A. Petrillo, R. Fusco, T. Petrosino, P. Vallone, V. Granata, M. Rubulotta, Paolo Pariante, N. Raiano, Giosuè Scognamiglio, A. Fanizzi, R. Massafra, Miria Lafranceschina, D. La Forgia, Laura Greco, Francesca Romana Ferranti, Valeria De Soccio, A. Vidiri, Francesca Botta, V. Dominelli, Enrico Cassano, Eugenio Sorgente, B. Pecori, V. Cerciello, Luca Boldrini
{"title":"A multicentric study of radiomics and artificial intelligence analysis on contrast-enhanced mammography to identify different histotypes of breast cancer.","authors":"A. Petrillo, R. Fusco, T. Petrosino, P. Vallone, V. Granata, M. Rubulotta, Paolo Pariante, N. Raiano, Giosuè Scognamiglio, A. Fanizzi, R. Massafra, Miria Lafranceschina, D. La Forgia, Laura Greco, Francesca Romana Ferranti, Valeria De Soccio, A. Vidiri, Francesca Botta, V. Dominelli, Enrico Cassano, Eugenio Sorgente, B. Pecori, V. Cerciello, Luca Boldrini","doi":"10.1007/s11547-024-01817-8","DOIUrl":"https://doi.org/10.1007/s11547-024-01817-8","url":null,"abstract":"","PeriodicalId":104709,"journal":{"name":"La radiologia medica","volume":"89 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140964150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
La radiologia medicaPub Date : 2022-11-01Epub Date: 2022-09-07DOI: 10.1007/s11547-022-01552-y
Francesco Giurazza, Nicola Cionfoli, Andrea Paladini, Mario Vallone, Fabio Corvino, Leonardo Teodoli, Lorenzo Moramarco, Pietro Quaretti, Carlo Catalano, Raffaella Niola, Pierleone Lucatelli
{"title":"PHIL<sup>®</sup> (precipitating hydrophobic injectable liquid): retrospective multicenter experience on 178 patients in peripheral embolizations.","authors":"Francesco Giurazza, Nicola Cionfoli, Andrea Paladini, Mario Vallone, Fabio Corvino, Leonardo Teodoli, Lorenzo Moramarco, Pietro Quaretti, Carlo Catalano, Raffaella Niola, Pierleone Lucatelli","doi":"10.1007/s11547-022-01552-y","DOIUrl":"https://doi.org/10.1007/s11547-022-01552-y","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to analyze safety and effectiveness of PHIL<sup>®</sup> (Microvention, CA-USA) in peripheral endovascular embolization procedures, both in elective and emergent scenarios.</p><p><strong>Materials and methods: </strong>This is a multicenter retrospective study, involving 178 patients from five interventional radiology departments from January 2017 to December 2021. Patients treated by an endovascular embolization with PHIL<sup>®</sup> were included; different PHIL<sup>®</sup> viscosities were adopted. Exclusion criteria were: neuroradiological endovascular interventions, other cohesive liquid embolics adopted during the same procedure, follow-up < 30 days. Technical success was intended as definitive target vessel occlusion without the need for other embolics after PHIL<sup>®</sup> injection. Clinical success was considered as restoration of hemodynamic status in case of emergent embolization and improvement of clinical conditions in case of elective procedures, without additional interventions at 30 days.</p><p><strong>Results: </strong>Sixty-four women and 114 men, mean age 62 years (range 6-91), were evaluated. Sixty-three patients were in elective scenarios (AVMs, type-II endoleaks, tumors, varices, aneurysms, varicoceles) and 115 were in emergent settings (hemorrhage, pseudoaneurysms, hemoptysis, priapism); 190 procedures were performed in 178 patients. Overall technical and clinical success rates were 94.7% and 92.1%, respectively. The complications rate was 7.4% (6 grade-I, 7 grade-III, 1 grade-IV). PHIL<sup>®</sup>-25 was the more adopted viscosity; totally, 311 vials were injected (rate: 1.64 vial/procedure).</p><p><strong>Conclusion: </strong>In this series, PHIL<sup>®</sup> proved to be a safe and effective liquid embolic in peripheral embolizations, both in elective and emergent scenarios. The pre-filled syringe preparation allowed operators to use it even when unplanned at beginning of the intervention.</p>","PeriodicalId":104709,"journal":{"name":"La radiologia medica","volume":" ","pages":"1303-1312"},"PeriodicalIF":8.9,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40354412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
La radiologia medicaPub Date : 2022-11-01Epub Date: 2022-09-19DOI: 10.1007/s11547-022-01559-5
Claudio Ventura, Silvia Baldassarre, Federico Cerimele, Laura Pepi, Elisabetta Marconi, Paola Ercolani, Chiara Floridi, Giulio Argalia, Gaia Goteri, Andrea Giovagnoni
{"title":"2D shear wave elastography in evaluation of prognostic factors in breast cancer.","authors":"Claudio Ventura, Silvia Baldassarre, Federico Cerimele, Laura Pepi, Elisabetta Marconi, Paola Ercolani, Chiara Floridi, Giulio Argalia, Gaia Goteri, Andrea Giovagnoni","doi":"10.1007/s11547-022-01559-5","DOIUrl":"https://doi.org/10.1007/s11547-022-01559-5","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the reproducibility of the 2D shear wave elastography (2D-SWE) method and to identify the prognostic factors of breast lesions.</p><p><strong>Methods: </strong>In this prospective study, 44 female patients were consecutively included from January 2020 to September 2021. All patients showing visible masses at B-mode ultrasound underwent to clinical evaluation, followed by qualitative and quantitative 2D-SWE by two different operators with over 15-year and 2-year experience, respectively. Subsequently, patients underwent to surgical treatment after core needle biopsy. Reproducibility of qualitative and quantitative 2D-SWE was evaluated by Cohen's kappa and intraclass correlation coefficient (ICC). Clinical, imaging, and histopathological data and 2D-SWE evaluations were analysed with Spearman's rank correlation test.</p><p><strong>Results: </strong>The mean age of the patients was 55 years ± 12. The mean histological and ultrasound tumour size of were 23.1 mm ± 13.2 and 17.2 mm ± 10.2, respectively. The interobserver agreement showed a good reproducibility limited to the qualitative evaluation colour maps (Cohen's kappa = 0.603) and to the quantitative evaluation E ratio (ICC = 0.771). Correlation analysis between the ultrasound and 2D-SWE values and the clinical-pathological parameters showed a significant relationship between E ratio and Elston-Ellis grading (P < 0.030) and between tumour size and Elston-Ellis grading (P < 0.041).</p><p><strong>Conclusion: </strong>The 2D-SWE has shown good reproducibility among operators with different experience. It could be a promising tool in the evaluation of some prognostic factors in ultrasound visible breast cancer.</p>","PeriodicalId":104709,"journal":{"name":"La radiologia medica","volume":" ","pages":"1221-1227"},"PeriodicalIF":8.9,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40368600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
La radiologia medicaPub Date : 2022-11-01Epub Date: 2022-09-21DOI: 10.1007/s11547-022-01558-6
Shenghui Wu, Ruiyang Li, Wei Wang, Yingqi Zhang, Jiong Mei
{"title":"Fracture line distribution in femoral head fractures: a complement to Pipkin, Brumback, and AO/OTA classifications.","authors":"Shenghui Wu, Ruiyang Li, Wei Wang, Yingqi Zhang, Jiong Mei","doi":"10.1007/s11547-022-01558-6","DOIUrl":"https://doi.org/10.1007/s11547-022-01558-6","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to explore the fracture line distribution and validate fracture classifications of Femoral head fractures (FHFs).</p><p><strong>Materials and methods: </strong>A total of 209 FHFs were reviewed retrospectively. Subjects were classified by associated injuries and commonly used fracture classifications (Pipkin, Brumback, and AO/OTA), and the universality degree of classifications was evaluated. The fracture line directions were determined in the coronal and axial CT planes. 3D mapping analysis of fracture lines was performed separately by each group. 3D maps were employed to analyze the discrimination degree of inter-subtype classifications and create a new classification. The subjects were subsequently reclassified. Correlations between classifications were analyzed to determine the matching degree of the three classifications.</p><p><strong>Results: </strong>The universality degrees were 98.6% (pipkin), 44.5% (Brumback), and 94.3% (AO/OTA). The cases of (100%) Brumback and (98.5%) AO/OTA can be classified by Pipkin. The mean angles of fracture lines to the coronal and axial axis of primary compressive trabeculae were 20.25° and 54.56°. The discrimination degrees of inter-subtype of classifications were 0 (Pipkin), 60% (Brumback), and 33% (AO/OTA). A new classification with three regions and five types was created on 3D maps. Pipkin and AO/OTA matched one region, while Brumback matched two regions.</p><p><strong>Conclusions: </strong>There were three distributed fracture regions in FHFs that mismatched Pipkin, Brumback, and AO/OTA classifications. The new classification, based on morphometric features of FHFs, could compensate for the shortcomings of commonly used classifications, improving their applicability in treating FHFs.</p>","PeriodicalId":104709,"journal":{"name":"La radiologia medica","volume":" ","pages":"1235-1244"},"PeriodicalIF":8.9,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40374873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
La radiologia medicaPub Date : 2022-11-01Epub Date: 2022-09-17DOI: 10.1007/s11547-022-01555-9
Stefano Cipollari, Martina Pecoraro, Alì Forookhi, Ludovica Laschena, Marco Bicchetti, Emanuele Messina, Sara Lucciola, Carlo Catalano, Valeria Panebianco
{"title":"Biparametric prostate MRI: impact of a deep learning-based software and of quantitative ADC values on the inter-reader agreement of experienced and inexperienced readers.","authors":"Stefano Cipollari, Martina Pecoraro, Alì Forookhi, Ludovica Laschena, Marco Bicchetti, Emanuele Messina, Sara Lucciola, Carlo Catalano, Valeria Panebianco","doi":"10.1007/s11547-022-01555-9","DOIUrl":"https://doi.org/10.1007/s11547-022-01555-9","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the impact of an artificial intelligence (AI) software and quantitative ADC (qADC) on the inter-reader agreement, diagnostic performance, and reporting times of prostate biparametric MRI (bpMRI) for experienced and inexperienced readers.</p><p><strong>Materials and methods: </strong>A total of 170 multiparametric MRI (mpMRI) of patients with suspicion of prostate cancer (PCa) were retrospectively reviewed by one experienced and one inexperienced reader three times, following a wash-out period. First, only the bpMRI sequences, including T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI) sequences, and apparent diffusion coefficient (ADC) maps, were used. Then, bpMRI and quantitative ADC values were used. Lastly, bpMRI and the AI software were used. Inter-reader agreement between the two readers and between each reader and the mpMRI original reports was calculated. Detection rates and reporting times were calculated for each group.</p><p><strong>Results: </strong>Inter-reader agreement with respect to mpMRI was moderate for bpMRI, Quantib, and qADC for both the inexperienced (weighted k of 0.42, 0.45, and 0.41, respectively) and the experienced radiologists (weighted k of 0.44, 0.46, and 0.42, respectively). Detection rate of PCa was similar between the inexperienced (0.24, 0.26, and 0.23) and the experienced reader (0.26, 0.27 and 0.27), for bpMRI, Quantib, and qADC, respectively. Reporting times were lower for Quantib (8.23, 7.11, and 9.87 min for the inexperienced reader and 5.62, 5.07, and 6.21 min for the experienced reader, for bpMRI, Quantib, and qADC, respectively).</p><p><strong>Conclusions: </strong>AI and qADC did not have a significant impact on the diagnostic performance of both readers. The use of Quantib was associated with lower reporting times.</p>","PeriodicalId":104709,"journal":{"name":"La radiologia medica","volume":" ","pages":"1245-1253"},"PeriodicalIF":8.9,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40364138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
La radiologia medicaPub Date : 2022-11-01Epub Date: 2022-09-17DOI: 10.1007/s11547-022-01551-z
Daniele Fresilli, Nicola Di Leo, Ombretta Martinelli, Luca Di Marzo, Patrizia Pacini, Vincenzo Dolcetti, Giovanni Del Gaudio, Fabrizio Canni, Ludovica Isabella Ricci, Corrado De Vito, Corrado Caiazzo, Raffaella Carletti, Cira Di Gioia, Iacopo Carbone, Steven B Feinstein, Carlo Catalano, Vito Cantisani
{"title":"3D-Arterial analysis software and CEUS in the assessment of severity and vulnerability of carotid atherosclerotic plaque: a comparison with CTA and histopathology.","authors":"Daniele Fresilli, Nicola Di Leo, Ombretta Martinelli, Luca Di Marzo, Patrizia Pacini, Vincenzo Dolcetti, Giovanni Del Gaudio, Fabrizio Canni, Ludovica Isabella Ricci, Corrado De Vito, Corrado Caiazzo, Raffaella Carletti, Cira Di Gioia, Iacopo Carbone, Steven B Feinstein, Carlo Catalano, Vito Cantisani","doi":"10.1007/s11547-022-01551-z","DOIUrl":"https://doi.org/10.1007/s11547-022-01551-z","url":null,"abstract":"<p><strong>Purpose: </strong>Our purpose is to assess Multiparametric Ultrasound (MPUS) efficacy for evaluation of carotid plaque vulnerability and carotid stenosis degree in comparison with Computed Tomography angiography (CTA) and histology.</p><p><strong>Material and methods: </strong>3D-Arterial Analysis is a 3D ultrasound software that automatically provides the degree of carotid stenosis and a colorimetric map of carotid plaque vulnerability. We enrolled 106 patients who were candidates for carotid endarterectomy. Prior to undergoing surgery, all carotid artery plaques were evaluated with Color-Doppler-US (CDUS), Contrast-Enhanced Ultrasound (CEUS), and 3D Arterial analysis (3DAA) US along with Computerized Tomographic Angiography (CTA) to assess the carotid artery stenosis degree. Post-surgery, the carotid specimens were fixed with 10% neutral buffered formalin solution, embedded in paraffin and used for light microscopic examination to assess plaque vulnerability morphological features.</p><p><strong>Results: </strong>The results of the CTA examinations revealed 91 patients with severe carotid stenoses with a resultant diagnostic accuracy of 82.3% for CDUS, 94.5% for CEUS, 98.4% for 3DAA, respectively. The histopathological examination showed 71 vulnerable plaques with diagnostic accuracy values of 85.8% for CDUS, 93.4% for CEUS, 90.3% for 3DAA, 92% for CTA, respectively.</p><p><strong>Conclusions: </strong>The combination of CEUS and 3D Arterial Analysis may provide a powerful new clinical tool to identify and stratify \"at-risk\" patients with atherosclerotic carotid artery disease, identifying vulnerable plaques. These applications may also help in the postoperative assessment of treatment options to manage cardiovascular risks.</p>","PeriodicalId":104709,"journal":{"name":"La radiologia medica","volume":" ","pages":"1254-1269"},"PeriodicalIF":8.9,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40364139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
La radiologia medicaPub Date : 2022-11-01Epub Date: 2022-09-19DOI: 10.1007/s11547-022-01553-x
Ryota Hyodo, Yasuo Takehara, Shinji Naganawa
{"title":"4D Flow MRI in the portal venous system: imaging and analysis methods, and clinical applications.","authors":"Ryota Hyodo, Yasuo Takehara, Shinji Naganawa","doi":"10.1007/s11547-022-01553-x","DOIUrl":"https://doi.org/10.1007/s11547-022-01553-x","url":null,"abstract":"<p><p>Thus far, ultrasound, CT, and 2D cine phase-contrast MRI has been adopted to evaluate blood flow and vascular morphology in the portal venous system; however, all these techniques have some shortcomings, such as limited field of view and difficulty in accurately evaluating blood flow. A new imaging technique, namely 3D cine phase-contrast (4D Flow) MRI, can acquire blood flow data of the entire abdomen at once and in a time-resolved manner, allowing visual, quantitative, and comprehensive assessment of blood flow in the portal venous system. In addition, a retrospective blood flow analysis, i.e., \"retrospective flowmetry,\" is possible. Although the development of 4D Flow MRI for the portal system has been delayed compared to that for the arterial system owing to the lower flow velocity of the portal venous system and the presence of respiratory artifacts, several useful reports have recently been published as the technology has advanced. In the first part of this narrative review article, technical considerations of image acquisition and analysis methods of 4D Flow MRI for the portal venous system and the validations of their results are described. In the second part, the current clinical application of 4D Flow MRI for the portal venous system is reviewed.</p>","PeriodicalId":104709,"journal":{"name":"La radiologia medica","volume":" ","pages":"1181-1198"},"PeriodicalIF":8.9,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40368599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostic performance of 2D-shear wave elastography in the diagnosis of breast cancer: a clinical appraisal of cutoff values.","authors":"Tommaso Vincenzo Bartolotta, Alessia Angela Maria Orlando, Mariangela Dimarco, Calogero Zarcaro, Fabiola Ferraro, Alessandra Cirino, Domenica Matranga, Salvatore Vieni, Daniela Cabibi","doi":"10.1007/s11547-022-01546-w","DOIUrl":"https://doi.org/10.1007/s11547-022-01546-w","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the role of 2D-shear wave elastography (2D-SWE) in differentiating benign from malignant focal breast lesions (FBLs), providing new vendor-specific cutoff values.</p><p><strong>Methods: </strong>158 FBLs (size: 3.5-50 mm) detected in 151 women (age: 21-87 years) were prospectively evaluated by means 2D-SWE. For each lesion, an expert radiologist assessed US BI-RADS category and calculated the following four 2D-SWE parameters: (1) elasticity maximum (E<sub>max</sub>); (2) mean elasticity (E<sub>mean</sub>); (3) minimum elasticity (E<sub>min</sub>); (4) elasticity ratio (E<sub>ratio</sub>). US-guided core-biopsy was considered as standard of reference for all the FBLs classified as BI-RADS 4 or 5. For each 2D-SWE parameter, the optimal cutoff value for a diagnostic test was calculated using the Youden method. Diagnostic performance of the US BI-RADS and 2D-SWE parameters was calculated accordingly.</p><p><strong>Results: </strong>83/158 (52.5%) FBLs were benign and 75/158 (47.5%) were malignant. Statistically significant higher stiffness values were observed in malignant FBLs for all 2D-SWE parameters than in benign ones (p < 0.001). 2D-SWE cutoff values were 82.6 kPa, 66.0 kPa and 53.6 kPa, respectively, for E<sub>max</sub>, E<sub>mean</sub>, E<sub>min</sub> and 330.8% for E<sub>ratio</sub>. The 2D-SWE parameter showing the best diagnostic accuracy was E<sub>max</sub> (85.44%). Considering US BI-RADS 3 (n = 60) and 4a (n = 32) FBLs, E<sub>max</sub> and E<sub>mean</sub> showed the best diagnostic accuracy (85.87% for both), without a statistically significant decrease in sensitivity (p = 0.7003 and p = 1, respectively).</p><p><strong>Conclusion: </strong>Our study provides new vendor-specific cutoff values for 2D-SWE, suggesting its possible clinical use in the adjunctive assessment of category US-BI-RADS 3 and 4a breast masses.</p>","PeriodicalId":104709,"journal":{"name":"La radiologia medica","volume":" ","pages":"1209-1220"},"PeriodicalIF":8.9,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40364140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}