Clin-Alert®Pub Date : 2016-10-01DOI: 10.1177/0069477016674891
{"title":"Reporting on Adverse Clinical Events","authors":"","doi":"10.1177/0069477016674891","DOIUrl":"https://doi.org/10.1177/0069477016674891","url":null,"abstract":"A retrospective cohort study of patients exposed to lithium over a 17-year period (1997 to 2013) evaluated the frequency of lithium intoxication, its clinical course, and impact on renal function. Data were collected from a county in Sweden. Lithium intoxication was defined as a level of at least 1.2 mmol/L or greater, with a level of at least 1.5 mmol/L or greater defined as the break point for risk of clinically significant intoxication. Of 1340 identified patients, 96 had experienced at least 1 episode of lithium levels at least 1.5 mmol/L or greater; an incidence of 0.01 per patient-year. Of 1101 patients who were analyzed, 77 had experienced 91 episodes of lithium intoxication with lithium levels at least1.5 mmol/L or greater. A total of 29 episodes occurred during the first 2 years of treatment. Episodes of intoxication were significantly more frequent in the summer and autumn. The most commonly cited symptoms included confusion, disorientation, or somnolence, which more likely to occur in patients with severe intoxication (P < .05). Infections were associated with approximately 10% of the cases of intoxication. Approximately 12.1% of the cases of intoxication were precipitated by drug interactions. Of 77 patients available for review, 34% required intensive care and 13% were treated with hemodialysis. There were no fatalities. In 27 of 37 episodes, the decline of renal function was probable and in 8 episodes possibly caused by comorbidities or factors other than lithium. Elderly patients, at least 65 years of age, were more likely to have had renal impairment prior to intoxication (P < .01). The authors concluded that lithium intoxication occurs but can be safely managed in most cases. Appropriate screening is important in the identification and management of lithium intoxication. Lithium [“Litho-bid,” “Lithium”] Ott M et al (M Ott, Department of Public Health and Clinical Medicine, University Hospital, 901 85 Umeå, Sweden; e-mail: author@ottm.eu) Lithium intoxication: incidence, clinical course and renal function—a population-based retrospective cohort study. J Psychopharmacol 30:1008–1019 (Oct) 2016","PeriodicalId":102871,"journal":{"name":"Clin-Alert®","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131194983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
求助内容：
应助结果提醒方式：