中华神经科杂志最新文献

{"title":"Acute necrotizing encephalitis caused by respiratory coronavirus-NL63: a case report","authors":"Y. Han, C. Song","doi":"10.3760/cma.j.cn113694-20210120-00052","DOIUrl":"https://doi.org/10.3760/cma.j.cn113694-20210120-00052","url":null,"abstract":"Coronavirus-NL63 is a common respiratory virus, which often causes severe respiratory symptoms such as fever, cough, expectoration, pneumonia and so on. The damage of central nervous system is rare. A case of acute necrotizing encephalitis caused by respiratory coronavirus-NL63 infection with cognitive impairment as the first symptom is reported, finding of CT/magnetic resonance imaging scanning indicating necrosis combined with a striated encephalomalacia of the corpus callosum and bilateral cerebral hemispheres.","PeriodicalId":10143,"journal":{"name":"中华神经科杂志","volume":"123 1","pages":"693-695"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76663288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of coronavirus disease 2019 with tuberculous meningitis","authors":"Liang Wang, J. Cai, H. Luo, H. Guan, Hongzhi Wang, Cheng Huang, F. Zhou","doi":"10.3760/CMA.J.CN113694-20200302-00134","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113694-20200302-00134","url":null,"abstract":"Novel coronavirus pneumonia, also known as coronavirus disease 2019 (COVID-19), is caused by a new coronavirus that infects the lungs. Although some patients with COVID-19 may be combined with neurological symptoms, there is no direct evidence that this new coronavirus can directly invade nerve system. A case of COVID-19 with tuberculous meningitis is reported to remind that when patients with COVID-19 present symptom of encephalitis or meningitis, a comprehensive pathogen examination is recommended. \u0000 \u0000Key words: \u0000Corona virus disease 2019; Novel coronavirus pneumonia; Meningitis, tuberculous","PeriodicalId":10143,"journal":{"name":"中华神经科杂志","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81007176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the mental health of patients with novel coronavirus pneumonia/ 中华神经科杂志","authors":"Qian Zhao, Caihong Hu, Renjie Feng, Yuan Yang","doi":"10.3760/CMA.J.CN113694-20200220-00102","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113694-20200220-00102","url":null,"abstract":"Objective \u0000To evaluate the status and influencing factors of the mental health of patients with COVID-19 during isolation treatment. \u0000 \u0000 \u0000Methods \u0000From February 2nd to 16th, 2020, 106 COVID-19 patients were anonymously investigated for their mental health status using onlinequestionnaires (including Patient Health Questionnaire-9, Generalized Anxiety Disorder Scale-7, Patient Health Questionnaire-15 scales). The patients were from Tongji Hospital Affiliated to Tongji Medical College ofHuazhong University of Science and Technology. After data processing, SPSS19.0 was used for statistical analysis. \u0000 \u0000 \u0000Results \u0000Of the 106 COVID-19 patients, 46 were male and 60 were female, with an age of (35.90±11.92) years. The detection rates of depression, anxiety and somatic symptoms in those patients were 49.06% (52/106) , 56.60% (60/106) and 69.81% (74/106) respectively. The severe cases of depression (scale score greater than 19) , anxiety (scale score greater than 14) and somatic symptoms (scale score greater than 14) accounted for 9.43% (10/106) , 15.09% (16/106) and 20.75% (22/106) respectively. In addition, 67.92% (72/106) of the patients had sleep problems, 24.53% (26/106) had self-mutilating or suicidal thoughts, and 28.30% (30/106) required psychological counseling—all of which were at significantly higher percentages than those of the general population. Only 39.62% (42/106) of the examined patients had neither deression nor anxiety. By using the non-parametric test of rank conversion for analysis, and the results showed that both married patients and nucleic-acid-positive patients had more severe depressions, and both married patients and anoxemicpatients had more severe somatic symptoms. \u0000 \u0000 \u0000Conclusion \u0000This mental health assessment showed that depression, anxiety, and various somatic symptoms exist among the COVID-19 patients, and therefore early identification and intervention should be conducted to avoid extreme events such asself-mutilating or suicidal impulsivity, with a greater focus on both married patients and patients with severe symptoms. \u0000 \u0000 \u0000Key words: \u0000COVID-19; Depression; Anxiety; Somatic symptoms","PeriodicalId":10143,"journal":{"name":"中华神经科杂志","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88723318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical, imaging, intestinal pathological characteristics of gluten ataxia: a case report in Chinese mainland","authors":"Weihe Zhang, Wei Wang, Jie Luo, Geng Qin, J. Jiao, Yu Wang, Yi Jin, Zhengyun Li, W. Gu","doi":"10.3760/CMA.J.ISSN.1006-7876.2019.02.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-7876.2019.02.006","url":null,"abstract":"Objective \u0000To investigate the clinical, imaging, intestinal pathological characteristics and prognosis of gluten ataxia (GA). \u0000 \u0000 \u0000Methods \u0000The clinical data, treatment and prognosis in a patient with GA that was confirmed by pathology and hospitalized in the Department of Neurology, China-Japan Friendship Hospital in July 2018, were analyzed retrospectively. The related literature was reviewed and the clinical feature was summarized. \u0000 \u0000 \u0000Results \u0000The patient is a 41-year old man. He suffered from progressive cerebellar ataxia, and the brain magnetic resonance imaging exhibited diffused cerebellar atrophy. Serum human leukocyte antigen (HLA) tests showed that the patient carried HLA-DQ2 genotype. IgA type anti-gliadin antibody was positive (39.39 RU/ml). Duodenoscopy biopsy revealed mild villus atrophy and lymphocytic infiltration, indicating celiac disease. The diagnosis of GA was established then and the patient was administered gluten-free diet combined with intravenous immunoglobulin, which markedly improved the cerebellar symptoms and signs of cerebellar speech, walk capability and daily living activities. He could do long distance driving independently two months later. \u0000 \u0000 \u0000Conclusions \u0000GA is one of immune-mediated reversible acquired cerebellar ataxia caused by gluten sensitivity. The genotype, serologic features, and clinical phenotype of GA in Chinese mainland population might be similar with those in European and American countries. \u0000 \u0000 \u0000Key words: \u0000Cerebellar ataxia; Glutens; Celiac disease; Biopsy; Anti-gliadin antibodies","PeriodicalId":10143,"journal":{"name":"中华神经科杂志","volume":"6 1","pages":"110-115"},"PeriodicalIF":0.0,"publicationDate":"2019-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82290676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on CT perfusion surface permeability of cerebral hemorrhage in the basal ganglia region in subacute stage","authors":"Jincheng Wang, Haoli Xu, Shuailiang Liu, Yue Zhang, Jinjin Liu, Wenwen He, X. Qin, Yunjun Yang, Q. Zhuge, K. Jin, Weijian Chen","doi":"10.3760/CMA.J.ISSN.1006-7876.2017.03.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-7876.2017.03.009","url":null,"abstract":"Objective \u0000To investigate alterations of permeability of surface (PS) in subacute stage patients with intracerebral hemorrhage (ICH) using computed tomography perfusion imaging (CTPI), and analyze relationships between PS and other factors. \u0000 \u0000 \u0000Methods \u0000CTPI was performed in 35 patients in subacute stage (4 days-2 weeks) after onset of ICH, who were recruited in the Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University from November 2015 to June 2016. Hematoma and edema volumes were measured, and perfusion parameters of perihematoma and mirror hemisphere side of marginal zone and outer zone of hematoma, including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), PS, and relative value (ipsilateral/contralateral) of CBF (rCBF), CBV (rCBV), MTT (rMTT) and PS (rPS), were calculated. Relationships between volumes of hematoma and edema, time from onset to CTPI performance, NIHSS scores and PS of perihematoma zone were analyzed by Pearson correlation analysis. \u0000 \u0000 \u0000Results \u0000The perihematoma PS ((1.87±0.48) ml·100 g-1·min-1) was higher than that in contralateral regions ((1.28±0.34) ml·100 g-1·min-1;t=-12.407, P 0.05). There were 20 patients with hematoma volume less than 10 ml and 15 patients with hematoma volume more than 10 ml, while the mean value of perihematoma PS of them showed no statistically significant difference (P>0.05). And there were no statistically significant correlations between perihematoma PS and NIHSS scores at the time of admission, CTPI examination and discharge (all P>0.05). \u0000 \u0000 \u0000Conclusions \u0000In subacute stage of ICH, the blood brain barrier permeability of perihematoma area is still abnormal, manifested as PS increases. The perihematoma PS positively correlates with the time of ICH onset. CTPI can accurately reflect this change, and potentially provide valuable information for evaluation and individual treatment of patients. \u0000 \u0000 \u0000Key words: \u0000Intracerebral hemorrhage; Tomography, X-ray computed; Perfusion; Capillary permeability; Subacute stage","PeriodicalId":10143,"journal":{"name":"中华神经科杂志","volume":"293 1","pages":"201-207"},"PeriodicalIF":0.0,"publicationDate":"2017-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78509265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial exploration on clinical application of resting-state functional magnetic resonance imaging amplitude of low-frequency fluctuation method on cognitive impairment in amyotrophic lateral sclerosis","authors":"Peng Pan, Li Xiaolu, C. Liying, Hou Bo, F. Feng, Shen Dongchao","doi":"10.3760/CMA.J.ISSN.1006-7876.2017.01.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-7876.2017.01.007","url":null,"abstract":"Objective \u0000To explore diagnostic value of amplitude of low-frequency fluctuation (ALFF) on cognitive impairment in amyotrophic lateral sclerosis (ALS) using resting-state functional magnetic resonance imaging (MRI). \u0000 \u0000 \u0000Methods \u0000Sixteen ALS patients from neurological clinic in Peking Union Medical College Hospital were enrolled between November 2013 and April 2015. The patients were divided into two groups by the presence (ALSi, n=7) or absence (ALSu, n=9) of cognitive impairment. Routine MRI structural images and resting-state functional MRI were collected for comparison between groups through voxel-based morphometry (VBM) and ALFF. \u0000 \u0000 \u0000Results \u0000(1) Neuropsychological analysis showed significant differences in Montreal Cognitive Assessment score (22.9±2.0 vs 25.8±2.3, t=2.622, P=0.020), Frontal Assessment Battery score (12.4±1.6 vs 15.1±1.4, t=3.600, P=0.003), animal listing test (13.6±1.8 vs 16.7±2.9, t=2.482, P=0.026), naming test (2(1) vs 0(1), Z=-2.746, P=0.006), similarity test (7.9±3.7 vs 17.3±2.8, t=5.846, P=0.000)and clock drawing test (2(2) vs 3(0), Z=2.516, P=0.012). (2) VBM analysis showed no significant differences in both gray matter and white matter density between the two groups. (3) ALFF analysis showed significantly increased signals in widespread areas of bilateral cerebrum and cerebellum in ALSi group compared to ALSu group. \u0000 \u0000 \u0000Conclusion \u0000ALFF value has the potential to provide more valuable imaging basis for early diagnosis on cognitive impairment in ALS. \u0000 \u0000 \u0000Key words: \u0000Amyotrophic lateral sclerosis; Cognition disorders; Magnetic resonance imaging; Diagnosis","PeriodicalId":10143,"journal":{"name":"中华神经科杂志","volume":"83 1","pages":"28-33"},"PeriodicalIF":0.0,"publicationDate":"2017-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80771502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the scales assessing the severity of myasthenia gravis","authors":"Xiang Gao, Xu Zhang, Huan Yang, Hongyu Zhou, Yan‐chen Xie, Wei Qiu, Li Xiao, Renhua Wang, Meng Xia, Lin Wang","doi":"10.3760/CMA.J.ISSN.1006-7876.2016.05.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-7876.2016.05.007","url":null,"abstract":"Objective \u0000To evaluate the reliability and validity of the 4 myasthenia gravis (MG) scales widely used for assessing the grades of disease severity in Chinese MG patients. \u0000 \u0000 \u0000Methods \u0000Sixty MG patients were examined by a neurologist with the following four MG scales: Quantitative Myasthenia Gravis Score (QMGS), Myasthenia Gravis Composite (MGC), Myasthenic Muscle Scale (MMS), Absolute and Relative Score of MG (ARS-MG). The whole assessment process was videotaped. MG Activities of Daily Living (MG-ADL) score was acquired after the examination. The patients were examined by the same neurologist with the same MG scales within 24 hours after the first examination. The original videotapes of each patient were assessed by five other neurologists independently. Interobserver reliability of each item of the four MG scales was assessed with weighted Kappa test. Internal consistency of the scales was assessed with Cronbach ɑ. Test-retest reliability and interobserver reliability among the five neurologists were assessed with intraclass correlation coefficience (ICC). The construct validity was assessed with factor analysis. Criterion validity was assessed by Spearman correlation analysis. \u0000 \u0000 \u0000Results \u0000Interobserver reliability of items of the 4 MG scales was moderate (k 0.310-0.891, P<0.01). All 4 MG scales showed good internal consistency (Cronbach ɑ 0.701-0.734) with high test-retest reliability (ICC 0.887-0.948, P<0.01) and interobserver reliability (ICC 0.853-0.917, P<0.01). Factor analysis showed good construct validity (accumulative dedication rate 66.49%-72.64%). There was moderate to strong correlation between QMGS (as criterion) and the other three scales (r 0.792-0.840, P<0.01), and moderate correlation between MG-ADL (as criterion) and the four scales (r 0.693-0.766, P<0.01). \u0000 \u0000 \u0000Conclusion \u0000The 4 widely used MG severity scales can effectively assess the grades of disease severity of MG with good reliability and validity. \u0000 \u0000 \u0000Key words: \u0000Myasthenia gravis; Evaluation studies; Reproducibity of results; Validation studies","PeriodicalId":10143,"journal":{"name":"中华神经科杂志","volume":"37 1","pages":"375-381"},"PeriodicalIF":0.0,"publicationDate":"2016-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86986010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and correlative factors of constipation in patients with Parkinson's disease","authors":"Xueliang Li, Xianwen Chen, Shangpei Wang, M. Jiang, Ai-ping Feng, Qian Yang, P. Hu","doi":"10.3760/CMA.J.ISSN.1006-7876.2016.04.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-7876.2016.04.005","url":null,"abstract":"Objective \u0000To investigate the characteristics and the correlative factors of constipation in Parkinson's disease (PD) patients. \u0000 \u0000 \u0000Methods \u0000The demographic information, clinical features and history of medications of 193 patients with idiopathic PD consulting in the outpatient department of the First Affiliated Hospital, Anhui Medical University were collected. Patients were evaluated using following scales: Unified Parkinson's Disease Rating ScaleⅢ(UPDRS Ⅲ), Hoehn-Yahr stage, Bristol Scoring Scale, Cleveland Constipation Scoring Scale (CCS), Scale for Outcomes in PD-autonomic for Autonomic Symptoms, Simple Food Frequency Questionnaire, Hamilton Depression Scale (HAMD), Mini Mental State Examination. The patients were divided into constipation group and non-constipation group based on Rome Ⅲ Criteria for Diagnosis of Functional Constipation, and the correlative factors of constipation were compared and analyzed between the two groups. The severity of constipation and influencing factors were also compared between patients with early onset constipation (occurred before present of motor symptoms) and patients with late onset constipation (occurred after present of motor symptoms). The impacts of anti-PD medication adjustments on constipation were assessed by observing the alteration of constipation severity in 41 PD patients. \u0000 \u0000 \u0000Results \u0000The incidence of constipation was 56.4% (109/193) in our cohort of PD patients, and 21.1% (23/109) of constipation was severe according to the assessing by CCS. The spectrum of constipation symptoms included defecation straining (89.9%, 98/109), poor stool output(67.9%, 74/109), reduced stool frequency (63.3%, 69/109) and dryness of stool (60.5%, 66/109). The age, disease duration, scores of Hoehn-Yahr stage, UPDRS Ⅲand HAMD, levodopa equivalent dose (LED), frequency of urination disturbance in constipation group were significantly higher than those in non-constipation group, while the daily quantities of vegetable and water intake in constipation group were significantly lower than those in non-constipation group. Age and HAMD scores were the independent risk factors of constipation (OR=1.049, 95% CI 1.014-1.086, P=0.006; OR=1.316, 95% CI 1.185-1.461, P=0.000). Among the 109 constipation patients, the course of PD, scores of Hoehn-Yahr stage, UPDRSⅢ and LED were positively correlated with the severity of constipation (r=0.269, 0.338, 0.315, 0.341, 0.371, all P<0.05), with HAMD score being the independent risk factor of constipation severity (OR=1.175, 95% CI 1.044-1.322, P<0.05). The severity of constipation and risk factors of constipation in patients with early onset constipation were not distinct from those with late onset constipation. \u0000 \u0000 \u0000Conclusions \u0000The incidence of constipation increases with the increment of age, disease duration, Hoehn-Yahr stage, UPDRSⅢ scores, LED, HAMD scores, urination disorder severity and the decrement of daily water and vegetable intakes. The severity of constipation is posit","PeriodicalId":10143,"journal":{"name":"中华神经科杂志","volume":"19 1","pages":"282-287"},"PeriodicalIF":0.0,"publicationDate":"2016-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89976658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical observation of rituximab in three patients with anti-N-methyl-D-aspartate receptor encephalitis","authors":"Q. Lu, H. Guan, H. Ren, Qing Liu, J. Niu, B. Peng, L. Cui","doi":"10.3760/CMA.J.ISSN.1006-7876.2016.01.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-7876.2016.01.007","url":null,"abstract":"Objective \u0000To investigate the efficacy and safety of rituximab in the treatment of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. \u0000 \u0000 \u0000Methods \u0000Three patients with anti-NMDAR antibodies in cerebrospinal fluid and serum hospitalized from May 2012 to July 2014 were retrospectively reviewed. The clinical syndrome, investigations, and therapeutic interventions by rituximab when first line immunotherapy failed were evaluated. \u0000 \u0000 \u0000Results \u0000All 3 patients were females with median age of 17 years (12, 17, and 22 years). One patient had ovarian teratoma. All 3 patients presented with psychiatric symptoms and movement disorders, 2 of which developed into a state of unresponsiveness. Brain magnetic resonance imaging of 2 patients was unremarkable, and 1 showed T2 and FLAIR hyperintensity among the areas of medulla, pons, caudex cerebri and callosum. Fluoro-2-deoxy-D-glucose-PET showed variable multifocal cortical and subcortical abnormalities that changed during the course of the disease. Electroencephalograms were abnormal in all patients, showing non-specific, slow, and disorganised activity, 1 showing extreme delta brush. The cerebrospinal fluid showed lymphocytic pleocytosis. All patients showed no response to treatment with first line immunotherapy (corticosteroids, intravenous immunoglobulin (400 mg·kg-1·d-1×5 d, 2-3 courses of treatment)). After the administration of rituximab, 1 patient responded slower, whereas the other 2 patients who recovered dramatically (375 mg/m2 every week for 3-4 weeks)continued immunosuppression with mycophenolatemofetil for 1 year. Relapse occurred in 1 patient when the immunotherapies discontinued 6 months later. During the treatment of rituximab, 2 patients had grade 3 infectious adverse events (hospitalization and intravenous administration of antibiotics). \u0000 \u0000 \u0000Conclusions \u0000Rituximab is effective for the patients with anti-NMDAR encephalitis who fail to respond to the first line immunotherapy. However the utility of rituximab is still a challenge due to the risk of infectious complications and off-label use. \u0000 \u0000 \u0000Key words: \u0000Anti-N-methyl-D-aspartate receptor encephalitis; Immunotherapy; Antibodies, monoclonal, murine-derived; Therapies, investigational; Infection","PeriodicalId":10143,"journal":{"name":"中华神经科杂志","volume":"44 1","pages":"30-34"},"PeriodicalIF":0.0,"publicationDate":"2016-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85751108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association study of α-synuclein gene polymorphism and non motor symptoms in Parkinson's disease","authors":"Wu Guoping, Wang Dayong, Kang Wenyan, L. Jun","doi":"10.3760/CMA.J.ISSN.1006-7876.2015.10.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-7876.2015.10.011","url":null,"abstract":"Objective To investigate the association between the single nucleotide polymorphisms (SNPs) rs894278 and rs11931074 of α-synuclein (SNCA) and non motor symptoms in Parkinson' s disease (PD).Methods One hundred and twenty PD patients and 100 healthy controls enrolled from Tonglu Hospital Affiliated to Ruijin Hospital and Ruijin Hospital,Shanghai Jiaotong University School of Medicine from 2012 to 2014 were recruited and the motor subscale of the Unified Parkinson' s Disease Rating Scale Ⅲ (UPDRS-Ⅲ) was used to evaluate motor function.The Mini-Mental State Examination (MMSE),17-item Hamilton Rating Scale (HAMD-17),the Rapid Eye Movement Behavior Disorder Screening Questionnaire (RBDSQ) and the ROME-Ⅲ criteria for chronic constipation were used to evaluate non motor symptoms.SNCA SNPs (rs894278,rs11931074) were genotyped by direct sequencing.Results There was no statistically significant difference in age,sex,non motor symptoms scores among the three genotypes of the two SNPs in control group.There was no statistically significant difference in age,sex,UPDRS-Ⅲ scores and Hoehn-Yahr stage among the three genotypes of the two SNPs in PD group.The results demonstrated that there was no association between the two SNPs and RBDSQ scores,HAMD-17 scores,MMSE scores and constipation in PD patients.However,additional analysis showed that patients with GG rs894278 had a greater proportion of clinical probable RBD than those with GT and TT types (GG 52.2％,12/23;GT 18.2％,10/55;TT 21.4％,9/42;x2 =9.254,P=0.002;x2 =6.424,P=0.005).In Logistic regression analyses adjusting for age and sex,we observed that rs894278 GG genotype could increase the risk of RBD in PD patients (OR =5.367,95％ CI =1.607-17.925,P =0.006).There was no association of RBD with allelic and genotypic distributions of SNCA rs11931074.Conclusion The results indicate that the rs894278 polymorphism correlates with RBD,while rs11931074 does not.","PeriodicalId":10143,"journal":{"name":"中华神经科杂志","volume":"31 1","pages":"870-875"},"PeriodicalIF":0.0,"publicationDate":"2015-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82350028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}