Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica最新文献

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Intestinal obstruction as a result of intra-abdominal hematoma: a complication of low molecular weight heparin in pediatric patients. 腹腔内血肿导致的肠梗阻:儿科低分子量肝素并发症。
M. Martínez Díaz, A. Costa Roig, ME Carazo Palacios, I. Vigúria Marco, A. Marco Macián, D. Crehuet Gramatyka
{"title":"Intestinal obstruction as a result of intra-abdominal hematoma: a complication of low molecular weight heparin in pediatric patients.","authors":"M. Martínez Díaz, A. Costa Roig, ME Carazo Palacios, I. Vigúria Marco, A. Marco Macián, D. Crehuet Gramatyka","doi":"10.54847/cp.2024.02.18","DOIUrl":"https://doi.org/10.54847/cp.2024.02.18","url":null,"abstract":"INTRODUCTION\u0000Hematomas are a rare cause of intestinal obstruction. Subcutaneous heparin can bring about direct punctures on small bowel loops, potentially leading to traumatic hematoma and intestinal obstruction.\u0000\u0000\u0000CASE REPORTS\u0000We present three cases of pediatric patients with clinical signs of intestinal obstruction treated with subcutaneous heparin. Two cases had increased acute-phase reactants and radiological signs of intestinal suffering, so surgical treatment was decided upon, with intramural hematoma emerging as an intraoperative finding. The third case was conservatively managed with anticoagulant discontinuation and gut rest, since the patient had an adequate general condition and no findings compatible with ischemia or necrosis were noted in the complementary tests.\u0000\u0000\u0000DISCUSSION\u0000The administration of subcutaneous heparin may cause intestinal wall hematomas due to its anticoagulating effect and to the risk of inadvertent punctures on small bowel loops.","PeriodicalId":10316,"journal":{"name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","volume":"261 ","pages":"84-88"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140762320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spanish primary care in pediatric trauma (AITP) consensus: An AITP checklist. 西班牙儿科创伤初级护理(AITP)共识:AITP 核对表。
J. G. Gómez Veiras, J. Lluna González, A. Prieto Campo, M. Gómez Tellado, L. Alonso Jiménez, M. López Díaz, JC de Agustín Asensio, M. Díaz González, JA Ruiz Domínguez, MS Fernández Córdoba, C. Barceló Cañellas, A. Laín Fernández, M. Prado Arias
{"title":"Spanish primary care in pediatric trauma (AITP) consensus: An AITP checklist.","authors":"J. G. Gómez Veiras, J. Lluna González, A. Prieto Campo, M. Gómez Tellado, L. Alonso Jiménez, M. López Díaz, JC de Agustín Asensio, M. Díaz González, JA Ruiz Domínguez, MS Fernández Córdoba, C. Barceló Cañellas, A. Laín Fernández, M. Prado Arias","doi":"10.54847/cp.2024.02.12","DOIUrl":"https://doi.org/10.54847/cp.2024.02.12","url":null,"abstract":"INTRODUCTION\u0000The course in Primary Care in Pediatric Trauma (ATIP in Spanish) has been taught in Spain since 1997, and there are currently 9 accredited training centers. Care of polytraumatized pediatric patients often takes place in an environment conducive to errors resulting from forgetfulness, which is why checklists - mnemonic tools widely used in industry and medicine - are particularly useful to avoid such errors. Although several checklists exist for pediatric trauma care, none have been developed within the setting of our course.\u0000\u0000\u0000MATERIALS AND METHODS\u0000The criteria for being selected as an expert in Primary Care in Pediatric Trauma were agreed upon with the scientific polytrauma committee of the Spanish Pediatric Surgery Society. The items that make up the checklist were obtained from a review of the literature and consultation with selected experts, using the Delphi Technique.\u0000\u0000\u0000RESULTS\u000010 experts representing the 9 groups or training centers in Primary Care in Pediatric Trauma were selected, and a 28-item checklist was drawn up in accordance with their design recommendations.\u0000\u0000\u0000CONCLUSIONS\u0000With the consensus of all the groups, a checklist for the treatment of polytraumatized pediatric patients was drawn up using the Delphi Technique, an essential requirement for the dissemination of this checklist, which should be adapted and validated for use in each healthcare center.","PeriodicalId":10316,"journal":{"name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","volume":"60 3","pages":"50-54"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140757429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complications after Nuss bar removal procedure for pectus excavatum. Analysis and proposal of a safety protocol. Nuss 杠铃切除术后的并发症。分析并提出安全方案。
JP Camacho, R. Boudou, PA Lobos, JM Moldes, GR Elmo
{"title":"Complications after Nuss bar removal procedure for pectus excavatum. Analysis and proposal of a safety protocol.","authors":"JP Camacho, R. Boudou, PA Lobos, JM Moldes, GR Elmo","doi":"10.54847/cp.2024.02.13","DOIUrl":"https://doi.org/10.54847/cp.2024.02.13","url":null,"abstract":"OBJECTIVE\u0000The Nuss bar removal procedure may bring about different complications. Some are mild while others can be life-threatening. An adequate surgery setup and the fulfilment of some security steps may reduce their incidence. This study aims to analyze our experience with the complications that occurred during bar removal and our safety protocol for the prevention and management of these complications.\u0000\u0000\u0000MATERIALS AND METHODS\u0000Observational cohort study from a retrospective chart review of all patients who underwent Nuss bar removal from November 2013 to March 2022 at a University hospital. Variables analyzed include patients' demographics; presence of comorbidities; time elapsed from bar placement to removal, and the occurrence of operative and postoperative complications. Study written under the 'PROCESS Guideline'.\u0000\u0000\u0000RESULTS\u0000Fourty (40) patients were included in the study; 37 were male. One bar was removed in 17 patients and two in 22 patients. Median age at surgery: 17.5 years (Percentile 25-75%: 16.75-19.25). Time elapsed from placement to removal: 26 months (Percentile 25-75%: 23.75-30.25). Complications: 10 in 9 patients (22.5%); 6 Clavien-Dindo class I (67%); 2 class II (22%); 1 class IIIb, 1 class IV. The hemorrhagic complication motivated the development of a safety protocol to reduce incidence of complications.\u0000\u0000\u0000CONCLUSION\u0000Nuss bar removal is a safe procedure with usually scant complications. Nonetheless, these may be serious sometimes. To prevent them, a protocol for a safe procedure is important.","PeriodicalId":10316,"journal":{"name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","volume":"773 ","pages":"55-60"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140757369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospective evaluation of the emetogenic profile and analgesic efficacy of intravenous ibuprofen and metamizole in the immediate postoperative period of pediatric acute appendicitis. 前瞻性评估小儿急性阑尾炎术后立即静脉注射布洛芬和甲硝唑的致吐性和镇痛效果。
J. Arredondo Montero, G. Antona, E. Murillo Jaso, P. Unzué Rico, I. Antuñano Unanua, N. Martín-Calvo
{"title":"Prospective evaluation of the emetogenic profile and analgesic efficacy of intravenous ibuprofen and metamizole in the immediate postoperative period of pediatric acute appendicitis.","authors":"J. Arredondo Montero, G. Antona, E. Murillo Jaso, P. Unzué Rico, I. Antuñano Unanua, N. Martín-Calvo","doi":"10.54847/cp.2024.02.15","DOIUrl":"https://doi.org/10.54847/cp.2024.02.15","url":null,"abstract":"BACKGROUND\u0000Literature comparing different alternatives for pain control in the immediate postoperative period of pediatric acute appendicitis (PAA) is scarce.\u0000\u0000\u0000MATERIALS AND METHODS\u0000We prospectively compared the analgesic and emetogenic profile of intravenous ibuprofen and metamizole in the immediate postoperative period of PAA. For this purpose, we used a sample of patients operated on in 2021 in our center. Participants were recruited on arrival at the Emergency Department and histopathological confirmation of the diagnosis was obtained in all of them. Pain was evaluated every 8 hours after the surgery with validated visual analog scales ranging from 0 to 10 points. Repeated measures ANOVA was used to compare the evolution of pain in the 48 hours after surgery between the two groups.\u0000\u0000\u0000RESULTS\u0000The sample included 95 patients (65% males) with a mean age of 9.7 years (sd: 3.14). 41 patients were treated with Ibuprofen (group 1) and 54 with metamizole (group 2). No significant differences were found in the level of pain either in the comparisons of point measurements or in its evolution in the 48 hours after surgery (p= 0.58). After adjusting for the received fluid therapy, children in the metamizole group had significantly more emetic episodes and needed significantly more doses of ondansetron.\u0000\u0000\u0000CONCLUSIONS\u0000In our cohort, ibuprofen had a similar analgesic efficacy and a better emetogenic profile than metamizole in the immediate postoperative period of PAA. Future prospective, adequately controlled studies with larger sample sizes are needed to validate these findings.","PeriodicalId":10316,"journal":{"name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","volume":"24 3","pages":"67-74"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140764302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eponyms and important names in the field of neuroblastoma. 神经母细胞瘤领域的地名和重要名称。
Ó. Girón Vallejo
{"title":"Eponyms and important names in the field of neuroblastoma.","authors":"Ó. Girón Vallejo","doi":"10.54847/cp.2024.02.11","DOIUrl":"https://doi.org/10.54847/cp.2024.02.11","url":null,"abstract":"","PeriodicalId":10316,"journal":{"name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","volume":"747 ","pages":"43-49"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140772936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing two vascular division techniques in laparoscopic varicocelectomy. A prospective study. 比较腹腔镜精索静脉曲张切除术中的两种血管分割技术。前瞻性研究。
A. Ramírez Calazans, M. I. Ibarra Rodríguez, SR Wiesner Torres, JI Garrido Pérez, F. Vázquez Rueda, RM Paredes Esteban
{"title":"Comparing two vascular division techniques in laparoscopic varicocelectomy. A prospective study.","authors":"A. Ramírez Calazans, M. I. Ibarra Rodríguez, SR Wiesner Torres, JI Garrido Pérez, F. Vázquez Rueda, RM Paredes Esteban","doi":"10.54847/cp.2024.02.16","DOIUrl":"https://doi.org/10.54847/cp.2024.02.16","url":null,"abstract":"INTRODUCTION\u0000Varicocele is the abnormal dilatation of the pampiniform plexus. It occurs in 15-20% of pre-adolescent/adult males. Varicocele diagnosis is important since it can induce testicular hypertrophy and fertility issues in adulthood. The objective of this study was to assess whether complications, including varicocele recurrence, depend on the vascular occlusion technique used -clipping + division vs. vascular sealer- in the laparoscopic Palomo technique used in our institution.\u0000\u0000\u0000MATERIALS AND METHODS\u0000A longitudinal, prospective study was carried out from 2017 to 2021. Two therapeutic groups were created according to the vascular occlusion method used during laparoscopic varicocelectomy -clipping + division vs. vascular sealer. Patients were randomly allocated to the groups in a systematic alternating consecutive manner. Variables -age, varicocele grade according to the Dubin-Amelar classification, postoperative complications, follow-up, and varicocele recurrence- were analyzed according to the method employed.\u0000\u0000\u0000RESULTS\u0000A total of 37 boys, with a mean age of 12 years (10-15 years) and a mean follow-up of 12 months, were studied. In 20 patients (54.1%), clipping + division was used, and in the remaining 17 (45.9%), the vascular sealer was employed. 24.3% had symptomatic Grade II varicocele and 75.7% had Grade III varicocele. 32.4% of the children had postoperative complications during follow-up. 29.7% of the patients had hydrocele following surgery -8 boys from the sealing group and 3 boys from the clipping group-, with 13.5% requiring re-intervention as a result of this. None of the patients had varicocele recurrence.\u0000\u0000\u0000CONCLUSIONS\u0000The laparoscopic Palomo technique is safe and effective, with good results in pediatric patients and few postoperative complications, regardless of the vascular occlusion device used. In our study, no statistically significant differences regarding the use of clipping or vascular sealer in this laparoscopic technique were found. However, further studies with a larger sample size are required to find potential differences.","PeriodicalId":10316,"journal":{"name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","volume":"255 ","pages":"75-78"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140779889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Purely robotic ileocystoplasty in children: why not? First case in Spain. 儿童纯机器人回肠膀胱成形术:为什么不?西班牙首例。
P. Ramos Rodríguez, J. Rodríguez de Alarcón, F. Ávila Ramírez, E. D. Domínguez Amillo, M. Gómez Cervantes, I. Galante Romo, C. Soto Beauregard
{"title":"Purely robotic ileocystoplasty in children: why not? First case in Spain.","authors":"P. Ramos Rodríguez, J. Rodríguez de Alarcón, F. Ávila Ramírez, E. D. Domínguez Amillo, M. Gómez Cervantes, I. Galante Romo, C. Soto Beauregard","doi":"10.54847/cp.2024.02.20","DOIUrl":"https://doi.org/10.54847/cp.2024.02.20","url":null,"abstract":"INTRODUCTION\u0000We present the first case of pediatric ileocystoplasty using a purely robotic approach in Spain.\u0000\u0000\u0000CASE REPORT\u000012-year-old male with neurogenic bladder of low capacity and high pressures. After failure of conservative treatment, bladder augmentation with ileum patch was decided upon. Surgery was carried out using a purely robotic approach with 4 robotic and 2 accessory ports. Surgery duration was 380 minutes in total, without intraoperative complications. He was discharged 2 weeks after cystographic control. During 32-months follow-up, he has remained continent.\u0000\u0000\u0000DISCUSSION\u0000The minimal invasion, surgical precision and ergonomics made the robotic approach an optimal option for complex surgical techniques. Given the little availability of the robot and the low pediatric volume, its standardization is a challenge. Our accumulated experience is consistent with the current literature and shows promising surgical and esthetic results. We hope this case report will contribute to the divulgation and progressive introduction of robotic surgery in our daily lives.","PeriodicalId":10316,"journal":{"name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","volume":"32 ","pages":"93-98"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140786826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-syndromic Hirschsprung's disease as a result of a RET gene variant. RET基因变异导致的非综合征性赫氏病。
R. Gietz, R. Armando, P. Lobos, D. Liberto
{"title":"Non-syndromic Hirschsprung's disease as a result of a RET gene variant.","authors":"R. Gietz, R. Armando, P. Lobos, D. Liberto","doi":"10.54847/cp.2024.02.19","DOIUrl":"https://doi.org/10.54847/cp.2024.02.19","url":null,"abstract":"INTRODUCTION\u0000Hirschsprung's disease (HD) is characterized by the absence of ganglion cells in the submucosal and myenteric plexuses of the colon as a result of disorders in the migration and differentiation of enteric neural crest cells during embryogenesis. It is a cross-factor condition, with more than 11 genes identified in its pathogenesis, including the RET proto-onco gene.\u0000\u0000\u0000CASE REPORTS\u0000We present the case of two siblings with total colon HD where a potentially pathogenic variant of the RET gene was found. Their father also had this condition.\u0000\u0000\u0000DISCUSSION\u0000Prenatal diagnosis through genetic testing allows for informed decisions and care planning for the newborn, thus reducing delayed diagnosis and treatment, and minimizing long-term complications. Mutations such as the RET gene variant highlight the importance of the genetic approach in understanding and managing HD.","PeriodicalId":10316,"journal":{"name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","volume":"72 3","pages":"89-92"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140756115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postoperative care in hypospadias. Common practices and evidence available. 尿道下裂术后护理。常见做法和可用证据。
S. Fuentes Carretero, C. Grande Moreillo, N. Vicente Sánchez, J. Margarit Mallol
{"title":"Postoperative care in hypospadias. Common practices and evidence available.","authors":"S. Fuentes Carretero, C. Grande Moreillo, N. Vicente Sánchez, J. Margarit Mallol","doi":"10.54847/cp.2024.02.17","DOIUrl":"https://doi.org/10.54847/cp.2024.02.17","url":null,"abstract":"INTRODUCTION\u0000There are many alternatives available regarding postoperative care in hypospadias surgery. The objective of this study was to assess the current care situation in our environment and to review the evidence available for pediatric surgeons who conduct this procedure.\u0000\u0000\u0000MATERIALS AND METHODS\u0000A survey regarding the main aspects of hypospadias postoperative care was created and distributed to pediatric surgeons. In addition, the evidence currently published in this field was reviewed.\u0000\u0000\u0000RESULTS\u0000A total of 46 replies were achieved. 100% of the surgeons leave in place a probe or stent, and more than 80% remove it after 5 or 7 days. 87.8% of the respondents use a double diaper, but only 65.2% discharge patients early in the postoperative period. 60.9% prescribe antibiotic prophylaxis for as long as the probe remains in place, and 34.8% use full-dose antibiotic therapy.\u0000\u0000\u0000DISCUSSION\u0000There was a general consensus regarding urethroplasty guiding and the use of compression dressings among the pediatric surgeons surveyed. However, more discrepancies were found in the use of antibiotic therapy and early discharge. The currently available evidence and international practice suggest using a probe with double diaper and early discharge, with postoperative antibiotics being limited. In the absence of clear evidence for a specific care type, the patient's experience could be used to choose the best postoperative protocol on an individual basis.","PeriodicalId":10316,"journal":{"name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","volume":"152 ","pages":"79-83"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140792410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental necrotizing enterocolitis using oral lipopolysaccharide and protective role of breastmilk. 利用口服脂多糖和母乳的保护作用实验性坏死性小肠结肠炎。
M. Gómez Cervantes, P. Luengo Batres, N. Huertos Soto, C. Rodríguez Bobada, MJ Fernández Aceñero, ´C Soto Beauregard
{"title":"Experimental necrotizing enterocolitis using oral lipopolysaccharide and protective role of breastmilk.","authors":"M. Gómez Cervantes, P. Luengo Batres, N. Huertos Soto, C. Rodríguez Bobada, MJ Fernández Aceñero, ´C Soto Beauregard","doi":"10.54847/cp.2024.02.14","DOIUrl":"https://doi.org/10.54847/cp.2024.02.14","url":null,"abstract":"INTRODUCTION\u0000Necrotizing enterocolitis (NEC) is a life-threatening condition that afflicts neonates. Breastfeeding has demonstrated to play a protective role against it. By administering lipopolysaccharides (LPS) orally in newborn rats (NBR), we have developed an experimental model to induce NEC-like gut damage. Our aim was to assess the macroscopic and microscopic appearance of the gut, to evaluate the presence of NEC and study the role of breast milk (BM).\u0000\u0000\u0000MATERIALS AND METHODS\u0000NBR were divided into 3 groups: Group A (control, n= 10) remained with the mother, group B (LPS, n= 25) was isolated after birth, gavage-fed with special rat formula and oral LPS, then submitted to stress (hypoxia after gavage) and group c (BM, n= 12) was breastfed once after birth, then isolated, and submitted to stress like group B. On day 4, NBR were sacrificed, and intestine was harvested and assessed.\u0000\u0000\u0000RESULTS\u0000In the control group NEC was not present either macroscopically or histologically. Both groups submitted to stress (B and C) presented a global incidence of NEC of 73%. Most of group B developed histologic signs of NEC (85%) and group C showed a statistically lower incidence of NEC (50%, p= 0.04), playing the BM a protective role against NEC (OR= 0.19; 95% CI: 0.40-0.904).\u0000\u0000\u0000CONCLUSION\u0000Our model showed a significant incidence of NEC in NBR (73%) with the same protective role of BM as in newborn humans, achieving a reliable and reproducible experimental NEC model. This will allow us to investigate new potential therapeutic targets for a devastating disease that currently lacks treatment.","PeriodicalId":10316,"journal":{"name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","volume":"18 1","pages":"61-66"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140763954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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