (<37 weeks gestation). Although outcomes are generally good, pre-conception planning is suboptimal, pregnancy is associated with increased complications and parenthood raises complex issues regarding prognosis. CF teams should have close links with maternal medicine services to meet the specific needs of wwCF.","PeriodicalId":10492,"journal":{"name":"Clinical Medicine","volume":" ","pages":"100340"},"PeriodicalIF":3.6,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Some sage advice: a case report of sage burning causing interstitial lung disease. 鼠尾草烧伤致间质性肺病1例。

IF 3.6 4区医学

Clinical Medicine Pub Date : 2025-06-08 DOI: 10.1016/j.clinme.2025.100337

Jonathan Ayling-Smith, Richard Attanoos, Nicola-Xan Hutchinson

引用次数: 0

Comparisons of efficacy and safety of immunotherapies for Alzheimer's disease treatment: a network meta-analysis of randomized controlled trials. 免疫疗法治疗阿尔茨海默病的疗效和安全性比较：随机对照试验的网络荟萃分析

IF 3.6 4区医学

Clinical Medicine Pub Date : 2025-06-03 DOI: 10.1016/j.clinme.2025.100336

Ching-Hui Su, Ying-Tzu Chang, Huan-Shu Tseng, Chan-Yen Kuo, Jin-Hua Chen, Po- Yu Chien, Yao-Jen Chang, Chin-Chuan Hung

{"title":"Comparisons of efficacy and safety of immunotherapies for Alzheimer's disease treatment: a network meta-analysis of randomized controlled trials.","authors":"Ching-Hui Su, Ying-Tzu Chang, Huan-Shu Tseng, Chan-Yen Kuo, Jin-Hua Chen, Po- Yu Chien, Yao-Jen Chang, Chin-Chuan Hung","doi":"10.1016/j.clinme.2025.100336","DOIUrl":"https://doi.org/10.1016/j.clinme.2025.100336","url":null,"abstract":"Background: Alzheimer's disease (AD) remains a major challenge due to limited effective therapies. Moreover, direct comparisons between newly developed and symptomatic drugs are lacking. This network meta-analysis aimed to compare the efficacy and safety of immunotherapies for AD.Methods: A systematic search of PubMed, Embase, the Cochrane Library, and ClinicalTrials.gov was conducted for randomised controlled trials (RCTs) up to 29 June 2024. Eligible studies included adults with AD receiving immunotherapy versus placebo or symptomatic treatment.Results: Fifty-nine RCTs were included. Donanemab and lecanemab ranked among the most effective treatments for improving cognitive function (Clinical Dementia Rating Scale-Sum of Boxes P-scores: 0.88 and 0.77) and daily activities (Alzheimer's Disease Cooperative Study-Activities of Daily Living P-scores: 0.85 and 0.90), based on network meta-analysis findings.Conclusions: Anti-Aβ mAbs, particularly donanemab and lecanemab, demonstrated superior efficacy over other immunotherapies in slowing cognitive deterioration, supporting their role in AD management.Prospero registration number: CRD42023461680.","PeriodicalId":10492,"journal":{"name":"Clinical Medicine","volume":" ","pages":"100336"},"PeriodicalIF":3.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harveian Oration 2024: From bench to bedside and beyond - new horizons for translational ageing research. 哈维演讲2024：从实验室到床边和超越-转化老化研究的新视野。

IF 3.6 4区医学

Clinical Medicine Pub Date : 2025-06-03 DOI: 10.1016/j.clinme.2025.100334

Avan Aihie Sayer

引用次数: 0

Opioid analgesics: Managing the predictable. 阿片类镇痛药：管理可预测的。

IF 3.6 4区医学

Clinical Medicine Pub Date : 2025-05-27 DOI: 10.1016/j.clinme.2025.100330

A Barnes, G Heppenstall-Harris, A Dickman

引用次数: 0

Impact of chronic liver disease (CLD) on mortality, complications, and early readmission in patients with spontaneous intracranial hemorrhage (ICH): A National Readmission Database Analysis 2016-2020. 慢性肝病（CLD）对自发性颅内出血（ICH）患者死亡率、并发症和早期再入院的影响：2016-2020年全国再入院数据库分析

IF 3.6 4区医学

Clinical Medicine Pub Date : 2025-05-26 DOI: 10.1016/j.clinme.2025.100332

Ping-Jui Tsai, Yu-Jen Kuo

{"title":"Impact of chronic liver disease (CLD) on mortality, complications, and early readmission in patients with spontaneous intracranial hemorrhage (ICH): A National Readmission Database Analysis 2016-2020.","authors":"Ping-Jui Tsai, Yu-Jen Kuo","doi":"10.1016/j.clinme.2025.100332","DOIUrl":"https://doi.org/10.1016/j.clinme.2025.100332","url":null,"abstract":"Background: Chronic liver disease (CLD) is associated with worse outcomes in many medical conditions, but its impact on patients with spontaneous intracranial hemorrhage (ICH) has not been fully explored. This study aims to evaluate the influence of CLD on in-hospital outcomes of patients with a spontaneous ICH.Methods: Data from the Nationwide Readmissions Database (NRD) between 2016 and 2020 were retrospectively reviewed. Patients ≥ 18 years old admitted for the first time with a spontaneous ICH were included. Study outcomes included in-hospital mortality, length of stay (LOS), major complications, and 90-day readmission rate. Patients with and without CLD were matched using 1:4 propensity score matching (PSM). Univariate and multivariable logistic and linear regression analyses were performed to determine the associations between CLD and outcomes of interest.Results: After applying PSM, 21,345 patients were included in the analysis of which 4,269 had CLD. After adjustment, compared to patients without CLD, those with CLD had significantly higher in-hospital mortality (adjusted odds ratio [aOR] = 1.23, 95% confidence interval [CI]: 1.13-1.34, p < 0.001), a longer LOS(aOR = 1.26, 95% CI: 1.12-1.39, p < 0.001), higher rates of major complications(aOR = 1.76, 95% CI: 1.62-1.91, p < 0.001), and increased 90-day readmission rates (aOR = 1.20, 95% CI: 1.09-1.31, p < 0.001).Conclusions: CLD is independently associated with higher mortality, more complications, longer LOS, and higher readmission rates in patients admitted for spontaneous ICH. These findings underscore the need for specialized care strategies for patients with an ICH and underlying CLD.","PeriodicalId":10492,"journal":{"name":"Clinical Medicine","volume":" ","pages":"100332"},"PeriodicalIF":3.6,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gout on the acute medical take. 痛风的急症治疗。

IF 3.6 4区医学

Clinical Medicine Pub Date : 2025-05-26 DOI: 10.1016/j.clinme.2025.100331

Abhishek Abhishek, Edoardo Cipolletta

引用次数: 0

Is pulmonary embolism a chronic disease? 肺栓塞是一种慢性病吗？

IF 3.6 4区医学

Clinical Medicine Pub Date : 2025-05-09 DOI: 10.1016/j.clinme.2025.100325

Gerard Gurumurthy, Lianna Reynolds, Kerstin de Wit, Lara N Roberts, Jecko Thachil

引用次数: 0