Clinical investigation最新文献_第8页

Anatomy and physiology of translation: the academic research imperative 翻译的解剖学和生理学:学术研究的必要性

Clinical investigation Pub Date : 2015-12-11 DOI: 10.4155/CLI.15.46

G. Apiou-Sbirlea, G. Tearney, R. Birngruber, T. Hasan, R. Anderson

引用次数: 6

Complications and management of hyperkalemia: implications for the use of the novel cation exchangers zirconium cyclosilicate and patiromer 高钾血症的并发症和处理:新型阳离子交换剂环硅酸锆和聚氰胺使用的意义

Clinical investigation Pub Date : 2015-10-30 DOI: 10.4155/CLI.15.48

L. Noureddine, B. Dixon

引用次数: 5

Solving clinical trial delays: innovative solutions 解决临床试验延误:创新解决方案

Clinical investigation Pub Date : 2015-10-26 DOI: 10.4155/CLI.15.41

Kavita Singh, M. A. Salam, R. Devarajan, D. Prabhakaran

引用次数: 1

Development of a generic laboratory manual for biological sample logistics in clinical pharmacokinetic studies 开发临床药代动力学研究中生物样品物流的通用实验室手册

Clinical investigation Pub Date : 2015-10-26 DOI: 10.4155/CLI.15.42

R. Abbott, Rebecca Sleigh, J. Long, C. Ekstrom, B. Matthes, José Groenboom-Nieuwenhuijzen

{"title":"Development of a generic laboratory manual for biological sample logistics in clinical pharmacokinetic studies","authors":"R. Abbott, Rebecca Sleigh, J. Long, C. Ekstrom, B. Matthes, José Groenboom-Nieuwenhuijzen","doi":"10.4155/CLI.15.42","DOIUrl":"https://doi.org/10.4155/CLI.15.42","url":null,"abstract":"2015 The European Bioanalysis Forum (EBF) has been organizing ‘Topic Teams’ on issues of importance to the bioanalytical community for several years [1]. Many of these teams focus on internal bioanalytical issues of importance to bioanalysts such as technological innovation, regulatory questions and novel assay validation approaches [2]. However, there is an increasing recognition that we do need to pay more attention to external factors such as interactions and communication regarding clinical, toxicology and project team participation [3]. Topic Team 12, a virtual team of ten EBF member companies and meeting every 2 to 3 weeks by teleconference, focused on topics of interest associated with clinical trial support. Following a member survey and extended team discussion it was felt that the generation of a generic laboratory manual for use in clinical pharmacokinetic studies would offer a potential solution to the common problems created by poor logistical sample management and communication in single and multicentre trials [4]. Such a document would create a single platform to which clinical sites, central laboratories and bioanalytical groups could all relate. The benefits could be significant since a harmonized document should stimulate a consistent way of working and would be a first step in the elimination of many current issues.","PeriodicalId":10369,"journal":{"name":"Clinical investigation","volume":"5 1","pages":"741-744"},"PeriodicalIF":0.0,"publicationDate":"2015-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85378647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engaging patients for drug repurposing: mapping the patient engagement continuum 让患者参与药物再利用:绘制患者参与连续体

Clinical investigation Pub Date : 2015-10-26 DOI: 10.4155/CLI.15.39

M. Allarakhia

{"title":"Engaging patients for drug repurposing: mapping the patient engagement continuum","authors":"M. Allarakhia","doi":"10.4155/CLI.15.39","DOIUrl":"https://doi.org/10.4155/CLI.15.39","url":null,"abstract":"Drug repurposing involves finding new indications for existing drugs or potential drug candidates. Drugs or candidates include those in clinical development with relevance to multiple diseases, drugs that have failed to demonstrate efficacy for a particular indication during clinical trials but have no major safety concerns, discontinued drugs, drugs not yet fully pursued and drugs for which patents are set to expire [1]. Opportunities for drug repositioning can arise from indirect observation as well as purposeful collaboration including physician and patient engagement. The focus of this editorial is primarily on the engagement of patients directly or through patient information to support drug repurposing endeavors. Engagement must permit the transition of patients from the role of simple participant to the mid-level informative role, and at the highest level of engagement the collaborative role. Table 1 outlines a newly devised continuum of patient engagement. The focus is on the engagement of the ‘lead patient’ [2]. ‘Lead patients’ – namely those patients that: are proactive with respect to their health, disease and treatment options, can provide a nuanced perspective to drug discovery, including through repurposing endeavors [2]. Specifically, patients can be a source of direct information with respect to off-label drug usage, patient records and patient communities can indirectly reveal drug repurposing opportunities, and patients can jointly collaborate in the search for new drug repurposing opportunities through the deciphering of information on drug pharmacology – system or – gene interaction or other design opportunities [3]. The engagement could not be more salient than for rare disease drug repurposing [4].","PeriodicalId":10369,"journal":{"name":"Clinical investigation","volume":"30 1","pages":"733-737"},"PeriodicalIF":0.0,"publicationDate":"2015-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81635442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Pharmacological treatment of left ventricular remodeling: recent trial results 左心室重构的药物治疗:最近的试验结果

Clinical investigation Pub Date : 2015-10-26 DOI: 10.4155/CLI.15.44

A. Tomasik, E. Nowalany-Kozielska

引用次数: 1

Interview with Graham Clarke 格雷厄姆·克拉克访谈

Clinical investigation Pub Date : 2015-10-26 DOI: 10.4155/CLI.15.40

G. Clarke

引用次数: 0

Apremilast in the treatment of moderate-to-severe plaque psoriasis: results from the ESTEEM studies 阿普拉米司特治疗中重度斑块型银屑病:来自ESTEEM研究的结果

Clinical investigation Pub Date : 2015-10-06 DOI: 10.4155/CLI.15.50

J. Cather, Elizabeth J Horn