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Clinical pharmacology and therapy最新文献

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Impact of type 2 diabetes on the course and outcomes of community-acquired pneumonia in hospitalized patients 2型糖尿病对住院患者社区获得性肺炎病程和结局的影响
Clinical pharmacology and therapy Pub Date : 2023-02-27 DOI: 10.32756/0869-5490-2023-1-30-35
R.E. Baisultanova, E. Osmanov, S.M. Akayeva, M. A. Karnaushkina
{"title":"Impact of type 2 diabetes on the course and outcomes of community-acquired pneumonia in hospitalized patients","authors":"R.E. Baisultanova, E. Osmanov, S.M. Akayeva, M. A. Karnaushkina","doi":"10.32756/0869-5490-2023-1-30-35","DOIUrl":"https://doi.org/10.32756/0869-5490-2023-1-30-35","url":null,"abstract":"To evaluate the clinical features, course and outcomes of community-acquired pneumonia (CAP) in hospitalized patients with type 2 diabetes.","PeriodicalId":10353,"journal":{"name":"Clinical pharmacology and therapy","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90086728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anxiety, depression and sleep disorders after COVID-19 COVID-19后的焦虑、抑郁和睡眠障碍
Clinical pharmacology and therapy Pub Date : 2023-02-27 DOI: 10.32756/0869-5490-2023-1-86-92
N. Ivashkina, O. Dorofeeva
{"title":"Anxiety, depression and sleep disorders after COVID-19","authors":"N. Ivashkina, O. Dorofeeva","doi":"10.32756/0869-5490-2023-1-86-92","DOIUrl":"https://doi.org/10.32756/0869-5490-2023-1-86-92","url":null,"abstract":"At the beginning of 2020, a novel coronavirus designated as SARS-CoV-2 emerged in China and caused an outbreak of coronavirus disease 2019 (COVID-19). Pandemic has threatened global mental health via disruptive societal changes and neuropsychiatric sequelae including depression, anxiety and sleep disorders after SARS-CoV-2 infection. Virus is able to access CNS through blood circulation or neural pathway. Brain damage can be also due to hypoxia, hypercoagulation and endothelial dysfunction. The effects of psychological stressors and drug therapy may be also relevant for development of neuropsychiatric disorders after COVID-19. Women and patients with a history of mental disorders are more susceptible to neuropsychiatric disorders and frequently present with more severe complications. Affective, anxiety or psychotic disorders can persist for 6 months after recovery from COVID-19. These data highlight the need in drug therapy to treat depression and anxiety, to normalize sleep and to prevent the development of serious neuropsychiatric sequelae of infection.","PeriodicalId":10353,"journal":{"name":"Clinical pharmacology and therapy","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85161388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AA-amyloidosis as a rare cause of kidney disease in patient with Takayasu’s arteritis aa -淀粉样变是高须动脉炎患者肾脏疾病的罕见病因
Clinical pharmacology and therapy Pub Date : 2023-02-27 DOI: 10.32756/0869-5490-2023-1-73-78
V. Logina, N. Bulanov, E. Kuznetsova, V. Rameev, A. Efimova, P. Novikov, S. Moiseev
{"title":"AA-amyloidosis as a rare cause of kidney disease in patient with Takayasu’s arteritis","authors":"V. Logina, N. Bulanov, E. Kuznetsova, V. Rameev, A. Efimova, P. Novikov, S. Moiseev","doi":"10.32756/0869-5490-2023-1-73-78","DOIUrl":"https://doi.org/10.32756/0869-5490-2023-1-73-78","url":null,"abstract":"Takayasu’s arteritis (TAK) is a systemic large vessel vasculitis that usually develops at young age in females and affects aorta and its branches (pulseless disease). Patients with TAK frequently present with renal artery stenosis associated with renovascular hypertension and ischemic nephropathy, whereas glomerular and interstitial kidney disease is very rare. As any other chronic inflammatory diseases, TAK can be complicated with AA-amyloidosis manifesting by progressive proteinuria, nephrotic syndrome and chronic renal failure. AA-amyloidosis in patients with TAK and other immune-mediated inflammatory disease justifies intensification of immunosuppressive and antiinflammatory therapy (e.g. using interleukin-6 inhibitors) that is essential to prevent progression of kidney amiloidosis.","PeriodicalId":10353,"journal":{"name":"Clinical pharmacology and therapy","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86869639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nephropathic cystinosis: pathophysiology and effects of treatment 肾病型胱氨酸病:病理生理及治疗效果
Clinical pharmacology and therapy Pub Date : 2023-02-27 DOI: 10.32756/0869-5490-2023-1-79-85
{"title":"Nephropathic cystinosis: pathophysiology and effects of treatment","authors":"","doi":"10.32756/0869-5490-2023-1-79-85","DOIUrl":"https://doi.org/10.32756/0869-5490-2023-1-79-85","url":null,"abstract":"Nephropathic cystinosis is a rare inherited disease characterized by cristallization of cystine in lyzosomes. Cystine accumulation is caused by the mutations in the CTNS gene encoding for cystinosine, a cystine transporter. Cystinosis commonly affects the kidneys leading to renal Fanconi sysnrome during the first year of life, followed by progressive kidney failure that necessitates initiation of renal replacement therapy in childhood or adolescence. In adulthood, patients also present with various systemic manifestations including photophobia, hypothyroidism, diabetes mellitus, hypogonadism (in males), myopathy, neurological disorders. Corneal crystal accumulation can be detected in all patients with cystinosis by slit-lamp examination. A diagnosis of cystinosis can be confirmed by measuring cystine levels in white blood cells and genetic testing. Early diagnosis is of vital importance given the availability of cysteamine, the specific cystinedepleting therapy, that delays the onset of end-stage renal disease and extrarenal manifestations.","PeriodicalId":10353,"journal":{"name":"Clinical pharmacology and therapy","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76889598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Ranquilon® pharmacokinetics, safety profile and tolerability in healthy volunteers: a phase I clinical trial. Ranquilon®在健康志愿者中的药代动力学、安全性和耐受性评估:一项I期临床试验。
Clinical pharmacology and therapy Pub Date : 2023-02-27 DOI: 10.32756/0869-5490-2023-1-49-55
O. Dorofeeva, K. Zakharov, A. Grigoriev, V. Vasilyuk, A. Sidorova, A. Piven, N. Ivashkina, A. Globenko, A. Kapashin, O. Kovchan, M. Pasko
{"title":"Evaluation of Ranquilon® pharmacokinetics, safety profile and tolerability in healthy volunteers: a phase I clinical trial.","authors":"O. Dorofeeva, K. Zakharov, A. Grigoriev, V. Vasilyuk, A. Sidorova, A. Piven, N. Ivashkina, A. Globenko, A. Kapashin, O. Kovchan, M. Pasko","doi":"10.32756/0869-5490-2023-1-49-55","DOIUrl":"https://doi.org/10.32756/0869-5490-2023-1-49-55","url":null,"abstract":"Comparative evaluation of the pharmacokinetics, safety profile and tolerability of Ranquilon® 1 mg tablets with a single administration under fasting and fed conditions among healthy male and female volunteers.","PeriodicalId":10353,"journal":{"name":"Clinical pharmacology and therapy","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83128675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive assessment of the hydration status in patients with acute decompensated heart failure: clinical associations and prognostic significance 急性失代偿性心力衰竭患者水合状态的综合评估:临床关联和预后意义
Clinical pharmacology and therapy Pub Date : 2023-02-27 DOI: 10.32756/0869-5490-2023-1-42-48
M. Vatsik-Gorodetskaya, V. Tolkacheva, E. Cabello Montoya Flora, B. Sarlykov, L. Nazarov, S. Galochkin, N. Khutsishvili, M. Diane, Z. Kobalava
{"title":"Comprehensive assessment of the hydration status in patients with acute decompensated heart failure: clinical associations and prognostic significance","authors":"M. Vatsik-Gorodetskaya, V. Tolkacheva, E. Cabello Montoya Flora, B. Sarlykov, L. Nazarov, S. Galochkin, N. Khutsishvili, M. Diane, Z. Kobalava","doi":"10.32756/0869-5490-2023-1-42-48","DOIUrl":"https://doi.org/10.32756/0869-5490-2023-1-42-48","url":null,"abstract":"To evaluate the clinical and prognostic significance of a comprehensive assessment of the hydration status in patients with acute decompensation of chronic heart failure (ADCHF).","PeriodicalId":10353,"journal":{"name":"Clinical pharmacology and therapy","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82998990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Granulomatosis with polyangiitis and microscopic polyangiitis: common features and differences 肉芽肿合并多血管炎与镜下多血管炎:共同特征与区别
Clinical pharmacology and therapy Pub Date : 2023-02-27 DOI: 10.32756/0869-5490-2023-1-64-72
M. Litvinova, N. Bulanov, P. Novikov, N. Vlasenko, E. Filatova, K. Kurginyan, A. Skvortsov, S. Moiseev
{"title":"Granulomatosis with polyangiitis and microscopic polyangiitis: common features and differences","authors":"M. Litvinova, N. Bulanov, P. Novikov, N. Vlasenko, E. Filatova, K. Kurginyan, A. Skvortsov, S. Moiseev","doi":"10.32756/0869-5490-2023-1-64-72","DOIUrl":"https://doi.org/10.32756/0869-5490-2023-1-64-72","url":null,"abstract":"Patients with ANCA-associated vasculitides usually present with similar clinical manifestations (fever, joint pain, lung and kidney diseases, purpura, etc.). However, signs of granulomatosis inflammation of the upper and lower respiratory tract and/or orbit allow to differentiate granulomatosis with polyangiitis (GPA) from microscopic polyangiitis (MPA). Circulating ANCAs are the key laboratory sign of ANCA-associated vasculitis, although they can be negative in a proportion of patients and can be found in patients with other diseases. GPA is usually associated with ANCAs againts proteinase-3, whereas ANCAs against myeloperoxidase are more common in patients with MPA. The authors present two patients with ANCA-associated vasculitides and discuss the common clinical features and differences between GPA and MPA and new classification criteria.","PeriodicalId":10353,"journal":{"name":"Clinical pharmacology and therapy","volume":"24 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74168076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patterns of interstitial lung disease in primary biliary cholangitis 原发性胆道胆管炎中肺间质性疾病的模式
Clinical pharmacology and therapy Pub Date : 2023-02-27 DOI: 10.32756/0869-5490-2023-1-21-29
{"title":"Patterns of interstitial lung disease in primary biliary cholangitis","authors":"","doi":"10.32756/0869-5490-2023-1-21-29","DOIUrl":"https://doi.org/10.32756/0869-5490-2023-1-21-29","url":null,"abstract":"To evaluate the occurrence and clinical features of interstitial lung disease (ILD) in a cohort of Russian patients with primary biliary cholangitis (PBC).","PeriodicalId":10353,"journal":{"name":"Clinical pharmacology and therapy","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74390208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vericiguate: a new treatment for chronic heart failure Vericiguate:治疗慢性心力衰竭的新方法
Clinical pharmacology and therapy Pub Date : 2023-02-27 DOI: 10.32756/0869-5490-2023-1-56-63
V. Khirmanov
{"title":"Vericiguate: a new treatment for chronic heart failure","authors":"V. Khirmanov","doi":"10.32756/0869-5490-2023-1-56-63","DOIUrl":"https://doi.org/10.32756/0869-5490-2023-1-56-63","url":null,"abstract":"The author reviews the pharmacological properties and clinical trials of vericiguate, a stimulant of soluble guanylate cyclase, that is intended for use in patients with chronic heart failure. The new medicine alleviates unfavorable effects of endothelial dysfunction and other disorders associated with a deficiency of bioavailable nitric oxide and suppressed activity of soluble guanylate cyclase. The efficacy of vericiguate in chronic heart failure with a reduced ejection fraction was established in clinical trials SOCRATES-REDUCED and VICTORIA.","PeriodicalId":10353,"journal":{"name":"Clinical pharmacology and therapy","volume":"110 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72882966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fabry disease as a cause of hypertrophic cardiomyopathy 法布里病是肥厚性心肌病的一种病因
Clinical pharmacology and therapy Pub Date : 2023-02-27 DOI: 10.32756/0869-5490-2023-1-36-41
S. Moiseev, E. Tao, A. Moiseev, E. Mershina, V. Sholomova, N. Bulanov, E. Pavlikova, V. Fomin
{"title":"Fabry disease as a cause of hypertrophic cardiomyopathy","authors":"S. Moiseev, E. Tao, A. Moiseev, E. Mershina, V. Sholomova, N. Bulanov, E. Pavlikova, V. Fomin","doi":"10.32756/0869-5490-2023-1-36-41","DOIUrl":"https://doi.org/10.32756/0869-5490-2023-1-36-41","url":null,"abstract":"To evaluate the occurence of cardiac phenotype imitating hypertrophic cardiomyopathy (HCMP) in adult patients with Fabry disease.","PeriodicalId":10353,"journal":{"name":"Clinical pharmacology and therapy","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86632623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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