Eurasian Journal of Medical Advances最新文献

The effect of hypochlorous acid on preventing postoperative peritoneal adhesions: An experimental study 次氯酸预防术后腹膜粘连的实验研究

Eurasian Journal of Medical Advances Pub Date : 1900-01-01 DOI: 10.14744/ejma.2022.44153

Özge Öztürk

{"title":"The effect of hypochlorous acid on preventing postoperative peritoneal adhesions: An experimental study","authors":"Özge Öztürk","doi":"10.14744/ejma.2022.44153","DOIUrl":"https://doi.org/10.14744/ejma.2022.44153","url":null,"abstract":"lo-Objectives: Postoperative peritoneal adhesion is a devastating complication without an ideal preventive and therapeutic modality. There is controversy about the effect of hypochlorous acid solutions and whether they contribute to the development or prevention of experimental peritoneal adhesions, given their anti-inflammatory and microbicidal properties. Therefore, the objective of this study is to evaluate the effect of the intraperitoneal hypochlorous acid application on the extension and severity of peritoneal adhesions in an experimental model. Methods: A total of 24 Wistar-albino rats were divided into three groups: Group 1 (Sham surgery), Group 2 (peritoneal adhesion using cecal serosal abrasion with parietal peritoneal excision and intraperitoneal saline), and Group 3 (peritoneal adhesion using cecal serosal abrasion with parietal peritoneal excision and intraperitoneal hypochlorous acid). On the postoperative 14th day, abdominal cavities were explored. Linsky's and Knightly's macroscopic adhesion classifications reflected the extent and intensity of adhesions. Zühlke’s classification was used to grade the adhesions microscopically. Results: Animals in all groups developed cecal and peritoneal adhesions to variable extents and at various severity levels, except for two (28.6%) animals in Group 3. Nevertheless, there was no significant difference between the groups in scores obtained from the Linsky’s peritoneal adhesion extent classification, the Knightly’s peritoneal adhesion severity classification, and the Zuhlke’s microscopic adhesion classification systems (p>0.05 for all). Conclusion: Intraperitoneal hypochlorous acid application did not lead to any significant improvement in the macroscopic and microscopic peritoneal adhesion scores.","PeriodicalId":102185,"journal":{"name":"Eurasian Journal of Medical Advances","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117259918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infectious spondylodiscitis, an overlooked cause of pain: a review 传染性脊柱炎，一种被忽视的疼痛原因:综述

Eurasian Journal of Medical Advances Pub Date : 1900-01-01 DOI: 10.14744/ejma.2022.08370

aysel çınar sayhan

{"title":"Infectious spondylodiscitis, an overlooked cause of pain: a review","authors":"aysel çınar sayhan","doi":"10.14744/ejma.2022.08370","DOIUrl":"https://doi.org/10.14744/ejma.2022.08370","url":null,"abstract":"The most common symptom Infectious spondyloarthritis occurs through the transmission of a microorganism by various routes, causing an infection in the spine. It can be diagnosed on any desired MRI based on clinical suspicion in the presence of an appropriate clinical manifestation (fever, pain, loss of strength) along with a significant increase in leukocyte, Erythrocyte Sedimentation Rate (ESR), and C-Reactive Protein (CRP) laboratory parameters. The definitive diagnosis is made by demonstration of the microorganism in the biopsy material. Since the disease is rare and low back pain is very common in the population, the diagnosis is often missed and delayed. [1] Therefore, it still remains an important cause of comorbidity. Delayed diagnosis of this disease, which can be treated with appropriate antibiotic therapy, may result in disability by causing neurological sequelae. [2] The aim of this review is to provide information about infectious spondylodiscitis at a level to manage the diagnosis, treatment, and follow-up process, to keep this diagnosis in mind in patients with risk factors who present with back pain and local tenderness in the spine, especially in patients from endemic regions of tuberculosis and brucellosis, and to expand the investigation in this direction.","PeriodicalId":102185,"journal":{"name":"Eurasian Journal of Medical Advances","volume":"170 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121072108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effects of Silymarin on Acetaminophen-Induced Toxic Hepatitis 水飞蓟素对对乙酰氨基酚所致中毒性肝炎的保护作用

Eurasian Journal of Medical Advances Pub Date : 1900-01-01 DOI: 10.14744/ejma.2022.32042

Abdilkerim Oyman

{"title":"Protective Effects of Silymarin on Acetaminophen-Induced Toxic Hepatitis","authors":"Abdilkerim Oyman","doi":"10.14744/ejma.2022.32042","DOIUrl":"https://doi.org/10.14744/ejma.2022.32042","url":null,"abstract":"Objectives: Acetaminophen can cause liver damage that can result with death when it is taken as high doses. In our study we proposed to examine the silymarin effect on acetaminophen induced hepatotoxicity. Methods: In this study, 40 wistar albino rats are randomly divided into 4 groups. 1 ml 0.9% serum physiologic was injected to intraperitoneal (IP) area in control group (group 1). 100 mg/kg silymarin was also injected to IP area in second group (group 2). 1250 mg/kg acetaminophen was injected to IP area in toxic group (group 3). And after 4 hours 1250 mg/kg IP injection of acetaminophen to treatment group (group 4) 100 mg/kg of silymarin was administered to this group. All rats were sacrificed after 24 hours. Results: In treatment group, acetaminophen, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, glutamyltransferase, total bilirubin, direct bilirubin levels which are found increased in toxic group, are found as decreased and statistically significant. The malondialdehyde, a lipid peroksidation product, levels are high in toxic group and low in treatment group and it was statistically significant. There was no significant difference between groups, liver histopathological features. Conclusion: With this findings it can be assumed that silymarin has hepatoprotective effect.","PeriodicalId":102185,"journal":{"name":"Eurasian Journal of Medical Advances","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125340405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure-based virtual screening of phytochemicals from Phyllanthus amarus as potent inhibitory phytocompounds against Marburg Virus Disease 以结构为基础的对马尔堡病毒病有抑制作用的毛茛植物化学物质的虚拟筛选

Eurasian Journal of Medical Advances Pub Date : 1900-01-01 DOI: 10.14744/ejma.2023.19483

P. Singh

{"title":"Structure-based virtual screening of phytochemicals from Phyllanthus amarus as potent inhibitory phytocompounds against Marburg Virus Disease","authors":"P. Singh","doi":"10.14744/ejma.2023.19483","DOIUrl":"https://doi.org/10.14744/ejma.2023.19483","url":null,"abstract":"and highly contagious pathogen, infects both human and non-human primates, and causes life-threatening Marburg virus disease. So far, there have been 14 MAVD outbreaks since August 1967. Influenza-like illness, manifestations related to abdomen, hemorrhagic, respiratory, and vascular system are among the signs and symptoms of MVD. The protein VP 35 is a multifunctional viral protein and binds to the double-strand RNA through its RBD and masks the dsRNA, which is a key sign of virus infection, recognized by host proteins including RIG-I and MDA-5. Here, we have performed molecular docking and MD simulation studies and shown that that phytochemicals stigmasterol (ΔG = -8.62 kcal/mol) and methyl ursolate (ΔG = -9.29 kcal/mol) isolated from Phyllanthus amarus showed biologically significant poses to block the binding site of VP35 protein. The MD simulation result analysis confirmed that the complex structure of stigmasterol with RBD of protein VP35 show stable conformational dynamics during the MD simulation while methyl ursolate shows certain fluctuations in RMSD at certain time point but later attain stability. Hence, Phyllanthus amarus, which contains multiple antiviral and antimicrobial phytochemicals could be a conceivable candidate in the search for a drug for the MVD.","PeriodicalId":102185,"journal":{"name":"Eurasian Journal of Medical Advances","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126394504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment in PFAPA Syndrome: A Review PFAPA综合征的治疗:综述

Eurasian Journal of Medical Advances Pub Date : 1900-01-01 DOI: 10.14744/ejma.2022.47965

A. Aydınoğlu

引用次数: 0

Primary Ewing Sarcoma of the Kidney in a 54-Year-Old Male: A Rare Case Report 54岁男性肾脏原发性尤文氏肉瘤一例罕见病例报告

Eurasian Journal of Medical Advances Pub Date : 1900-01-01 DOI: 10.14744/ejma.2023.46855

Yusuf Ilhan

{"title":"Primary Ewing Sarcoma of the Kidney in a 54-Year-Old Male: A Rare Case Report","authors":"Yusuf Ilhan","doi":"10.14744/ejma.2023.46855","DOIUrl":"https://doi.org/10.14744/ejma.2023.46855","url":null,"abstract":"Ewing sarcomas/Primitive neuroectodermal tumors are aggressive tumors, typically seen in children and young adults. These tumors are of neuroectodermal origin and, also known as Ewing sarcoma family tumors. They are most commonly seen in the bones and soft tissues. Primary Ewing sarcoma of the kidney is rarely seen. It has nonspecific symptoms and imaging findings. Therefore, it is mostly diagnosed postoperatively. Its diagnosis is based on histological morphology, immunohistochemistry and, molecular genetic tests. A multi-modality treatment approach is very important. Here, we presented a male patient with primary Ewing sarcoma of the kidney, relatively in older age. A 54-year-old male patient admitted to the hospital with right flank pain and hematuria. He was operated successfully and than received adjuvant vincristine, doxorubicin, cyclophosphamide, and ifosfamide, etoposide chemotherapy regimens. No treatment-related toxicity was observed and the patient is still in remission. Despite using surgery and adjuvant chemotherapy in treat-ment, because of its rarity there was no randomized trial about kidney Ewing sarcomas. These rare tumors still need robust therapeutic treatment regimens.","PeriodicalId":102185,"journal":{"name":"Eurasian Journal of Medical Advances","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128956850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relevancy of Serum SuPAR, PAI-1, MMP-9 Level, And Prognosis Of Metastatic Colorectal Cancer During Diagnosis 血清SuPAR、PAI-1、MMP-9水平与转移性结直肠癌诊断预后的相关性

Eurasian Journal of Medical Advances Pub Date : 1900-01-01 DOI: 10.14744/ejma.2023.49368

M. Kalender

引用次数: 0

Role of 'Serial D-Dimer Level' in predicting Severity and outcome in COVID-19 pneumonia: A Prospective multicentric Observational Study of 1000 cases in Tertiary Care Setting in India “序列d -二聚体水平”在预测COVID-19肺炎严重程度和结局中的作用:印度三级医疗机构1000例前瞻性多中心观察研究

Eurasian Journal of Medical Advances Pub Date : 1900-01-01 DOI: 10.14744/ejma.2022.36854

S. Patil

引用次数: 4

The Effect of Positive İnotropic Therapy on Serum Adiponectin Level in Patients with Acute Decompensated Heart Failure İnotropic阳性治疗对急性失代偿性心力衰竭患者血清脂联素水平的影响

Eurasian Journal of Medical Advances Pub Date : 1900-01-01 DOI: 10.14744/ejma.2022.68552

Mustafa Kaplangoray

引用次数: 0

How Should Immature Ovarian Teratoma with Gliomatosis Peritonei Be Treated? A Series of Three Rare Cases and Review of the Literature 未成熟卵巢畸胎瘤合并腹膜胶质瘤病该如何治疗?三个罕见病例系列及文献综述

Eurasian Journal of Medical Advances Pub Date : 1900-01-01 DOI: 10.14744/ejma.2022.69875

Yusuf Ilhan

引用次数: 0