Clinical Neuropharmacology最新文献_第10页

Aripiprazole-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Case Study. 阿立哌唑诱导的史蒂文斯-约翰逊综合征/中毒性表皮坏死松解:一例研究。

IF 1 4区医学

Clinical Neuropharmacology Pub Date : 2023-06-20 DOI: 10.1097/WNF.0000000000000560

Christian J Coulson, Marie Yrastorza-Daghman

{"title":"Aripiprazole-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Case Study.","authors":"Christian J Coulson, Marie Yrastorza-Daghman","doi":"10.1097/WNF.0000000000000560","DOIUrl":"https://doi.org/10.1097/WNF.0000000000000560","url":null,"abstract":"Objectives: The use of medications in management of disease is an integral part of treatment to patients in both the inpatient and outpatient setting; however, these medications often have risk of adverse effects associated with their benefits of use. Adverse cutaneous reactions are one of the most frequent types of adverse drug reactions. Two major phenotypes of cutaneous adverse drug reactions are toxic epidermal necrolysis (TEN), and Stevens-Johnson syndrome (SJS). Aripiprazole is an antipsychotic drug with a well-documented profile of adverse effects for physicians to be aware of; however, SJS/TEN is not known to be included in that profile.Methods: The authors encountered a case of aripiprazole-induced SJS/TEN and used the electronic medical records from this encounter to summarize this novel case in detail. Existing literature was reviewed using public databases for evaluation of similar cases.Results: We present a case of SJS/TEN induced by aripiprazole use for bipolar disorder, type 1, which is not an adverse effect of the drug that has been documented in the literature. We include patient history, hospital course, images, and treatment of disease throughout admission as well as a thorough discussion of the topic.Conclusions: We present a case of an adverse drug reaction that has not previously been documented in the literature with the goal of informing readers of the potential for this life-threatening atypical effect and the severity of disease it may cause.","PeriodicalId":10449,"journal":{"name":"Clinical Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10019502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammation Markers Among Schizophrenia Patients Who Use Cannabis. 使用大麻的精神分裂症患者的炎症标志物

IF 1 4区医学

Clinical Neuropharmacology Pub Date : 2023-06-20 DOI: 10.1097/WNF.0000000000000558

Jonathan Fridman, Esther Bloemhof-Bris, Shira Weizman, Tal Kessler, Dorit Porat, Amos Ivry, Aviva Wolf, Rafael Stryjer, Assaf Shelef

{"title":"Inflammation Markers Among Schizophrenia Patients Who Use Cannabis.","authors":"Jonathan Fridman, Esther Bloemhof-Bris, Shira Weizman, Tal Kessler, Dorit Porat, Amos Ivry, Aviva Wolf, Rafael Stryjer, Assaf Shelef","doi":"10.1097/WNF.0000000000000558","DOIUrl":"https://doi.org/10.1097/WNF.0000000000000558","url":null,"abstract":"Objectives: The mechanism of inflammation of the immune system, for example, such circulatory markers as the neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV), has been shown in many studies to be associated with schizophrenia. In addition, it has been shown that the cannabidiol component reduces the activation of the acquired immune system. This study examined the differences in the levels of NLR and MPV among schizophrenia patients with cannabis use versus those without.Methods: In 2019 to 2020, a retrospective cross-sectional study was conducted based on digital medical records. Demographic, clinical, and complete blood cell count data were collected from records of rehospitalization of active psychotic schizophrenia inpatients. Data on NLR, MPV values, and demographic and clinical characteristics were compared between the groups and according to the degree of prevalence of cannabis use.Results: No differences were found in the NLR and MPV values between the groups.Conclusion: The results were contrary to our expectations. These results may be explained by the presentation of a \"pseudo-balanced\" picture created when multiple processes affect inflammatory indices.","PeriodicalId":10449,"journal":{"name":"Clinical Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9717341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Botulinum Toxins and Zinc: From Theory to Practice-A Systematic Review. 肉毒杆菌毒素与锌:从理论到实践-系统综述。

IF 1 4区医学

Clinical Neuropharmacology Pub Date : 2023-06-20 DOI: 10.1097/WNF.0000000000000557

Farid Mallat, Jerome Kaikati, Elio Kechichian

引用次数: 0

ABCB1 Gene Polymorphisms Are Closely Associated With Drug-Resistant Epilepsy: Evidence Based on 377 Subjects in Chinese Pediatric Patients. ABCB1基因多态性与耐药癫痫密切相关:基于377例中国儿科患者的证据

IF 1 4区医学

Clinical Neuropharmacology Pub Date : 2023-06-07 DOI: 10.1097/WNF.0000000000000555

Ting Zhao, Hong-Jian Li, Jing Yu, Hui-Lan Zhang, Jie Feng, Ting-Ting Wang, Lu-Hai Yu, Yan Sun

{"title":"ABCB1 Gene Polymorphisms Are Closely Associated With Drug-Resistant Epilepsy: Evidence Based on 377 Subjects in Chinese Pediatric Patients.","authors":"Ting Zhao, Hong-Jian Li, Jing Yu, Hui-Lan Zhang, Jie Feng, Ting-Ting Wang, Lu-Hai Yu, Yan Sun","doi":"10.1097/WNF.0000000000000555","DOIUrl":"https://doi.org/10.1097/WNF.0000000000000555","url":null,"abstract":"Objective: P-glycoprotein plays a role in drug resistance of epileptic patients by limiting gastrointestinal absorption and brain access to antiseizure medications. This study aimed to evaluate the association between ABCB1 polymorphisms and drug resistance in epileptic pediatric patients.Methods: Three hundred seventy-seven epileptic pediatric patients were treated with antiseizure medications and subsequently divided into the drug-responsive group (n = 256, 68%) and drug-resistant group (n = 121, 32%). The genomic DNA of patients in the different groups was extracted, followed by the determination of the ABCB1 gene polymorphisms using polymerase chain reaction-fluorescence staining in situ hybridization.Results: Drug-resistant patients significantly exhibited a combined generalized and focal onset than drug-responsive patients (χ2 = 12.278, P < 0.001). The TT (χ2 = 5.776, P = 0.016) genotypes of G2677T and CT (χ2 = 6.165, P = 0.013) and TT (χ2 = 11.121, P = 0.001) genotypes of C3435T were significantly more frequent in drug-resistant patients than drug-responsive patients. Similarly, the GT-CT diplotype was significantly more frequent in drug-resistant patients than in drug-responsive patients.Conclusion: Our study findings suggest that the ABCB1 G2677T and C3435T polymorphisms are significantly associated with drug resistance in epileptic patients.","PeriodicalId":10449,"journal":{"name":"Clinical Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9579433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics and Treatments of Coronavirus Disease 2019 Patients Presenting With Persistent Hiccups: A Scoping Review. 2019冠状病毒病患者持续打嗝的特征和治疗:一项范围综述

IF 1 4区医学

Clinical Neuropharmacology Pub Date : 2023-05-22 DOI: 10.1097/WNF.0000000000000554

Michael Boulis, Mary Boulis, Marianne Cosgrove, Ken He

{"title":"Characteristics and Treatments of Coronavirus Disease 2019 Patients Presenting With Persistent Hiccups: A Scoping Review.","authors":"Michael Boulis, Mary Boulis, Marianne Cosgrove, Ken He","doi":"10.1097/WNF.0000000000000554","DOIUrl":"https://doi.org/10.1097/WNF.0000000000000554","url":null,"abstract":"Objectives: Over the time of the pandemic, coronavirus disease 2019 (COVID-19) has surprised us with a growing list of atypical presentations, one of which is persistent hiccups that last more than 48 hours. The aim of this review is to investigate the characteristics of COVID-19 patients presenting with persistent hiccups and explore treatments used to control persistent hiccups in such cases.Methods: This scoping review was performed utilizing the methodological approach proposed by Arksey and O'Malley.Results: Fifteen relevant cases were identified. All reported cases were males, aged between 29 and 72 years. More than one-third of the cases did not have symptoms of infection. All cases had a positive severe acute respiratory syndrome coronavirus reverse transcriptase-polymerase chain reaction, as well as lung involvement evident on chest imaging. The medications most frequently used for hiccups in the reported cases were chlorpromazine (6 cases, 83% success), metoclopramide (5 cases, 0% success), and baclofen (3 cases, 100% success).Conclusions: In patients presenting with persistent hiccups during this pandemic, even in those lacking systemic or other manifestations of COVID-19 or pneumonia, clinicians are encouraged to consider COVID-19 as one of the differential diagnoses. In light of the findings of this review, it is recommended to include a severe acute respiratory syndrome coronavirus reverse transcriptase-polymerase chain reaction test and a chest imaging as part of the workup for these patients. When considering treatment options, this scoping review shows that chlorpromazine has more favorable outcomes compared with metoclopramide for controlling persistent hiccups in COVID-19 patients.","PeriodicalId":10449,"journal":{"name":"Clinical Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9498042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Oral Cenesthopathy Treated With the Combination of Brexpiprazole and Mirtazapine. 布雷哌唑联合米氮平治疗口腔肺脏病1例。

IF 1 4区医学

Clinical Neuropharmacology Pub Date : 2023-05-01 DOI: 10.1097/WNF.0000000000000545

Yojiro Umezaki, Haruhiko Motomura, Rui Egashira, Akira Toyofuku, Toru Naito

引用次数: 0

The Downside of Botulinum Injections for Anterocollis: A Case Series and a Review of the Literature. 注射肉毒杆菌治疗前结肠的缺点:一个病例系列和文献综述。

IF 1 4区医学

Clinical Neuropharmacology Pub Date : 2023-05-01 DOI: 10.1097/WNF.0000000000000548

Gilad Yahalom, Eden Atlan, Amir Janah, Melania Dominko, Ilana Israel, Gustavo Rajz, Stefan Mausbach, Roni Eichel

{"title":"The Downside of Botulinum Injections for Anterocollis: A Case Series and a Review of the Literature.","authors":"Gilad Yahalom, Eden Atlan, Amir Janah, Melania Dominko, Ilana Israel, Gustavo Rajz, Stefan Mausbach, Roni Eichel","doi":"10.1097/WNF.0000000000000548","DOIUrl":"https://doi.org/10.1097/WNF.0000000000000548","url":null,"abstract":"Objectives: This is a case series and a review of the literature of therapeutic outcomes of botulinum toxin (BT) injections for anterocollis.Methods: Data collected included gender, age, age at onset, muscles targeted, and doses injected. Routine forms were filled out during each visit: Patient Global Impression of Change, Clinician Global Impression of Severity, Tsui scale. The effect duration and side effects (SEs) of the previous treatment were noted.Results: We described 4 patients (3 men, 13 visits) with anterocollis, as primary postural abnormality of the neck, emphasizing the therapeutic response to BT injection. Mean age at onset was 75.3 ± 7.0 years, age at first injection was 80.7 ± 3.5 years. The mean total dose per treatment was 290.0 ± 95.6 units. Patient Global Impression of Change with any grade of favorable effect was reported in 27.3% of the treatments. In objective assessment, Global Impression of Severity and Tsui scores did not show a consistent tendency of improvement. Neck weakness was prevalent in 18.2% of the visits of the anterocollis group while no other SEs were noted. We found 15 articles describing experience with BT for anterocollis in 67 patients (19 in deep and 48 in superficial neck muscles).Conclusions: This case series describes the poor outcome of BT treatment for anterocollis, with low efficacy and bothersome SE. Levator scapulae injection for anterocollis is not effective and is highly associated with head drop and should perhaps be abandoned. Injection to the longus colli might give some benefit in non-responders.","PeriodicalId":10449,"journal":{"name":"Clinical Neuropharmacology","volume":"46 3","pages":"89-94"},"PeriodicalIF":1.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9678046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical Cannabis in the Treatment of Parkinson's Disease. 医用大麻治疗帕金森病

IF 1 4区医学

Clinical Neuropharmacology Pub Date : 2023-05-01 DOI: 10.1097/WNF.0000000000000550

Traci S Aladeen, Anna G Mattle, Kory Zelen, Moustafa Mesha, Michelle M Rainka, Tanya Geist, Bennett Myers, Laszlo Mechtler

{"title":"Medical Cannabis in the Treatment of Parkinson's Disease.","authors":"Traci S Aladeen, Anna G Mattle, Kory Zelen, Moustafa Mesha, Michelle M Rainka, Tanya Geist, Bennett Myers, Laszlo Mechtler","doi":"10.1097/WNF.0000000000000550","DOIUrl":"https://doi.org/10.1097/WNF.0000000000000550","url":null,"abstract":"Objectives: Medical cannabis (MC) has recently garnered interest as a potential treatment for neurologic diseases, including Parkinson's disease (PD). A retrospective chart review was conducted to explore the impact of MC on the symptomatic treatment of patients with PD.Methods: Patients with PD treated with MC in the normal course of clinical practice were included (n = 69). Data collected from patient charts included MC ratio/formulation changes, PD symptom changes after initiation of MC, and adverse events (AEs) from MC use. Information regarding changes in concomitant medications after MC initiation, including opioids, benzodiazepines, muscle relaxants, and PD medications, was also collected.Results: Most patients were initially certified for a 1:1 (∆ 9 -tetrahydrocannabinol:cannabidiol) tincture. Eight-seven percent of patients (n = 60) were noted to exhibit an improvement in any PD symptom after starting MC. Symptoms with the highest incidence of improvement included cramping/dystonia, pain, spasticity, lack of appetite, dyskinesia, and tremor. After starting MC, 56% of opioid users (n = 14) were able to decrease or discontinue opioid use with an average daily morphine milligram equivalent change from 31 at baseline to 22 at the last follow-up visit. The MC was well-tolerated with no severe AEs reported and low rate of MC discontinuation due to AEs (n = 4).Conclusions: The MC may improve motor and nonmotor symptoms in patients with PD and may allow for reduction of concomitant opioid medication use. Large, placebo-controlled, randomized studies of MC use in patients with PD are required.","PeriodicalId":10449,"journal":{"name":"Clinical Neuropharmacology","volume":"46 3","pages":"98-104"},"PeriodicalIF":1.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9488637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Effects of Exercise on Testosterone and Implications of Drug Abuse: A Review. 运动对睾酮的影响及药物滥用的影响:综述。

IF 1 4区医学

Clinical Neuropharmacology Pub Date : 2023-05-01 DOI: 10.1097/WNF.0000000000000546

Brendan Perreault, Nikki Hammond, Panayotis K Thanos

{"title":"Effects of Exercise on Testosterone and Implications of Drug Abuse: A Review.","authors":"Brendan Perreault, Nikki Hammond, Panayotis K Thanos","doi":"10.1097/WNF.0000000000000546","DOIUrl":"https://doi.org/10.1097/WNF.0000000000000546","url":null,"abstract":"Objective: Research points to exercise having a positive effect in fighting relapse and use of drugs of abuse. Through conducting this research, differences have been observed in the effects of exercise on drug abuse between sexes. Many of the studies found that exercise tends to cause a more profound effect in blocking drug relapse or reinstatement in males when compared with females.Methods: Our hypothesis is that these differences in response to drugs of abuse after an exercise regimen could in part be attributed to variations in testosterone levels between males and females.Results: Testosterone has been shown to have a modulatory impact on the dopaminergic activity in the brain, causing an effect on the brain's response to drugs of abuse. Exercise has demonstrated a causal effect on increasing testosterone levels in males, whereas drugs of abuse decrease testosterone levels in males.Conclusions: Thus, exercise raising testosterone levels in males helps to decrease the dopaminergic response in the brain to drugs of abuse causing attenuation to drugs. To find sex-specific exercise treatments for drugs of abuse, it is important to continue researching exercise's efficacy against drugs of abuse.","PeriodicalId":10449,"journal":{"name":"Clinical Neuropharmacology","volume":"46 3","pages":"112-122"},"PeriodicalIF":1.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10052435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case Report of Delusions in a Patient Receiving Cabergoline Therapy for Prolactinoma: Pathophysiology and Proposed Treatment With Aripiprazole. 1例接受卡麦角林治疗催乳素瘤患者的妄想:病理生理及拟用阿立哌唑治疗。

IF 1 4区医学

Clinical Neuropharmacology Pub Date : 2023-05-01 DOI: 10.1097/WNF.0000000000000547

Charles Springer, Robert Rodgers, Gina Vivino, Saritha Attanagoda, Charles Dylan Miks

引用次数: 0