Clinics in Endocrinology and Metabolism最新文献_第9页

4 Inborn errors of trace element metabolism 4微量元素代谢先天错误

Clinics in Endocrinology and Metabolism Pub Date : 1985-08-01 DOI: 10.1016/S0300-595X(85)80008-6

David M. Danks

引用次数: 12

Recent issues 最近的问题

Clinics in Endocrinology and Metabolism Pub Date : 1985-08-01 DOI: 10.1016/S0300-595X(85)80002-5

引用次数: 0

5 Epidemiology and trace elements 流行病学和微量元素

Clinics in Endocrinology and Metabolism Pub Date : 1985-08-01 DOI: 10.1016/S0300-595X(85)80009-8

Peter C. Elwood

{"title":"5 Epidemiology and trace elements","authors":"Peter C. Elwood","doi":"10.1016/S0300-595X(85)80009-8","DOIUrl":"10.1016/S0300-595X(85)80009-8","url":null,"abstract":"<div><p>Basically, epidemiology is the making of measurements of known reproducibility, in a bias-free manner, on representative samples of subjects drawn from defined communities. Epidemiology has become a relatively precise science and its value in medicine is widely appreciated. So too are its limitations: the difficulties in achieving a high response rate, in identifying and controlling confounding factors in the examination of an association, and the ultimate difficulties in distinguishing causation from association. While the value of community-based studies seems to be recognized by those interested in man and his environment, the need for the strict application of epidemiological procedures, and the limitations imposed on conclusions drawn from studies in which these procedures have been compromised, does not seem to be adequately understood.</p><p>There are certain known links between trace elements in the environment and disease: for example the level of iodine in soil and water and the prevalence of goitre; the level of fluoride in water and the prevalence of dental caries. The investigation of other possible associations is difficult for a number of reasons, including interrelationships between trace elements, confounding of trace element levels (and disease) with social and dietary factors, and the probability that relationships are generally weak.</p><p>Two conditions in which associations are likely are cardiovascular disease and cancer. Despite research along a number of lines, the relevance of trace elements to cardiovascular disease is not clear, and certainly the apparent association with hardness of domestic water supply seems unlikely to be causal. The same general conclusion seems reasonable for cancer, and although there are a very few well established associations which are likely to be causal, such as exposure to arsenic and skin cancer, the role of trace elements is obscure, and likely to be very small.</p></div>","PeriodicalId":10454,"journal":{"name":"Clinics in Endocrinology and Metabolism","volume":"14 3","pages":"Pages 617-628"},"PeriodicalIF":0.0,"publicationDate":"1985-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0300-595X(85)80009-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15018759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

10 Assessment of trace element status 10微量元素状况评估

Clinics in Endocrinology and Metabolism Pub Date : 1985-08-01 DOI: 10.1016/S0300-595X(85)80014-1

H.T. Delves

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引用次数: 78

Forthcoming issue 即将出版

Clinics in Endocrinology and Metabolism Pub Date : 1985-08-01 DOI: 10.1016/S0300-595X(85)80003-7

引用次数: 0

1 Physiology and metabolism of essential trace elements: An outline 1必需微量元素的生理与代谢:概述

Clinics in Endocrinology and Metabolism Pub Date : 1985-08-01 DOI: 10.1016/S0300-595X(85)80005-0

P.J. Aggett

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引用次数: 119

7 Intellectual and behavioural consequences of low level lead exposure: A review of recent studies 低水平铅暴露对智力和行为的影响:近期研究综述

Clinics in Endocrinology and Metabolism Pub Date : 1985-08-01 DOI: 10.1016/S0300-595X(85)80011-6

Marjorie Smith

引用次数: 11

9 Therapeutic uses of trace elements 微量元素的治疗用途

Clinics in Endocrinology and Metabolism Pub Date : 1985-08-01 DOI: 10.1016/S0300-595X(85)80013-X

Andrew Taylor

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引用次数: 50

6 Selenium deficiency 6硒缺乏

Clinics in Endocrinology and Metabolism Pub Date : 1985-08-01 DOI: 10.1016/S0300-595X(85)80010-4

Jean Neve, Françoise Vertongen, Léopold Molle

{"title":"6 Selenium deficiency","authors":"Jean Neve, Françoise Vertongen, Léopold Molle","doi":"10.1016/S0300-595X(85)80010-4","DOIUrl":"10.1016/S0300-595X(85)80010-4","url":null,"abstract":"<div><p>Selenium is undoubtedly an essential trace element: its involvement in GPx structure, the presence of deleterious effects of selenium deficiency in animals, and the recognition of deficiency states in man attest to its importance.</p><p>However, if the consequences of selenium deficiency in man are now widely recognized, the mechanisms underlying these conditions are poorly understood. The definition of the exact role of selenium in human homeostasis has been hampered by the lack of a sensitive parameter, usable in routine investigation, to assess selenium status. Measurements of plasma and urinary levels, although useful in clinical practice, are inadequate indicators. The only true evidence of selenium deficiency lies in a positive response to selenium therapy.</p><p>Deficiency states have been demonstrated for inhabitants of regions where selenium supply is limited, in protein-energy malnutrition, and in patients maintained on total parenteral nutrition without selenium supplementation.</p><p>The benefit of selenium supplementation, together with other antioxidant drugs, in non-deficient subjects is still a matter of debate; its protective effect in neoplastic, cardiovascular and neurological degenerative diseases is not yet proven.</p></div>","PeriodicalId":10454,"journal":{"name":"Clinics in Endocrinology and Metabolism","volume":"14 3","pages":"Pages 629-656"},"PeriodicalIF":0.0,"publicationDate":"1985-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0300-595X(85)80010-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15049581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 69

Trace elements in human disease. 人类疾病中的微量元素。

Clinics in Endocrinology and Metabolism Pub Date : 1985-08-01

引用次数: 0