Clinical investigation最新文献_第3页

Oral dextrose v/s breast milk for the pain relief of newborn infants 口服葡萄糖/母乳用于新生儿疼痛缓解

Clinical investigation Pub Date : 2020-01-01 DOI: 10.37532/2041-6792.2020.10(3).172

Tharun C. Varghese, A. Paul, Santhosh T. Soans

{"title":"Oral dextrose v/s breast milk for the pain relief of newborn infants","authors":"Tharun C. Varghese, A. Paul, Santhosh T. Soans","doi":"10.37532/2041-6792.2020.10(3).172","DOIUrl":"https://doi.org/10.37532/2041-6792.2020.10(3).172","url":null,"abstract":"Aim: Pain management in newborn infants especially for mild to moderate pain is underused. The use of sucrose and glucose are found to be effective. This study is to find the effect of oral dextrose solution on pain relief in term neonates. Methodology: In a randomized controlled clinical trial, 124 term neonates were enrolled in the study. They were randomized to receive oral dextrose (25%) or breast milk two minutes before venipunctures. Pain reactions were scored with the NIPS pain scoring system, heart rate, and oxygen saturation after venipunctures was recorded. Results: There were significantly lower pain score in dextrose group after venipunctures (NIPS pain score: 4.67+1.04 and 6.62+0.82 at 1st minute, 2.04 ± 1.45 and 4.08 ± 1.05 at 2nd minutes and 1.63+0.76 and 3.02+1.08 at 3rd minute respectively) The mean heart rate of the group I (166.57± 12.25/min) was high compared to the group II (144.8 ± 12.44/min). There was desaturation noted in both the groups. Conclusion: Using 2 ml of 25% oral dextrose solution is a useful, easy, non-expensive, and non-pharmacologic method for managing mild to moderate pain in neonates.","PeriodicalId":10369,"journal":{"name":"Clinical investigation","volume":"341 1","pages":"90-94"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79742420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Binge eating disorder among obese/overweight in Pakistan: Under-diagnosed, undertreated and misunderstood 巴基斯坦肥胖/超重人群中的暴食症:诊断不足、治疗不足和误解

Clinical investigation Pub Date : 2019-01-01 DOI: 10.37532/2041-6792.2019.9(2).152

M. Malik, Waseem Shaukat, A. Hussain

{"title":"Binge eating disorder among obese/overweight in Pakistan: Under-diagnosed, undertreated and misunderstood","authors":"M. Malik, Waseem Shaukat, A. Hussain","doi":"10.37532/2041-6792.2019.9(2).152","DOIUrl":"https://doi.org/10.37532/2041-6792.2019.9(2).152","url":null,"abstract":"Introduction: Obese persons with BED have compromised functioning mostly in psycho-social aspects of Health-Related Quality of Life (HRQoL) as poor physical functioning is related to obesity. Despite the higher prevalence of BED compared with other eating disorders, lack of understanding of BED by physicians and inadequate physician-patient communication regarding BED may result in it’s under diagnosis. Objective: The objective of the study was to assess binge eating disorder among overweight/obese in two major cities of Pakistan. Method: A descriptive cross-sectional study design was used. A pre-validated data collection tool Binge Eating Disorder Screener-7 (BEDS-7) was distributed to a sample of 382 obese/overweight individuals. Binge Eating Disorder Screener-7 (BEDS-7) questionnaires is comprised of seven questions that directly evaluate the patient’s eating patterns and behaviors for binge eating disorder. Convenient sampling technique was used to select the respondents. After data collection, the data was cleaned, coded and entered in SPSS version-21. Chi-square test (p ≥ 0.05) was performed to find out the association between different variables. Results: The results revealed that nearly half of the respondents of the overweight/obese had an eating disorder among them. Out of the total sample 35.1% (n=134) respondent, agreed that they had episodes of excessive overeating during the last 3 months. The results highlighted that 64.9% (n=248) had no binge eating disorder while 15.7% (n=60) of the respondents had moderate binge eating disorder and 14.9% (n=57) had severe binge eating disorder. Conclusion: The current study concluded that moderate binge eating disorder was seen among most of the obese individuals but BED in most of the cases goes undiagnosed. Binge eating disorder was more common among students and non-smokers. Early detection and evidence-based treatment strategies can help the patients to recover on initial stages and prevent from a further complication of binge eating disorder.","PeriodicalId":10369,"journal":{"name":"Clinical investigation","volume":"21 1","pages":"75-80"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78130988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Mac-2-binding Protein Glycosylation isomer well correlates with the Controlling Nutritional Status Score in Hepatitis Viruses-related Liver Diseases mac -2结合蛋白糖基化异构体与肝炎病毒相关肝病的控制营养状况评分密切相关

Clinical investigation Pub Date : 2019-01-01 DOI: 10.37532/2041-6792.2019.9(1).147

H. Nishikawa, R. Takata, Kazunori Yoh, H. Enomoto, N. Ishii, Y. Iwata, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Kunihiro Hasegawa, Yukihisa Yuri, Tomoyuki Takashima, H. Iijima, S. Nishiguchi

{"title":"Mac-2-binding Protein Glycosylation isomer well correlates with the Controlling Nutritional Status Score in Hepatitis Viruses-related Liver Diseases","authors":"H. Nishikawa, R. Takata, Kazunori Yoh, H. Enomoto, N. Ishii, Y. Iwata, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Kunihiro Hasegawa, Yukihisa Yuri, Tomoyuki Takashima, H. Iijima, S. Nishiguchi","doi":"10.37532/2041-6792.2019.9(1).147","DOIUrl":"https://doi.org/10.37532/2041-6792.2019.9(1).147","url":null,"abstract":"Purpose: Examining the clinical significance of Mac-2-binding protein glycosylation isomer (M2BPGi), which was recently introduced as a novel liver fibrotic biomarker in chronic liver disease patients with unique fibrosis associated glycol chain protein alteration, other than liver fibrotic marker appears to be of importance. We sought to examine the relevance between M2BPGi and the Controlling Nutrition (CONUT) score in hepatitis B and C viruses-related patients (the HBVrelated cohort (Br-cohort, n=249) and the HCV-related cohort (Cr-cohort, n=386)) comparing with other liver fibrotic markers. Patients and Methods: We checked the correlation between the CONUT score and four liver fibrotic markers (M2BPGi, FIB-4 index, hyaluronic acid, and platelet count) in the two cohorts. Receiver operating characteristics (ROC) analyses associated with elevated CONUT score (CONUT score ≥ 1,2,3,4 or 5) were also conducted. Results: The median CONUT score (range) were 1 (0-5) in the Br-cohort and 2 (0-8) in the Crcohort (P<0.0001). In the Br-cohort, advanced fibrosis or more (F3 or F4) was noted in 60 patients (24.1%), while in the Cr-cohort, it was noted in 212 patients (54.9%). In the Br-cohort, the highest correlation coefficient was identified in the FIB-4 index (r=0.436, P<0.0001), followed by M2BPGi (r=0.376, P<0.0001). In the Cr-cohort, the highest correlation coefficient was noted in M2BPGi (r=0.690, P<0.0001), followed by the FIB-4 index (r=0.598, P<0.0001). For the ROC analyses linked to the elevated CONUT score, in the Cr-cohort, M2BPGi yielded the highest AUC in all ROC analyses, whereas in the Br-cohort, such tendencies were not noted. Conclusion: M2BPGi can be a useful marker for predicting nutritional condition as determined by the CONUT score especially in chronic hepatitis C patients.","PeriodicalId":10369,"journal":{"name":"Clinical investigation","volume":"47 1","pages":"21-32"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88556836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraductal papilloma of the breast: Short-review 乳腺导管内乳头状瘤:简要回顾

Clinical investigation Pub Date : 2019-01-01 DOI: 10.37532/2041-6792.2019.9(3).157

Shinya Tajima, I. Maeda, K. Kishimoto, S. Naruki, A. Endo, M. Doi, M. Chosokabe, K. Tsugawa, M. Takagi, J. Koike

引用次数: 0

Research on the treatment of metastatic colon cancer patients treated by FOLFOXIRI: Efficacy and toxicity of first-line treatment in stage IV metastatic colorectal cancer patients FOLFOXIRI治疗转移性结肠癌患者的研究:一线治疗对IV期转移性结直肠癌患者的疗效和毒性

Clinical investigation Pub Date : 2018-01-01 DOI: 10.4172/Clinical-Investigation.1000138

Trinh Le Huy, Bui My Hanh

{"title":"Research on the treatment of metastatic colon cancer patients treated by FOLFOXIRI: Efficacy and toxicity of first-line treatment in stage IV metastatic colorectal cancer patients","authors":"Trinh Le Huy, Bui My Hanh","doi":"10.4172/Clinical-Investigation.1000138","DOIUrl":"https://doi.org/10.4172/Clinical-Investigation.1000138","url":null,"abstract":"Background: In recent years, the new trend in treatment of colorectal cancer is the use of target drug. We conduct the study to evaluate efficacy of triplet combination chemotherapy of 5-fluorouracil/leucovorin, oxapilatin, and irinotecan (FOLFOXIRI) in the treatment of stage IV colorectal cancer patients. Method: Uncontrolled clinical trial carried on 39 stage IV colorectal cancer patients Results: The overall response rate of the treatment was 75%. Mean of progression free survival was 13.4 ± 9 months. The overall survival rate at 12th month and 24th month were 90% and 76%, respectively. The proportion of granulocytopenia was 48.9%, no grade 3 or 4. Side effect beyond hematology was most seen in hepatic toxicity with 52.5%, mainly at grade 1. Vomiting was 18.3%, all at grade 1. Other toxicity was very low at percentage. Conclusion: The triplet combination FOLFOXIRIN chemotherapy improves the outcome of patient with metal colorectal cancer in term of response rate, overall survival rate and progression free survival, and the level of toxicity was acceptable..","PeriodicalId":10369,"journal":{"name":"Clinical investigation","volume":"45 1","pages":"123-129"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80033815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proximate composition, mineral and some vitamin contents of tigernut (Cyperus esculentus) 虎坚果(Cyperus esculentus)的基本成分、矿物质和部分维生素含量

Clinical investigation Pub Date : 2018-01-01 DOI: 10.4172/CLINICAL-INVESTIGATION.1000143

M. Suleiman, J. Olajide, J. Omale, O. Abbah, D. Ejembi

引用次数: 24

Ph and residual gastric volume after mannitol preparation: A randomized controlled study comparing ingestion three versus six hours prior to the procedure 甘露醇制备后的Ph值和残余胃容量:一项随机对照研究，比较手术前3小时和6小时的摄入情况

Clinical investigation Pub Date : 2018-01-01 DOI: 10.4172/Clinical-Investigation.1000131

R. Ruiz, J. Jukemura, P. Alves, M. Santos

{"title":"Ph and residual gastric volume after mannitol preparation: A randomized controlled study comparing ingestion three versus six hours prior to the procedure","authors":"R. Ruiz, J. Jukemura, P. Alves, M. Santos","doi":"10.4172/Clinical-Investigation.1000131","DOIUrl":"https://doi.org/10.4172/Clinical-Investigation.1000131","url":null,"abstract":"Objective: The main objective of the study is to compare gastric volume and pH values after the ingestion of mannitol three hours versus six hours before a colonoscopy procedure. Methods: This study is a parallel randomized controlled trial with a 1:1 allocation ratio, involving ambulatory patients scheduled to undergo a colonoscopy procedure, not having previous gastric surgeries, with an American Society of Anesthesiology risk of less than III, older than 18 years of age, and with a fasting period for solid food of over eight hours. All participants underwent a bowel preparation with mannitol, being randomized to start the preparation either three or six hours before the colonoscopy procedure. Outcomes of interest were pH and gastric residual volume. Results: The study sample included 102 subjects with subjects in the three-hour group being significantly older than individuals in the six-hour group (59.73 (± 18.69) vs. 51.71 (± 20.46); p=0.041) and subjects in the six-hour group presented higher BMI than individuals in the three-hour group (28.55 (± 5.15) vs. 26.35 (± 5.78); p=0.046). When evaluating study outcomes adjusting for baseline imbalances in age and BMI, we found no statistically significant differences between the three and the six-hour arms. In a subgroup analysis among the subgroup of patients with Diabetes Mellitus, the six-hour arm presented a significantly higher gastric volume when compared to the three-hour arm (127 versus 43.4 and 116 versus 37.8), respectively. Conclusion: Our results are in line with the notion that a three-hour fasting period is safe to prevent aspiration from gastric content during bowel preparation with mannitol. Considering that long fasting protocols may result in adverse outcomes such as dehydration and electrolyte imbalance, we provide evidence to support the practice of short fasting periods.","PeriodicalId":10369,"journal":{"name":"Clinical investigation","volume":"7 1","pages":"75-85"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84242005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Edible Oyster Mushroom (Pleurotus ostreatus) on Oxidative Stress and Neurological Cognitive Disorder in Streptozotocin-Diabetic Rats 食用平菇对链脲佐菌素-糖尿病大鼠氧化应激和神经认知障碍的影响

Clinical investigation Pub Date : 2018-01-01 DOI: 10.4172/CLINICAL-INVESTIGATION.1000128

J. Bindhu, Arunava Das

{"title":"Evaluation of Edible Oyster Mushroom (Pleurotus ostreatus) on Oxidative Stress and Neurological Cognitive Disorder in Streptozotocin-Diabetic Rats","authors":"J. Bindhu, Arunava Das","doi":"10.4172/CLINICAL-INVESTIGATION.1000128","DOIUrl":"https://doi.org/10.4172/CLINICAL-INVESTIGATION.1000128","url":null,"abstract":"Pleurotus ostreatus is drawn into lime light for the treatment of Diabetes mellitus for the last few years, but now it is evidently proven for the recovery of the diabetes mellitus-induced memory impairments in streptozoticin induced diabetic rats. Oxidative stress, neurological disorders, cognitive and spatial learning associated to Diabetic-Alzheimer’s is irreversibly inhibited by P. ostreatus. The availability and cost effectively makes a stepping stone for the middle to low income people to rely on P. ostreatus rather than of costly medications for the treatment of neurological and cognitive disorders associated with Diabetes. The research was done to identify a potent free radical bioactive compound against cognitive impairment in streptozotocin –diabetic rats. Five weeks after diabetic induction, P. ostreatus extract was administered orally (2 mg/lt). The cognitive, cerebral and perceptive behaviour was examined with T Maze (Radial Arm Maze), Morris Water Maze (MWM), Novel object recognition task in wistar rats (male). Besides oxidative stress parameters like Lipid peroxidation (LPO), FRAP (Ferric reducing ability of plasma), antioxidant assay and Thiol assay to determine total Thiol group in the blood was carried out to determine the neurological disorders associated with brain. P. ostreatus showed significant improvements in Spatial and Cognitive disorders when compared to the diabetic and healthy control. Also the FRAP and thiol group in blood showed tremendous increase due to the P. ostreatus proving the effectiveness of Pleurotus extract on Cognitive impairment and Oxidative stress in Diabetic mellitus.","PeriodicalId":10369,"journal":{"name":"Clinical investigation","volume":"84 1","pages":"43-52"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85850638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The effect of nurses' communication skills with Nulliparous mothers on exclusive breastfeeding: A Clinical Trial Study 护士与未分娩母亲沟通技巧对纯母乳喂养的影响:一项临床试验研究

Clinical investigation Pub Date : 2018-01-01 DOI: 10.4172/CLINICAL-INVESTIGATION.1000139

M. Shariat, N. Abedinia, F. Haghollahi, A. Noorbala, A. Karimi, J. Zebardast

{"title":"The effect of nurses' communication skills with Nulliparous mothers on exclusive breastfeeding: A Clinical Trial Study","authors":"M. Shariat, N. Abedinia, F. Haghollahi, A. Noorbala, A. Karimi, J. Zebardast","doi":"10.4172/CLINICAL-INVESTIGATION.1000139","DOIUrl":"https://doi.org/10.4172/CLINICAL-INVESTIGATION.1000139","url":null,"abstract":"Exclusive breastfeeding (EBF) in the first six months of life has many benefits for mother and newborn. The purpose of the present study was to investigate the effect of medical staff communication skills training on breastfeeding in nulliparous mothers. This is a clinical trial study. One hundred- seventy nulliparous pregnant women were selected from Vali-e-Asr Hospital of Tehran. The samples were divided into two groups of intervention (n=85) and control (n=85) by randomized blocks method. The intervention in this study was in the form of therapeutic communication training to the ten nurses in delivery emergency department ward on how to communicate with mothers. The Therapeutic communication skills training course consisted of four communication skills (Empathy skills, Interpersonal skills, Stress and emotional management). Chi-square test and analysis of variance were used to analyze the data and compare the groups. There was a significant difference between the two groups regarding the exclusive breastfeeding for 6 months (P=0.046).The frequency of exclusive breastfeeding in interventional group was higher than the control group (37.5% vs. 23.5%). At six months old, the babies in the study group grew more than the control group (8218.82 ± 2308.57 vs. 7442.23 ± 1923.27 gr, p=0.018) The professional therapeutic relationship of medical staff with the mothers led to an increase in exclusive breastfeeding and continuation of breastfeeding in the first 6 months of childbirth. It seems that breastfeeding is associated with the higher baby growth and lower use of formula feeding.","PeriodicalId":10369,"journal":{"name":"Clinical investigation","volume":"35 1","pages":"131-137"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84562874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prescription Pattern Analysis of Antidiabetic Drugs in Diabetes Mellitus and Associated Comorbidities 糖尿病及相关合并症患者降糖药处方模式分析

Clinical investigation Pub Date : 2018-01-01 DOI: 10.4172/CLINICAL-INVESTIGATION.1000123

Mohd. Mahmood, R. C. Reddy, J. Lahari, S. Fatima, P. Shinde, S. An, Reddy, P. PranaliS.

{"title":"Prescription Pattern Analysis of Antidiabetic Drugs in Diabetes Mellitus and Associated Comorbidities","authors":"Mohd. Mahmood, R. C. Reddy, J. Lahari, S. Fatima, P. Shinde, S. An, Reddy, P. PranaliS.","doi":"10.4172/CLINICAL-INVESTIGATION.1000123","DOIUrl":"https://doi.org/10.4172/CLINICAL-INVESTIGATION.1000123","url":null,"abstract":"Background: The treatment options for Diabetes mellitus and their prescribing has increased over years. This needs appropriate selection of drugs. The main objective of this study was to highlight the current prescribing trends in Diabetes mellitus patients with other co-morbid conditions. Methods: A prospective observational study was conducted on inpatients admitted to various wards in a tertiary care hospital for period of 6 months between October 2016- March 2017. Prescriptions of the patients are collected in a designed questionnaire form and the relevant information is recorded and analysed. Results: 235 patient prescription patterns were studied, out of which 62.97% were males and 37.02% were females. Most of the patients were in the age group of 41-60. Hypertension was the most commonly found co-morbid condition. Rapid acting insulin was mostly prescribed during hospital stay. Metformin was the commonly prescribed oral hypoglycemic agent followed by glimeperide. Conclusion: The adverse drug reactions can be minimized by replacing the drugs with novel therapeutic agents like Glucagon-like peptide agonist, Dipeptidyl peptidase inhibitors and Sodium-glucose transport inhibitors. The management of drug interactions should be done by clinical significance and correlation","PeriodicalId":10369,"journal":{"name":"Clinical investigation","volume":"21 2 1","pages":"4-12"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90921925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13