{"title":"Does routinely prescribing antibiotics at exacerbation of COPD reduce the likelihood of further exacerbations?","authors":"","doi":"10.1016/j.rmedu.2009.02.005","DOIUrl":"https://doi.org/10.1016/j.rmedu.2009.02.005","url":null,"abstract":"","PeriodicalId":101083,"journal":{"name":"Respiratory Medicine: COPD Update","volume":"5 1","pages":"Page 27"},"PeriodicalIF":0.0,"publicationDate":"2009-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmedu.2009.02.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137256876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Salmeterol with fluticasone and tiotropium is better at improving lung function in moderate to severe COPD than any one or two elements of the combination","authors":"","doi":"10.1016/j.rmedu.2008.08.008","DOIUrl":"https://doi.org/10.1016/j.rmedu.2008.08.008","url":null,"abstract":"","PeriodicalId":101083,"journal":{"name":"Respiratory Medicine: COPD Update","volume":"4 4","pages":"Page 134"},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmedu.2008.08.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91724092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Are shorter courses of antibiotics adequate in exacerbations of COPD?","authors":"","doi":"10.1016/j.rmedu.2008.08.014","DOIUrl":"https://doi.org/10.1016/j.rmedu.2008.08.014","url":null,"abstract":"<div><h3>Background</h3><p>A study was undertaken to determine whether a short course of antibiotic treatment (< or=5 days) is as effective as the conventional longer treatment in acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease (COPD).</p></div><div><h3>Methods</h3><p>MEDLINE, EMBASE and the Cochrane central register of controlled trials were searched to July 2006. Studies considered eligible were double-blind randomised clinical trials including adult patients > or=18 years of age with a clinical diagnosis of exacerbation of COPD or chronic bronchitis, no antimicrobial therapy at the time of diagnosis and random assignment to antibiotic treatment for<or=5 days versus >5 days. The primary outcome measure was clinical cure at early follow-up on an intention-to-treat basis.</p></div><div><h3>Results</h3><p>Twenty-one studies with a total of 10,698 patients were included. The average quality of the studies was high: the mean (SD) Jadad score was 3.9 (0.9). At early follow-up (< 25 days), the summary odds ratio (OR) for clinical cure with short treatment versus conventional treatment was 0.99 (95% CI 0.90–1.08). At late follow-up the summary OR was 1.0 (95% CI 0.91–1.10) and the summary OR for bacteriological cure was 1.05 (95% CI 0.87–1.26). Similar summary ORs were observed for early cure in trials with the same antibiotic in both arms and in studies grouped by the antibiotic class used in the short-course arm.</p></div><div><h3>Conclusions</h3><p>A short course of antibiotic treatment is as effective as the traditional longer treatment in patients with mild to moderate exacerbations of chronic bronchitis and COPD.</p><p>Reproduced with permission from the BMJ Publishing Group.</p></div>","PeriodicalId":101083,"journal":{"name":"Respiratory Medicine: COPD Update","volume":"4 4","pages":"Page 140"},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmedu.2008.08.014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90015197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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