中草药杂志最新文献

{"title":"Distribution rules of antiviral traditional Chinese medicine based on data driven analysis","authors":"Y. Wei, J. T. Li, X. Ren, X. Fu","doi":"10.7501/j.issn.0253-2670.2021.16.021","DOIUrl":"https://doi.org/10.7501/j.issn.0253-2670.2021.16.021","url":null,"abstract":"Objective: To mine the distribution rules of antiviral traditional Chinese medicine (TCM), in order to provide the basis for the screening of antiviral activity of TCM and candidate prescriptions for current epidemic prevention and control. Methods: Taking the Research and Application of Antiviral Chinese Herbal Medicine and the literature reports of antiviral TCM in CNKI and Web of science as information sources, the relevant information was standardized, and the distribution rules of medicinal properties, families and genera, active ingredients and activity of antiviral TCM were mined by frequency analysis, co-occurrence analysis and phylogenetic tree construction methods. Results: A total of 511 antiviral TCM were screened, containing 41 of the 48 herbs involved in the \"three medicines and three prescriptions\" of coronavirus disease 2019 (COVID-19). Mostly with medicinal properties such as cold nature, bitter taste, return to the lung and liver meridian, among which Bailangen (Isatidis Radix), Huangqin (Scutellariae Radix), and Jinyinhua (Lonicerae Japonicae Flos) were the most common. The data of coronaviridae was 135, and the high-frequency TCM were Chaihu (Bupleuri Radix), Gancao (Glycyrrhizae Radix et Rhizoma), and Isatidis Radix. Meanwhile, it was found that Isatidis Radix and Kudouzi (the seed of Sophora alopecuroides) were the most studied TCM during the SARS period in 2003, while in 2020, the research on Sangbaipi (Mori Cortex) was the first when COVID-19 was sudden. The effective ingredients of antiviral TCM were mostly polysaccharides and flavonoids. TCM with antiviral effects involved a total of 564 base source species, which had significant clustering on phylogenetic trees and were mainly distributed in the chrysanthemum and rose branches of the seed plant phylum, with Asteraceae, Labiatae, Leguminosae, and Rosaceae having the most antiviral TCM. Conclusion: These results suggested that the attributes of TCM with antiviral effects are mainly bitter, cold, lung and liver meridian. TCM origin from Asteraceae, Labiatae, and Leguminosae are more likely to have antiviral effects. Their effective components such as astragalus polysaccharide, Isatidis Radix polysaccharide, quercetin, caffeic acid and ursolic acid are polysaccharides or flavonoids, and these rules are basically consistent with the \"three medicines and three prescriptions\" promoted and used in this fight against the COVID-19 epidemic. This study provides a reference for the screening of antiviral TCM activity, especially for the screening of candidate TCM for the prevention and control of the current COVID-19.","PeriodicalId":10295,"journal":{"name":"Chinese Traditional and Herbal Drugs","volume":"92 1","pages":"4959-4972"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80550779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Logistic regression combined with ROC curve model to predict risk of critically ill-patients with COVID-19","authors":"Meng Luo, Xiao-Dong Huang, Bo Jiang, K. Lv, Qian Yang, Qinguo Sun","doi":"10.7501/J.ISSN.0253-2670.2020.20.022","DOIUrl":"https://doi.org/10.7501/J.ISSN.0253-2670.2020.20.022","url":null,"abstract":"Objective: To build a model to predict critically ill-patients with coronavirus disease 2019 (COVID-19), and provide a new idea for the rapid identification of clinical progression in the early stage of critically ill-patients Methods: A retrospective analysis of the general data of 152 general patients and 323 critically ill-patients diagnosed with COVID-19 from Jan 17th, 2020 to Feb 25th, 2020 in Wuhan Third Hospital was carried out;At the same time, the differences in fever, blood routine, liver and kidney function, coagulation function, C-reactive protein (CRP), and nucleic acid reagent testing results from the day of admission were statistically analyzed Factors with statistical significance were included in a multivariate logistic regression analysis to obtain independent relevant factors that affect the critical ill-patients with COVID-19 Then a prediction model was built based on these factors and its accuracy was evaluated by the receiver operating characteristic (ROC) curve Results: The sensitivities of age, fever, neutrophil ratio, lymphocyte ratio, serum creatinine (Scr) and combined diagnosis were 0 664, 0 671, 0 607, 0 669, 0 302 and 0 710, respectively;The specificities were 0 669, 0 585, 0 795, 0 685, 0 895 and 0 802, respectively;The area under the curve (AUC) were 0 725, 0 628, 0 721, 0 681, 0 590 and 0 795, respectively;The AUC of combined diagnosis was higher than that of single diagnosis (P < 0 05) Conclusion: The logistic regression and combined with ROC curve model based on multi-factors, including age, fever status, neutrophil ratio, lymphocyte ratio, and Scr, can play a good role in predicting the occurrence of critically ill-patients with COVID-19, which is worthy of further promotion and application","PeriodicalId":10295,"journal":{"name":"Chinese Traditional and Herbal Drugs","volume":"31 1","pages":"5287-5292"},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78093517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening novel inhibitors targeting SARS-CoV-2 S protein-ACE2 interaction based on molecular docking","authors":"Lei Song, Siwei Bi, J. Gu, Tong Wu, L. He","doi":"10.7501/J.ISSN.0253-2670.2020.09.010","DOIUrl":"https://doi.org/10.7501/J.ISSN.0253-2670.2020.09.010","url":null,"abstract":"Objective: To screen inhibitors targeting SARS-CoV-2 S protein-ACE2 interaction by molecular docking Methods: Candidate natural products were collected from Selleck China natural product library (Catalog No L1400, 2 054 natural products) The structure of SARS-CoV-2 S protein-ACE2 had been determined by Qiang Zhou team (PDB: 6M17) The molecular docking was performed by Discovery Studio Results: Based on the virtual amino acid mutation experiment which determined the key amino acids, the binding cavity was created Then, 11 compounds were screened out from the natural compound library: digitonin, Lonicera grisea saponin A, forsythiaside B, L grisea saponin B, Dipsacus asperges saponin B, hederacoside D, platycodon D, echinacoside, ginsenoside Rb2, ginsenoside Rc, and chlorogenic acid C Conclusion: The 11 potential inhibitors targeting SARS-CoV-2 S protein-ACE2 interaction were screened out from natural products library, which provides a reference for the research of new anti SARS-CoV-2 drugs","PeriodicalId":10295,"journal":{"name":"Chinese Traditional and Herbal Drugs","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87443760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment on potential toxic and side effects of raw materials in Chinese materia medica cosmetics","authors":"Wei Zhou, W. Kong, Mei-hua Yang, Ming Zhao, Zhen Ouyang","doi":"10.7501/J.ISSN.0253-2670.2016.02.027","DOIUrl":"https://doi.org/10.7501/J.ISSN.0253-2670.2016.02.027","url":null,"abstract":"","PeriodicalId":10295,"journal":{"name":"Chinese Traditional and Herbal Drugs","volume":"32 1","pages":"352-357"},"PeriodicalIF":0.0,"publicationDate":"2016-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77558141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical constituents from Glechoma longituba","authors":"Qu Haibin","doi":"10.4268/cjcmm20140428","DOIUrl":"https://doi.org/10.4268/cjcmm20140428","url":null,"abstract":"Objective To study the chemical constituents from Glechoma longituba and their anti-oxidant activity in vitro.Methods The chemical constituents were isolated and purified by solvent extraction,repeated silica gel column chromatography,and reverse phase preparative HPLC.Their structures were identified on the basis of ESI-MS and NMR spectra.The anti-oxidant activities of these compounds were screened by DPPH free radical scavenging assay in vitro.Results Ten compounds were isolated and elucidated as cosmosiin(1),dihydrocaffeic acid(2),caffeic acid(3),isololiolide(4),vomifoliol(5),glecholone(6),apigenin(7),aurantiamide(8),(+)-lariciresinol(9),and()-syringaresinol(10).Conclusion Compounds 2,4,and 8—10 are isolated from the plants in Glechoma L.for the first time;Compounds 9 and 10 are lignans firstly obtained from this plant.DPPH free radical scavenging assays show that compounds 2,3,9,and 10 exhibit potential anti-oxidant activity.","PeriodicalId":10295,"journal":{"name":"Chinese Traditional and Herbal Drugs","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78251482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical constituents of mangrove plant Aegiceras corniculatum","authors":"Wu Jun","doi":"10.1021/np030477z.s001","DOIUrl":"https://doi.org/10.1021/np030477z.s001","url":null,"abstract":"Objective To study the chemical constituents in ethyl acetate fraction from the stem bark of Aegiceras corniculatum. Methods The compounds were isolated by silica gel column chromatography and their structures were elucidated by means of spectral analyses. Results Six compounds were identified as 16α, 28-dihydroxyl-3-oxo-12-oleanene (Ⅰ), 5-O-methylembelin (Ⅱ), stigasterol (Ⅲ), α-spinosterol (Ⅳ), fucosterol (Ⅴ), palmitic acid (Ⅵ). Conclusion Compound Ⅰ is a new triterpene named as aegi-cornin and compounds Ⅲ-Ⅵ are isolated from this plant for the first time.","PeriodicalId":10295,"journal":{"name":"Chinese Traditional and Herbal Drugs","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88847701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonflavanoid compounds from Epimedium koreanum","authors":"Lt, strong gt, 程岩 lt, 王新峦, 张大威, 王乃利, 姚新生","doi":"10.3321/J.ISSN:0253-2670.2007.08.003","DOIUrl":"https://doi.org/10.3321/J.ISSN:0253-2670.2007.08.003","url":null,"abstract":"","PeriodicalId":10295,"journal":{"name":"Chinese Traditional and Herbal Drugs","volume":"31 1","pages":"1135-1138"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73962717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}