Chemical constituents from Glechoma longituba

Q3 Pharmacology, Toxicology and Pharmaceutics

中草药杂志 Pub Date : 2013-01-01 DOI:10.4268/cjcmm20140428

Qu Haibin

引用次数: 1

Abstract

Objective To study the chemical constituents from Glechoma longituba and their anti-oxidant activity in vitro.Methods The chemical constituents were isolated and purified by solvent extraction,repeated silica gel column chromatography,and reverse phase preparative HPLC.Their structures were identified on the basis of ESI-MS and NMR spectra.The anti-oxidant activities of these compounds were screened by DPPH free radical scavenging assay in vitro.Results Ten compounds were isolated and elucidated as cosmosiin(1),dihydrocaffeic acid(2),caffeic acid(3),isololiolide(4),vomifoliol(5),glecholone(6),apigenin(7),aurantiamide(8),(+)-lariciresinol(9),and()-syringaresinol(10).Conclusion Compounds 2,4,and 8—10 are isolated from the plants in Glechoma L.for the first time;Compounds 9 and 10 are lignans firstly obtained from this plant.DPPH free radical scavenging assays show that compounds 2,3,9,and 10 exhibit potential anti-oxidant activity.

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长角草的化学成分

目的研究经眼草的化学成分及其体外抗氧化活性。方法采用溶剂萃取、重复硅胶柱层析、反相制备高效液相色谱等方法对其化学成分进行分离纯化。通过ESI-MS和NMR对其结构进行了鉴定。通过体外DPPH自由基清除实验对这些化合物的抗氧化活性进行了筛选。结果共分离得到10个化合物，分别为cosmosiin(1)、二氢咖啡酸(2)、咖啡酸(3)、异oliolide(4)、vomifioliol(5)、glecholone(6)、芹菜素(7)、aurantiamide(8)、(+)-lariciresinol(9)和()-丁香醇(10)。结论化合物2、4、8 ~ 10为首次从该植物中分离得到，化合物9、10为首次从该植物中分离得到的木脂素类化合物。DPPH自由基清除实验表明，化合物2、3、9和10具有潜在的抗氧化活性。

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来源期刊

中草药杂志 Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

1.10

自引率

0.00%

发文量

23538

期刊介绍： hinese Traditional and Herbal Drugs, a monthly journal with “zhongcaoyao” as Chinese name, the initial issue was distributed in January, 1970 and its ISSN is 0253-2670. The journal is an academic and technical journal sponsored by Chinese Pharmaceutical Association and Tianjin Institute of Pharmaceutical Research (TIPR). The journal, which has a long history of 41 years, offers the columns of research papers, brief reports, reviews, dissertation, and special treatises to report the recent achievements of our basic study, production, quality control, and clinic application on traditional Chinese medicine and Chinese materia medica. The editorial committee consists of over one hundred of specialists with a great academic attainment in pharmaceutical research, education, production, quality control, and clinic application.