Uludağ Üniversitesi Tıp Fakültesi Dergisi最新文献

{"title":"Proximal Renal Tubular Acidosis and Fanconi Syndrome Secondary to Tenofovir Disopyroxil Fumarat: Importance of Arterial Blood Gases Analysis in Differrential Diagnosis in Severe Hypokalemia","authors":"R. Deniz, Şevket Ali Ekmen, Gani Berk Ünal, M. Hurşitoğlu, Zeynep Karaali","doi":"10.32708/uutfd.1096828","DOIUrl":"https://doi.org/10.32708/uutfd.1096828","url":null,"abstract":"Proximal renal tubular acidosis (pRTA) may occur alone or with Fanconi syndrome and may be idiopathic or associated with many drugs and diseases. A 71-year-old female patient was admitted with persistent, symptomatic hypokalemia, who used tenofovir disoproxil fumarate (TDF) for chronic HBV infection. While the diagnosis could not be reached by venous blood gas analysis, arterial blood gas analysis showed isolated normal anion gap hypokalemic hyperchloremic metabolic acidosis, and hypomagnesemia, hypouricemia, and hypophosphatemia were detected in biochemistry, suggesting pRTA and Fanconi syndrome. Since other etiologic causes were excluded and the history was compatible, this was attributed to the use of TDF, and clinical and laboratory response was achieved when TDF was switched into tenofovir alfenamide (TAF). TDF-associated pRTA and Fanconi syndrome may occur independently from the duration of TDF use, and switching into TAF may control this complication without disrupting the treatment of HBV infection. Requesting arterial blood gas analysis at least once is in patients presenting with acid-base disorder is valuable and determining for differential diagnosis.","PeriodicalId":101995,"journal":{"name":"Uludağ Üniversitesi Tıp Fakültesi Dergisi","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127807552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics of Our Follow-Up Patients with the Rare Disease Relapsing Polychondritis: A Single-Center Study","authors":"B. Yağız, B. N. Coşkun, S. Çelik, Y. Pehlivan, H. E. Dalkılıç","doi":"10.32708/uutfd.1125512","DOIUrl":"https://doi.org/10.32708/uutfd.1125512","url":null,"abstract":"Relapsing polychondritis (RP) is an immune-mediated, systemic inflammatory and degenerative disease that affects cartilaginous structures particularly the ears, nose, eyes, joints, and respiratory tract and other tissues in the body. RP targets non-cartilaginous structures such as skin, kidney, heart, and the central nervous system in addition to cartilage-containing structures. Since it is a rare disease, data on its epidemiology are insufficient. It is prevalent between the ages of 40 and 60. Men and women are affected equally. Clinical characteristics vary among patients. The disease's rarity and broad clinical spectrum frequently result in misdiagnosis or delayed diagnosis. To prevent related complications and death, and to improve prognosis, early diagnosis and timely treatment of RP are crucial. Glucocorticoids, dapsone, disease-modifying antirheumatic drugs (DMARDs), and biologics are available as treatment options. The prognosis, such as the clinical presentation, varies depending on the extent of organ damage. 10 patients with RP had a mean onset age of 49.5±4.1. The median time between symptom onset and diagnosis was 3 months (2-60). 80% of the patients were male. The most frequent clinical manifestation is auricular chondritis (100%). During treatment, oral prednisolone was administered to all patients at least once. Intravenous methylprednisolone was administered to two patients. Due to ineffectiveness of DMARDs, one patient was switched to infliximab. A patient died due to pneumosepsis. This article aims to increase clinicians' awareness of this rare disease that can affect multiple systems by providing an overview of its pathogenesis, clinical course, diagnosis, and treatment.","PeriodicalId":101995,"journal":{"name":"Uludağ Üniversitesi Tıp Fakültesi Dergisi","volume":"236 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124603680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new therapeutic target in the glutathione mechanism: Inhibition of tumor-associated CA-IX isoenzyme and oxidative stress","authors":"Emine Terzi, Beyza Ecem Öz Bedir, Özen Özensoy Güler","doi":"10.32708/uutfd.1124693","DOIUrl":"https://doi.org/10.32708/uutfd.1124693","url":null,"abstract":"Oksidatif stres, renal kanser için önemli parametrelerden birisidir. Antioksidan sistem renal kanser oluşumunda devreye girerek oksidatif strese karşı koyar. Endojen antioksidanlar olarak tanımlanan GR ve GPx, böbreklerin antioksidan sistemindeki önemli enzimleridir. Çalışmamızın temel amacı, bir karbonik anhidraz enzim inhibitörü olan AZA’nın glutatyon mekanizması üzerine olan etkisinin renal kanserde incelenmesidir. Deneysel çalışmalarda öncelikle renal kanser hücre hattı olan CAKI-2 çoğaltılarak WST-1 sitotoksisite testi ile AZA’nın uygun dozu 48. saatte 8.65 µM olarak bulunmuştur. CAKI-2 hücrelerine AZA uygulandıktan sonra GR ve GPx üzerine olan etkisinin belirlenmesi için “Glutathione Reductase Assay Kit” ve “Glutathione Peroxidase Assay Kit” kullanılarak Epoch™ Microplate Spectrophotometer cihazında 340 nm’de ölçüm yapılmıştır. AZA uygulaması sonrası GR ve GPx enzim aktivitelerinde artış görülmüştür (p","PeriodicalId":101995,"journal":{"name":"Uludağ Üniversitesi Tıp Fakültesi Dergisi","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126541457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Cognitive Status and Long-Term Thyroid Functions in Methimazole-induced Rat Hypothyroidism Model","authors":"Oguzhan E Efe, Selda Emre Aydıngöz, K. M. Lux, E. Özer, Ayşegül Süzer, M. Tuncer","doi":"10.32708/uutfd.1081090","DOIUrl":"https://doi.org/10.32708/uutfd.1081090","url":null,"abstract":"Methimazole, a widely used agent in the treatment of hyperthyroidism, is also used to induce hypothyroidism in experimental studies. In this study, we aimed to evaluate cognitive functions in a methimazole-induced rat hypothyroidism model and also to determine long-term thyroid functions. Twelve adult female/male Wistar rats (250-300 g) were randomly divided into two groups, one of which was given 0.02% methimazole in drinking water for 4 weeks, as the other group was given normal water. After 4 weeks, Morris water maze, elevated plus maze, tail suspension test, passive avoidance test were applied. Serum free T4 and TSH levels were measured 8 weeks after discontinuation of methimazole, and thyroid tissue was evaluated histopathologically. There was no significant difference between the groups in the Morris water maze and passive avoidance test (p > 0.05). In the elevated plus maze, hypothyroid rats spent more time in the open-field (123.5  35.5 sec vs. 12.5  7.9 sec; p = 0.012); made more entries into the open and middle area (3.0  0.4 vs. 0.7  0.5; p = 0.006 and 6.2  1.2 vs. 2.8  0.7; p = 0.042, respectively). In the tail suspension test, the duration of immobility was significantly longer in the hypothyroid group (186.2  19.5 sec vs. 110.3  26.2 sec; p = 0.043). In the histopathological examination, colloid vacuolization was observed in the hypothyroid group, but serum free T4 and TSH levels did not show difference between the groups. In conclusion, methimazole-induced hypothyroidism decreases anxiety and increases tendency to depression without impairing learning and memory. Additionally, although thyroid follicle distortion is observed histopathologically, serum thyroid functions return to normal in the long-term. On this basis, further studies should be planned to elucidate the relationship between hypothyroidism and cognitive functions.","PeriodicalId":101995,"journal":{"name":"Uludağ Üniversitesi Tıp Fakültesi Dergisi","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125514306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FEMORAL ARTERY: AN ALTERNATIVE CANNULATION LOCALIZATION IN THE ANGIOGRAPHIC TREATMENT OF DYSFUNCTIONAL ARTERIOVENOUS FISTULAS. SINGLE-CENTER EXPERIENCE.","authors":"Ö. Oto, F. R. Ulusoy","doi":"10.32708/uutfd.1121595","DOIUrl":"https://doi.org/10.32708/uutfd.1121595","url":null,"abstract":"Background: Although endovascular interventions are the most commonly used treatment modalities in the treatment of dysfunctional AVFs, there is no consensus on the optimal puncture site. In this retrospective single-center study, we present the short-term clinical success rates and complications of our interventions for dysfunctional AVFs via the femoral artery. \u0000 Material Methods: 29 hemodialysis patients who were diagnosed with AVF dysfunction between January 2016 and December 2019 and therefore underwent percutaneous transluminal angioplasty (PTA) were included in this study. All PTAs were performed by the same experienced interventional cardiologist. Demographic, clinical data of the patients, and data on primary patency and procedural complications used were obtained from the hospital database and electronic records of the patient's own hemodialysis center. Detection of \"thrill\" after the procedure, successful cannulation, and adequate hemodialysis immediately after the treatment was considered a clinical success. \u0000Results \u0000A total of 29 hemodialysis patients underwent PTA due to AVF dysfunction. The median age of the patients was 61 (IQR 55.0-68.0) and 72.4% were male. 41% of patients were diabetic. The Median AVF age was 44.0 (24.0-92.0) months. Juxtaanastomotic (48.3%) and efferent venous stenosis (37.9%) were the main causes of AVF dysfunction. Paclitaxel-released balloon angioplasty was performed on 27 patients. The clinical success rate of the procedure was 93.1%. Two patients developed a local hematoma at the femoral artery puncture site; no other major or minor complications were detected. \u0000Conclusion: PTA via the femoral artery is an effective and safe treatment modality for AVF dysfunctions.","PeriodicalId":101995,"journal":{"name":"Uludağ Üniversitesi Tıp Fakültesi Dergisi","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126465897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Blood Glucose Level and Body Temperature on Prognosis in Pediatric Head Traumas","authors":"Ayşen Çakir, V. Durak, M. Ö. Taşkapilioğlu, Güven Özkaya, N. Kahveci̇","doi":"10.32708/uutfd.1066850","DOIUrl":"https://doi.org/10.32708/uutfd.1066850","url":null,"abstract":"Pediatrik kafa travması çocukluk çağının önemli mortalite ve morbidite sebepleri arasındadır. Acil servise başvuru anındaki parametrelere göre prognozun önceden bilinmesi tedavi ve yakın takip için uyarıcı olabilecektir. Bu çalışmada başvuru anındaki kan glukoz değerinin (KGD) ve vücut sıcaklığının prognoz üzerine etkisinin Modifiye Rankın Skoru ile değerlendirilmesi planlanmıştır. Çalışmada XXXXXX Üniversitesi Tıp Fakültesi Acil Servisi’ne başvuran 0-16 yaş aralığındaki 301 olgu incelenmiştir. Başvuru anındaki Glasgow Koma Skoru (GKS) ile KGD arasında ters yönde korelasyon saptanmıştır. Ayrıca GKS ile Modifiye Rankın Skoru arasında da ters yönde korelasyon gözlenirken, KGD ile Modifiye Rankın Skoru arasında pozitif yönde zayıf korelasyon saptanmıştır. Bu sonuçlar başvuru anındaki GKS’nin yanı sıra KGD’nin yüksekliğinin prognoz tayininde önemli olabileceğini göstermiştir.","PeriodicalId":101995,"journal":{"name":"Uludağ Üniversitesi Tıp Fakültesi Dergisi","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115149796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Body Mass Index Emotional Behavioral Problems and Prosocial Behaviours in Children and Adolescents","authors":"Ş. Eray, Akgün Zengi̇n, V. Şahin, Serkan Turan, C. Mutlu","doi":"10.32708/uutfd.1088803","DOIUrl":"https://doi.org/10.32708/uutfd.1088803","url":null,"abstract":"Objective: It is important to investigate the body mass indexes of children and adolescents who applied to child and adolescent psychiatry outpatient clinics and their possible relationship with prosocial characteristics, emotional and behavioral problems, to better understand the negative effects of obesity, which is a public health problem, and to offer suggestions for its solution. \u0000The aim of our study is to examine the relationship between BMI z-score, prosocial skills, and emotional behavior problems of children and adolescents who applied to the child and adolescent psychiatry outpatient clinic. \u0000Method: Our study included 130 pediatric and adolescent patients who applied to the Child and Adolescent Psychiatry outpatient clinic of Bursa Uludağ University Medical Faculty Hospital between June 2021 and September 2021. The study procedure was also verbally explained to all participants who gave written informed consent. \u0000The permission of the study was obtained from Uludağ University Non-Interventional Clinical Research Ethics Committee. \u0000The diagnosis of the patients was made using the Turkish form of the DSM-5 semi-structured interview of the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Now and Lifetime Version (CDS-PL). Emotional difficulties and prosocial characteristics of individuals were evaluated with the Strengths-Difficulties Questionnaire-Parent scale. \u0000The BMI of the patients will be measured by the same nurse by measuring their height and weight. Results: The average age of the children and adolescents participating in the study is 11.9+-3.74 years. \u0000Considering the genders, 53.4% of the participants (n:63) were female. 5.9% (n=7) of the study participants were obese, 12.7% (n=15) were overweight, 12.7% (n=42) normal weight, 37.3% (n=44) underweight, 8.5% (n=10) extremely thin. \u0000There was no difference between the genders in terms of obesity (p=0.72). \u0000Conclusion: Our study is important as it is a study that examines the relationship between prosocial characteristics and body mass index, emotional-behavioral problems and diseases of adolescents who applied during the pandemic period. \u0000Recognition of possible problems caused by obesity in children and adolescents is important in terms of predicting mental problems that may accompany and making early intervention. \u0000In addition, recognizing and meeting appropriate needs is important in terms of preventive mental health. In this sense, the increase in studies defining and investigating risk factors has an important place in terms of public health.","PeriodicalId":101995,"journal":{"name":"Uludağ Üniversitesi Tıp Fakültesi Dergisi","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115924715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilgisayarlı tomografi eşliğinde transtorasik ince iğne aspirasyon biyopsilerinde pnömotoraks risk faktörlerinin değerlendirilmesi","authors":"Erdi Tangobay, E. Birgi, Önder Eraslan, Onur Ergun, Hasanali Durmaz, Azad Hekimoğlu, Tuğba TAŞKIN TÜRKMENOĞLU, Baki Hekimoğlu","doi":"10.32708/uutfd.1074846","DOIUrl":"https://doi.org/10.32708/uutfd.1074846","url":null,"abstract":"","PeriodicalId":101995,"journal":{"name":"Uludağ Üniversitesi Tıp Fakültesi Dergisi","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134014987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sistemik Sklerozis İlişkili İnterstisyel Akciğer Hastalığında Tedavi Yanıtını İzlemede Bilgisayarlı Tomografiye Dayalı Yeni Parametreler","authors":"Duygu TEMİZ KARADAĞ, Ö. Çakır, Fatma TUNCER KURU, Ayten Yazici, Ayşe Çefle","doi":"10.32708/uutfd.1081311","DOIUrl":"https://doi.org/10.32708/uutfd.1081311","url":null,"abstract":"","PeriodicalId":101995,"journal":{"name":"Uludağ Üniversitesi Tıp Fakültesi Dergisi","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117100178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Farklı Likefaksiyon Sıcaklıklarının Semen Ozmolalitesi ve Sperm Canlılığı Üzerine Etkileri","authors":"Duru ARAS TOSUN, Elmas Yaren Sui̇çmez, Derya Gökmen, Sinan Özkavukçu","doi":"10.32708/uutfd.1082243","DOIUrl":"https://doi.org/10.32708/uutfd.1082243","url":null,"abstract":"","PeriodicalId":101995,"journal":{"name":"Uludağ Üniversitesi Tıp Fakültesi Dergisi","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121753778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}