CMAJ : Canadian Medical Association Journal最新文献_第3页

Amyloïdose héréditaire à transthyrétine accompagnée d’un syndrome du canal carpien 遗传性转甲状腺素淀粉样变性伴腕管综合征

CMAJ : Canadian Medical Association Journal Pub Date : 2024-04-14 DOI: 10.1503/cmaj.230671-f

Nicole Zaki, Nicholas J. Miller, Patrick Frosk, Aditya Sharma

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CMAJ : Canadian Medical Association Journal Pub Date : 2024-04-14 DOI: 10.1503/cmaj.231339

Shaleesa Ledlie, David Juurlink, Mina Tadrous, M. Mamdani, J. M. Paterson, Tara Gomes

{"title":"Opioid-related deaths between 2019 and 2021 across 9 Canadian provinces and territories","authors":"Shaleesa Ledlie, David Juurlink, Mina Tadrous, M. Mamdani, J. M. Paterson, Tara Gomes","doi":"10.1503/cmaj.231339","DOIUrl":"https://doi.org/10.1503/cmaj.231339","url":null,"abstract":"Background: The drug toxicity crisis continues to accelerate across Canada, with rapid increases in opioid-related harms following the onset of the COVID-19 pandemic. We sought to describe trends in the burden of opioid-related deaths across Canada throughout the pandemic, comparing these trends by province or territory, age, and sex. Methods: We conducted a repeated cross-sectional analysis of accidental opioid-related deaths between Jan. 1, 2019, and Dec. 31, 2021, across 9 Canadian provinces and territories using aggregated national data. Our primary measure was the burden of premature opioid-related death, measured by potential years of life lost. Our secondary measure was the proportion of all deaths attributable to opioids; we used the Cochrane–Armitage test for trend to compare proportions. Results: Between 2019 and 2021, the annual number of opioid-related deaths increased from 3007 to 6222 and years of life lost increased from 126 115 to 256 336 (from 3.5 to 7.0 yr of life lost per 1000 population). In 2021, the highest number of years of life lost was among males (181 525 yr) and people aged 30–39 years (87 045 yr). In 2019, we found that 1.7% of all deaths among those younger than 85 years were related to opioids, rising to 3.2% in 2021. Significant increases in the proportion of deaths related to opioids were observed across all age groups (p < 0.001), representing 29.3% and 29.0% of deaths among people aged 20–29 and 30–39 years in 2021, respectively. Interpretation: Across Canada, the burden of premature opioid-related deaths doubled between 2019 and 2021, representing more than one-quarter of deaths among younger adults. The disproportionate loss of life in this demographic group highlights the critical need for targeted prevention efforts.","PeriodicalId":10359,"journal":{"name":"CMAJ : Canadian Medical Association Journal","volume":"36 4","pages":"E469 - E476"},"PeriodicalIF":0.0,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140705949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inclusion body myositis 包涵体肌炎

CMAJ : Canadian Medical Association Journal Pub Date : 2024-04-14 DOI: 10.1503/cmaj.231815

J. Warman-Chardon, Ari Breiner, P. Bourque

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Diagnosis and treatment of hyperemesis gravidarum 妊娠剧吐的诊断和治疗

CMAJ : Canadian Medical Association Journal Pub Date : 2024-04-14 DOI: 10.1503/cmaj.221502

L. Jansen, Victoria Shaw, I. Grooten, M. H. Koot, Caitlin R Dean, Rebecca C Painter

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Schizophrenic poetry, queerness, and the limits of self-expression 精神分裂症诗歌、同性恋和自我表达的限制

CMAJ : Canadian Medical Association Journal Pub Date : 2024-04-14 DOI: 10.1503/cmaj.231440

Nam S Hoang

引用次数: 0

Pantoufles usées 旧拖鞋

CMAJ : Canadian Medical Association Journal Pub Date : 2024-04-14 DOI: 10.1503/cmaj.230747-f

Amanda Pendergast

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Burton line and basophilic stippling in lead poisoning 铅中毒中的伯顿线和嗜碱性斑纹

CMAJ : Canadian Medical Association Journal Pub Date : 2024-04-14 DOI: 10.1503/cmaj.231405

Takahide Morita, Toshinori Nishizawa, Toru Morikawa

引用次数: 0

Hormonothérapie substitutive chez les personnes présentant des antécédents de cancer gynécologique 有妇科癌症病史者的激素替代疗法

CMAJ : Canadian Medical Association Journal Pub Date : 2024-04-14 DOI: 10.1503/cmaj.231066-f

Maryam Kotait, Alison L. Shea, J. Nguyen

引用次数: 0

Abandon du tabagisme au moyen de la stimulation magnétique transcrânienne répétitive 利用重复经颅磁刺激戒烟

CMAJ : Canadian Medical Association Journal Pub Date : 2024-04-14 DOI: 10.1503/cmaj.230806-f

Christine Ibrahim, Victor M Tang, Daniel M Blumberger, Bernard Le Foll

引用次数: 0

Characteristics of primary care practices by proportion of patients unvaccinated against SARS-CoV-2: a cross-sectional cohort study 按未接种 SARS-CoV-2 疫苗的患者比例划分的初级保健机构的特点：一项横断面队列研究

CMAJ : Canadian Medical Association Journal Pub Date : 2024-04-07 DOI: 10.1503/cmaj.230816

J. Shuldiner, Michael E. Green, Tara Kiran, Shahriar Khan, E. Frymire, Rahim Moineddin, Meghan Kerr, Mina Tadrous, D. Nowak, Jeffrey C. Kwong, Jia Hu, Holly O. Witteman, Bryn Hamilton, Isaac Bogoch, Lydia-Joy Marshall, Sophia Ikura, Stacey Bar-Ziv, David Kaplan, Noah Ivers

{"title":"Characteristics of primary care practices by proportion of patients unvaccinated against SARS-CoV-2: a cross-sectional cohort study","authors":"J. Shuldiner, Michael E. Green, Tara Kiran, Shahriar Khan, E. Frymire, Rahim Moineddin, Meghan Kerr, Mina Tadrous, D. Nowak, Jeffrey C. Kwong, Jia Hu, Holly O. Witteman, Bryn Hamilton, Isaac Bogoch, Lydia-Joy Marshall, Sophia Ikura, Stacey Bar-Ziv, David Kaplan, Noah Ivers","doi":"10.1503/cmaj.230816","DOIUrl":"https://doi.org/10.1503/cmaj.230816","url":null,"abstract":"Background: Variations in primary care practices may explain some differences in health outcomes during the COVID-19 pandemic. We sought to evaluate the characteristics of primary care practices by the proportion of patients unvaccinated against SARS-CoV-2. Methods: We conducted a population-based, cross-sectional cohort study using linked administrative data sets in Ontario, Canada. We calculated the percentage of patients unvaccinated against SARS-CoV-2 enrolled with each comprehensive-care family physician, ranked physicians according to the proportion of patients unvaccinated, and identified physicians in the top 10% (v. the other 90%). We compared characteristics of family physicians and their patients in these 2 groups using standardized differences. Results: We analyzed 9060 family physicians with 10 837 909 enrolled patients. Family physicians with the largest proportion (top 10%) of unvaccinated patients (n = 906) were more likely to be male, to have trained outside of Canada, to be older, and to work in an enhanced fee-for-service model than those in the remaining 90%. Vaccine coverage (≥ 2 doses of SARS-CoV-2 vaccine) was 74% among patients of physicians with the largest proportion of unvaccinated patients, compared with 87% in the remaining patient population. Patients in the top 10% group tended to be younger and live in areas with higher levels of ethnic diversity and immigration and lower incomes. Interpretation: Primary care practices with the largest proportion of patients unvaccinated against SARS-CoV-2 served marginalized communities and were less likely to use team-based care models. These findings can guide resource planning and help tailor interventions to integrate public health priorities within primary care practices.","PeriodicalId":10359,"journal":{"name":"CMAJ : Canadian Medical Association Journal","volume":"12 7","pages":"E432 - E440"},"PeriodicalIF":0.0,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140732712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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