{"title":"Surgical management of Cushing's disease: a personal perspective.","authors":"Edward H Oldfield","doi":"10.1227/neu.0b013e3182269d3f","DOIUrl":"https://doi.org/10.1227/neu.0b013e3182269d3f","url":null,"abstract":"<p><p>One of the rewards of studying Cushing's disease is that the understanding of the stages of these tumors provides insight into what happens during the evolution of all types of pituitary tumors. The evolution of the development of the pseudocapsule at the margin of small adenomas begins to occur at about 2 to 3 mm in diameter, the minimum size at which we can identify them during surgical exploration. Certain advantages derive from removal of pituitary adenomas using the histological pseudocapsule as a surgical capsule and as a defined tissue plane. Other unresolved issues need our focus over the next few years. Surgical success would be enhanced if we had more accurate ways of localizing the very smallest tumors, either before or during surgery, in patients with Cushing's disease and negative MRI. We also need better therapies for tumors that invade the cavernous sinus, and we need to understand the biological basis of invasion in patients who have truly invasive tumors. Finally, it would be rewarding to understand the molecular basis of the relative resistance to negative cortisol feedback characterizing these tumors and why it is linked to tumor formation. We still have much to do.</p>","PeriodicalId":10381,"journal":{"name":"Clinical neurosurgery","volume":"58 ","pages":"13-26"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1227/neu.0b013e3182269d3f","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30139919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaisorn L Chaichana, Scott L Parker, Debraj Mukherjee, Joseph S Cheng, Ziya L Gokaslan, Matthew J McGirt
{"title":"Assessment of the extent of surgical resection as a predictor of survival in patients with primary osseous spinal neoplasms.","authors":"Kaisorn L Chaichana, Scott L Parker, Debraj Mukherjee, Joseph S Cheng, Ziya L Gokaslan, Matthew J McGirt","doi":"10.1227/neu.0b013e318226fff7","DOIUrl":"https://doi.org/10.1227/neu.0b013e318226fff7","url":null,"abstract":"","PeriodicalId":10381,"journal":{"name":"Clinical neurosurgery","volume":"58 ","pages":"117-21"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1227/neu.0b013e318226fff7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30140934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Excellence in neurosurgery program building: enhancing the academic mission.","authors":"James T Rutka, Christopher Wallace","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10381,"journal":{"name":"Clinical neurosurgery","volume":"57 ","pages":"100-11"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29637747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mechanisms of evasion to antiangiogenic therapy in glioblastoma.","authors":"Samuel D Rose, Manish K Aghi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10381,"journal":{"name":"Clinical neurosurgery","volume":"57 ","pages":"123-8"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29637749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mandy J Binning, Adnan H Siddiqui, Elad I Levy, L Nelson Hopkins
{"title":"Pursuing excellence in neurosurgical innovation.","authors":"Mandy J Binning, Adnan H Siddiqui, Elad I Levy, L Nelson Hopkins","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10381,"journal":{"name":"Clinical neurosurgery","volume":"57 ","pages":"56-9"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29637740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neurological Society of India Guest Lecture: optimally invasive skull base surgery.","authors":"Basant Kumar Misra","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10381,"journal":{"name":"Clinical neurosurgery","volume":"57 ","pages":"79-90"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29637743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The measurement of pain in patients with trigeminal neuralgia.","authors":"H Isaac Chen, John Y K Lee","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10381,"journal":{"name":"Clinical neurosurgery","volume":"57 ","pages":"129-33"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29637750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Excellence in spinal neurosurgery.","authors":"Volker K H Sonntag","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10381,"journal":{"name":"Clinical neurosurgery","volume":"57 ","pages":"15-8"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29637819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Defining excellence in vascular neurosurgery.","authors":"Nader Sanai, Robert F Spetzler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Success as a vascular neurosurgeon almost always begins with passion, an inherent love for the work that drives an insatiable desire for personal improvement. A personal definition of excellence in vascular neurosurgery includes several fundamental qualities: mastery of the basics, refinement of technique, advancement of technology, investigative study, advanced decision making, microsurgical innovation, a well-rounded surgical armamentarium, and a lifelong commitment to teaching. Ultimately, the reward for these efforts is the ability to influence generations to come, particularly as one follows the rising careers of former trainees, each redefining the term \"excellence\" in vascular neurosurgery.</p>","PeriodicalId":10381,"journal":{"name":"Clinical neurosurgery","volume":"57 ","pages":"23-7"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29637822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}