Clinical Diabetology最新文献_第3页

Low-Dose Glimepiride and Metformin Fixed-Dose Combination in treating Maturity-Onset Diabetes of the Young Type (MODY): A Cross Sectional Survey 低剂量格列美脲和二甲双胍联合固定剂量治疗年轻型成熟型糖尿病(MODY)的横断面调查

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Clinical Diabetology Pub Date : 2023-08-26 DOI: 10.5603/dk.a2023.0028

B. Sharma, Amit Dey, J. George, Lakshmi Nagendra, S. Mittal, Ajoy Tewari, Ashish Birla, Ashish Prasad, Aushili M

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Investigation of the Mutation Spectrum in Pediatric Patients with Maturity-Onset Diabetes of Youth (MODY): Experience from a Diagnostic Center in Türkiye 青壮年型糖尿病(MODY)患儿突变谱的研究:来自<s:1>基耶诊断中心的经验

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Clinical Diabetology Pub Date : 2023-08-26 DOI: 10.5603/dk.a2023.0030

Neslihan Duzkale, C. Emiroğlu

{"title":"Investigation of the Mutation Spectrum in Pediatric Patients with Maturity-Onset Diabetes of Youth (MODY): Experience from a Diagnostic Center in Türkiye","authors":"Neslihan Duzkale, C. Emiroğlu","doi":"10.5603/dk.a2023.0030","DOIUrl":"https://doi.org/10.5603/dk.a2023.0030","url":null,"abstract":"Objective: This study was aimed to determine the ge-netic background of pediatric patients with a clinical diagnosis of maturity-onset diabetes of youth (MODY). Materials and methods: In this study, MODY-related genes of 80 pediatric patients diagnosed with MODY in Türkiye between January 2016 and January 2022 were investigated using three different large gene panels and next-generation sequencing. Results: Causal variants were detected in the genes investigated in 16 (20%) of 80 patients included in the study. The GCK gene was responsible for the clinical findings in 13 (82%) of 16 patients with a molecular diagnosis, and the HNF1A , HNF1B , and ABCC8 genes in the remaining three patients. This study identified six of the detected genomic variants for the first time in the literature. Conclusions: MODY is a group of diseases that differ from each other in terms of clinical findings, treatment, progression, genetic etiopathogenesis and incidence. For this reason, genetic analyses using multigene panels will enable accurate identification of MODY subtypes, genetic counseling of patients, guidance to optimal treatment options, and screening of carrier relatives. (Clin Diabetol 2023; 12; 4: 232–238)","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":"42 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85657232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Novel Formulas Derived from Triglyceride–Glucose Index for Assessment of Insulin Resistance in Patients with Type 2 Diabetes 由甘油三酯-葡萄糖指数衍生的新公式评估2型糖尿病患者的胰岛素抵抗

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Clinical Diabetology Pub Date : 2023-08-26 DOI: 10.5603/dk.a2023.0029

Marwan S. Al-Nimer

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Factors Affecting Outcomes of COVID-19 Infection among Older Adults with Type 2 Diabetes: A Single Center, Cross-Sectional Study 影响老年2型糖尿病患者COVID-19感染结局的因素:一项单中心、横断面研究

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Clinical Diabetology Pub Date : 2023-08-26 DOI: 10.5603/dk.a2023.0026

A. E. El Feky, Mohamed G. Abdrabo, M. Abdou, Sandra H. Sabry, A. Badr, Ahmed M. Mohsen

{"title":"Factors Affecting Outcomes of COVID-19 Infection among Older Adults with Type 2 Diabetes: A Single Center, Cross-Sectional Study","authors":"A. E. El Feky, Mohamed G. Abdrabo, M. Abdou, Sandra H. Sabry, A. Badr, Ahmed M. Mohsen","doi":"10.5603/dk.a2023.0026","DOIUrl":"https://doi.org/10.5603/dk.a2023.0026","url":null,"abstract":"Objective: COVID-19 infection and the factors affecting it are major concerns worldwide. This retrospective study aimed to ‎investigate clinical, laboratory and radiological characteristics associated with disease severity and hospitalization among older adults with type 2 diabetes mellitus (T2D) with COVID-19. Materials and methods: A retrospective case series study was conducted to review the records of older adults with T2D infected with COVID-19. Sociodemo-graphic, COVID-19-related data, laboratory tests at the time of COVID-19 diagnosis and CT findings were collected. Bivariate and multivariate regression analysis were done to determine the predictors of the studied outcome, either hospitalization or complete recovery. Results: A total of 343 patients’ records were reviewed, with a mean age of 73.6 ± 6.4 years. Most of patients had fever and cough at the time of diagnosis and ground glass opacities was found on CT in 62.1% of patients. Hospitalized patients had higher duration of diabetes, suffered more from dyspnea, body aches and chest pain, had higher HbA1c, CRP and ferritin and lower lymphocytes and hemoglobin. Fasting plasma glucose and HbA1c positively affected the duration from onset of symptoms till resolution, while hemoglobin level negatively affected it. Logistic regression analysis revealed that duration of diabetes, HbA1c, ferritin and dyspnea were significant predictors of hospitalization. Conclusions: Among older adults with T2D infected with COVID-19, poor glycemic control is associated with higher risk of hospitalization and longer duration till recovery of symptoms. Longer duration of diabetes, high serum ferritin and the presence of dyspnea are associated with higher risk for hospitalization among these patients. (Clin Diabetol 2023; 12; 4: 239–246)","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":"25 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75810181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Predictors of Medication Adherence in Patients with Type 2 Diabetes: A Cross-Sectional Study 2型糖尿病患者药物依从性的预测因素:一项横断面研究

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Clinical Diabetology Pub Date : 2023-08-26 DOI: 10.5603/dk.a2023.0031

I. Zeidi, Aisa Maleki, Zahra Najafpuor, S. Moosavi, R. Kalhor

{"title":"Predictors of Medication Adherence in Patients with Type 2 Diabetes: A Cross-Sectional Study","authors":"I. Zeidi, Aisa Maleki, Zahra Najafpuor, S. Moosavi, R. Kalhor","doi":"10.5603/dk.a2023.0031","DOIUrl":"https://doi.org/10.5603/dk.a2023.0031","url":null,"abstract":"Objective: This study aimed to investigate the predictors of medication adherence behavior and the role of self-efficacy in the medication adherence of people with diabetes. Materials and methods: This is a cross-sectional descrip-tive-analytical study. One hundred forty-eight samples were selected through the formula of difference of means. Measure tools consisted of a demographic questionnaire, Morisky Medication Adherence Scale, and psychological constructs questionnaires. SPSS20 software was used for descriptive statistics tests and calculation of correlation coefficients between vari - ables. Amos 8.80 was used to implement the structural equation modeling method. Results: The mean age of participants was 54.1 ± 8.2 and mean of body mass index (BMI) was 28.3 ± 4.5. Correlation coefficients between medication com - pliance behavior and the constructs of knowledge (r = 0.382, p < 0.01), attitude (r = 0.422, p < 0.01), subjective norms (r = 0.312, 05 p < 0.05), self-efficacy (r = 0.481, p < 0.05) and fear (r = 0.305, p < 0.05) were positive and significant. In general, the strongest correlation coefficient was reported between attitude and self-efficacy (r = 0.516, p < 0.01). The fit indices generally showed that the data fitted well with the assumed model. Self-efficacy was the most impor - tant construct that directly influenced medication adherence ( β = 0.585, p < 0.05), followed by attitude ( β = 0.328, p < 0.05) and fear ( β = 0.265, p < 0.05). Conclusions: According to the findings of this study, it was shown that various factors affect medication adherence behavior, among which self-efficacy is the most important reason, and subjective norms, attitude and norms and awareness of factors affecting medication adherence behavior. (Clin Diabetol 2023; 12; 4: 253–260)","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":"18 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81156008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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‘Clinical Diabetology’: Progress and Future Directions “临床糖尿病学”:进展和未来方向

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Clinical Diabetology Pub Date : 2023-08-26 DOI: 10.5603/dk.a2023.0032

Viral N Shah

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Can We Predict the Insulin Therapy Need and Early Postpartum Prediabetes in Patients with Gestational Diabetes Mellitus? 妊娠期糖尿病患者胰岛素治疗需求及产后早期前驱糖尿病的预测?

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Clinical Diabetology Pub Date : 2023-08-26 DOI: 10.5603/dk.a2023.0024

Magdalena Dolecka-Ślusarczyk, Aleksander Ślusarczyk, Cezary Ślusarczyk, O. Adamczyk-Gruszka, Agnieszka Ciba-Stemplewska, Z. Siudak

{"title":"Can We Predict the Insulin Therapy Need and Early Postpartum Prediabetes in Patients with Gestational Diabetes Mellitus?","authors":"Magdalena Dolecka-Ślusarczyk, Aleksander Ślusarczyk, Cezary Ślusarczyk, O. Adamczyk-Gruszka, Agnieszka Ciba-Stemplewska, Z. Siudak","doi":"10.5603/dk.a2023.0024","DOIUrl":"https://doi.org/10.5603/dk.a2023.0024","url":null,"abstract":"Objective: The authors aimed to identify risk factors for insulin therapy need and for the development of postpartum prediabetes in women with gestational diabetes mellitus (GDM). Materials and methods: This was a prospective observational single-center study including pregnant women with GDM. Women with overt diabetes were excluded. Risk factors for insulin use and prediabetes were identified using logistic regression. Univariable analyses were performed to select factors for multivariable analysis. Stepwise logistic regression was used to create multivariable models. Results: Among 135 women with GDM, 63 (46.7%) required insulin therapy. Multivariable analysis demonstrated that family history of diabetes, abnormal pre-pregnancy body mass index (> 25 kg/m 2 ), the performance of 75 g oral glucose tolerance test (OGTT) before 24 Hbd, fasting plasma glucose (FPG) at pregnancy diagnosis constitute predictive factors for further insulin therapy need. Thirteen women (9.6%) developed prediabetes shortly (6–12 weeks postpartum) after gestation. In multivariable analysis family history of diabetes, rapid weight gain, 1 h plasma glucose (PG) in OGTT, 2 h PG in OGTT and glycated hemoglobin (HbA1c) concentration were identified as independent risk factors for prediabetes postpartum. Conclusions: Many easily-available parameters individually and combined in prediction models can be useful in assessing the risk of insulin therapy need and early postpartum prediabetes in women with GDM. Evaluation of the risk of above complications at GDM diagnosis is possible using metabolic parameters and family history of diabetes. (Clin Diabetol 2023; 12; 4: 223–231)","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":"30 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85499163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Effect of Yoga on Insulin Resistance in Type 2 Diabetes: A Systematic Review and Meta-Analysis 瑜伽对2型糖尿病胰岛素抵抗的影响:系统回顾和荟萃分析

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Clinical Diabetology Pub Date : 2023-06-30 DOI: 10.5603/dk.a2023.0022

Biswajit Dhali, Sridip Chatterjee, S. Das, M. D. Cruz

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Association between Serum Adiponectin and Insulin Resistance in Children and Adolescents with Type 1 Diabetes: A Cross-Sectional, Single Center Study from Egypt 1型糖尿病儿童和青少年血清脂联素与胰岛素抵抗之间的关系:一项来自埃及的横断面单中心研究

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Clinical Diabetology Pub Date : 2023-06-30 DOI: 10.5603/dk.a2023.0014

Hend Soliman, Doaa I. A. Mostafa, Ahmed M. Helmy, Radwa A. Shamma

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Cardiovascular Risk Assessment in Women after Pregnancy Complicated by Gestational Diabetes Mellitus: A Cross-Sectional, Single Center Study 妊娠合并妊娠期糖尿病妇女的心血管风险评估:一项横断面单中心研究