The Asia Pacific Heart Journal最新文献_第5页

Calcium cycling in the aged heart 老年人心脏中的钙循环

The Asia Pacific Heart Journal Pub Date : 1999-09-01 Epub Date: 2004-04-15 DOI: 10.1016/S1328-0163(99)90070-2

Ying-Ying Zhou MD, PhD, Edward G. akatta MD, Rui-Ping Xiao MD, PhD

{"title":"Calcium cycling in the aged heart","authors":"Ying-Ying Zhou MD, PhD, Edward G. akatta MD, Rui-Ping Xiao MD, PhD","doi":"10.1016/S1328-0163(99)90070-2","DOIUrl":"10.1016/S1328-0163(99)90070-2","url":null,"abstract":"<div>One of the most important hallmarks of the aged heart is altered calcium homeostasis, possibly due to age-associated alterations in several major calcium cycling processes involved in cardiac excitation-contraction coupling. During ageing, the magnitude of the L-type Ca2+ channel current (ICa,L) becomes significantly increased in parallel with the enlargement of cardiac myocytes, resulting in an unaltered ICa,L density. Since the inactivation of ICa,L is slowed, and the action potential duration is prolonged, the net Ca2+ influx during each action potential is increased in cells of senescent myocardium relative to cells of adult control. While neither mRNA nor protein levels of the sarcoplasmic reticulum (SR) Ca2+ release channel (ryanodine receptor) significantly change with advancing adult age, the mRNA abundance and the density of SR Cat+ pump decrease with ageing and are associated with a diminished SR Ca2+ sequestration rate in the aged heart. In addition, cardiac chronotropic and inotropic responses to β-adrenergic receptor stimulation are also reduced with advancing age. The multiple changes in Ca cycling that occur during ageing result in an augmented Cat+ influx, slowed SR Ca2+ sequestration and prolonged durations of the Cai transient and contraction. These alterations which prolong electromechanical systole may be construed as an adaptation in that they prolong the force-bearing capacity of the senescent cells following excitation. This is helpful with respect to maintaining the cardiac function in the aged heart. However, they also increase the risk of Ca2+ overload and Cat2+-dependent arrhythmias during stress in the senescent heart. Although reduced (3-adrenergic responses with ageing contribute to diminished contraction reserve, these may be viewed in part, as adaptive, in that they protect against Ca2+ overload during stress.</div>","PeriodicalId":101218,"journal":{"name":"The Asia Pacific Heart Journal","volume":"8 2","pages":"Pages 88-96"},"PeriodicalIF":0.0,"publicationDate":"1999-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1328-0163(99)90070-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83735513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brief communications for the journal 杂志的简短通讯

The Asia Pacific Heart Journal Pub Date : 1999-09-01 Epub Date: 2004-04-15 DOI: 10.1016/S1328-0163(99)90081-7

引用次数: 0

New range of stethoscopes 新型听诊器

The Asia Pacific Heart Journal Pub Date : 1999-09-01 Epub Date: 2004-04-15 DOI: 10.1016/S1328-0163(99)90086-6

引用次数: 0

Council of the Australasian society of cardiac and thoracic surgeons 澳大利亚心脏和胸外科学会理事会

The Asia Pacific Heart Journal Pub Date : 1999-09-01 Epub Date: 2004-04-15 DOI: 10.1016/S1328-0163(99)90079-9

引用次数: 0

Forthcoming events 即将到来的事件

The Asia Pacific Heart Journal Pub Date : 1999-09-01 Epub Date: 2004-04-15 DOI: 10.1016/S1328-0163(99)90089-1

引用次数: 0

Experience with tissue glue in aortic surgery, 1993–1998 组织胶在主动脉手术中的应用经验，1993-1998

The Asia Pacific Heart Journal Pub Date : 1999-05-01 Epub Date: 2004-04-15 DOI: 10.1016/S1328-0163(99)90015-5

J. Bingley, M. Gardner, R. Tam, H. Jalali, T. Mau, M.F. O'Brien, P. Pohiner, P. Tesar, G. Stafford

引用次数: 0

Expression Of aquaporin-1 (AQP-1) in rat heart 大鼠心脏水通道蛋白-1 (AQP-1)的表达

The Asia Pacific Heart Journal Pub Date : 1999-05-01 Epub Date: 2004-04-15 DOI: 10.1016/S1328-0163(99)90007-6

Jing-Sheng Zheng MD, PhD , Yanshan Dai MD, PhdD , Jun Li MD , Xilin Long MD, PhD , Lydia O'Neill BA , Zhihe Li MD, PhD , W.J. Lederer MD, PhD , Heping Cheng PhD , Bruce J. Baum DMD, PhD , Edward G. Lakatta MD , Michael T. Crow PhD , Marvin O. Boluyt PhD

{"title":"Expression Of aquaporin-1 (AQP-1) in rat heart","authors":"Jing-Sheng Zheng MD, PhD , Yanshan Dai MD, PhdD , Jun Li MD , Xilin Long MD, PhD , Lydia O'Neill BA , Zhihe Li MD, PhD , W.J. Lederer MD, PhD , Heping Cheng PhD , Bruce J. Baum DMD, PhD , Edward G. Lakatta MD , Michael T. Crow PhD , Marvin O. Boluyt PhD","doi":"10.1016/S1328-0163(99)90007-6","DOIUrl":"10.1016/S1328-0163(99)90007-6","url":null,"abstract":"<div>Background. AQP-1, a channel-forming integral membrane protein of 28 kDa prevalent in red blood cells and renal proximal tubules, was recently shown to be expressed in rat heart.Aims: Our purpose was to charaterise the experssion of the AQO-1 gene in rat heart with respect to cell type, developmental stage and pathophysiological condition. Methods: To determine in which heart cell type the water channel was expressed, we measured AQP-1 mRNA and protein levels and immunolocalised protein in freshly isolated myocytes from adult rats and cultured myocytes and fibroblasts from neonatal rats. Results: Northern blot analysis showed that AQP-1 mRNA is expressed in adult cardiac myocytes, neonatal myocytes, and neonatal cardiac fibroblasts of rats at levels nearly as high as those observed in rat kidney. Western blot analysis, however, detected AQP-1 protein only in purified adult and neonatal cardiac myocytes at levels markedly less than kidney. Immunohistochemistry and confocal imaging localised AQP-1 protein to the sarcolemmal membrane of myocytes. Since the expression of other membrane-spanning proteins is altered during hypertrophy, we determined the level of AQP-1 mRNA in hearts of aortic-constricted (AC) rats. The level of AQP-1 mRNA decreased progressively after AC, and was 42% less than the level in left ventricles (LVs) of sham-operated control rats after 3 days of AC. Conclusions: These data indicate that AQP-1 is expressed in cardiac myocytes of adult and neonatal rats, and its expression is modulated in the rat heart during pressure-overload hypertrophy.</div>","PeriodicalId":101218,"journal":{"name":"The Asia Pacific Heart Journal","volume":"8 1","pages":"Pages 36-43"},"PeriodicalIF":0.0,"publicationDate":"1999-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1328-0163(99)90007-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76404683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Histopathology of the radial artery: A conduit for CABG 桡动脉组织病理学:冠脉搭桥的导管

The Asia Pacific Heart Journal Pub Date : 1999-05-01 Epub Date: 2004-04-15 DOI: 10.1016/S1328-0163(99)90022-2

P. Ruengsakulrach, R. Sinclair, I. Gordon, B. Buxton

引用次数: 0

Transmyocardial laser revascularisation using CO2 laser CO2激光心肌激光血管重建术

The Asia Pacific Heart Journal Pub Date : 1999-05-01 Epub Date: 2004-04-15 DOI: 10.1016/S1328-0163(99)90011-8

M.S. Bayfield, S.M. Herman, R. Jeremy, C.F. Hughes

引用次数: 0

Minimally invasive cardiac surgery using the heartport technique 使用心脏移植技术的微创心脏手术

The Asia Pacific Heart Journal Pub Date : 1999-05-01 Epub Date: 2004-04-15 DOI: 10.1016/S1328-0163(99)90005-2

James I. Fann MD , Thomas A. Burdon MD, FRCS , Mario F. Pompili MD, FRCS

{"title":"Minimally invasive cardiac surgery using the heartport technique","authors":"James I. Fann MD , Thomas A. Burdon MD, FRCS , Mario F. Pompili MD, FRCS","doi":"10.1016/S1328-0163(99)90005-2","DOIUrl":"10.1016/S1328-0163(99)90005-2","url":null,"abstract":"<div>Background: Minimally invasive cardiac surgery has been developed in part as a result of progress in video-assisted and endovascular surgical techniques. Port-access cardiac surgery, which provides cardiopulmonary bypass, cardioplegic arrest, myocardial protection, and ventricular decompression, permits various procedures to be performed through smaller, less invasive incisions. Methods: Proper patient selection is emphasised in order to minimise potential complications with the port-access system. For port-access coronary revascularisation procedures, a limited left anterior thoracotomy allows harvesting of the internal mammary artery and access to the target coronary arteries. The ascending aorta can be exposed for placement of vein grafts. For port-access mitral valve surgery, a limited right thoracotomy provides direct visualisation of the left atrium and the mitral valve. Results: The feasibility and efficacy of port-access coronary revascularisation and mitral valve surgery have been demonstrated in experimental and clinical settings. Peripheral cardiopulmonary bypass with cardioplegic arrest has been reproducibly achieved based on indices of cardiac function. Port-access multivessel coronary revascularisation and port-access mitral valve procedures have been performed with acceptable results. Conclusions: The port-access catheter system effectively achieves peripheral cardiopulmonary bypass, aortic occlusion, cardioplegia delivery, and left ventricular decompression. Alternative, less invasive methods of coronary revascularisation and various intracardiac procedures can be performed without a conventional median sternotomy.</div>","PeriodicalId":101218,"journal":{"name":"The Asia Pacific Heart Journal","volume":"8 1","pages":"Pages 19-26"},"PeriodicalIF":0.0,"publicationDate":"1999-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1328-0163(99)90005-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84964625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4