Clinical reproduction and fertility最新文献_第8页

Therapeutic alternatives in infertile men. 不育男性的治疗选择。

Clinical reproduction and fertility Pub Date : 1986-02-01

A Conway

引用次数: 0

Contraceptive development and clinical trials. 避孕发展和临床试验。

Clinical reproduction and fertility Pub Date : 1986-02-01

I S Fraser

引用次数: 0

Immunoglobulins on human sperm: validation of a screening test for sperm autoimmunity. 人类精子的免疫球蛋白:精子自身免疫筛选试验的验证。

Clinical reproduction and fertility Pub Date : 1985-12-01

M G Jennings, M P McGowan, H W Baker

{"title":"Immunoglobulins on human sperm: validation of a screening test for sperm autoimmunity.","authors":"M G Jennings, M P McGowan, H W Baker","doi":"","DOIUrl":"","url":null,"abstract":"The immunobead test (IBT) is a new method of detecting antisperm antibodies with the advantages of enabling determination of the presence of antisperm antibodies during routine semen analysis, immunoglobulin isotypes and antibody specificity for binding to sperm structures such as head or tail. The IBT is compared with the conventional methods of detecting antisperm antibodies in serum; the tray agglutination test (TAT) and the sperm immobilization test (SIT). Positive IBT (50% or more of washed motile sperm binding to anti-IgG and/or anti-IgA immunobeads) were found in 6.8% of 689 men being investigated for infertility. Both IgG and IgA were found to be present in all cases. The IBT correlated closely with the serum antisperm antibody tests; of the 202 men tested by all three methods, 200 (99%) were either positive for circulating antibodies and IBT or negative for both. No men with serum antisperm antibodies lacked local antisperm antibodies as detected by IBT, and only two men (1%) were IBT positive in the absence of either one or both types of circulating antibodies. Individually, the TAT and the SIT correlated equally well with the IBT; 97% and 98% of men tested by TAT and IBT, and SIT and IBT respectively, were either positive by both or negative by both. It is concluded that the IBT is an excellent procedure for the detection of sperm antibodies.","PeriodicalId":10478,"journal":{"name":"Clinical reproduction and fertility","volume":"3 4","pages":"335-42"},"PeriodicalIF":0.0,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14947917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating and tissue concentrations of pregnancy-associated plasma protein-A (PAPP-A) in tubal ectopic gestation. 输卵管异位妊娠中妊娠相关血浆蛋白a (PAPP-A)的循环和组织浓度。

Clinical reproduction and fertility Pub Date : 1985-12-01

M J Sinosich, A Ferrier, B Teisner, R Porter, J G Westergaard, D M Saunders, J G Grudzinskas

{"title":"Circulating and tissue concentrations of pregnancy-associated plasma protein-A (PAPP-A) in tubal ectopic gestation.","authors":"M J Sinosich, A Ferrier, B Teisner, R Porter, J G Westergaard, D M Saunders, J G Grudzinskas","doi":"","DOIUrl":"","url":null,"abstract":"Concentrations of pregnancy-associated plasma protein-A (PAPP-A), human chorionic gonadotrophin (hCG) and pregnancy specific beta 1-glycoprotein (SP1) were measured by radioimmunoassay in 164 serum and 29 tissue samples obtained from 87 non-pregnant and 29 pregnant women with either tubal (n = 16) or intrauterine (n = 13) pregnancies. Of the 47 serum samples obtained from patients with a tubal pregnancy only two were positive for PAPP-A, whereas in excess of 94% of the samples were positive for both hCG and SP1. Serial measurements of hCG, and SP1, demonstrated an apparently normal growth rate for the tubally implanted trophoblast for the first 6 weeks of pregnancy. Thereafter, the tubal trophoblast is compromised since the tissue content of PAPP-A and hCG was significantly lower than that in intra-uterine derived trophoblastic tissue. By contrast, the content of both PAPP-A and hCG was significantly greater in the trophoblastic, both intra or extra-uterine derived, than in the endometrial/decidual, tissue. Furthermore, the absence of immunoreactive PAPP-A and the severely depressed circulating levels of PAPP-A in women with tubal pregnancies can be attributed to diminished secretion of PAPP-A into the maternal circulation. Therefore, in conjunction with a positive pregnancy test and the patient's clinical history, a severely depressed or absent serum PAPP-A level may aid in the diagnosis of extrauterine pregnancy.","PeriodicalId":10478,"journal":{"name":"Clinical reproduction and fertility","volume":"3 4","pages":"311-7"},"PeriodicalIF":0.0,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13569315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical status of antiprogesterone steroids. 抗黄体酮类固醇的临床状况。

Clinical reproduction and fertility Pub Date : 1985-12-01

D L Healy

引用次数: 0

Sperm survival studies in peritoneal fluid from infertile women with endometriosis and unexplained infertility. 子宫内膜异位症和不明原因不孕症不孕妇女腹膜液中精子存活研究

Clinical reproduction and fertility Pub Date : 1985-12-01

M K Oak, E N Chantler, C A Williams, M Elstein

引用次数: 0

Sperm autoimmunity in vasectomized men and its relationship to atherosclerotic coronary artery disease. 输精管切除术男性精子自身免疫及其与冠状动脉粥样硬化性疾病的关系

Clinical reproduction and fertility Pub Date : 1985-12-01

S C Liu, G H Tang