International Journal on Gastroenterology and Liver Disorders最新文献

{"title":"Colorectal Surgery: Single Tertiary Center Experience","authors":"","doi":"10.51626/ijgld.2023.03.00013","DOIUrl":"https://doi.org/10.51626/ijgld.2023.03.00013","url":null,"abstract":"Objectives: Laparoscopic approach is nowadays being used widely for the treatment of various surgical diseases in many centers, but it has not considered as the gold standard in colorectal surgery yet.The aim of this study was to examine and compare the postoperative clinical and oncological outcomes of laparoscopic and open colorectal surgery in the light of literatüre.\u0000\u0000Methods: 526 patients who had colorectal cancer surgery in our clinic in between May 2015 and March 2023 were enrolled in this retrospective comparative study. Patients treated with open surgery were included in Group 1 (OS group) and ones treated laparoscopically includedin Group 2 (LS group). Demographics (age,sex), types of operations, ASA scores, evaluation of resected specimen, dissected lymph nodes, T\u0000invasion of tumors in groups, postoperative complications, operation time and hospital stay times and short-term morbidity and mortality were noted and compared with each other.\u0000\u0000Results: Patients in LS group had less blood loss compared with those in OS group (median 80 mL (range 0-1300) vs 155 mL (0–2000),p<0•0001), although laparoscopic surgery lasted longer than did open surgery (p<0•0001). The patients who underwent the laparoscopic surgery showed faster recovery then those who underwent open surgery, regarding first passing bowel gas (p=0.045), time of first bowel motion\u0000(p=0.04), time to resume normal diet (p=0.041), and time to ambulate independently (p=0.037). Hospital stay time was significantly shorter in Laparoscopy group (p<0.001). Oncological satisfaction of resection as assessed by number of removed lymph nodes, distal resection margin did not differ between groups (p=0.564, p=0.698). Although wound infection was significantly higher in OS group (p<0.001), other morbidity\u0000parameters and mortality after colectomy did not differ between two groups.\u0000\u0000Conclusion: Laparoscopic colorectal surgery gives satisfactory outcomes as compared to open surgery in many aspects such as clinical and\u0000oncological outcomes and early recovery. Considering the short-term outcomes of the present study, laparoscopic colorectal surgery in experienced hands seems to be safe and feasible for the treatment of the colorectal cancers.","PeriodicalId":102500,"journal":{"name":"International Journal on Gastroenterology and Liver Disorders","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134129149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric Inverted Hamartomatous Polyp with Active H. Pylori Gastritis and Anemia: A Rare Presentation","authors":"","doi":"10.51626/ijgld.2022.02.00008","DOIUrl":"https://doi.org/10.51626/ijgld.2022.02.00008","url":null,"abstract":"Background: Gastric inverted hamartomatous polyps are rare polyps constituting less than one percent of all the gastric polyps and characterized by an inverted growth pattern of benign gastric mucosal components into the submucosa. Gastric inverted hamartomatous polyps are known to have malignant potential. Because of their rarity, gastric inverted hamartomatous polyps can pose a histological and clinical challenge.\u0000Case presentation: We present a case of a 54-year-old female with gastric inverted hamartomatous polyp with underlying active H. pylori gastritis manifesting as symptomatic anemia and melena. Esophagogastroduodenoscopy showed a 3 cm pedunculated gastric polyp on the lesser curvature with dilated vessels and bleeding on its surface. Due to its long stalk, the polyp was initially found prolapsing through the pylorus but returned spontaneously into the intragastric position (ball valve phenomenon). The polyp was resected with a hot snare and retrieved. Histology\u0000revealed an endophytic growth of benign hyperplastic glands with variable cystic dilation into the submucosa with focal benign smooth muscle proliferation. Associated focal erosion and active H. pylori gastritis, confirmed by immunohistochemistry were also identified. The patient was discharged on quadruple H. pylori therapy with a follow-up plan for repeat esophagogastroduodenoscopy in two months.\u0000Conclusion: GIHP may be symptomatic presenting as anemia, gastrointestinal obstruction, or involved by H.pylori infection. The pathogenesis of GIHP is still unclear due to rare, reported cases. H. pylori gastritis could be a contributing factor in the pathogenesis of GIHP and warrants further studies.\u0000Keywords: Gastric inverted polyp; H. pylori; Anemia; Ball valve mechanism; Histology","PeriodicalId":102500,"journal":{"name":"International Journal on Gastroenterology and Liver Disorders","volume":"201 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132809303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Non-Alcoholic Fatty Liver, Intestine, And Microbioata","authors":"","doi":"10.51626/ijgld.2022.02.00007","DOIUrl":"https://doi.org/10.51626/ijgld.2022.02.00007","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is a serious disease that can contribute to liver cancer and death associated with liver diseases. There is a close relationship between the liver and the intestine via the portal vein, and gut microbiota plays a role in the pathogenesis of NAFLD. As a result of increased intestinal permeability and endotoxin transmission due to bacterial overgrowth in the intestine, the production of proinflammatory cytokines and chemokines in the liver increases. It triggers fatty liver. In this mini-review, we will describe the relationship between NAFLD, intestine, and microbiota.","PeriodicalId":102500,"journal":{"name":"International Journal on Gastroenterology and Liver Disorders","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129868801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Transfigured Ingot-Gastrointestinal Stromal Tumour","authors":"","doi":"10.51626/ijgld.2022.02.00006","DOIUrl":"https://doi.org/10.51626/ijgld.2022.02.00006","url":null,"abstract":"Gastrointestinal stromal tumour is a frequently discerned, mesenchymal neoplasm occurring within gastrointestinal tract. Predominantly incriminating gastric region, tumefaction arises from interstitial cells of Cajal which constitute myenteric plexus situated within muscularis propria. Previously designated as gastrointestinal smooth muscle tumour, gastrointestinal autonomic nerve tumour, leiomyoblastoma, smooth muscle tumour of uncertain malignant potential or gastrointestinal pacemaker cell tumour, gastrointestinal stromal tumour may exhibit malignant biological behaviour [1,2]. Of\u0000obscure aetiology, majority of neoplasms are sporadic. However, few familial neoplasms may occur. Chromosomal mutations of KIT and PDGFRA genes are singularly associated with the tumour. Neoplasm may be discovered incidentally during various imaging or endoscopic procedures of gastrointestinal tract [1,2].","PeriodicalId":102500,"journal":{"name":"International Journal on Gastroenterology and Liver Disorders","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127370823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should LI-RADS or Liver Biopsy be used to Diagnose Suspected Hepatocellular Carcinoma? Assessment of Current Practice Patterns and Perspective from a Metropolitan Cancer Center","authors":"","doi":"10.51626/ijgld.2022.02.00005","DOIUrl":"https://doi.org/10.51626/ijgld.2022.02.00005","url":null,"abstract":"Worldwide, liver cancer is the fifth most common malignancy and the fourth leading cause of malignancy-related deaths [1]. Hepatocellular carcinoma (HCC) makes up >80% of new cases of liver cancer, with >80% of those cases occurring in sub-Saharan Africa or in East\u0000Asia. In fact, China alone holds >50% of new cases of HCC [2,3]. In the United States, HCC is the fastest growing cause of cancer-related death in men, although notably, the largest proportional increases occurred among whites (Hispanics and Non-Hispanics) [4].","PeriodicalId":102500,"journal":{"name":"International Journal on Gastroenterology and Liver Disorders","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116959192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L-Ornithine L-Aspartate for Prevention and Treatment of Hepatic Encephalopathy in Patients with Cirrhosis","authors":"","doi":"10.51626/ijgld.2022.02.00004","DOIUrl":"https://doi.org/10.51626/ijgld.2022.02.00004","url":null,"abstract":"In cirrhosis, the loss of metabolic capacity of periportal and perivenous hepatocytes coupled with the development of portal-systemic shunting frequently results in severe hyperammonemia. Molecular Imaging and Spectroscopic techniques reveal increases in the cerebral metabolic rate for ammonia and increased brain glutamine as a function of the severity of hepatic encephalopathy [HE]. L-Ornithine L-Aspartate [LOLA] is effective for the lowering of blood, muscle and brain ammonia and does so via three independent\u0000mechanisms namely [i] the stimulation of ammonia removal via the urea cycle in residual hepatocytes, [ii] prevention of hepatocellular damage due to the production of antioxidants [glutathione, glutamine] and [iii] the prevention of muscle wasting [sarcopenia] thus protecting the ammonia-detoxification pathway via muscle glutamine synthesis. Results of RCTs, systematic reviews and meta-analyses provide evidence for the efficacy of LOLA for the prevention and treatment of HE in all its forms [MHE, OHE, episodic HE, post-TIPSS HE] and for primary, secondary and post-TIPSS prophylaxis.\u0000Keywords: L-ornithine L-aspartate; LOLA; Hepatic encephalopathy; Cirrhosis; Treatment; Prevention; Prophylaxis; Ammonia; Hepatoprotection; Sarcopenia; Combination therapy","PeriodicalId":102500,"journal":{"name":"International Journal on Gastroenterology and Liver Disorders","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129145611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring Quality of Life in Home Parenteral Nutrition Outpatients is a Complex Art","authors":"Geisler","doi":"10.51626/ijgld.2021.01.00003","DOIUrl":"https://doi.org/10.51626/ijgld.2021.01.00003","url":null,"abstract":"Background: Patients treated with home parenteral nutrition often have impaired quality of life (QoL). The use of QoL measurements, may provide the possibility to prioritize problems between clinician and patient and to monitor response to treatment.\u0000Objective: To find the two tools most suited for assessment of QoL in our HPN-patients. Further, to investigate quality of life, patient’s perception of tools, and the sensitivity to hand grip strength (HGS) and internal validity of the preferred tool.\u0000Methods: The iterative multi-method design included document analysis, semi-structured patient interviews, and a questionnaire based investigation using the two tools. Results were compared to HGS. For statistics, unpaired t-test and Mann-Whitney were used.\u0000Results: EORTC-QLQ-C30 and HPN-QOL address the eight domains found in the 13 patient interviews. Thirty-one patients replied to QOL-questionnaires. Low QoL was found by EORTC-QLQ-C30, General Health (GH)=51.26 (SD±4.28). Using HPN-QOL, QoL was slightly better (GH=69.85 (SD±3.62)). Worst items were employment, sexual function, ability to holiday, fatigue and sleep. Differences between tools were seen for physical function (p=0.00), and fatigue (p=0.02). For the preferred “HPN-QOL” the association between “General Health” and “The physical function score” and HGS were insignificant. Evaluation of internal validity with Cronbach`s α test 64.28% were above 0.7.\u0000Conclusion: Eight domains found by interviews were reflected in EORTC-QLQ-C30 and HPN-QOL. Patients preferred the HPN-QOL. QOL was decreased and an ongoing assessment using HPN-QOL seems relevant, even though our measures did not show association with HGS. Internal validity was fair for HPN-QOL.\u0000Keywords: Home parenteral nutrition; Intestinal failure; Quality of life; Patients; Outpatients; HPN-QOL","PeriodicalId":102500,"journal":{"name":"International Journal on Gastroenterology and Liver Disorders","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114955112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}