Clinical ophthalmology最新文献

{"title":"Comments on: Internal Limiting Membrane Peeling and Gas Tamponade for Full-Thickness Macular Holes of Different Etiology - Is It Still Relevant? [Response to Letter].","authors":"Andrii Ruban, Beáta Éva Petrovski, Goran Petrovski, Lyubomyr M Lytvynchuk","doi":"10.2147/OPTH.S402222","DOIUrl":"10.2147/OPTH.S402222","url":null,"abstract":"","PeriodicalId":10442,"journal":{"name":"Clinical ophthalmology","volume":"17 ","pages":"103-105"},"PeriodicalIF":2.5,"publicationDate":"2023-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a2/28/opth-17-103.PMC9831524.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9091812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Terson Syndrome - Clinical Presentation, Management, and Visual Outcomes in a Tertiary Centre.","authors":"Mario Lima-Fontes,&nbsp;Mariana Leuzinger-Dias,&nbsp;Rita Rodrigues,&nbsp;Ricardo Barros-Pereira,&nbsp;Manuel Falcão,&nbsp;Vítor Fernandes,&nbsp;Pedro Alves-Faria,&nbsp;Fernando Falcão-Reis,&nbsp;Amândio Rocha-Sousa","doi":"10.2147/OPTH.S396781","DOIUrl":"https://doi.org/10.2147/OPTH.S396781","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to characterize the clinical presentation, management strategy and visual outcomes of patients diagnosed with Terson syndrome and followed in a tertiary centre in Portugal.</p><p><strong>Patients and methods: </strong>A single-centre retrospective study was performed, based on the survey review of the medical records of every consecutive patient diagnosed with Terson syndrome and followed from January 2018 to August 2021. The change in best-corrected visual acuity (BCVA) from baseline to the final evaluation was the primary outcome.</p><p><strong>Results: </strong>Fifteen eyes from 8 patients (50% female) were included. The mean age at diagnosis was 55±7 years. The neurological event was traumatic brain injury in 37.5% (n=3) and subarachnoid haemorrhage in 62.5% of the patients (n=5). Bilateral intraocular haemorrhage occurred in 875% (n=7) of the patients. Vitreous and preretinal haemorrhages occurred each in 66.7% (n=10), intraretinal in 30% (n=3) and subretinal in 13.3% (n=2) of the eyes. In 40% of the eyes (n=6), spontaneous resolution of intraocular haemorrhage occurred, while PPV was performed in the remaining 60% (n=9). Ocular haemorrhage detection occurred 58.47 ± 40.94 days after the neurological event (range 11 to 121 days). Baseline BCVA was 1.11 ± 1.01 logMAR and improved to 0.32 ± 0.69 logMAR in the follow-up period (p=0.004). A positive correlation was found between initial and final BCVA (Spearman's rho = 0.643, p=0.01). Baseline BCVA of eyes undergoing PPV was lower than of those conservatively managed (1.84±0.72 vs 0.20±0.28 logMAR, p<0.001). However, there were no statistically significant differences in final BCVA after surgery or observation (0.56 ± 0.90 vs 0.04 ± 0.04 logMAR, p=0.149). Longer periods between the neurological and the ophthalmological diagnosis were correlated with worse final BCVA (Spearman's rho = 0.688, p=0.005).</p><p><strong>Conclusion: </strong>Terson syndrome is a potential cause of irreversible visual loss. Diagnosis delay may affect visual prognosis. PPV is indicated when intraocular haemorrhage is dense and does not resolve spontaneously or when visual acuity at presentation is low, allowing for good visual outcomes with minimal complications.</p>","PeriodicalId":10442,"journal":{"name":"Clinical ophthalmology","volume":"17 ","pages":"351-359"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dc/06/opth-17-351.PMC9884450.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9170112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kahook Dual Blade versus Trabectome (KVT): Comparing Outcomes in Combination with Cataract Surgery.","authors":"Greg D Fliney,&nbsp;Eliott Kim,&nbsp;Miriam Sarwana,&nbsp;Sze Wong,&nbsp;Tak Yee Tania Tai,&nbsp;Ji Liu,&nbsp;Soshian Sarrafpour,&nbsp;Nisha Chadha,&nbsp;Christopher C Teng","doi":"10.2147/OPTH.S391527","DOIUrl":"https://doi.org/10.2147/OPTH.S391527","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the safety and efficacy of Kahook Dual Blade (KDB) versus Trabectome with cataract surgery in reducing intraocular pressure (IOP) and medications used by patients with glaucoma.</p><p><strong>Methods: </strong>Retrospective chart review comparing eyes after KDB or Trabectome with cataract surgery at 2 academic centers. Surgical success was defined as IOP <21 mmHg with ≥20% IOP reduction at post-operative month 12 (POM12). Changes in IOP, number of glaucoma medications, and adverse events were assessed.</p><p><strong>Results: </strong>Ninety eyes in the KDB group and 125 eyes in the Trabectome group were included. Mean changes in IOP at POM12 were -1.9 ± 4.9 mmHg (11.2%, <i>P</i> = 0.002) in the KDB group and -3.5 ± 5.5 mmHg (19.1%, <i>P</i> < 0.001) in the Trabectome group, without a significant difference between the groups (<i>P</i> = 0.20). Mean change in glaucoma medications at POM12 was -0.8 ± 1.5 in the KDB group (58%, <i>P</i> < 0.001) and -0.3 ± 1.3 (38%, <i>P</i> = 0.003) in the Trabectome group, with KDB having a greater decrease in medications (<i>P</i> = 0.02). The percentage of eyes achieving success was 30% for the KDB group and 54% for the Trabectome group (<i>P</i> = 0.01). Hyphema was the most common complication, with an incidence of 3% for the KDB group and 14% for the Trabectome group (<i>P</i> = 0.01).</p><p><strong>Conclusion: </strong>KDB or Trabectome with cataract surgery is safe and effective at lowering IOP and medication burden, with KDB resulting in a greater reduction in medications and Trabectome more frequently achieving success with an increased incidence of hyphema. Considering the study's limitations, the outcomes were similar.</p>","PeriodicalId":10442,"journal":{"name":"Clinical ophthalmology","volume":"17 ","pages":"145-154"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ae/63/opth-17-145.PMC9840398.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9170930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Dry Eye Disease Among Medical Students and Its Association with Sleep Habits, Use of Electronic Devices and Caffeine Consumption: A Cross-Sectional Questionnaire.","authors":"Luai Abu-Ismail,&nbsp;Mohammad T Abuawwad,&nbsp;Mohammad J Taha,&nbsp;Almu'atasim Khamees,&nbsp;Dima Y Abu Ismail,&nbsp;Mohammad Sanwar,&nbsp;Yaqeen Al-Bustanji,&nbsp;Abdulqadir Nashwan,&nbsp;Omran Hamdan Alameri,&nbsp;Hamzeh Mohammad Alrawashdeh,&nbsp;Hashem Abu Serhan,&nbsp;Jocob Abu-Ismail","doi":"10.2147/OPTH.S397022","DOIUrl":"https://doi.org/10.2147/OPTH.S397022","url":null,"abstract":"<p><strong>Introduction: </strong>Dry eye disease (DED) is a common and multifactorial disease of the ocular surface which causes visual disturbance and feelings of discomfort among patients. The prevalence rate among medical students is an important issue to consider. This study investigates the relationship between caffeine consumption, sleeping habits, use of electronic devices, and DED among a convenient sample of medical students in Jordan.</p><p><strong>Methods: </strong>This cross-sectional online survey enrolled medical students from all six medical schools in Jordan. The questionnaire, which was shared via social media platforms, assessed socio-demographics, caffeine consumption amounts and patterns, sleep quality, and the use of electronic devices and their relation to ocular discomfort, DED, and related symptoms. The ocular surface disease index (OSDI) questionnaire was also administered to quantify the symptoms of DED.</p><p><strong>Results: </strong>A total of 1223 students participated in this study (RR=24.46%); 64% were females, and 43% were in their clinical placement years. Of the participants, 317 (25.92%) had normal eyes, and 906 (74.08%) had symptomatic DED. Of the students, 1206 (98.6%) used electronic devices directly before bed, and only 399 (32.62%) used blue-light-protective glasses. Lower DED risk was linked to male gender (OR=0.535, 95% CI 0.392-0.73, p <0.01), clinical years of medical school (OR=0.564, 95% CI 0.424-0.75, p<0.01). Poor sleep quality corresponded to more incidence of DED, regardless of sleeping for 5-6 hours (OR=3.046, 95% CI 1.299-7.139, p=0.01) or for less than 5 hours (OR=3.942, 95% CI 1.824-8.519, p<0.01). Also, caffeine consumption only marginally affected its incidence, but the results were statistically insignificant.</p><p><strong>Conclusion: </strong>Female gender, basic science years, and spending more than 6 hours looking at screens were significantly associated with symptomatic DED. Caffeine consumption did not pose any significant risk to the incidence of DED.</p>","PeriodicalId":10442,"journal":{"name":"Clinical ophthalmology","volume":"17 ","pages":"1013-1023"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9336696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison Between Pulsed and Continuous Accelerated Corneal Cross-Linking Protocols.","authors":"Mohamed Omar Yousif,&nbsp;Rania Serag Elkitkat,&nbsp;Noha Abdelsadek Alaarag,&nbsp;Mouamen Moustafa Seleet,&nbsp;Ashraf Hassan Soliman","doi":"10.2147/OPTH.S409178","DOIUrl":"https://doi.org/10.2147/OPTH.S409178","url":null,"abstract":"<p><strong>Purpose: </strong>To compare between two accelerated corneal cross-linking (A-CXL) protocols in the management of keratoconus (KC) as regard to the extent of corneal treatment.</p><p><strong>Methods: </strong>This retrospective, comparative study included patients having mild to moderate, progressive KC. The study population was divided into two groups; group 1 enrolled 103 eyes of 62 patients who received pulsed light A-CXL (pl-CXL) at a power of 30 mW/cm² with an irradiation time of 4 minutes, while group 2 comprised 87 eyes of 51 patients who received continuous light A-CXL (cl-CXL) at a power of 12 mW/cm² with an irradiation time of 10 minutes. Recordings of the central and peripheral demarcation line depths (DD), and the maximum (DDmax) and minimum (DDmin) DD, using anterior segment optical coherence tomography, were compared between the two studied groups one month after the treatment protocol. Treatment stability was also evaluated pre and postoperatively (one year following surgery) by comparing the refractive and keratometric outcomes in both groups.</p><p><strong>Results: </strong>The differences between the preoperative corneal thickness (minimum and central) and the epithelial thickness measurements between both groups were not statistically significant. Although group 1 had slightly larger central DD (223.4 ± 62.3 um), DDmax (240.4 ± 61.8 um), and DDmin (201 ± 54 um) than those of group 2 (221.8 ± 37 um, 229.1 ± 38.4 um, and 212 ± 37.2 um, respectively), the differences between both groups' measurements were not statistically significant. Also, the two groups showed statistically insignificant differences regarding the subjective refraction and the average and maximum keratometry pre and postoperatively, denoting visual, refractive, and keratometric stability in both groups.</p><p><strong>Conclusion: </strong>Longer duration cl-CXL seems to be as effective as pl-CXL regarding both postoperative stability and the extent of corneal tissue penetration by the ultraviolet treatment.</p>","PeriodicalId":10442,"journal":{"name":"Clinical ophthalmology","volume":"17 ","pages":"1407-1413"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d1/0b/opth-17-1407.PMC10199693.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9503748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Feasibility of an Educational Cartoon Video for Improving Adherence with Amblyopia Treatment in Children.","authors":"Saeed Aljohani,&nbsp;Jingyun Wang,&nbsp;Mitchell Scheiman,&nbsp;Qing-Qing Tan,&nbsp;Hongxin Xu,&nbsp;Nawaf Almutairi,&nbsp;Saleh Alshammeri","doi":"10.2147/OPTH.S415892","DOIUrl":"https://doi.org/10.2147/OPTH.S415892","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have shown that it is necessary to evaluate adherence during the treatment process, using educational intervention methods which have been shown to improve adherence with patching treatment. A previous study reported that an educational cartoon had significantly improved adherence with patching. However, this black-white cartoon is not commercially available.</p><p><strong>Objective: </strong>This study investigates the feasibility of a 4-minute educational cartoon video in improving adherence with patching therapy for amblyopic children.</p><p><strong>Methods: </strong>Children (3 to 10 years old) with unilateral amblyopia who were prescribed 2 hours or 6 hours of patching per day were enrolled. Objective adherence to the treatment was tracked using a microsensor. Children returned after 4 weeks ± 2 days to measure adherence. Participants with adherence ≤50% were eligible to watch the educational cartoon video. They continued with the previously prescribed treatment (2 hours or 6 hours patching) for an additional week to evaluate the follow-up adherence.</p><p><strong>Results: </strong>A total of 27 participants were enrolled. The mean age (SD) was 6.6 (1.5) years. Twenty-two participants (12 in the 2 hours patching group and 10 in the 6 hours patching group) had adherence ≤50% and watched our cartoon video. The cartoon video improved mean adherence (SD) from 29.6% (11.9%) to 56.8% (12.1%) in all 22 participants from both regimens (paired 2-tailed <i>t</i>-test, <i>t</i>= -11, <i>P</i> < 0.000).</p><p><strong>Conclusion: </strong>The Educational cartoon video is feasible for use in a clinical setting. These data showed a trend of improvement in adherence with both patching regimens in children after watching the educational cartoon video.</p>","PeriodicalId":10442,"journal":{"name":"Clinical ophthalmology","volume":"17 ","pages":"1639-1646"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b4/31/opth-17-1639.PMC10257930.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9618074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Cellular Infiltration into Posterior Vitreous in Eyes with Uveitis on the Classification Basis Assessed Using Optical Coherence Tomography.","authors":"Wataru Matsumiya,&nbsp;Sentaro Kusuhara,&nbsp;Noriyuki Sotani,&nbsp;Kyung Woo Kim,&nbsp;Ryuto Nishisho,&nbsp;Rei Sotani,&nbsp;Hisanori Imai,&nbsp;Akihito Uji,&nbsp;Makoto Nakamura","doi":"10.2147/OPTH.S394441","DOIUrl":"https://doi.org/10.2147/OPTH.S394441","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the characteristics of posterior vitreous cells in patients with uveitis on the classification basis using spectral domain optical coherence tomography (SD-OCT).</p><p><strong>Methods: </strong>In this retrospective chart review, all eyes were classified into three groups: infectious uveitis (IFU, n=7), noninfectious granulomatous uveitis (NIGU, n=13), and noninfectious nongranulomatous uveitis (NINGU, n=13). We measured the size, number, and density of vitreous hyperreflective particles in the posterior vitreous area that was defined as the space between the vitreous top and the internal limiting membrane on OCT. The correlations between vitreous haze and vitreous particles were also evaluated.</p><p><strong>Results: </strong>Thirty-three eyes from 23 patients with active posterior uveitis were included. IFU had significantly more particles than NIGU and NINGU (<i>P</i>=0.03 and <i>P</i><0.001, respectively). The vitreous particle density was higher in IFU than in NIGU and NINGU (<i>P</i>=0.03 and <i>P</i>=0.003, respectively). The mean largest particle size was greater in IFU and NIGU than in NINGU (<i>P</i>=0.01 and <i>P</i>=0.03, respectively). The median vitreous haze of 2+ in IFU, 1+ in NIGU and NINGU showed no significant difference among three groups (<i>P</i>=0.21). Conversely, the correlation of the largest particle size with vitreous haze was significant at <i>ρ</i>= 0.44 (<i>P</i>=0.01).</p><p><strong>Conclusion: </strong>SD-OCT may be useful for assessing ocular inflammation based on morphological characteristics of vitreous particles on the uveitis classification basis.</p>","PeriodicalId":10442,"journal":{"name":"Clinical ophthalmology","volume":"17 ","pages":"165-174"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/10/c4/opth-17-165.PMC9843505.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9103301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Phacoemulsification Grooving Efficiency in Longitudinal vs Transversal Handpieces.","authors":"Samuel W Wilkinson,&nbsp;Emilie L Ungricht,&nbsp;William B West,&nbsp;Jacob T Harris,&nbsp;Brian Zaugg,&nbsp;Randall J Olson,&nbsp;Jeff H Pettey","doi":"10.2147/OPTH.S391928","DOIUrl":"https://doi.org/10.2147/OPTH.S391928","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the difference, if any, in grooving efficiency at various settings on the Whitestar Signature Pro phacoemulsification (phaco) system.</p><p><strong>Methods: </strong>Cataractous lenses were simulated by exposing porcine lenses to formalin for 2 hours. A total of 120 lenses were analyzed at various power settings on both longitudinal and transversal handpieces. Twenty trials each were performed with power set to 25%, 50%, and 75% on both handpieces. A Whitestar Phaco Handpiece System was used to provide longitudinal power, and a Whitestar Signature Ellipsis Handpiece provided transversal power. Lenses were placed within a plastic chamber and grooved by an investigator blinded to settings. A second investigator recorded times and adjusted settings. The Whitestar Signature Pro phaco system was used for grooving.</p><p><strong>Results: </strong>There was no significant difference in grooving times between the longitudinal and transverse handpieces at any power setting (P > 0.05). There was a significant decrease in grooving times when comparing the 25% power setting with the 75% power setting for the transversal handpiece (<i>P</i>=0.021).</p><p><strong>Conclusion: </strong>Both longitudinal and transversal handpieces on the Whitestar Signature Pro phaco system produce similar results to one another at each power setting. There is a general trend toward shorter grooving times, reflecting greater efficiency, at higher power settings. Grooving efficiency on the transversal handpiece may be more affected by changes in the power settings as compared with the longitudinal settings.</p>","PeriodicalId":10442,"journal":{"name":"Clinical ophthalmology","volume":"17 ","pages":"191-195"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e1/ea/opth-17-191.PMC9844818.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9103305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Treatment Options for Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration.","authors":"Hannah Khan,&nbsp;Aamir A Aziz,&nbsp;Humza Sulahria,&nbsp;Huma Khan,&nbsp;Abrahim Ahmed,&nbsp;Netan Choudhry,&nbsp;Raja Narayanan,&nbsp;Carl Danzig,&nbsp;Arshad M Khanani","doi":"10.2147/OPTH.S367089","DOIUrl":"https://doi.org/10.2147/OPTH.S367089","url":null,"abstract":"<p><p>Age-related macular degeneration (AMD) is characterized as a chronic, multifactorial disease and is the leading cause of irreversible blindness. Advanced AMD is classified as neovascular (wet) AMD and non-neovascular (dry) AMD. Dry AMD can progress to a more advanced form that manifests as geographic atrophy (GA), which significantly threatens vision, leading to progressive and irreversible loss of visual function. There are currently no approved therapeutics commercially available for GA patients. However, data from various clinical trials have demonstrated favorable results with significant reduction in GA lesion growth. This review furthers the understanding of the pathophysiology of GA, as well as current clinical trial data on investigational therapeutics.</p>","PeriodicalId":10442,"journal":{"name":"Clinical ophthalmology","volume":"17 ","pages":"321-327"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/90/dc/opth-17-321.PMC9892637.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10661455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Triglyceride Glucose Index with Prevalence and Incidence of Diabetic Retinopathy in a Singaporean Population.","authors":"Kumari Neelam,&nbsp;Khin Chaw Yu Aung,&nbsp;Keven Ang,&nbsp;Subramaniam Tavintharan,&nbsp;Chee Fang Sum,&nbsp;Su Chi Lim","doi":"10.2147/OPTH.S382336","DOIUrl":"https://doi.org/10.2147/OPTH.S382336","url":null,"abstract":"<p><strong>Objective: </strong>To examine the association of triglyceride glucose (TyG) index (product of fasting triglyceride and glucose) with prevalence and incidence of diabetic retinopathy (DR) in type 2 diabetes.</p><p><strong>Methods: </strong>1339 patients from an ongoing Singapore Study of Macro-angiopathy and Micro-Vascular Reactivity in Type 2 Diabetes (SMART2D) were included in this study. Fasting triglyceride and glucose levels were quantified and color fundus photographs were assessed for DR presence and severity. Logistic regression models were used to evaluate associations of TyG index with DR prevalence and incidence (median follow-up period = 3.2 years).</p><p><strong>Results: </strong>Mean TyG index was higher in patients with DR than no DR (9.24±0.7 versus 9.04± 0.6, p<0.001). TyG index was significantly associated with DR prevalence (OR=1.4, CI 1.1-1.7, p=0.002) and incidence (OR=1.8, CI 1.04-2.9, p=0.03), after adjusting for confounders. In a stratified analysis, the association between TyG index and DR prevalence reached significance only in the subgroup with HbA1c levels < 7.0% (OR=2, CI 1.1-3.8, p=0.03). TyG index significantly predicted DR prevalence and incidence with area under receiver operating curve as 0.77 (CI 0.74-0.80, p <0.001) and 0.66 (CI 0.57-0.76, p value <0.01), respectively.</p><p><strong>Conclusion: </strong>TyG index is a good predictor for DR prevalence and incidence. It can also be a secondary treatment target for patients with optimally controlled levels of HbA1c.</p>","PeriodicalId":10442,"journal":{"name":"Clinical ophthalmology","volume":"17 ","pages":"445-454"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/2c/opth-17-445.PMC9901446.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10681618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}