Clinical breast cancer最新文献

{"title":"Exploring Imaging Biomarkers to Improve Equity in Supplemental and High-Risk Breast Cancer Screening Between Black and White Women: A Perspective on Background Parenchymal Enhancement and Breast Density.","authors":"Mattia A Mahmoud, Oluwadamilola M Fayanju, Anne Marie McCarthy, Carla R Zeballos Torrez, Christine E Edmonds","doi":"10.1016/j.clbc.2025.07.009","DOIUrl":"https://doi.org/10.1016/j.clbc.2025.07.009","url":null,"abstract":"<p><strong>Purpose: </strong>Breast density is recognized as a well-established risk factor for breast cancer, influencing screening recommendations. While quantitative measures of breast density have been developed to address limitations of qualitative measures, the role of racial differences in quantitative measures and their effect on breast cancer risk, especially in Black women, remains unclear. Additionally, while background parenchymal enhancement (BPE) is an established as a predictor of breast cancer risk, no research has been conducted to investigate whether the impact of BPE varies by race or ethnicity. This perspective reviews existing data on BPE, specifically its relationship with breast density and breast cancer risk and emphasizes the need for further investigation in Black women.</p><p><strong>Discussion: </strong>Current supplemental screening methods are heavily reliant on qualitative breast density assessments, which may disadvantage Black women. Although BPE has been significantly associated with breast cancer risk independent of breast density, no studies were found that explored the relationship between BPE and breast cancer risk in Black women.</p><p><strong>Conclusion: </strong>The limited data on absolute quantitative density measures, such as dense volume, which could improve screening practices, is highlighted in this review. While BPE is well-established as a breast cancer risk factor, further research is needed to investigate racial differences in BPE and its association with breast cancer risk, particularly among Black women.</p>","PeriodicalId":10197,"journal":{"name":"Clinical breast cancer","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention's Price-30-Day Outcomes of Risk-Reducing Mastectomy and Immediate Free Flap Breast Reconstruction.","authors":"Samuel Knoedler, Fortunay Diatta, Kevin Hu, Felix Klimitz, Julius M Wirtz, Thomas Schaschinger, Filippo A G Perozzo, Giuseppe Sofo, Francesco Marena, Bong-Sung Kim, Bohdan Pomahac, Martin Kauke-Navarro","doi":"10.1016/j.clbc.2025.07.003","DOIUrl":"https://doi.org/10.1016/j.clbc.2025.07.003","url":null,"abstract":"<p><strong>Background: </strong>Risk-reducing mastectomy (RRM) with free flap breast reconstruction (FFBR) is increasingly utilized for breast cancer prevention. While its oncological benefits are well-established, data on perioperative safety remain limited. To address this gap, we analyzed postoperative outcomes and risk factors for complications utilizing the American college of surgeons national surgical quality improvement program (ACS-NSQIP) database.</p><p><strong>Methods: </strong>The American college of surgeons national surgical quality improvement program (ACS-NSQIP) (2008-2022) database was queried to identify adult female patients who underwent RRM-FFBR. Primary outcomes included 30-day rates of reoperation, readmission, and surgical or medical complications. Confounder-adjusted multivariate logistic regression was used to identify factors associated with postoperative complications.</p><p><strong>Results: </strong>A total of 985 patients were included, with a mean age and BMI of 46 ± 9.4 years and 31 ± 5.7 kg/m², respectively. The most common comorbidities were obesity (n = 492; 50%) and hypertension (n = 170; 17%). Complications occurred in 171 (17%) cases, with 134 (14%) reoperations and 69 (7.0%) readmissions. 125 (13%) surgical complications were recorded, the majority of which were bleeding events (n = 105; 11%). Medical complications were rare (n = 33; 3.4%). Multivariable analyses revealed that higher hypertension (OR 1.8; 95% CI, 1.1-2.8; P = .017) and diabetes (OR 2.2.; 95% CI, 1.1-4.6; P = .031) were significantly associated with the occurrence of postoperative complications.</p><p><strong>Conclusion: </strong>This multi-institutional study revealed 30-day complication and reoperation rates of 17% and 14%, respectively, following RRM-FFBR. Hypertension and diabetes were significant predictors of postoperative morbidity. Preoperative optimization of these modifiable risk factors may help improve surgical outcomes. These findings underscore the importance of individualized patient management and informed decision-making in RRM-FFBR.</p>","PeriodicalId":10197,"journal":{"name":"Clinical breast cancer","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Farnesyltransferase Inhibitor (R115777) Targets CENPF to Inhibit Breast Cancer Bone Metastasis by Regulating the PI3k/AKT/mTOR/PTHrP Pathway.","authors":"Jialong Liu, Jingbo Sun, Hongquan Fang, Junjie Luo, Mee Phangphongphanh, Yang Zou, Yiyi Jin, Xinyi Tao, Kun Zhou, Yunyao Deng, Lixin Liu, Gang Xiao, Ninglei Li, Xiaolong Liu","doi":"10.1016/j.clbc.2025.07.002","DOIUrl":"https://doi.org/10.1016/j.clbc.2025.07.002","url":null,"abstract":"<p><strong>Background: </strong>Farnesyltransferase inhibitor R115777 has shown promising antitumor effects in various types of cancer by targeting RAS proteins and CENPF farnesylation. To explore its potential in breast cancer (BC), In our study, we aimed to uncover its specific efficacy and underlying mechanisms.</p><p><strong>Methods: </strong>Through knockdown experiments, we observed that inhibiting CENPF effectively suppressed the growth and metastasis of BC cells, both in vitro and in vivo.</p><p><strong>Results: </strong>Remarkably, R115777 displayed a selective affinity for CENPF, leading to the inhibition of its-mediated proliferation and bone metastasis in BC cells. Further investigation unveiled that this inhibitory effect was linked to the activation of the PI3K-AKT-mTOR signaling pathway by R115777. Consequently, the secretion of parathyroid hormone-related peptide (PTHrP), a factor crucial for bone marrow development, was detected and inhibited by R115777. As a result, this cascade of events significantly impeded bone metastasis in BC.</p><p><strong>Conclusion: </strong>Our findings highlight the potential of R115777 as a novel therapeutic strategy for preventing bone metastasis in breast cancer. By specifically targeting CENPF and modulating the PI3K-AKT-mTORC1 pathway, R115777 emerges as a promising targeted treatment option in combating the progression and metastasis of breast cancer.</p>","PeriodicalId":10197,"journal":{"name":"Clinical breast cancer","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Interrelationships of Lymphedema with Pain, Physical Function, and Demographic and Medical Variables in Women with Breast Cancer and Pain.","authors":"Grace H Amaden, Kelly A Hyland, Joseph G Winger, Sarah A Kelleher, Allison K Diachina, Shannon N Miller, Kelly Westbrook, Gretchen Kimmick, Linda Sutton, Mei R Fu, Tamara J Somers","doi":"10.1016/j.clbc.2025.07.008","DOIUrl":"https://doi.org/10.1016/j.clbc.2025.07.008","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the relationship of lymphedema with pain, physical function, and demographic and medical variables in women with breast cancer and pain.</p><p><strong>Methods: </strong>Secondary analysis of baseline data from a study of women with breast cancer and pain. Self-report questionnaires assessed lymphedema, pain severity, pain medication use behavior, pain-related cognitions (ie, pain self-efficacy, pain catastrophizing), and physical function (ie, basic and intermediate activities of daily living (ADLs)). Demographic and medical variables were extracted from the medical record. Univariate analyses examined relationships among lymphedema and variables of interest.</p><p><strong>Results: </strong>Women (N = 347, M_age = 57 years, 63% White) reported moderate pain severity (M = 4.04). Twenty-six percent of women (n = 85) reported having lymphedema. Women with lymphedema endorsed greater pain severity (P = .007) and pain catastrophizing (P = .015) than women without lymphedema; groups did not differ on pain medication use or pain self-efficacy. Women with lymphedema reported a reduced capacity to complete intermediate ADLs compared to women without lymphedema (P = .044); groups did not differ on ability to complete basic ADLs. Women with lymphedema were more likely to be non-White, have lower educational attainment, have undergone lymph node removal or dissection, and received radiation therapy.</p><p><strong>Conclusion: </strong>In women with breast cancer and moderate pain, lymphedema is associated with greater pain severity and pain catastrophizing, and decreased ability to complete intermediate ADLs. Women with lymphedema and pain may benefit from tailored, accessible cognitive-behavioral-physiological interventions to improve self-management (eg, Pain Coping Skills Training, interventions to promote lymph flow and reduce inflammation). Disparities in lymphedema prevalence by race and education warrant further exploration.</p>","PeriodicalId":10197,"journal":{"name":"Clinical breast cancer","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physician and Software Assessed Cosmetic Outcomes Following Whole Breast or Partial Breast Radiation Therapy for Breast Cancer.","authors":"Anna Okabe, Wai Lone J Ho, May Lin Tao, Jason C Ye","doi":"10.1016/j.clbc.2025.07.006","DOIUrl":"https://doi.org/10.1016/j.clbc.2025.07.006","url":null,"abstract":"<p><strong>Aim: </strong>This study aims to compare the cosmetic outcomes in early-stage breast cancer patients treated with whole breast irradiation (WBI) or partial-breast irradiation (PBI), using both subjective and objective tools, to assess clinical factors contributing to cosmesis scores, and to compare radiation toxicity outcomes.</p><p><strong>Methods: </strong>Breast cosmesis was scored by using the physician-rated Harvard cosmesis scale at the time of consultation and at each follow-up visit and objectively using the BCCT.core software on standardized photographs.</p><p><strong>Results: </strong>Ninety-nine patients received WBI, and thirty-six received PBI. 91% of patients treated with WBI and 86.1% with PBI scored excellent/good by physician ratings at follow-up vs. 68.4% and 72.2 % by BCCT.core software. Agreement between both tools was low (κ = 0.057 for WBI patients and κ = 0.012 for PBI patients). There was less than a 15% decline in physician-rated cosmetic scores for either WBI or PBI patients, but a 27.3% decline for WBI patients by BCCT.core software scoring. There was no association of prone vs. supine position, tumor bed boost, fractionation scheme, or addition of regional nodal irradiation with long-term cosmesis scores determined by either assessment tool, except for oncoplastic surgery which was associated with a higher score.</p><p><strong>Conclusions: </strong>Breast cosmesis scores after either WBI or PBI are favorable; however, the agreement between physician rating and the BCCT.core software is poor. The BCCT.core software was more likely to indicate a decline in cosmetic results over time. Surgical outcomes may be the most impactful clinical factor in predicting long-term breast cosmesis.</p>","PeriodicalId":10197,"journal":{"name":"Clinical breast cancer","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Area Deprivation Index (ADI) as a Predictor of Surgical Complications in Patients Undergoing Mastectomy.","authors":"Felix J Klimitz, Laetitia S Chiarella, Lioba Huelsboemer, Stav Brown, Sam Boroumand, Alejandro Kochen, Alexander J Kammien, SeungJu Jackie Oh, Martin Kauke-Navarro, Fortunay Diatta, Bohdan Pomahac","doi":"10.1016/j.clbc.2025.07.004","DOIUrl":"https://doi.org/10.1016/j.clbc.2025.07.004","url":null,"abstract":"<p><strong>Introduction: </strong>Socioeconomic disparities significantly influence health outcomes, particularly in surgical care. The Area Deprivation Index (ADI), a comprehensive measure of neighborhood-level socioeconomic status, is increasingly recognized as a predictor of clinical outcomes. This study examines the association between ADI and postoperative complications in patients undergoing mastectomy, hypothesizing that higher ADI scores correlate with worse outcomes.</p><p><strong>Methods: </strong>A retrospective cohort analysis was conducted using the ACS-NSQIP database to evaluate 1141 female patients who underwent mastectomy between 2017 and 2022. Patients were categorized into tertiles based on their ADI scores. Preoperative characteristics, surgical details, and 30-day postoperative outcomes were analyzed. Statistical significance was assessed using chi-square tests for categorical variables and ANOVA for continuous variables.</p><p><strong>Results: </strong>Patients in the highest ADI tertile had significantly higher rates of medical complications (17.3%) compared to those in the lowest tertile (9.2%, P = .01). Pneumonia was notably more frequent in the most deprived group (4.7% vs. 0.8%, P = .01). Other complications, such as unplanned readmissions and surgical complications, showed no significant differences between tertiles. Black patients were disproportionately represented in the highest ADI tertile, highlighting intersectional disparities. Household income and insurance type varied significantly across ADI tertiles, reflecting broader socioeconomic inequities.</p><p><strong>Conclusion: </strong>Higher ADI scores are associated with increased medical complications, particularly pneumonia, in mastectomy patients. These findings emphasize the importance of integrating socioeconomic factors into surgical risk assessments and developing targeted interventions to address disparities in care and outcomes.</p>","PeriodicalId":10197,"journal":{"name":"Clinical breast cancer","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidden Costs of Endocrine Therapy for Black Breast Cancer Survivors: A Qualitative Examination of Patient and Provider Experiences.","authors":"Kimberley T Lee, Carley Geiss, Hayden J Fulton, Dannelle Charles, Brian D Gonzalez, Heather S L Jim, N Lynn Henry, Dawn L Hershman, Shelley S Tworoger, Angela Bradbury, Oluwadamilola M Fayanju, Susan T Vadaparampil, Clement K Gwede","doi":"10.1016/j.clbc.2025.06.010","DOIUrl":"https://doi.org/10.1016/j.clbc.2025.06.010","url":null,"abstract":"<p><strong>Background: </strong>Non-adherence to endocrine therapy (ET) remains an unsolved clinical issue that decreases rates of survival. Non-white race and socioeconomic status have been associated with ET non-adherence, but the reasons for these disparities are unclear. Addressing this issue effectively requires the characterization of the contributing factors to these inequities. This qualitative study aims to explore the influence of race and socioeconomic status on ET adherence through the perspectives of Black breast cancer survivors (BCS) and oncology providers.</p><p><strong>Methods: </strong>We conducted individual semi-structured interviews with 24 Black BCS and 9 providers at a single cancer center.</p><p><strong>Results: </strong>BCS had a median age of 55 years (IQR = 17 years). About 1/4 had ≤high school diploma (26.1%) and 37.7% completed ≥college education. About 1/3 of BCS had annual household incomes of ≤$40,000 (30.4%), $40,000 to $100,000 (34.8%), or ≥$100,000 (34.8%). Forty-three percent of BCS had private insurance; 39.1% were insured through Medicaid, Medicare, or the federal healthcare exchange; 13% were uninsured. Five qualitative themes emerged from both patients and providers: (1) Limited access to initial and continued care; (2) patient discomfort, distrust, and fear of discrimination; (3) cost of ET can be a barrier to adherence; (4) costs of managing symptoms can be a barrier to adherence; and (5) time toxicity - time and effort needed to coordinate symptom management.</p><p><strong>Conclusions: </strong>In addition to cost of ET medications, we identified additional financial and time toxicity related to side-effect management. Black BCS face a myriad of costs which can potentially impact ET adherence.</p>","PeriodicalId":10197,"journal":{"name":"Clinical breast cancer","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential Role of Ubiquitin-Conjugating Enzyme E2C (UBE2C) in Breast Cancer Progression by Regulating the JNK Signaling Pathway.","authors":"Siqi Liu, Xin Sun, Na Liu, Fangcai Lin","doi":"10.1016/j.clbc.2025.07.001","DOIUrl":"https://doi.org/10.1016/j.clbc.2025.07.001","url":null,"abstract":"<p><strong>Background: </strong>We explored the relation and critical roles of ubiquitin-conjugating enzyme E2C (UBE2C) in breast cancer (BC).</p><p><strong>Methods: </strong>The UBE2C expression levels and relation with clinical features and prognosis in BC patients were examined using online data. UBE2C expression in BC cell lines was assessed using quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and western blot. To assess cell proliferation, migration, invasion, and apoptosis, tests were conducted using CCK-8, colony formation assay, wound healing assay, transwell assay, and flow cytometry. Subcutaneous tumor model was used to evaluate the effects of UBE2C on tumor growth in mice. The effects of UBE2C on tumor formation in mice were assessed by subcutaneous tumor model, and UBE2C, E-cadherin, Ki-67, and p53 were detected by an immunohistochemistry assay. Finally, the connection of UBE2C with Epithelial-mesenchymal transition markers and proteins of proliferation, apoptosis, JNK pathway were tested by western blot.</p><p><strong>Results: </strong>UBE2C was upregulated in BC tissues in TCGA and Gene expression omnibus (GEO) datasets, and high levels UBE2C was correlated with the advanced stage cases, some molecular types and poor prognosis in BC patients. In vitro, UBE2C was also overexpressed in BC cell lines, and suppressed apoptosis and encouraged cell growth, migration, invasion, and metastasis. Moreover, UBE2C knockdown suppressed the growth of transplanted tumor in mice.</p><p><strong>Conclusions: </strong>These results suggested that UBE2C facilitated the process of proliferation, metastasis through the modulation of the JNK signaling pathway, highlighting a previously underexplored mechanistic axis and predicting the potentiality of UBE2C as a therapeutic target for BC patients.</p>","PeriodicalId":10197,"journal":{"name":"Clinical breast cancer","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Level 1 Oncoplastic Technique for Breast Conserving Surgery: The Rhomboid Rotation Glandular Flap.","authors":"Ashley DiPasquale, Anna Paula Maiato, Jenny-Claude Millochau, Isabelle Sarfati, Claude Nos, Krishna B Clough","doi":"10.1016/j.clbc.2025.06.014","DOIUrl":"https://doi.org/10.1016/j.clbc.2025.06.014","url":null,"abstract":"<p><p>OPS techniques have many advantages over standard lumpectomies. They allow for immediate breast reshaping, helping to eliminate postoperative defects, and they offer wider resection possibilities. Level I OPS techniques are those employed when less than 20% of the breast volume is excised, and no mammoplasty is needed for reshaping. In this article, we present a level-1 rhomboid glandular rotational flaps (GRF) that can effectively treat any quadrant defect that involves excision of less than 20% of the breast volume in select patients. This paper provides details on patient selection, surgical technique, and potential complications associated with this procedure.</p>","PeriodicalId":10197,"journal":{"name":"Clinical breast cancer","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extended Discussion on the Dutch Study: Future Directions for Precision in Chemotherapy Indications for Breast Cancer.","authors":"Mufeng Liang","doi":"10.1016/j.clbc.2025.06.013","DOIUrl":"https://doi.org/10.1016/j.clbc.2025.06.013","url":null,"abstract":"","PeriodicalId":10197,"journal":{"name":"Clinical breast cancer","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}