Clinical medicine and diagnostics最新文献_第2页

Radio-wave Therapy of Inferior Turbinates for Treatment of Intractable Vasomotor Rhinitis - a Clinical Study of the Subjective Long-term Outcome 下鼻甲无线电波治疗顽固性血管舒缩性鼻炎的临床研究——主观远期疗效的观察

Clinical medicine and diagnostics Pub Date : 2012-08-31 DOI: 10.5923/J.CMD.20120201.01

E. Jaatun, C. Laurent

引用次数: 1

Pituitary Adenoma Complicated by Multifocal Fibrosclerosis Involving Sella and Retroperitoneum 垂体腺瘤并发累及蝶鞍及腹膜后的多灶性纤维硬化

Clinical medicine and diagnostics Pub Date : 2012-08-31 DOI: 10.5923/J.CMD.20110101.03

J. Hackney, K. Riley, M. Vaphiades, A. Bag, C. Palmer

引用次数: 1

Central Sensitization: Clinical Implications for Chronic Head and Neck Pain 中枢致敏:慢性头颈部疼痛的临床意义

Clinical medicine and diagnostics Pub Date : 2012-08-31 DOI: 10.5923/J.CMD.20110101.01

Arthur Roberts

引用次数: 6

Cardiac Syndrome X Electrocardiographic Patterns Using Signal-Averaged Orthogonal Leads and VCG Indices 使用信号平均正交导联和VCG指数的心脏综合征X心电图模式

Clinical medicine and diagnostics Pub Date : 2012-08-31 DOI: 10.5923/J.CMD.20120203.03

M. Matveev, V. Krasteva, S. Tsonev, R. Prokopova, M. Milanova

引用次数: 0

Antibiotics Overuse in Children with Upper Respiratory Tract Infections in Saudi Arabia: Risk Factors and Potential Interventions 沙特阿拉伯上呼吸道感染儿童抗生素过度使用:危险因素和潜在干预措施

Clinical medicine and diagnostics Pub Date : 2012-08-31 DOI: 10.5923/J.CMD.20110101.02

Arwa Alumran, C. Hurst, X. Hou, S. Arabia

{"title":"Antibiotics Overuse in Children with Upper Respiratory Tract Infections in Saudi Arabia: Risk Factors and Potential Interventions","authors":"Arwa Alumran, C. Hurst, X. Hou, S. Arabia","doi":"10.5923/J.CMD.20110101.02","DOIUrl":"https://doi.org/10.5923/J.CMD.20110101.02","url":null,"abstract":"Background: Antibiotics misuse is currently one of the major public health issues worldwide. This misuse lead to the development of bacterial resistance, increasing the burden of chronic diseases, rising costs of health services, and the development of side effects. Several factors may influence this pattern of overuse. Objectives:This article will re- view the pertinent factors contributing to the overuse of antibiotics worldwide, and to assess the intervention strategies to limit this overuse. Methods: studies about antibiotics use in children were reviewed from several electronic databases, such as MEDLINE and Pubmed. Results: Factors contributing to the overuse of antibiotics could include psychosocial factors, such as behaviors and attitudes (e.g. self-medication, over-the-counter medication, or patients/parents pressure), and demo- graphic factors, such as socio-economic status and education level. Several intervention strategies were reported to be ef- fective in reducing the overuse of antibiotics, such as health education, doctor-patient communication, and policies change. Multifaceted interventions were found to be the most effective in reducing the antibiotics overuse.","PeriodicalId":101352,"journal":{"name":"Clinical medicine and diagnostics","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130656737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 61

Value of New Modification of Tuberculosis Score in Diagnosis of Childhood Pulmonary Tuberculosis 结核评分新修订在儿童肺结核诊断中的价值

Clinical medicine and diagnostics Pub Date : 2012-06-01 DOI: 10.1016/J.IJID.2012.05.955

H. Koura, A. Mohammed

引用次数: 1

Predictors of Poor Prognosis in Patients with Malignant Ascites: A Prospective Study 恶性腹水患者预后不良的预测因素:一项前瞻性研究

Clinical medicine and diagnostics Pub Date : 2012-04-09 DOI: 10.5923/J.CMD.20120202.01

A. Ayantunde, S. Parsons

{"title":"Predictors of Poor Prognosis in Patients with Malignant Ascites: A Prospective Study","authors":"A. Ayantunde, S. Parsons","doi":"10.5923/J.CMD.20120202.01","DOIUrl":"https://doi.org/10.5923/J.CMD.20120202.01","url":null,"abstract":"Malignant ascites is a manifestation of end stage events in a variety of cancers with significant morbidity and a poor prognosis.This study prospectively evaluated factors predicting poor prognosis in patients with malignant ascites. Clinico-pathologic data of patients with malignant ascites at our institution over a period of 18 months were prospectively analysed. Predictors of poor survival were evaluated and survival compared among different cancer groups. A total of 150 patients (96 females, 54 males) with median age of 63 (19-95) years were studied. The commonest cancer was ovarian. Liver metastases were significantly commoner in the gastrointestinal cancers (P=0.0001). Serial paracentesis was offered to 131, chemotherapy in 89, diuretics in 35, intraperitoneal monoclonal antibody in 6 and 7 patients had drainage at surgery. The median survival after the diagnosis of malignant ascites was 9.2 months. Ovarian cancer and female gender favour longer survival while poor performance status, low serum albumin/serum protein, liver metastases, high serum urea, creatinine and total bilirubin levels adversely affected survival. The independent prognostic factors for survival were poor performance status, cancer type, liver metastases, low serum albumin and high urea levels. The cancer type and performance status significantly influence the choice of treatment option.","PeriodicalId":101352,"journal":{"name":"Clinical medicine and diagnostics","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114370547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Comparison of an Immunochromatographic Rapid Strip Test, ELISA and PCR in the Diagnosis of Hepatitis C in HIV Patients in Hospital Settings in Cameroon 免疫层析快速试纸、ELISA和PCR在喀麦隆HIV患者丙型肝炎诊断中的比较

Clinical medicine and diagnostics Pub Date : 2012-01-09 DOI: 10.5923/J.CMD.20110101.04

T. Kwenti, R. Njouom, L. Njunda, H. Kamga

{"title":"Comparison of an Immunochromatographic Rapid Strip Test, ELISA and PCR in the Diagnosis of Hepatitis C in HIV Patients in Hospital Settings in Cameroon","authors":"T. Kwenti, R. Njouom, L. Njunda, H. Kamga","doi":"10.5923/J.CMD.20110101.04","DOIUrl":"https://doi.org/10.5923/J.CMD.20110101.04","url":null,"abstract":"Cameroon belongs to the group of countries highly endemic for hepatitis C viruses. Coinfection of hepatitis C and HIV are also common due to the shared route of transmission of both viruses. In hospital settings in Cameroon, diagnosis prior to treatment of hepatitis C is based solely on the results obtained with an immunochromatographic rapid strip test (97%). This study was aimed at determining the validity of the results that is obtained when an immunochromatographic rapid strip test is used to diagnose hepatitis C virus infection in HIV-positive patients in comparison with more sensitive and specific methods like ELISA and PCR. In a cross-sectional study in two parts, 700 participants were enrolled, 350 were HIV-positive patients and a control group of 350 individuals not infected with HIV. All participants were screened for anti-HCV antibodies using ACON HCV strip test, an assay commonly used in 57·1% of Cameroon hospitals. While using the rapid strip test, of the 350 HIV-positive patients, 25 (7·1%) were found to be positive with the rapid strip test of whom 3(12%) were positive with an ELISA and all 3(100%) positive with the ELISA were also positive with PCR. Evaluation of the rate of false positives with the rapid strip test using ELISA as the gold standard gave a rate of 6·3%. Meanwhile in the control group, after screening with the rapid strip test, 39 (11·1%) were positive of whom 6 (15·4%) were positive with the ELISA and 3 (50%) of the 6 positive with the ELISA were positive with the PCR. Evaluation of the rate of false positives with the rapid strip test in the control group using ELISA as the gold gave a rate of 9·6%. False positive results with this immunochromatographic rapid strip test for the diagnosis of hepatitis C virus infection is therefore common and therefore reinforce the need for a confirmatory test prior to treatment in hospital settings in Cameroon.","PeriodicalId":101352,"journal":{"name":"Clinical medicine and diagnostics","volume":"153 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124065396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Clinical Genomic Analysis and Diagnosis --Genomic Analysis Ex Vivo, in Vitro and in Silico. 临床基因组分析和诊断——体内、体外和硅体内的基因组分析。

Clinical medicine and diagnostics Pub Date : 2012-01-01 DOI: 10.5923/j.cmd.20120204.04

Biaoru Li

{"title":"Clinical Genomic Analysis and Diagnosis --Genomic Analysis Ex Vivo, in Vitro and in Silico.","authors":"Biaoru Li","doi":"10.5923/j.cmd.20120204.04","DOIUrl":"10.5923/j.cmd.20120204.04","url":null,"abstract":"Seven years ago, I systemically reviewed single cell techniques with genomic and proteomic analyses which was called Single-Cell Genomic Analysis. After many years of arduous work, single cell techniques with downstream genomic and proteomic analysis have been applied to clinical fields including molecular pathology, molecular genetics, forensic medicine and biomarker discovery. On top of that, dynamic cell-sorting technique combined with downstream cell culture and genomic analysis of stem cell for regeneration medicine and cancer stem cell for differentiation have also been greatly developed in clinical fields. More importantly, tissue level sampling with in silico analysis has been applied in therapeutic targeting for advanced neoplastic disease. Recent development in sorting homogeneous cells in vitro (or single cells technique), ex vivo (dynamic analysis or small number of cell culture with downstream genomic analysis) and insilico (tissue level sampling with in silico analysis) have allowed physician scientists with a choice to select one of these above techniques with genomic analysis to apply to their clinical research fields. To fully understand these modern techniques, this manual will review recently developed methods or clinical genomic analysis in vitro, in silico and ex vivo. In the review paper, I will also introduce how to utilize these techniques in different clinical fields. The manual will also address some of the challenges for clinical genomics analysis and diagnosis due to mixed cells from clinical specimens.","PeriodicalId":101352,"journal":{"name":"Clinical medicine and diagnostics","volume":"2 4","pages":"37-44"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71416493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic performance of serum bone turnover marker lysylpyridinoline in diabetic foot osteomyelitis: a preliminary study 血清骨转换标志物赖氨酸吡啶在糖尿病足骨髓炎中的诊断性能:初步研究

Clinical medicine and diagnostics Pub Date : 1900-01-01 DOI: 10.5923/J.CMD.20160603.02

O. G. Hayes, V. Vangaveti, U. Malabu

{"title":"Diagnostic performance of serum bone turnover marker lysylpyridinoline in diabetic foot osteomyelitis: a preliminary study","authors":"O. G. Hayes, V. Vangaveti, U. Malabu","doi":"10.5923/J.CMD.20160603.02","DOIUrl":"https://doi.org/10.5923/J.CMD.20160603.02","url":null,"abstract":"Objectives: The aim of the study was to determine whether serum levels of lysylpyridinoline (LP) differ between diabetic foot osteomyelitis (DFO) and diabetic foot ulcers without osteomyelitis (cellulitis). \u0000 \u0000Methods: A case controlled study was designed comparing the aforementioned groups. Subjects were classified as osteomyelitis and controls based on the International Working Group diagnostic criteria. Serum LP samples were analysed using enzyme linked immunosorbent assay. \u0000 \u0000Results: The serum LP levels were significantly higher in the DFO group (n: 16) than the control group (n: 11): LP median ± SD of 9.3 ± 3.5 nmol/l, interquartile range (IQR) 6.8-11.2 in DFO compared to 2.1 nmol/l 3.5, IQR 0.7-4.2 in the controls, p=0.001. The receiver operator characteristic curve in the DFO was 0.9. The diagnostic sensitivity, specificity, positive and negative predictive values were 100%, 77.8%, 89.0% and 100% respectively. \u0000 \u0000Conclusions: This appears to be the first evidence of serum LP elevation in diabetic foot osteomyelitis with potential diagnostic value in clinical setting.","PeriodicalId":101352,"journal":{"name":"Clinical medicine and diagnostics","volume":"174 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116133332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0