Revista de Psiquiatría y Salud Mental (English Edition)最新文献

{"title":"Amerindians may need clozapine dosing similar to that of Asians","authors":"Dinora F. González-Esquivel , Helgi Jung-Cook , Trino Baptista , Jose de Leon","doi":"10.1016/j.rpsmen.2020.11.003","DOIUrl":"10.1016/j.rpsmen.2020.11.003","url":null,"abstract":"","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"14 3","pages":"Pages 177-179"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173505021000418/pdfft?md5=03a35fdbdbf1510820947597205e006d&pid=1-s2.0-S2173505021000418-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39364134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clozapine in patients with schizoaffective disorder: A systematic review","authors":"Diana Rey Souto ,&nbsp;Justo Pinzón Espinosa ,&nbsp;Eduard Vieta ,&nbsp;Antoni Benabarre Hernández","doi":"10.1016/j.rpsmen.2021.07.001","DOIUrl":"10.1016/j.rpsmen.2021.07.001","url":null,"abstract":"<div><p>Schizoaffective disorder is defined by the appearance of positive psychotic symptomatology as well as affective features, even when it is considered a controversial nosologic entity, proving difficult to accord on its definition or diagnostic criteria. Due to these conceptual differences, it has been a challenge to study effective therapeutic measures and, consequently, the availability of data in the current literature, resulting in the extrapolation of clinical guidelines and recommendations initially established for patients with schizophrenia or bipolar disorder. The current study aimed to systematically search and summarize the published evidence to date about the use of clozapine in patients with schizoaffective disorder. Seven studies were identified, that are heterogeneous on their designs and methodology, including samples of patients mixed with bipolar or schizophrenic disorders. The evidence was summarized both in a table and a narrative fashion, suggesting that clozapine may be an effective treatment for both psychotic and affective symptoms, indistinctively of an acute or maintenance phase.</p></div>","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"14 3","pages":"Pages 148-156"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rpsmen.2021.07.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39317099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic and metabolic profiling of chronic patients with schizophrenia induced by a physical activity program: Pilot study","authors":"María del Carmen Vallejo-Curto ,&nbsp;Daniela Rodrigues-Amorim ,&nbsp;Laura Jardón-Golmar ,&nbsp;María Blanco-Formoso ,&nbsp;Tania Rivera-Baltanás ,&nbsp;Cynthia Rodriguez-Jamardo ,&nbsp;Patricia Fernández-Palleiro ,&nbsp;María Álvarez-Ariza ,&nbsp;Marta López-García ,&nbsp;Alejandro García-Caballero ,&nbsp;Elena de las Heras ,&nbsp;José Manuel Olivares ,&nbsp;Carlos Spuch","doi":"10.1016/j.rpsmen.2021.07.002","DOIUrl":"10.1016/j.rpsmen.2021.07.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Schizophrenia is a chronic illness often accompanied by metabolic disorders, diabetes, obesity and cardiovascular problems often associated with unhealthy lifestyles, as well as neuroendocrine problems caused by the disease itself. Lifestyle changes, such as regular physical exercise, have a positive effect on metabolic disorders and mental health, although the molecular changes that occur in this type of patient and how they explain the changes in their response are unknown. This study wants to analyze in a novel way the proteins and molecular pathways involved in critical plasmatic proteins in plasma to reveal the pathways involved in the implementation of physical exercise and the changes that occur among patients who participate in such programs with those who leave.</p></div><div><h3>Methods</h3><p>Twenty-one patients with chronic schizophrenia underwent a daily, 6-month aerobic training program. We divided them into a group that completed the program (12 patients) and a second group that left the training program (9 patients). The biochemical and clinical data of each patient were analyzed and the proteomic profile of the plasma was studied using ESI-LC–MS/MS.</p></div><div><h3>Results</h3><p>Proteomic analysis recognizes 21.165 proteins and peptides in each patient, of which we identified 1.812 proteins that varied between both groups linked to the metabolic and biological regulation pathways. After clinical analysis of each patient we found significant differences in weight, BMI, abdominal perimeter, diastolic blood pressure, and HDL cholesterol levels. The main change that vertebrates both groups is the Self-Assessment Anhedonia Scale, where we detected higher levels in the dropout group (no physical activity) compared to the active group.</p></div><div><h3>Conclusion</h3><p>The benefits of physical exercise are clear in chronic patients with schizophrenia, as it substantially improves their BMI, as well as their clinical and biochemical parameters. However, our study reveals the biological and molecular pathways that affect physical exercise in schizophrenia, such as important metabolic proteins such as ApoE and ApoC, proteins involved in neuronal regulation such as tenascin and neurotrophins, neuroinflammatory regulatory pathways such as lipocalin-2 and protein 14-3-3, as well as cytoskeleton proteins of cells such as spectrins and annexines. Understanding these molecular mechanisms opens the door to future therapies in the chronicity of schizophrenia.</p></div>","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"14 3","pages":"Pages 125-138"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rpsmen.2021.07.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39305402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of aripiprazole and risperidone effectiveness in first episode non-affective psychosis: Rationale and design of a prospective, randomized, 3-phase, investigator-initiated study (PAFIP-3)","authors":"Mayoral-van Son J. ,&nbsp;Marcos Gómez-Revuelta ,&nbsp;Rosa Ayesa-Arriola ,&nbsp;Javier Vázquez-Bourgón ,&nbsp;Víctor Ortiz-García de la Foz ,&nbsp;Miguel Ruiz-Veguilla ,&nbsp;Nathalia Garrido ,&nbsp;Diana Tordesillas-Gutiérrez ,&nbsp;Esther Setién-Suero ,&nbsp;Benedicto Crespo-Facorro","doi":"10.1016/j.rpsmen.2021.08.002","DOIUrl":"10.1016/j.rpsmen.2021.08.002","url":null,"abstract":"<div><h3>Background</h3><p>Selecting the most effective treatment represents a critical challenge with the potential of modifying the long-term prognosis of individuals suffering a first break of psychosis. Head-to-head clinical trials comparing effectiveness among antipsychotic drugs in individuals with a first-episode of non-affective psychosis (FEP) are scarce.</p></div><div><h3>Methods</h3><p>The rationale and design of a 3 phases clinical trial (PAFIP-3, <span>NCT02305823</span><svg><path></path></svg>) comparing the effectiveness of aripiprazole and risperidone, and to additionally assess the benefits of an early use of clozapine in primary treatment-resistant patients is reported. The design encompasses of 5 work packages (medication algorithm, cognitive functioning, psychoeducation/vocational functioning, imaging and biological markers) addressing critical issues and needs of first episode psychosis individuals and their cares. The primary outcome measure was treatment effectiveness assessed by all-cause treatment discontinuation rate.</p></div><div><h3>Results</h3><p>266 individuals have been included in the randomization study phase I (risperidone vs. aripiprazole). At 3 months, the retention rate was of 94% (249/266), 48(19.3%) patients have gone through phase II (olanzapine treatment), and 7(2.8%) entered the clozapine phase (phase III).</p></div><div><h3>Discussion</h3><p>The PAFIP 3 clinical trial may provide relevant information about clinical guidelines to optimally treat patients with a first episode of non-affective psychosis and the benefits and risks of an early use of clozapine in treatment resistant patients.</p><p>Clinicaltrials.gov: <span>NCT02305823</span><svg><path></path></svg>.</p></div>","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"14 3","pages":"Pages 157-163"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S217350502100042X/pdfft?md5=7f1fb7529c0dabb4e4947835319e1410&pid=1-s2.0-S217350502100042X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39364131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevention of relapses in first episodes of schizophrenia: The 2EPs Project, background, rationale and study design","authors":"Miguel Bernardo ,&nbsp;Silvia Amoretti ,&nbsp;Manuel Jesús Cuesta ,&nbsp;Mara Parellada ,&nbsp;Gisela Mezquida ,&nbsp;2EPs Group ,&nbsp;The acronym 2EPs Group responds to the authorship of the principal investigators of the fifteen centres that have participated in this coordinated multicenter project,&nbsp;Ana González-Pinto ,&nbsp;Daniel Bergé ,&nbsp;Antonio Lobo ,&nbsp;Eduardo J. Aguilar ,&nbsp;Judith Usall ,&nbsp;Iluminada Corripio ,&nbsp;Julio Bobes ,&nbsp;Roberto Rodríguez-Jiménez ,&nbsp;Salvador Sarró ,&nbsp;Fernando Contreras ,&nbsp;Ángela Ibáñez ,&nbsp;Miguel Gutiérrez ,&nbsp;Juan Antonio Micó","doi":"10.1016/j.rpsmen.2021.08.001","DOIUrl":"10.1016/j.rpsmen.2021.08.001","url":null,"abstract":"<div><p>Up to 80% of first-episode psychosis patients suffer a relapse within five years of the remission. Relapse should be an important focus of prevention given the potential harm to the patient and family. It threatens to disrupt their psychosocial recovery, increases the risk of resistance to treatment and has been associated with greater direct and indirect costs for society.</p><p>Based on a previous project entitled “Genotype–phenotype and environment. Application to a predictive model in first psychotic episodes” (PEPs Project), the project “Clinical and neurobiological determinants of second episodes of schizophrenia. Longitudinal study of first episode of psychosis” was designed, also known as the 2EPs Project. It aimed to identify and characterize those factors that predict a relapse within the years immediately following a first episode. This project has focused on following the clinical course, with neuropsychological assessments, biological and neuroanatomical measures, genetic adherence and physical health monitoring in order to compare a subgroup of patients with a second episode to another group of patients which remains in remission. The main objective of the present article is to describe the rationale of the 2EPs Project, explaining the measurement approach adopted and providing an overview of the selected clinical and functional measures.</p><p>2EPs Project is a multicenter, coordinated, naturalistic, longitudinal follow-up study over three years in a Spanish sample of patients in remission after a first-psychotic episode of schizophrenia. It is closely monitoring the clinical course of the cases recruited to compare the subgroup of patients with a second episode to that which remains in remission. The sample is composed of 223 subjects recruited from 15 clinical centres in Spain with experience of the preceding PEPs Study project, albeit 2EPs being an expanded version with new basic groups in biological research. From the total sample recruited, 63 patients presented a relapse (44%).</p><p>2EPs arose to characterize first episodes in an exhaustive, novel and multimodal way, thus contributing towards the development of a predictive model of relapse. Identifying the characteristics of patients who relapse could improve early detection and intervention.</p></div>","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"14 3","pages":"Pages 164-176"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rpsmen.2021.08.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39364133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 lockdown influence in the psychiatric emergencies: Drastic reduction and increase in severe mental disorders","authors":"Juan Pablo Carrasco ,&nbsp;Borja Herraiz ,&nbsp;Laura O. Sanchez ,&nbsp;Ana Luengo ,&nbsp;Oriol R. Fusalba ,&nbsp;Eduardo J. Aguilar","doi":"10.1016/j.rpsmen.2021.05.002","DOIUrl":"10.1016/j.rpsmen.2021.05.002","url":null,"abstract":"","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"14 2","pages":"Pages 117-118"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rpsmen.2021.05.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9228823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Informing the response to COVID-19 in Spain: priorities for mental health research","authors":"J.L. Ayuso-Mateos ,&nbsp;R. Mediavilla ,&nbsp;K.R. Rodriguez ,&nbsp;M.F. Bravo","doi":"10.1016/j.rpsmen.2021.04.001","DOIUrl":"10.1016/j.rpsmen.2021.04.001","url":null,"abstract":"","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"14 2","pages":"Pages 79-82"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rpsmen.2021.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9235388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health interventions for healthcare workers during the first wave of COVID-19 pandemic in Spain","authors":"Amador Priede ,&nbsp;Inés López-Álvarez ,&nbsp;Diego Carracedo-Sanchidrián ,&nbsp;César González-Blanch","doi":"10.1016/j.rpsmen.2021.05.004","DOIUrl":"10.1016/j.rpsmen.2021.05.004","url":null,"abstract":"<div><h3>Objective</h3><p>In order to reduce distress associated with working with COVID-19 patients, several psychological intervention programmes for healthcare workers have been developed in Spain. We aimed to describe the main characteristics and components of these programmes for healthcare workers treating COVID-19 patients in Spanish hospitals.</p></div><div><h3>Material and methods</h3><p>An online survey was designed to evaluate the main characteristics of psychological intervention programmes for healthcare workers during the first wave of COVID-19 pandemic.</p></div><div><h3>Results</h3><p>Valid responses were received from 36 hospitals. Most of these programmes offered both in-person and online therapy. The most common aim of these interventions was emotional regulation, which was treated by psychoeducational and cognitive-behavioural techniques in individual interventions. Group interventions mainly used psychoeducation and mindfulness. Only half of the teams that offered in-person interventions received training in the proper use of personal protective equipment.</p></div><div><h3>Conclusions</h3><p>Several hospitals in Spain have developed mental health interventions for healthcare workers during the COVID-19 pandemic, deploying a wide range of therapeutic modalities and techniques. The rapid implementation of these programmes during the pandemic suggests that safety may not have received sufficient attention. The planning and development of interventions for healthcare workers during pandemics merits greater attention by national and regional authorities and institutions.</p></div>","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"14 2","pages":"Pages 83-89"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rpsmen.2021.05.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9235391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatrists as internists: Some considerations following a COVID-19 redeployment experience","authors":"Jorge Gómez-Arnau,&nbsp;Raúl González-Lucas,&nbsp;Patricia Sánchez-Páez","doi":"10.1016/j.rpsmen.2020.07.006","DOIUrl":"10.1016/j.rpsmen.2020.07.006","url":null,"abstract":"","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"14 2","pages":"Pages 121-122"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rpsmen.2020.07.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9235389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 and the education of health professionals in mental health: Challenges in practical teaching","authors":"Santiago Ovejero ,&nbsp;Maria Luisa Barrigon ,&nbsp;Héctor Guadalajara ,&nbsp;Eloísa Pérez-Santos ,&nbsp;Enrique Baca-Garcia","doi":"10.1016/j.rpsmen.2021.05.001","DOIUrl":"10.1016/j.rpsmen.2021.05.001","url":null,"abstract":"","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"14 2","pages":"Pages 119-121"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rpsmen.2021.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9235524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}