Allergologie select最新文献

Airborne exposure-induced occupational type I allergy to Tenebrio molitor: Case report and studies on immunological reactivity. 空气暴露诱发对黄粉虫职业性I型过敏：病例报告及免疫反应性研究。

IF 6

Allergologie select Pub Date : 2025-07-22 eCollection Date: 2025-01-01 DOI: 10.5414/ALX02580E

Laura Weißenborn, Sabine Kespohl, Silke Maryska, Ingrid Sander, Jakob Bickhardt, Thomas Henle, Monika Raulf

{"title":"Airborne exposure-induced occupational type I allergy to Tenebrio molitor: Case report and studies on immunological reactivity.","authors":"Laura Weißenborn, Sabine Kespohl, Silke Maryska, Ingrid Sander, Jakob Bickhardt, Thomas Henle, Monika Raulf","doi":"10.5414/ALX02580E","DOIUrl":"10.5414/ALX02580E","url":null,"abstract":"This occupational case report describes a 28-year-old woman, employed since November 2020 as a research assistant working with mealworms (Tenebrio molitor), who developed symptoms of mild shortness of breath and severe redness and swelling of the eyes in early 2022, leading to the diagnosis of occupational allergic asthma due to respiratory sensitization to mealworm. Subsequent tests confirmed mono-sensitization to T. molitor and additional cross-sensitization to flour beetle (Tribolium confusum). Further studies aimed to determine the antigenic and allergenic potency of different protein fractions and rearing material isolated from T. molitor regarding protein pattern and immunological activity by T. molitor-specific polyclonal rabbit IgG and human IgE. The highest antigen content of T. molitor was measured in the rearing material, followed by mealworm flour and aqueous extraction. Allergenic proteins are particularly detected in mealworm flour and aqueous fraction at molecular weights of 24 and 11 kDa, which appear to be specific for primary airway sensitization. In addition, the airborne T. molitor antigen levels in the workplace were monitored using electrostatic dust collectors to identify hotspots of exposure. The disposal of dry insect material was shown to be responsible for the unintentional release of potential allergens. Therefore, awareness of the potential risk of a type I allergy due to the release of airborne insect allergens in the workplace should be raised.","PeriodicalId":101298,"journal":{"name":"Allergologie select","volume":"9 ","pages":"66-74"},"PeriodicalIF":6.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Legumes in bread baking: A hidden risk for an IgE-mediated inhalant allergy. 面包烘焙中的豆类：ige介导的吸入性过敏的潜在风险。

IF 6

Allergologie select Pub Date : 2025-07-15 eCollection Date: 2025-01-01 DOI: 10.5414/ALX02581E

Sabine Kespohl, Christian Eisenhawer, Silke Maryska, Ingrid Sander, Irene Mittermann, Martina Aumayr, Monika Raulf

{"title":"Legumes in bread baking: A hidden risk for an IgE-mediated inhalant allergy.","authors":"Sabine Kespohl, Christian Eisenhawer, Silke Maryska, Ingrid Sander, Irene Mittermann, Martina Aumayr, Monika Raulf","doi":"10.5414/ALX02581E","DOIUrl":"10.5414/ALX02581E","url":null,"abstract":"New protein-rich flour blends from legumes are increasingly being processed for gluten-free bakery products, which may increase the risk of IgE-mediated sensitization through inhalation exposure. In the described case of a 29-year-old baker, work incapacity occurred due to respiratory complaints following exposure to various gluten-free baking ingredients. Occupation-related sensitization to \"chestnut pea flour\" (flour from lightly roasted and ground yellow peas) was identified, while the patient showed no IgE sensitization to five other ingredients. Significant allergic respiratory reactions occurred during bronchial challenge test with \"chestnut pea\" extract. Based on the test results and typical workplace-related symptoms, recognition of occupational disease was recommended. Further identification of potential causal allergens using IgE blot and allergen component-resolved diagnostics revealed IgE bindings to typical storage proteins, 2S albumin and vicilin, as well as to Bet v 1 homologous of \"chestnut pea\" and non-specific lipid transfer proteins. This case illustrates that the processing of protein-rich legume flours can pose new sensitization risks for workers, which should be considered in the future.","PeriodicalId":101298,"journal":{"name":"Allergologie select","volume":"9 ","pages":"58-65"},"PeriodicalIF":6.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of irreversibility in high-resolution computed tomography in chronic hypersensitivity pneumonitis. 慢性超敏性肺炎高分辨率计算机断层扫描的不可逆性特征。

Allergologie select Pub Date : 2025-07-02 eCollection Date: 2025-01-01 DOI: 10.5414/ALX02560E

Beate Rehbock, Andreas Gschwendtner, Okka W Hamer

引用次数: 0

Nasal eosinophil count and visual analog scale in patients with allergic rhinitis. 变应性鼻炎患者鼻腔嗜酸性粒细胞计数及视觉模拟量表的研究。

Allergologie select Pub Date : 2025-05-07 eCollection Date: 2025-01-01 DOI: 10.5414/ALX02577E

Giorgio Ciprandi, Irene Schiavetti

引用次数: 0

Occupational buckwheat allergy in a health food store employee: From inhalative exposure to anaphylaxis. 保健食品店员工的职业性荞麦过敏：从吸入性暴露到过敏反应。

Allergologie select Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI: 10.5414/ALX02561E

Julia Felicitas Pilz, Valentina Faihs, Claudia Kugler, Ulf Darsow, Tilo Biedermann, Knut Brockow

引用次数: 0

Recent findings from the anaphylaxis registry: Where are we, where do we want to go? 来自过敏反应登记处的最新发现：我们在哪里，我们想去哪里？

Allergologie select Pub Date : 2025-03-06 eCollection Date: 2025-01-01 DOI: 10.5414/ALX02529E

Margitta Worm, Sabine Dölle-Bierke, Lea Faust, Veronika Höfer

{"title":"Recent findings from the anaphylaxis registry: Where are we, where do we want to go?","authors":"Margitta Worm, Sabine Dölle-Bierke, Lea Faust, Veronika Höfer","doi":"10.5414/ALX02529E","DOIUrl":"10.5414/ALX02529E","url":null,"abstract":"The anaphylaxis registry collects structured data across Europe regarding elicitors, accompanying circumstances and other diseases as well as the treatment of severe allergic reactions. By March 2024, 16,988 cases had been registered, of which ~ 1/3 were children and 2/3 were adults. Among children, boys are most frequent affected, while among adults, women are most frequently affected. The most common elicitors depend on age and continue to be dominated by the food allergens in children and by insect venom in adults. The occurrence of anaphylaxis without skin symptoms is not uncommon and occurs in children in the range of 5%, regardless of the trigger, while in adults the frequency is generally higher (up to 15%) and there are trigger-dependent differences. The analysis of the rare food allergens that trigger anaphylaxis shows, for example, spices such as saffron and sumac and vegetables such as chicory or spring onions. One case was elicited by a mealworm. Food shows an increase in triggering anaphylaxis in children. The trigger spectrum of foods is large and relevant due to the increasing plant-based diets. Rare allergens can cause anaphylaxis and should be further considered and monitored in the coming years to determine their frequency as triggers of severe reactions.","PeriodicalId":101298,"journal":{"name":"Allergologie select","volume":"9 ","pages":"21-27"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on Reese et al. 2023 "Vegan Diets from an Allergy Point of View - Position Paper of the DGAKI Working Group on Food Allergy". Allergologie Select. 2023; 7: 57-83. 对 Reese 等人 2023 年 "从过敏角度看素食--DGAKI 食物过敏工作组的立场文件 "的评论。Allergologie Select.2023; 7: 57-83.

Allergologie select Pub Date : 2025-03-06 eCollection Date: 2025-01-01 DOI: 10.5414/ALX02572E

Christian Koeder

引用次数: 0

Recommendations on how to proceed in case of suspected allergy to penicillin/β-lactam antibiotics: Position paper of the German Society for Allergology and Clinical Immunology (DGAKI) in cooperation with the German Society for Pediatric Allergology (GPA), Austrian Society for Allergology and Immunology (ÖGAI) and the Swiss Society for Allergology and Immunology (SGAI). 关于在疑似青霉素/β-内酰胺类抗生素过敏的情况下如何进行的建议：德国过敏学和临床免疫学学会（DGAKI）与德国儿科过敏学学会（GPA）、奥地利过敏学和免疫学学会（ÖGAI）和瑞士过敏学和免疫学学会（SGAI）合作的立场文件。

Allergologie select Pub Date : 2025-03-06 eCollection Date: 2025-01-01 DOI: 10.5414/ALX02531E

Knut Brockow, Wolfgang Pfützner, Bettina Wedi, Gerda Wurpts, Axel Trautmann, Burkhard Kreft, Timo Buhl, Mathias Sulk, Andreas Recke, Kathrin Scherer, Stefan Wöhrl, Irena Neustädter, Regina Treudler, Christiane Querbach, Margitta Worm

{"title":"Recommendations on how to proceed in case of suspected allergy to penicillin/β-lactam antibiotics: Position paper of the German Society for Allergology and Clinical Immunology (DGAKI) in cooperation with the German Society for Pediatric Allergology (GPA), Austrian Society for Allergology and Immunology (ÖGAI) and the Swiss Society for Allergology and Immunology (SGAI).","authors":"Knut Brockow, Wolfgang Pfützner, Bettina Wedi, Gerda Wurpts, Axel Trautmann, Burkhard Kreft, Timo Buhl, Mathias Sulk, Andreas Recke, Kathrin Scherer, Stefan Wöhrl, Irena Neustädter, Regina Treudler, Christiane Querbach, Margitta Worm","doi":"10.5414/ALX02531E","DOIUrl":"10.5414/ALX02531E","url":null,"abstract":"β-lactam antibiotics (BLAs) are still the antibiotics of first choice for the treatment of many bacterial infections. Treatment with a BLA is often hindered by a suspected allergy, up to 10% of the population report an allergy to penicillin. After allergological evaluation of the suspected allergic reaction to a BLA, most patients show a low probability of a BLA allergy; only in a minority of cases an allergic reaction to the repeated administration of a BLA appear likely in view of the previous history. In > 90% of cases, the suspected BLA allergy can be ruled out by allergy diagnostics. We recommend a risk-stratified approach in the context of an urgent need for BLA, which should enable most patients to receive a BLA therapy. After acute therapy, allergy diagnostics have to be done to clearly prove or reliably rule out a BLA allergy.","PeriodicalId":101298,"journal":{"name":"Allergologie select","volume":"9 ","pages":"28-39"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The importance of registries in clinical practice: Insights from the national atopic dermatitis registry TREATgermany. 登记在临床实践中的重要性：来自德国国家特应性皮炎登记的见解。

Allergologie select Pub Date : 2025-03-06 eCollection Date: 2025-01-01 DOI: 10.5414/ALX02545E

Tatjana Honstein, Barbara Kind, Dora Stölzl, Inken Harder, Sigrid Müller, Thomas Birkner, Luise Heinrich, Sascha Fischer, Nicole Sander, Annice Heratizadeh, Jochen Schmitt, Stephan Weidinger, Thomas Werfel

{"title":"The importance of registries in clinical practice: Insights from the national atopic dermatitis registry TREATgermany.","authors":"Tatjana Honstein, Barbara Kind, Dora Stölzl, Inken Harder, Sigrid Müller, Thomas Birkner, Luise Heinrich, Sascha Fischer, Nicole Sander, Annice Heratizadeh, Jochen Schmitt, Stephan Weidinger, Thomas Werfel","doi":"10.5414/ALX02545E","DOIUrl":"10.5414/ALX02545E","url":null,"abstract":"Atopic dermatitis (AD) is an inflammatory, multifactorial skin disease characterized by eczematous skin lesions, severe itching, and serious limitations in quality of life. Since 2016, TREATgermany has been a national clinical registry for patients with moderate to severe AD with around 2,550 participating patients, enabling the collection of physical, patient-reported social and psychological data as well as the collection of biosamples in routine care. TREATgermany is one of the largest academically managed AD registries in the world. This current review summarizes a selection of published analyses from registry data from TREATgermany, which retrospectively identified important correlations with regard to treatment response and safety, and investigated quality of life, performance, and mental health under everyday conditions. In addition, initial molecular signatures were identified from the blood and skin samples obtained from the patients included in the registry, which may be useful as prognostic markers.","PeriodicalId":101298,"journal":{"name":"Allergologie select","volume":"9 ","pages":"40-46"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to Letter to the Editor from Christian Koeder . 对Christian Koeder给编辑的信的回应 。

Allergologie select Pub Date : 2025-03-06 eCollection Date: 2025-01-01 DOI: 10.5414/ALX02573E

Imke Reese, Christiane Schäfer, Barbara Ballmer-Weber, Kirsten Beyer, Sabine Dölle-Bierke, Suzanne van Dullemen, Uta Jappe, Sabine Schnadt, Regina Treudler

引用次数: 0