Circulation research最新文献

{"title":"Order From Noise: What the Pacemaker Pays for Stochastic Resonance.","authors":"L Fernando Santana, Colleen E Clancy","doi":"10.1161/CIRCRESAHA.126.329305","DOIUrl":"https://doi.org/10.1161/CIRCRESAHA.126.329305","url":null,"abstract":"","PeriodicalId":10147,"journal":{"name":"Circulation research","volume":"139 5","pages":"e329305"},"PeriodicalIF":18.0,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13474614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AMPKγ2 Meets Myosin: A New Link Between Metabolism and Sarcomere Function.","authors":"Shanshan Gao, Suet Nee Chen, Matthew R G Taylor, Luisa Mestroni","doi":"10.1161/CIRCRESAHA.126.329303","DOIUrl":"https://doi.org/10.1161/CIRCRESAHA.126.329303","url":null,"abstract":"","PeriodicalId":10147,"journal":{"name":"Circulation research","volume":"139 5","pages":"e329303"},"PeriodicalIF":18.0,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13474711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Single-Cell Atlas of Cardiac Endothelial Cell Heterogeneity in Pressure Overload.","authors":"Giulia Demenego, Simone Puccio, Giada Andrea Cassanmagnago, Fabrizio Gianferro, Pierluigi Carullo, Gabriele De Simone, Federico S Colombo, Marcello Rubino, Gianluca Basso, Enrico Lugli, Carolina M Greco, Clelia Peano, Gianluigi Condorelli","doi":"10.1161/RES.0000000000000765","DOIUrl":"https://doi.org/10.1161/RES.0000000000000765","url":null,"abstract":"","PeriodicalId":10147,"journal":{"name":"Circulation research","volume":"139 5","pages":"e000765"},"PeriodicalIF":18.0,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet Reactivity and Sex Differences: Clinical Implications for Women.","authors":"Anu Aggarwal, Tessa J Barrett, Puja K Mehta, Michael C Honigberg, Judith M E M Cosemans, Wendy A Goodman, Niti R Aggarwal, Michael Holinstat, Leslie Cho, Scott J Cameron","doi":"10.1161/CIRCRESAHA.126.328602","DOIUrl":"10.1161/CIRCRESAHA.126.328602","url":null,"abstract":"<p><p>Platelets are central to hemostasis and thrombosis. Excessive platelet activation contributes to arterial thrombotic events, including myocardial infarction, ischemic stroke, and complications of peripheral artery disease, whereas excessive platelet inhibition increases bleeding risk. Antiplatelet therapy remains a cornerstone of secondary prevention in atherosclerotic and thrombotic cardiovascular diseases, yet current treatment paradigms do not fully account for biological heterogeneity in platelet function, including differences related to sex, age, hormonal status, and disease context. This state-of-the-art review examines current antiplatelet strategies, fundamental mechanisms of signal transduction, clinical indications, and limitations of preclinical and clinical studies, with a focus on sex-specific considerations and opportunities for personalized antiplatelet therapy. Aspirin and P2Y₁₂ receptor antagonists are widely used for secondary prevention. However, women have been underrepresented in many pivotal clinical trials, limiting the precision of sex-specific estimates of efficacy and bleeding risk. In parallel, commonly used preclinical models often fail to recapitulate the physiological conditions in which platelets interact with the vasculature, leukocytes, and soluble factors. Emerging therapeutic approaches seek to refine platelet inhibition by targeting pathways that reduce thrombotic risk while preserving hemostasis. Advancing antiplatelet therapy will require integration of mechanistic platelet biology with diverse clinical trial populations, standardized platelet phenotyping, and disease-specific approaches that account for how platelet function is altered across health and vascular disease.</p>","PeriodicalId":10147,"journal":{"name":"Circulation research","volume":"139 5","pages":"e328602"},"PeriodicalIF":18.0,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13479948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation.","authors":"Michail Spanos, Priyanka Gokulnath, Gaurav Behera, Christopher Azzam, Saumya Das","doi":"10.1161/CIRCRESAHA.126.327198","DOIUrl":"https://doi.org/10.1161/CIRCRESAHA.126.327198","url":null,"abstract":"<p><p>Cardiovascular diseases remain the leading global cause of mortality, highlighting the need for improved early detection and targeted interventions. Extracellular vesicles (EVs) are nano-sized, bilipid-layered particles released by all cell types that carry RNAs, proteins, lipids, and metabolites reflective of their parent cells. They mediate intercellular communication by transferring cargo that alters recipient cell transcriptomic and proteomic states, and this property may be leveraged for therapeutic delivery. This review provides a comprehensive, cardiovascular disease-focused synthesis of EV biology with emphasis on what is clinically actionable and mechanistically novel. The review describes EV biogenesis and their multiomic cargo composition, followed by tissue-resolved and cell type-resolved EV signaling across cell types relevant to cardiovascular disease. A dedicated section addresses EV-mediated interorgan crosstalk across the heart-kidney, heart-liver, brain-heart, and adipose-heart axes as a systems-level framework for cardiometabolic disease. We next turn to translational applications, describing EV cargo composition under pathological conditions with implications for disease-related signaling and the potential for biomarker development. For liquid biopsy applications, the review introduces a 3-tier evidence framework classifying circulating EV biomarkers by clinical validation status, supported by a practical preanalytical checklist for cardiovascular plasma studies. Engineered, stem cell-derived, and RNA-loaded EV therapeutic modalities are evaluated, and active clinical trials are catalogued along with key challenges in cargo loading, biodistribution, immunogenicity, and regulatory standardization. We conclude with a structured future directions and perspectives section identifying the most tractable open questions required to advance EVs from discovery to cardiovascular clinical practice.</p>","PeriodicalId":10147,"journal":{"name":"Circulation research","volume":"139 5","pages":"e327198"},"PeriodicalIF":18.0,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13474702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet the First Authors.","authors":"","doi":"10.1161/RES.0000000000000766","DOIUrl":"https://doi.org/10.1161/RES.0000000000000766","url":null,"abstract":"","PeriodicalId":10147,"journal":{"name":"Circulation research","volume":"139 5","pages":"e000766"},"PeriodicalIF":18.0,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis Is Not Vascularly Inert: Proatherogenic Inflammation in Youth.","authors":"Caitlin Giannis, Mark Chandy, Leila Mohammadi, Naomi M Hamburg","doi":"10.1161/CIRCRESAHA.126.329347","DOIUrl":"https://doi.org/10.1161/CIRCRESAHA.126.329347","url":null,"abstract":"","PeriodicalId":10147,"journal":{"name":"Circulation research","volume":"139 5","pages":"e329347"},"PeriodicalIF":18.0,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shifting the Balance: Mitochondrial Heteroplasmy as a Driver of Cardiac Disease.","authors":"Andriana Papadaki, Itamar Braga Dias, Christoph Maack, Peter van der Meer, Nils Bomer","doi":"10.1161/CIRCRESAHA.126.328769","DOIUrl":"https://doi.org/10.1161/CIRCRESAHA.126.328769","url":null,"abstract":"<p><p>Mitochondrial heteroplasmy represents a fundamental determinant of mitochondrial function and disease, yet its consequences vary across different tissues. Although mitotic tissues possess mechanisms, such as cell division and mitochondrial turnover, to dilute or remove deleterious variants, postmitotic tissues lack this renewal capacity and are disproportionately vulnerable. Neuromuscular and neurodegenerative disorders have illustrated the impact of heteroplasmic mutations, but the (postmitotic) heart remains underexplored. Current reliance on blood-derived samples provides only an indirect view of cardiac heteroplasmy, highlighting the need for alternative approaches, such as endomyocardial biopsies and human induced pluripotent stem cell-derived cardiomyocytes. Expanding cardiac-focused research is essential for identification, clarifying pathogenesis, improving risk stratification, and guiding patient monitoring. Emerging therapies, including mitochondrial transplantation and mitochondrial-targeted DNA editing, demonstrate potential to modulate heteroplasmy and restore equilibrium. Integrating these strategies with precision medicine will be vital for addressing tissue-specific vulnerabilities. Ultimately, bridging the gap in cardiac heteroplasmy research will be critical for translating basic mitochondrial biology into meaningful clinical advances.</p>","PeriodicalId":10147,"journal":{"name":"Circulation research","volume":"139 5","pages":"e328769"},"PeriodicalIF":18.0,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13475731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipose-Myocardial Border in Atrial Fibrillation.","authors":"Timothy Fitzgibbons, Khanh-Van Tran","doi":"10.1161/CIRCRESAHA.126.329119","DOIUrl":"https://doi.org/10.1161/CIRCRESAHA.126.329119","url":null,"abstract":"","PeriodicalId":10147,"journal":{"name":"Circulation research","volume":"139 5","pages":"e329119"},"PeriodicalIF":18.0,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13474729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging Disrupts L-type Ca²⁺ Channel Organization and Function in Pacemaker Cells.","authors":"Oscar Vivas, Matthias Baudot, Roxanne Madden, Wendy L Piñon-Teal, Martina S Hunt, Sabrina Choi, Roya Pournejati, Victor A Flores-Tamez, L Fernando Santana, Claudia M Moreno","doi":"10.1161/CIRCRESAHA.125.327894","DOIUrl":"10.1161/CIRCRESAHA.125.327894","url":null,"abstract":"<p><strong>Background: </strong>Every heartbeat is initiated by a spontaneous electrical signal generated inside the cardiac pacemaker. This signal depends on the coordinated activity of ion channels, where voltage-gated L-type calcium channels play a central role. All mammals experience a progressive decline in pacemaker rate with age, which in humans can become pathological and drive the need for artificial pacemaker implantation. Yet the mechanisms underlying this age-associated slowdown remain incompletely understood.</p><p><strong>Methods: </strong>We combined patch-clamp electrophysiology, single-channel recording, calcium imaging, immunocytochemistry, and super-resolution microscopy to investigate L-type calcium channel density, organization, and function in sinoatrial node pacemaker cells from young and old mice.</p><p><strong>Results: </strong>Aging reduced L-type calcium channel density at the plasma membrane, disrupted channel clustering, and decreased open probability, collectively diminishing calcium current density by 50%. Pharmacological enhancement of channel open probability with Bay K 8644 was sufficient to accelerate diastolic depolarization and restore pacemaker rate in old cells to young levels. These channel alterations were paralleled by a decline in caveolin-3 expression. Disrupting caveolae in young cells recapitulated the loss of channel clustering, pointing to caveolae as a structural basis for the age-associated channel alterations.</p><p><strong>Conclusions: </strong>Aging impairs L-type calcium channel organization and function in cardiac pacemaker cells. This impairment is mediated by an age-associated reduction of caveolae, key membrane microdomains for channel organization. The resulting decline in L-type calcium channel density and activity is an important driver of the age-associated slowdown of the cardiac pacemaker.</p>","PeriodicalId":10147,"journal":{"name":"Circulation research","volume":" ","pages":"e327894"},"PeriodicalIF":18.0,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13418876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}