The American Journal of Medicine Supplements最新文献

Association between COVID-19 infection and pulmonary fibrosis: a nested case-control study. COVID-19感染与肺纤维化之间的关系:一项巢式病例对照研究

The American Journal of Medicine Supplements Pub Date : 2023-08-01 DOI: 10.2139/ssrn.4385523

R. Najjar-Debbiny, O. Barnett-Griness, J. Khoury, N. Gronich, G. Weber, Yochay Adir, Michal Steinberg, Sonia Shneir, Lokesh Sharma, W. Saliba

{"title":"Association between COVID-19 infection and pulmonary fibrosis: a nested case-control study.","authors":"R. Najjar-Debbiny, O. Barnett-Griness, J. Khoury, N. Gronich, G. Weber, Yochay Adir, Michal Steinberg, Sonia Shneir, Lokesh Sharma, W. Saliba","doi":"10.2139/ssrn.4385523","DOIUrl":"https://doi.org/10.2139/ssrn.4385523","url":null,"abstract":"BACKGROUND\u0000Pulmonary fibrosis is associated with significant morbidity. Data are scarce on the link between COVID-19 and pulmonary fibrosis. We aimed to assess the association between COVID-19 with pulmonary fibrosis.\u0000\u0000\u0000METHODS\u0000We conducted a nested case-control study in a cohort of 2,894,801 adults without a diagnosis of pulmonary fibrosis. The underlying cohort consisted of members of the largest healthcare provider in Israel aged 18 years or older as of May 1, 2020. Subjects were followed up from cohort entry until June 30, 2022 for the occurrence of pulmonary fibrosis. Ten randomly selected controls were matched to each case of pulmonary fibrosis on age, sex and calendar time. To account for surveillance bias a lag-time of 60 days was used for ascertainment of prior COVID-19 and COVID-severity.\u0000\u0000\u0000RESULTS\u0000During follow-up 1,284 patients were newly diagnosed with pulmonary fibrosis and matched with 12,840 controls. Multivariable conditional logistic-regression models showed that the OR for pulmonary fibrosis was 1.80 (95% CI, 1.47-2.19) in patients with COVID-19 compared to no COVID-19. The multivariable OR for pulmonary fibrosis was 1.33 (1.06-1.68), 2.98 (1.16-7.65), and 9.30 (5.77-14.98) for mild, moderate, and severe COVID-19, respectively, compared to no COVID-19. The magnitude of the association was attenuated but remained statistically significant for severe disease when the lag-time was extended to 180 days; 1.08 (0.78-1.49), 2.37 (0.75-7.46), and 5.34 (2.75-10.36) for mild, moderate, and severe COVID-19, respectively.\u0000\u0000\u0000CONCLUSIONS\u0000COVID-19 appears to be associated with an increased risk of pulmonary fibrosis and the magnitude of the association increases with COVID-19 severity.","PeriodicalId":101216,"journal":{"name":"The American Journal of Medicine Supplements","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81084764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of tooth loss and diet quality with acceleration of aging: Evidence from NHANES. 牙齿脱落和饮食质量与加速衰老的关系:来自NHANES的证据。

The American Journal of Medicine Supplements Pub Date : 2023-04-01 DOI: 10.2139/ssrn.4310422

Kehui Xu, Ling Li, Shuailin Jia, Qihong Li, Jiaxin Hao, Sai Ma, Zikang He, Qianqian Wan, Yunfan Cai, Zhiting Li, Franklin Tay, Lina Niu

{"title":"Association of tooth loss and diet quality with acceleration of aging: Evidence from NHANES.","authors":"Kehui Xu, Ling Li, Shuailin Jia, Qihong Li, Jiaxin Hao, Sai Ma, Zikang He, Qianqian Wan, Yunfan Cai, Zhiting Li, Franklin Tay, Lina Niu","doi":"10.2139/ssrn.4310422","DOIUrl":"https://doi.org/10.2139/ssrn.4310422","url":null,"abstract":"INTRODUCTION\u0000Although tooth loss is widely recognized as a typical sign of aging, whether it is associated with accelerated aging, and to what extent diet quality mediates this association are unknown.\u0000\u0000\u0000METHODS\u0000Data were collected from the National Health and Nutrition Examination Survey. The missing tooth counts were recorded as the number of edentulous sites. Phenotypic accelerated aging was calculated using nine routine clinical chemistry biomarkers and chronological age. Healthy Eating Index 2015 (HEI-2015) score was used to evaluate diet quality. Multivariate logistic regression and linear regression were used to analyze the association between tooth loss and accelerated aging. Mediation analyses were used to examine the mediation role of diet quality in the association.\u0000\u0000\u0000RESULTS\u0000The association between tooth loss and accelerated aging was confirmed. The highest quartile of tooth loss showed a positive association with accelerated aging (β=1.090; 95%CI 0.555, 1.625; P<0.001). Diet quality decreased with increase number of missing teeth and showed a negative association with accelerated aging. Mediation analysis suggested that the HEI-2015 score partially mediated the association between tooth loss and accelerated aging (proportion of mediation: 5.302%; 95%CI 3.422%, 7.182%; P<0.001). Plant foods such as fruits and vegetables were considered the key mediating food.\u0000\u0000\u0000CONCLUSIONS\u0000The association between tooth loss and accelerated aging, as well as the partially mediating role of dietary quality in this association, was confirmed. These findings suggested that more attention should be paid to the population with severe tooth loss and the changes of their dietary quality.","PeriodicalId":101216,"journal":{"name":"The American Journal of Medicine Supplements","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88347827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

STEROID-RESPONSIVE FULMINANT LYMPHOCYTIC MYOCARDITIS MIMICKING GIANT-CELL MYOCARDITIS. 类固醇反应性暴发性淋巴细胞性心肌炎模拟巨细胞性心肌炎。

The American Journal of Medicine Supplements Pub Date : 2023-03-01 DOI: 10.1016/s0735-1097(23)03098-x

Arturo Hernandez, Brendan A. Andres, P. Jagadish, Suzanne K. Oskouie, Tushar Acharya, E. Juneman, D. Acharya

引用次数: 0

It Is Time to Abandon the Use of Body Surface Area Derived From a 100-Year-Old Formula. 是时候放弃使用从100年前的公式中推导出来的体表面积了。

The American Journal of Medicine Supplements Pub Date : 2022-09-01 Epub Date: 2022-04-23 DOI: 10.1016/j.amjmed.2022.03.035

Haoyi Zheng

引用次数: 0

The Two Pandemics. 两大流行病

The American Journal of Medicine Supplements Pub Date : 2022-09-01 Epub Date: 2022-04-25 DOI: 10.1016/j.amjmed.2022.03.026

Michelle M Kittleson

引用次数: 0

Peripherally Inserted Central Catheter Line Misuse Among People Who Inject Drugs While on Therapy for Infective Endocarditis. 注射药物治疗感染性心内膜炎患者中外周插入中心导管的误用。

The American Journal of Medicine Supplements Pub Date : 2022-09-01 Epub Date: 2022-03-16 DOI: 10.1016/j.amjmed.2022.02.021

Janica Adams, Tara Elton-Marshall, Esfandiar Shojaei, Michael Silverman

{"title":"Peripherally Inserted Central Catheter Line Misuse Among People Who Inject Drugs While on Therapy for Infective Endocarditis.","authors":"Janica Adams, Tara Elton-Marshall, Esfandiar Shojaei, Michael Silverman","doi":"10.1016/j.amjmed.2022.02.021","DOIUrl":"10.1016/j.amjmed.2022.02.021","url":null,"abstract":"Background: People who inject drugs and have infective endocarditis have a high risk of recurrent infective endocarditis and death. We aimed to characterize clinical factors associated with mortality and assess the probability of infective endocarditis recurrence in the presence of death as a competing risk.Methods: A retrospective cohort study was conducted of people who inject drugs, identified between April 5, 2007 and March 15, 2018 with the Modified Duke Criteria for definite infective endocarditis. Fine-Gray sub-distribution and Cox proportional hazards modeling were conducted to determine variables associated with the rate of infective endocarditis recurrence and mortality, respectively.Results: Of the 310 patients with infective endocarditis who inject drugs, 236 experienced a single episode and 74 experienced recurrent episodes. Peripherally inserted central catheter misuse was associated with an increased rate of infective endocarditis recurrence (sub-distribution hazard ratio 2.41; 95% confidence interval [CI], 1.17-4.98; P = .02) and mortality (hazard ratio [HR] 2.44; 95% CI, 1.15-5.17; P = .02). Non-right-sided infection, peripheral intravenous therapy, and intensive care unit admission were also associated with increased mortality. Oral therapy (HR 0.38; 95% CI, 0.16-0.91; P = .03), outpatient treatment (HR 0.39; 95% CI, 0.19-0.82; P = .01), and inpatient referral to addiction services (HR 0.39; 95% CI, 0.22-0.70; P = .002) were associated with a decrease in mortality.Conclusions: Patients who misuse their peripherally inserted central catheter are at higher risk of recurrent infective endocarditis and death. Avoidance of peripherally inserted central catheter lines and use of intravenous peripheral therapy did not reduce mortality, but oral therapy was associated with reduced risk. Inpatient addiction services referral is important.","PeriodicalId":101216,"journal":{"name":"The American Journal of Medicine Supplements","volume":"82 1","pages":"e324-e336"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89006758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Importance of Adding Discernment to the Acting Internship - A Necessary Shift in Culture Towards Competency-Based Metrics. 在表演实习中增加洞察力的重要性——文化向基于能力的指标的必要转变。

The American Journal of Medicine Supplements Pub Date : 2022-06-01 DOI: 10.1016/j.amjmed.2022.05.032

A. Garber, A. Ferris, T. Vu

引用次数: 0

WILSON'S DISEASE - NEVER TOO LATE. 威尔逊氏症，永远不会太迟。

The American Journal of Medicine Supplements Pub Date : 2022-05-01 DOI: 10.1016/j.amjmed.2022.04.025

A. Annamalai, V. Prajna, Gunja Chowdhury, R. Santhi, Mariappan Kannan, S. Vedantham, M. Gurnell

引用次数: 3

Artificial intelligence-based stethoscope for the diagnosis of aortic stenosis. 基于人工智能的听诊器用于主动脉瓣狭窄的诊断。

The American Journal of Medicine Supplements Pub Date : 2022-05-01 DOI: 10.1016/j.amjmed.2022.04.032

Tamer Ghanayim, L. Lupu, Sivan Naveh, N. Bachner-Hinenzon, D. Adler, S. Adawi, S. Banai, A. Shiran

引用次数: 10

Face Off: 3D Printed Masks as a Cost-Effective and Reusable Alternative to N95 Respirators: A Feasibility Study. Face Off: 3D打印口罩作为N95呼吸器的成本效益和可重复使用的替代品:可行性研究。

The American Journal of Medicine Supplements Pub Date : 2022-05-01 DOI: 10.1016/j.amjmed.2022.04.026

Marc Levine, L. Levine, Helen Xun, Prakash J Mathew, Devinder Singh, Adam Gerber, Michael Antonietti

引用次数: 3