Bioscientia Medicina : Journal of Biomedicine and Translational Research最新文献_第3页

Collecting Duct Carcinoma in the Kidneys: A Rare Case Report 肾集合管癌：罕见病例报告

Bioscientia Medicina : Journal of Biomedicine and Translational Research Pub Date : 2024-04-24 DOI: 10.37275/bsm.v8i7.1023

Julpa Nurul Aini, Noza Hilbertina, Pamelia Mayorita

{"title":"Collecting Duct Carcinoma in the Kidneys: A Rare Case Report","authors":"Julpa Nurul Aini, Noza Hilbertina, Pamelia Mayorita","doi":"10.37275/bsm.v8i7.1023","DOIUrl":"https://doi.org/10.37275/bsm.v8i7.1023","url":null,"abstract":"Background: Collecting duct carcinoma (CDC) is one of the rare pathological subtypes of renal cell carcinoma, with high malignancy and poor prognosis. Pathological examination is the gold standard in confirming the diagnosis of CDC. CDC is described as a tumor that has a tubulopapillary architecture and forms a hobnail pattern along the glandular tube. \u0000Case presentation: A 56-year-old woman with the main complaint of a lump in the right abdomen for 1.5 months before entering the hospital. The lump in the stomach is getting bigger, complaints are accompanied by intermittent pain, nausea, vomiting, body feeling weak, and decreased appetite. The patient then underwent a CT-Scan examination of the abdomen and concluded that fluid/water was found next to the right kidney, and a hypodense lesion appeared in segment 6 of the right lobe of the liver. Histopathological examination of large tissue shows pieces of kidney tissue with a connective tissue capsule on the outside containing glomeruli and tubules lined by cuboidal epithelium as well as a proliferation of tumor cells that grow infiltratively in the connective tissue stroma which is partly desmoplastic and fatty tissue between the glomeruli and tubules. Tumor cells are arranged to form tubulopapillary and tubulocystic structures. These cells with pleomorphic nuclei, some hyperchromatic, some vesicular, coarse chromatin, clear nuclei, and atypical mitoses can be found and tumor cell embolism in the blood vessels and perineural invasion can be seen. There were spots and clusters of lymphocytes and plasma cells as well as areas of bleeding and necrosis. \u0000Conclusion: The patient was diagnosed with collecting duct carcinoma (CDC).","PeriodicalId":102064,"journal":{"name":"Bioscientia Medicina : Journal of Biomedicine and Translational Research","volume":"84 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140659527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in Mean Anti-Pertussis Antibody Levels in Children with Acellular Pertussis Immunization and Whole Pertussis Without Booster 接种无细胞百日咳疫苗和未接种百日咳疫苗的儿童平均抗百日咳抗体水平的差异

Bioscientia Medicina : Journal of Biomedicine and Translational Research Pub Date : 2024-04-23 DOI: 10.37275/bsm.v8i7.1022

Wenny Rahmalia Rezki, Rinang Mariko, Rizanda Machmud, Rusdi, Asrawati, Indra Ihsan

{"title":"Differences in Mean Anti-Pertussis Antibody Levels in Children with Acellular Pertussis Immunization and Whole Pertussis Without Booster","authors":"Wenny Rahmalia Rezki, Rinang Mariko, Rizanda Machmud, Rusdi, Asrawati, Indra Ihsan","doi":"10.37275/bsm.v8i7.1022","DOIUrl":"https://doi.org/10.37275/bsm.v8i7.1022","url":null,"abstract":"Background: The incidence of pertussis is increasing every year, especially in developing countries. Low immunization coverage and decreased immunity are some of the factors causing the re-increase in pertussis cases. The protection provided by the pertussis vaccine whole and acellular pertussis given as a baby will decrease with age. This study aims to determine the difference in mean levels of anti-pertussis antibodies in children who received acellular pertussis and whole pertussis immunization without a booster. \u0000Methods: A cross-sectional study was carried out at the pediatric polyclinic of Dr. M. Djamil General Hospital Padang from December 2022 to December 2023. Research subjects were children aged 5-9 years with a history of whole pertussis immunization (DPwT) 3 times or acellular pertussis immunization (DPaT) 3 times. The research subjects were examined for anti-pertussis antibody titers using the ELISA technique. \u0000Results: Thirty-four children with a history of DPwT immunization 3 times and 34 children with a history of DPwT immunization 3 times were research subjects, with mean age 6.94±1.49 in the DPwT group and 6.88 ±1.61 in the DPaT group. The mean anti-pertussis antibody level in the DPwT group (9.54 IU/mL) was higher than the DPaT group (6.96 IU/mL) but was not statistically significant (p>0.05). The average antibody results showed that the antibody levels in both groups were below the antibody titer threshold that provides protection against pertussis. The results of the analysis showed that there was a significant difference in the incidence of AEFI between the DPwT and DPaT immunization groups (p<0.05). \u0000Conclusion: There was no difference in anti-pertussis antibody levels in children who received DPwT and DPaT immunization 3 times. Pertussis immunization is a required booster so that antibody levels are sufficient to provide protection against pertussis.","PeriodicalId":102064,"journal":{"name":"Bioscientia Medicina : Journal of Biomedicine and Translational Research","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140670841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of 3% Binahong (Anredera cordifolia) Leaf Extract Nanogel on the Alveolar Bone Healing: BMP-2 Modulation in Rat Models 3% Binahong (Anredera cordifolia) 叶提取物纳米凝胶对牙槽骨愈合的研究：大鼠模型中的 BMP-2 调节作用

Bioscientia Medicina : Journal of Biomedicine and Translational Research Pub Date : 2024-04-18 DOI: 10.37275/bsm.v8i7.1020

Bernard Bernard, Syafruddin Ilyas, O. A. Hanafiah

{"title":"Investigation of 3% Binahong (Anredera cordifolia) Leaf Extract Nanogel on the Alveolar Bone Healing: BMP-2 Modulation in Rat Models","authors":"Bernard Bernard, Syafruddin Ilyas, O. A. Hanafiah","doi":"10.37275/bsm.v8i7.1020","DOIUrl":"https://doi.org/10.37275/bsm.v8i7.1020","url":null,"abstract":"Background: Alveolar bone healing relies on osteoblasts activity and differentiation, with bone morphogenetic protein-2 (BMP-2) playing a crucial regulatory role. Binahong leaf extract (BLE) has demonstrated efficacy in bone healing due to its rich phytochemical composition. Nanogel offers enhanced bioavailability and targeted release to effectively deliver therapeutic agents. This study aims to assess the impact of 3% BLE nanogel on BMP-2 expression in tooth extraction socket healing. \u0000Methods: Thirty male Wistar rat underwent anaesthesia for the extraction of their lower incisors to induce alveolar bone healing. Subjects were randomly assigned into treatment (BLE nanogel) and control (base nanogel) group. Five rats from each group were respectively sacrificed at 7, 14, and 28 days after procedures. BMP-2 expression was assessed by performing immunohistochemistry analysis using BMP antibody reagent. Data were analysed using chi-square. \u0000Results: The analysis of BMP-2 expression showed no significant difference between treatment and control groups on days 7, 14, and 28 (p>0,05). However, a subtle increase was observed in the treatment group throughout observation period. \u0000Conclusion: Application of 3% BLE nanogel may enhance the expression of BMP-2, even though it was not significantly increase. The findings underscore the complex interplay between Binahong leaf extract, nanogel and BMP-2 expression.","PeriodicalId":102064,"journal":{"name":"Bioscientia Medicina : Journal of Biomedicine and Translational Research","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140686040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Thrombocytopenia with Partial Splenic Embolization in Liver Cirrhosis 肝硬化患者通过部分脾栓塞治疗血小板减少症

Bioscientia Medicina : Journal of Biomedicine and Translational Research Pub Date : 2024-04-03 DOI: 10.37275/bsm.v8i6.1015

Septia Harma Putri, Arnelis, Saptino Miro

引用次数: 0

Spinal Anesthesia with Ultrasonography (USG) Marker in Morbidly Obese Pregnant Women Undergoing Cesarean Section Surgery: A Case Report 在接受剖腹产手术的病态肥胖孕妇中使用超声波（USG）标记的脊髓麻醉：病例报告

Bioscientia Medicina : Journal of Biomedicine and Translational Research Pub Date : 2024-02-15 DOI: 10.37275/bsm.v8i4.977

Made Septyana Parama Adi, I Gusti Ngurah Mahaalit Aribawa, I Gusti Agung Gede Utara Hartawan, I Putu Fajar Narakusuma, Gusti Agung Made Wibisana Kurniajaya

{"title":"Spinal Anesthesia with Ultrasonography (USG) Marker in Morbidly Obese Pregnant Women Undergoing Cesarean Section Surgery: A Case Report","authors":"Made Septyana Parama Adi, I Gusti Ngurah Mahaalit Aribawa, I Gusti Agung Gede Utara Hartawan, I Putu Fajar Narakusuma, Gusti Agung Made Wibisana Kurniajaya","doi":"10.37275/bsm.v8i4.977","DOIUrl":"https://doi.org/10.37275/bsm.v8i4.977","url":null,"abstract":"Background: Spinal anesthesia is a regional anesthesia technique used to provide analgesia or numbness in the lower part of the body. This technique has long been employed in childbirth and cesarean section surgeries due to its numerous advantages for pregnant women. Obese pregnant patients often have increased adipose tissue in the back area, making it challenging to identify the appropriate interspinous space. \u0000Case presentation: A 26-year-old primigravida at 38 weeks of gestation with morbid obesity, standing at 158 cm tall and weighing 140 kg, with a body mass index (BMI) of 56.1 kg/m², underwent cesarean section surgery under spinal anesthesia. The identification of the spinal needle insertion site was performed using pre-procedural ultrasound (USG) marker at the L3-L4 level, with heavy bupivacaine 0.5% 12.5 mg used as the anesthetic agent. The surgery lasted for 1 hour and 20 minutes, with stable hemodynamics and a blood loss of 450 ml. A female infant was delivered, weighing 3080 grams, with a length of 50 cm and an APGAR score of 8-9-10. \u0000Conclusion: The use of USG markers can assist in determining the precise location for spinal anesthesia injection, thereby reducing complications from repeated needle insertions.","PeriodicalId":102064,"journal":{"name":"Bioscientia Medicina : Journal of Biomedicine and Translational Research","volume":"3 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139774023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spinal Anesthesia with Ultrasonography (USG) Marker in Morbidly Obese Pregnant Women Undergoing Cesarean Section Surgery: A Case Report 在接受剖腹产手术的病态肥胖孕妇中使用超声波（USG）标记的脊髓麻醉：病例报告

Bioscientia Medicina : Journal of Biomedicine and Translational Research Pub Date : 2024-02-15 DOI: 10.37275/bsm.v8i4.977

Made Septyana Parama Adi, I Gusti Ngurah Mahaalit Aribawa, I Gusti Agung Gede Utara Hartawan, I Putu Fajar Narakusuma, Gusti Agung Made Wibisana Kurniajaya

{"title":"Spinal Anesthesia with Ultrasonography (USG) Marker in Morbidly Obese Pregnant Women Undergoing Cesarean Section Surgery: A Case Report","authors":"Made Septyana Parama Adi, I Gusti Ngurah Mahaalit Aribawa, I Gusti Agung Gede Utara Hartawan, I Putu Fajar Narakusuma, Gusti Agung Made Wibisana Kurniajaya","doi":"10.37275/bsm.v8i4.977","DOIUrl":"https://doi.org/10.37275/bsm.v8i4.977","url":null,"abstract":"Background: Spinal anesthesia is a regional anesthesia technique used to provide analgesia or numbness in the lower part of the body. This technique has long been employed in childbirth and cesarean section surgeries due to its numerous advantages for pregnant women. Obese pregnant patients often have increased adipose tissue in the back area, making it challenging to identify the appropriate interspinous space. \u0000Case presentation: A 26-year-old primigravida at 38 weeks of gestation with morbid obesity, standing at 158 cm tall and weighing 140 kg, with a body mass index (BMI) of 56.1 kg/m², underwent cesarean section surgery under spinal anesthesia. The identification of the spinal needle insertion site was performed using pre-procedural ultrasound (USG) marker at the L3-L4 level, with heavy bupivacaine 0.5% 12.5 mg used as the anesthetic agent. The surgery lasted for 1 hour and 20 minutes, with stable hemodynamics and a blood loss of 450 ml. A female infant was delivered, weighing 3080 grams, with a length of 50 cm and an APGAR score of 8-9-10. \u0000Conclusion: The use of USG markers can assist in determining the precise location for spinal anesthesia injection, thereby reducing complications from repeated needle insertions.","PeriodicalId":102064,"journal":{"name":"Bioscientia Medicina : Journal of Biomedicine and Translational Research","volume":"260 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139833526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Anti-PD 1 (Programmed Cell Death-1) (Pembrolizumab) in Hepatocellular Carcinoma: A Narrative Literature Review 抗 PD 1（程序性细胞死亡-1）（Pembrolizumab）在肝细胞癌中的作用：叙述性文献综述

Bioscientia Medicina : Journal of Biomedicine and Translational Research Pub Date : 2024-02-15 DOI: 10.37275/bsm.v8i4.975

Nelila Pasmah Fitriani, Suyata

引用次数: 0

The Role of Anti-PD 1 (Programmed Cell Death-1) (Pembrolizumab) in Hepatocellular Carcinoma: A Narrative Literature Review 抗 PD 1（程序性细胞死亡-1）（Pembrolizumab）在肝细胞癌中的作用：叙述性文献综述

Bioscientia Medicina : Journal of Biomedicine and Translational Research Pub Date : 2024-02-15 DOI: 10.37275/bsm.v8i4.975

Nelila Pasmah Fitriani, Suyata

引用次数: 0

Gut Microbiota in Chronic Kidney Disease: A Narrative Literature Review 慢性肾脏病中的肠道微生物群：叙述性文献综述

Bioscientia Medicina : Journal of Biomedicine and Translational Research Pub Date : 2024-02-15 DOI: 10.37275/bsm.v8i4.976

Novandra Abdillah, Zulklhair Ali, Novadian, Ian Effendi, Suprapti, Elfiani, Rery TF Yuniarti

引用次数: 0

Gut Microbiota in Chronic Kidney Disease: A Narrative Literature Review 慢性肾脏病中的肠道微生物群：叙述性文献综述

Bioscientia Medicina : Journal of Biomedicine and Translational Research Pub Date : 2024-02-15 DOI: 10.37275/bsm.v8i4.976

Novandra Abdillah, Zulklhair Ali, Novadian, Ian Effendi, Suprapti, Elfiani, Rery TF Yuniarti

引用次数: 0