Vineet Dhar, Abdullah A Marghalani, Homa Amini, Tegwyn Brickhouse, Erica Caffrey, Jayakumar Jayaraman, Martha Ann Keels, Anna Messner, Kimberly K Patterson, Nikhila Raol, Poojan Shrestha, Christopher M Stark, Harlyn K Susarla, Jennifer Thomas
{"title":"Diagnostic Assessment of Ankyloglossia and Association With Infant Feeding Challenges: A Systematic Review and Meta-Analysis-Part 1.","authors":"Vineet Dhar, Abdullah A Marghalani, Homa Amini, Tegwyn Brickhouse, Erica Caffrey, Jayakumar Jayaraman, Martha Ann Keels, Anna Messner, Kimberly K Patterson, Nikhila Raol, Poojan Shrestha, Christopher M Stark, Harlyn K Susarla, Jennifer Thomas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p><b>Purpose:</b> To assess the diagnostic criteria for restrictive lingual frenum and the association with feeding difficulties in mother-infant dyads. <b>Methods:</b> The protocol was registered with PROSPERO (CRD42024482618). Ovid MEDLINE, CINAHL, Embase, and Cochrane Library databases were searched from 1946 to May 2025 for studies meeting inclusion criteria. The population included mother-infant dyads with or without feeding difficulties, where infants had a restrictive frenum. Outcomes measured included diagnostic accuracy of tools assessing ankyloglossia and the association of ankyloglossia with feeding difficulties. Fourteen reviewers screened studies, performed data extraction, and assessed risk of bias using risk of bias and Office of Health Assessment and Translation tools. A Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach determined the quality of evidence. <b>Results:</b> Fourteen out of 20 included studies qualified for analysis, examining 5 ankyloglossia-specific diagnostic tools. For diagnosing ankyloglossia, the Bristol Tongue Assessment Tool/Tongue-tie and Breastfed Babies Assessment Tool (BTAT/TABBY) demonstrated high discriminative accuracy (AUC ROC=0.95, >2000 clinical cases), acceptable internal consistency (α=0.708) and strong correlation with the Hazelbaker Assessment Tool for Lingual Frenulum Function (HATLFF, r=0.89). Ten of the included studies examining feeding difficulties showed a trend favoring association with restrictive lingual frenum. Infants with ankyloglossia had a higher odds of maternally reported feeding difficulties (pooled OR= 5.57, 95% CI 0.44-70.02), though the effect did not reach statistical significance (P=0.18) and heterogeneity was substantial (I 2=96%). <b>Conclusion:</b> Very-low certainty evidence supports the use of standardized anatomical and functional (tongue mobility) assessments for restrictive lingual frenum. A consistent direction of association between restrictive lingual frenum and feeding difficulties was observed across studies, though pooled estimates did not reach statistical significance.</p>","PeriodicalId":101357,"journal":{"name":"Pediatric dentistry","volume":"48 2","pages":"82-68E"},"PeriodicalIF":1.7,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu-Chen Cheng, Jui-Min Su, Jungyi Alexis Liu, Hung-Chi Liao, Guangyu Zhang, Christopher Perry, Jung-Wei Chen
{"title":"A Comparison of Immediate Monomer Release of 3D Printing Materials and Poly(methyl methacrylate) Used in Pediatric Dentistry.","authors":"Yu-Chen Cheng, Jui-Min Su, Jungyi Alexis Liu, Hung-Chi Liao, Guangyu Zhang, Christopher Perry, Jung-Wei Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p><b>Purpose:</b> To compare the monomer leaching of 3D-printed denture base materials (NextDent® Denture 3D+ [D3D]) and orthodontic base material (NextDent® Ortho Flex [OF]) with conventional poly-methyl methacrylate (PMMA) resins at 5 time points. <b>Methods:</b> Fifteen standardized samples (N=5 /group) of D3D, OF, and PMMA materials were submerged in artificial saliva for 48 hours. The solutions were extracted, and the monomer release rate and amount were measured using high-performance liquid chromatography (HPLC) at 0, 8, 16, 24, and 48 hours. One-way analysis of variance, independent t-tests, and post-hoc least significant difference tests were used to compare monomer release rates and amounts across different time intervals and materials. <b>Results:</b> Methyl methacrylate was detected in the PMMA group at 0.0034 wt%, which is below the ISO threshold (<4.5 wt%). Significant differences were observed in monomer release rates and patterns among the groups (P<0.001). The highest monomer release occurred within the first 8 hours and decreased drastically over time (P<0.001). Among 3D printing groups, the OF group exhibited a higher release rate than the D3D group at all time points (0, 8, 16, 24, and 48 hours; P <0.001). The D3D group maintained a consistently low release rate. <b>Conclusions:</b> The levels of monomer release in this in vitro study would be considered safe for use in pediatric dentistry. Due to the highest monomer release occurring within the first 8 hours, it is recommended that appliances be delivered at least 8 hours after fabrication to minimize initial exposure.</p>","PeriodicalId":101357,"journal":{"name":"Pediatric dentistry","volume":"48 2","pages":"113-E70"},"PeriodicalIF":1.7,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"How effective are intranasal treatments for sleep disordered breathing in children?","authors":"Gillian M Nixon","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":101357,"journal":{"name":"Pediatric dentistry","volume":"48 2","pages":"81"},"PeriodicalIF":1.7,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostic Accuracy for Breathing Sounds in Using an AI-Assisted Stethoscope Versus a Conventional Stethoscope.","authors":"Farin Ezzati, Jung-Wei Chen, Jungyi Alexis Liu, Yuan-Ren Cheng","doi":"","DOIUrl":"","url":null,"abstract":"<p><p><b>Purpose:</b> This study compares the accuracy of dental students in diagnosing different breathing sounds using traditional versus artificial intelligence-assisted precordial stethoscopes (AIPS). <b>Methods:</b> The study involved 45 3rd- and 4th-year dental students who completed a pre-test to assess their baseline knowledge of breathing sounds. After watching a learning video, participants were randomized into 3 groups: conventional stethoscopes (Group A), AIPS (Group B) with audio, and AIPS with audio and video (Group C). Participants were evaluated in their diagnosis ability by listening to 10 recorded episodes of specific breathing sounds and then took post-tests to evaluate their learning. A post-survey was administered to evaluate the confidence and satisfaction of the participants with diagnostic responses, and to collect demographic information. Statistical significance was evaluated using a 1-way analysis of variance and paired sample t-test (P<0.05). <b>Results:</b> Significant improvements were observed in diagnostic accuracy (P<0.001) and knowledge (P=0.047) across all groups. AI groups demonstrated higher diagnostic accuracy for specific sounds (normal breathing, partial airway obstruction, and apnea). The confidence and satisfaction of the participants were strongly correlated with diagnostic accuracy (P<0.001), with those in Groups B and C reporting higher satisfaction. Group C responded fastest for apnea (P=0.021) and Group A for normal breathing (P=0.005), while Group A had the highest missing diagnosis proportion (53.3%). <b>Conclusions:</b> Artificial intelligence-assisted precordial stethoscopes enhance diagnostic accuracy and learning outcomes, particularly for students with lower baseline knowledge. These findings suggest that integrating artificial intelligence tools can improve the detection of respiratory complications during sedation, enhancing patient safety.</p>","PeriodicalId":101357,"journal":{"name":"Pediatric dentistry","volume":"48 2","pages":"130-136"},"PeriodicalIF":1.7,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Azza Tagelsir Ahmed, Majd Alsaleh, Sahar Alrayyes, Yousef Khader
{"title":"The Financial Burden of Dental Treatment of Children with Molar Hypomineralization: Preliminary Findings.","authors":"Azza Tagelsir Ahmed, Majd Alsaleh, Sahar Alrayyes, Yousef Khader","doi":"","DOIUrl":"","url":null,"abstract":"<p><p><b>Purpose:</b> To evaluate the burden of managing permanent first molars (PFMs) in children with molar hypomineralization (MH). <b>Methods:</b> Retrospective data on the cost of treatment of PFMs in children with MH in a university-based pediatric clinic were collected. Data included demographics, health status, zip code, treatment type, number of visits, behavioral guidance (BG), and retreatment. The cost was calculated based on the billing codes for operative treatment and BG. <b>Results:</b> A total of 199 MH patient charts were included. The mean age was 8.07 years (±1.46 standard deviation). Over 25% had behavioral and medical conditions and lived more than 25 miles from the clinic. Operative treatment costs differed significantly by age (P<0.001). Male patients, patients travelling more than 25 miles, and patients with behavioral conditions had significantly higher BG and total treatment costs (P<0.05). <b>Conclusion:</b> Gender, distance from the clinic, and health status were related to higher treatment burden of permanent first molars in children with molar hypomineralization.</p>","PeriodicalId":101357,"journal":{"name":"Pediatric dentistry","volume":"48 2","pages":"106-110"},"PeriodicalIF":1.7,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brittaney Hill, Diamond Grady-Williams, Lewis L Hsu, Patrick Smith
{"title":"The Use of Nitrous Oxide for Routine Dental Treatment in Pediatric Patients with Sickle Cell Disease.","authors":"Brittaney Hill, Diamond Grady-Williams, Lewis L Hsu, Patrick Smith","doi":"","DOIUrl":"","url":null,"abstract":"<p><p><b>Purpose:</b> The purpose of this study was to examine for differences in mean oxygenation levels of healthy pediatric patients and pediatric patients with sickle cell disease (SCD) receiving nitrous oxide (N₂O) for dental procedures and to determine if N₂O decreases oxygen saturation levels for SCD patients. <b>Methods:</b> Patients aged 2 to 17 years with SCD and healthy age-matched patients were recruited at their preventive or restorative dental visits between 2019 and 2023. Up to 50% N₂O was administered during routine restorative treatment. Oxygen saturation was measured via a pulse oximeter before starting nitrous, at 10-minute intervals throughout treatment, and after nitrous oxide termination. Descriptive and bivariate analyses were conducted using statistical software with statistical significance set at P<0.05. <b>Results:</b> There was a significant difference in average oxygen saturation at baseline between cases and controls; however, there was no significant difference at 10, 20, or 30 minutes. There was no significant difference in oxygen saturation between cases and controls after terminating N₂O. <b>Conclusions:</b> Use of up to 50% nitrous oxide for dental treatment was found to be safe in this cohort of sickle cell disease patients. The oxygen saturation of healthy patients and patients with SCD increases with the use of N₂O. In addition, N₂O use in patients with SCD may alleviate anxiety and increase the pain threshold, decreasing the risk for vaso-occlusive crisis.</p>","PeriodicalId":101357,"journal":{"name":"Pediatric dentistry","volume":"48 2","pages":"120-123"},"PeriodicalIF":1.7,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Expect Turbulence: So Buckle Up.","authors":"Paul S Casamassimo","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":101357,"journal":{"name":"Pediatric dentistry","volume":"48 2","pages":"78-79"},"PeriodicalIF":1.7,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association of Prenatal Oral Health Guidance With Dental Visits Before 1 Year of Age: A Cohort Study in Southern Brazil.","authors":"Andréia Drawanz Hartwig, Mariana Gonzalez Cademartori, Andréa Damaso Bertoldi, Marcos Britto Correa, Marie-Charlotte Huysmans, Flavio Fernando Demarco, Marina Sousa Azevedo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p><b>Purpose:</b> To investigate the association between pregnant women receiving oral health guidance from health care professionals and their children visiting a dentist before 12 months of age. <b>Methods:</b> Data were drawn from multiple follow-ups of the 2015 Pelotas Birth Cohort. The main outcome was whether the child had a dental visit in the first year of life, either for preventive care or treatment of dental problems. The primary exposure was the mother's receipt of oral health guidance from a health care professional during pregnancy. Potential confounders included socioeconomic and demographic characteristics, maternal experience of dental caries, and dental visits during pregnancy. Multinomial logistic regression was used for the analysis, comprising 3,938 mother-child dyads. <b>Results:</b> Children whose mothers received oral health guidance during pregnancy had a 60% higher prevalence of preventive dental visits compared to those whose mothers did not receive such guidance (prevalence ratio=1.60; 95% confidence interval [CI]=1.19 to 2.15). <b>Conclusion:</b> This study found that professional oral health guidance provided to mothers during pregnancy was positively associated with a higher likelihood of their children receiving preventive dental care during the first year of life.</p>","PeriodicalId":101357,"journal":{"name":"Pediatric dentistry","volume":"48 2","pages":"124-129"},"PeriodicalIF":1.7,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vineet Dhar, Abdullah A Marghalani, Homa Amini, Tegwyn Brickhouse, Erica Caffrey, Jayakumar Jayaraman, Martha Ann Keels, Anna Messner, Kimberly K Patterson, Nikhila Raol, Poojan Shrestha, Christopher M Stark, Harlyn K Susarla, Jennifer Thomas
{"title":"Frenotomy for Ankyloglossia Associated With Feeding Challenges in Infants: Effectiveness, Technique, and Safety-A Systematic Review and Meta-Analysis, Part 2.","authors":"Vineet Dhar, Abdullah A Marghalani, Homa Amini, Tegwyn Brickhouse, Erica Caffrey, Jayakumar Jayaraman, Martha Ann Keels, Anna Messner, Kimberly K Patterson, Nikhila Raol, Poojan Shrestha, Christopher M Stark, Harlyn K Susarla, Jennifer Thomas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p><b>Purpose:</b> To assess the effectiveness, surgical techniques, and safety outcomes of lingual frenum release in infants with feeding difficulties. <b>Methods:</b> The protocol was registered with PROSPERO (CRD42024482618). Ovid MEDLINE, CINAHL, Embase, and Cochrane Library databases were searched from 1946 to May 2025 for studies meeting inclusion criteria. The population included mother-infant dyads with feeding difficulties where infants with restrictive frenum underwent surgical release. The primary outcome measured included feeding difficulties, technique comparison, post-care, and adverse events. Fourteen reviewers screened studies, performed data extraction, and assessed risk of bias (ROB). A Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach determined the quality of evidence. <b>Results:</b> Forty-seven studies qualified for analysis, including 8 randomized controlled trials and 39 observational studies. Maternal nipple pain reduction showed large standardized mean differences sustained from immediate through long-term follow-up. Maternal perception of breastfeeding showed improvement over time. Latch, audible swallowing, type of nipple, comfort, and hold (LATCH) scores showed large improvements in single-arm studies but minimal differences compared to controls in randomized clinical trials. Scissors and lasers appeared comparably effective based on limited evidence. The pooled adverse event frequency was 4%, with bleeding being most common. <b>Conclusion:</b> Very low certainty evidence supports frenotomy for documented functional impairment in carefully selected cases where conservative management has failed, emphasizing multidisciplinary evaluation and individualized decision-making with comprehensive informed consent.</p>","PeriodicalId":101357,"journal":{"name":"Pediatric dentistry","volume":"48 2","pages":"33E-68E"},"PeriodicalIF":1.7,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A 10-Year Study Assessing the Adverse Events of Moderate Sedation in Pediatric Dentistry.","authors":"John H Unkel, Elizabeth J Berry, Alex Hubrecht","doi":"","DOIUrl":"","url":null,"abstract":"<p><p><b>Purpose:</b> This retrospective study assessed the presence of adverse events during moderate sedation for pediatric dental procedures performed in a dental clinic. <b>Methods:</b> Dental treatment completed with sedation between June 2014 to November 2024 was assessed for the presence of any adverse events (AEs). AEs were classified by the modified Tracking and Reporting Outcomes of Procedural Sedation (TROOPS) scale and an adverse event list from the Pediatric Sedation Research Consortium (PSRC). <b>Results:</b> There were 923 completed patient sedation records between the ages of 2 and 16 years from 9 different sedation regimens within the dental clinic included in this study. Overall, the proportion of adverse events was low (4.55%) with an increase in AE with the intranasal dexmedetomidine/orally administered midazolam (odds ratio [OR]=4.7, P<0.01) and a decrease in AE with triazolam (OR equals 0.2, P<0.01). No adverse events required medical intervention. <b>Conclusions:</b> Overall, adverse event proportions were low with pediatric dental moderate sedation supporting the safety of this modality of treatment. More studies are needed to assess adverse events and adverse event scales in pediatric dental sedation.</p>","PeriodicalId":101357,"journal":{"name":"Pediatric dentistry","volume":"48 2","pages":"100-105"},"PeriodicalIF":1.7,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}