Diabetes & metabolism最新文献

SGLT2 inhibitor and urothelial carcinoma incidence in type 2 diabetes patients. SGLT2抑制剂与2型糖尿病患者尿路上皮癌发病率的关系

IF 4.7

Diabetes & metabolism Pub Date : 2025-08-05 DOI: 10.1016/j.diabet.2025.101694

Yu-Chuan Lu, Chao-Hsiang Chang, Chen-Hsun Ho, Jian-Hua Hong, Huei-Ming Yeh, Yi-Huei Chang, Po-Jen Hsiao, Chi-Shun Lien, Laing-You Wu, Chi-Jung Chung

{"title":"SGLT2 inhibitor and urothelial carcinoma incidence in type 2 diabetes patients.","authors":"Yu-Chuan Lu, Chao-Hsiang Chang, Chen-Hsun Ho, Jian-Hua Hong, Huei-Ming Yeh, Yi-Huei Chang, Po-Jen Hsiao, Chi-Shun Lien, Laing-You Wu, Chi-Jung Chung","doi":"10.1016/j.diabet.2025.101694","DOIUrl":"10.1016/j.diabet.2025.101694","url":null,"abstract":"Aims: The association between sodium glucose cotransporter-2 (SGLT2) inhibitors and the risk of urothelial carcinoma (UC) remains controversial. This study aimed to investigate this relationship in Asian populations where upper tract urothelial carcinoma (UTUC) is prevalent.Methods: Using Taiwan's National Health Insurance Database from 2016 to 2021, we conducted a nationwide cohort study comparing SGLT2 (n = 150,278) and dipeptidyl peptidase-4 (DPP4) inhibitor users (n = 363,178). Inverse probability of treatment weighting was applied to balance baseline characteristics, including demographics, comorbidities, and concurrent medications. Cumulative drug days were used to evaluate medication exposure. The primary outcome was the incidence of UC, including bladder cancer and UTUC. To avoid reverse causation and consider cancer latency, outcomes were assessed starting one year after treatment initiation.Results: During a mean follow-up of 2.62 years, we found no significant association between the use of SGLT2 inhibitors as a class and the risk of UC compared to DPP4 inhibitors (adjusted hazard ratio = 0.99, 95 % confidence interval: 0.77-1.27). This null association was consistent for both bladder cancer and UTUC. Furthermore, no significant associations were observed when analyses were stratified by individual drug type or cumulative drug days. Although some trends were noted in exploratory sensitivity analyses, no findings remained robustly significant after accounting for multiple comparisons.Conclusion: SGLT2 inhibitor use was not associated with an increased risk of UC, with potential protective associations in specific subgroups requiring further investigation.","PeriodicalId":101305,"journal":{"name":"Diabetes & metabolism","volume":" ","pages":"101694"},"PeriodicalIF":4.7,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intact fish skin graft for deep diabetic foot ulcers: results from the KEREFISH randomized controlled trial. 完整鱼皮移植治疗糖尿病足溃疡：KEREFISH随机对照试验的结果。

IF 4.7

Diabetes & metabolism Pub Date : 2025-07-23 DOI: 10.1016/j.diabet.2025.101691

Dured Dardari, Louis Potier, Ariane Sultan, Maud Francois, Jocelyne M'Bemba, Benjamin Bouillet, Lucy Chaillous, Laurence Kessler, Aurélie Carlier, Abdulkader Jalek, Ayoub Sbaa, Hilmar Kjartansson, Baldur Tumi Baldursson, Guillaume Charpentier, John C Lantis

{"title":"Intact fish skin graft for deep diabetic foot ulcers: results from the KEREFISH randomized controlled trial.","authors":"Dured Dardari, Louis Potier, Ariane Sultan, Maud Francois, Jocelyne M'Bemba, Benjamin Bouillet, Lucy Chaillous, Laurence Kessler, Aurélie Carlier, Abdulkader Jalek, Ayoub Sbaa, Hilmar Kjartansson, Baldur Tumi Baldursson, Guillaume Charpentier, John C Lantis","doi":"10.1016/j.diabet.2025.101691","DOIUrl":"10.1016/j.diabet.2025.101691","url":null,"abstract":"Introduction: The main objective : To assess the efficacy of Intact fish skin graft (IFSG) for the closure of University of Texas (UT) Grade 2 and 3 Diabetic foot ulcers (DFUs) versus local standard of care (SOC).Methods: In the French subgroup of a multinational randomized trial, 180 (179 in primary endpoint analysis) patients with UT grade 2 and 3 DFUs (8 centers) were randomized to receive IFSG or SOC, that adhered to the International Working Group on the Diabetic Foot (IWGDF) guidelines. Primary endpoint was complete epithelialization at 16 weeks. Secondary endpoints were healing curve, percentage of wounds healed to 80 % or more in an average of 16 weeks, percentage healed at 20 weeks.Results: The primary endpoint was 41.6 % closure rate in IFSG group versus 22.2 % in SOC group (P = 0.0053). In the intent to treat analysis (ITT), there was a statistically significant difference (P < 0.05) in mean relative wound area between the IFSG and SOC arms at weeks 6.The proportion of patients with complete epithelialization at 20 weeks was 2.11 times higher in the IFSG group than in the SOC group. For those patients that healed a median of 7 graft applications was required.Conclusions: In France, the addition of IFSG to the care plan of patients with deep diabetic foot wounds improved the closure rate by 41.6 % in IFSG group versus 22.2 % in SOC.","PeriodicalId":101305,"journal":{"name":"Diabetes & metabolism","volume":" ","pages":"101691"},"PeriodicalIF":4.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In adults living with type 1 diabetes, additional autoimmune diseases are associated with more chronic complications and depression. A BETTER registry analysis. 在患有1型糖尿病的成年人中，额外的自身免疫性疾病与更多的慢性并发症和抑郁症相关。更好的注册表分析。

Diabetes & metabolism Pub Date : 2025-06-04 DOI: 10.1016/j.diabet.2025.101667

Cassandra A A Locatelli, Meryem K Talbo, Virginie Messier, Caroline Grou, Maha Lebbar, Erin E Mulvihill, Anne-Sophie Brazeau, Rémi Rabasa-Lhoret

{"title":"In adults living with type 1 diabetes, additional autoimmune diseases are associated with more chronic complications and depression. A BETTER registry analysis.","authors":"Cassandra A A Locatelli, Meryem K Talbo, Virginie Messier, Caroline Grou, Maha Lebbar, Erin E Mulvihill, Anne-Sophie Brazeau, Rémi Rabasa-Lhoret","doi":"10.1016/j.diabet.2025.101667","DOIUrl":"10.1016/j.diabet.2025.101667","url":null,"abstract":"Aim: People living with type 1 diabetes (T1D) are at elevated risk of additional autoimmune diseases (ADs) than the general population. We aimed to describe the association between additional ADs and T1D-related physical and mental burden in adults.Methods: This was a cross-sectional analysis using data from the BEhaviors, Therapies, TEchnologies, and hypoglycemic Risk in T1D (BETTER) registry. Using patient reported-outcomes and validated questionnaires, we compared prevalence of vascular complications, hypoglycemia, and mental health issues between those with T1D alone (AD-) and T1D with additional AD (AD+).Results: Among 3222 participants (66.2 % female, 42.7 ± 15.0 years), 36.3 % reported ≥ 1 AD+. The AD+ group was older (+4.4 years) and more female (+17.7 %) than the AD- group. The AD+ group had similar HbA1c (P = 0.20) but was more likely to report level 2 hypoglycemia in the past month (OR: 1.27 [95 %Cl 1.06-1.52]) and level 3 hypoglycemia since diagnosis (1.22 [1.05-1.42]). The AD+ group reported more cardiovascular disease (1.40 [1.03 to 1.90]), nephropathy (1.49 [1.19-1.86]), neuropathy (1.38 [1.13-1.69]), retinopathy (1.48 [1.22-1.78]), higher depression scores (p = 0.015), and anxiety/depression medication use (1.31 [1.10-1.56]). Number of AD+ was positively associated with depression scores (1 AD+ P = 0.055, 2+ AD+ p = 0.027), level 3 hypoglycemia since diagnosis (1 AD+ p = 0.037, 2+ AD+ P = 0.025), and number of chronic complications (1 AD+ P < 0.001, 2+ AD+ P < 0.001).Conclusion: For people with T1D, living with additional ADs is associated with higher levels of physical and mental diabetes complications, warranting regular screening in this population.","PeriodicalId":101305,"journal":{"name":"Diabetes & metabolism","volume":" ","pages":"101667"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association of sweetened beverage intake with risk of type 2 diabetes in an Australian population: A longitudinal study. 澳大利亚人群中含糖饮料摄入与2型糖尿病风险的关系：一项纵向研究。

Diabetes & metabolism Pub Date : 2025-05-16 DOI: 10.1016/j.diabet.2025.101665

Robel Hussen Kabthymer, Tongzhi Wu, Sara Beigrezaei, Oscar H Franco, Allison M Hodge, Barbora de Courten

{"title":"The association of sweetened beverage intake with risk of type 2 diabetes in an Australian population: A longitudinal study.","authors":"Robel Hussen Kabthymer, Tongzhi Wu, Sara Beigrezaei, Oscar H Franco, Allison M Hodge, Barbora de Courten","doi":"10.1016/j.diabet.2025.101665","DOIUrl":"10.1016/j.diabet.2025.101665","url":null,"abstract":"Aim: Globally, sugar intake from sugar-sweetened beverages (SSBs) exceeds the daily recommended limits for intake levels of free sugar. Artificially sweetened beverages (ASBs), widely used to replace SSBs, are increasingly linked to adverse health outcomes. Hence, we assessed the association of sweetened beverage intake (SSBs and ASBs) with the risk of type 2 diabetes (T2DM).Methods: Data from the Melbourne Collaborative Cohort Study (MCCS) on 36,608 individuals aged 40 to 69 years were used. Self-reported data on diabetes were collected. The frequency of SSBs and ASBs consumption was categorized as: never or < 1 time/month; 1-3 per month; 1-6 times per week; ≥1 time / day. The association of sweetened beverage intake with the incidence of T2DM was assessed using modified Poisson regression, adjusted for lifestyle, obesity, socioeconomic, and other confounders.Results: Intakes of SSBs and ASBs were associated with an increased risk of T2DM. A high intake (≥ 1 time/day) compared to a low intake (never or < 1 time / month) was associated with increased risk of T2DM for SSB intake (incidence risk ratio (IRR) = 1.23; 95 % CI: 1.05-1.45; P for trend = 0.006) and for ASB intake (IRR = 1.38; 95 % CI: 1.18-1.61; P for trend < 0.001). Further adjustment for body mass index (BMI) and waist-to hip ratio (WHR) eliminated the association for SSBs, but not ASBs intake.Conclusions: Both sugar and artificially sweetened beverages were linked to an increased risk of T2DM. The findings highlight the need for public health measures to control the intake of sweetened beverages.","PeriodicalId":101305,"journal":{"name":"Diabetes & metabolism","volume":" ","pages":"101665"},"PeriodicalIF":0.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the link between different types of maternal diabetes and the onset of autism spectrum disorders. 了解不同类型的孕产妇糖尿病与自闭症谱系障碍发病之间的联系。

Diabetes & metabolism Pub Date : 2024-05-16 DOI: 10.1016/j.diabet.2024.101543

Wenyu Shao, Yichun Su, Jiayin Liu, Yu Long Liu, Jinghui Zhao, Xiaotang Fan

{"title":"Understanding the link between different types of maternal diabetes and the onset of autism spectrum disorders.","authors":"Wenyu Shao, Yichun Su, Jiayin Liu, Yu Long Liu, Jinghui Zhao, Xiaotang Fan","doi":"10.1016/j.diabet.2024.101543","DOIUrl":"https://doi.org/10.1016/j.diabet.2024.101543","url":null,"abstract":"Autism spectrum disorders (ASD) encompass a collection of neurodevelopmental disorders that exhibit impaired social interactions and repetitive stereotypic behaviors. Although the exact cause of these disorders remains unknown, it is widely accepted that both genetic and environmental factors contribute to their onset and progression. Recent studies have highlighted the potential negative impact of maternal diabetes on embryonic neurodevelopment, suggesting that intrauterine hyperglycemia could pose an additional risk to early brain development and contribute to the development of ASD. This paper presents a comprehensive analysis of the current research on the relationship between various forms of maternal diabetes, such as type 1 diabetes mellitus, type 2 diabetes mellitus, and gestational diabetes mellitus, and the likelihood of ASD in offspring. The study elucidates the potential mechanisms through which maternal hyperglycemia affects fetal development, involving metabolic hormones, immune dysregulation, heightened oxidative stress, and epigenetic alterations. The findings of this review offer valuable insights for potential preventive measures and evidence-based interventions targeting ASD.","PeriodicalId":101305,"journal":{"name":"Diabetes & metabolism","volume":" ","pages":"101543"},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Steatotic liver disease, MASLD and risk of chronic kidney disease. 脂肪肝、MASLD 和慢性肾病风险。

Diabetes & metabolism Pub Date : 2023-12-01 DOI: 10.1016/j.diabet.2023.101506

Josh Bilson, A. Mantovani, Christopher D. Byrne, G. Targher

引用次数: 0