Respiratory Medicine: COPD Update最新文献

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Events 事件
Respiratory Medicine: COPD Update Pub Date : 2009-02-01 Epub Date: 2009-03-11 DOI: 10.1016/j.rmedu.2009.02.012
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引用次数: 0
Reviews: Self-Assessment Answers 回顾:自我评估答案
Respiratory Medicine: COPD Update Pub Date : 2009-02-01 Epub Date: 2009-03-11 DOI: 10.1016/j.rmedu.2009.02.011
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引用次数: 0
COPD and osteoporosis 慢性阻塞性肺病和骨质疏松
Respiratory Medicine: COPD Update Pub Date : 2009-02-01 Epub Date: 2009-02-27 DOI: 10.1016/j.rmedu.2009.01.001
Charlotte E. Bolton
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引用次数: 1
Does routinely prescribing antibiotics at exacerbation of COPD reduce the likelihood of further exacerbations? 慢性阻塞性肺病加重时常规开抗生素能降低进一步加重的可能性吗?
Respiratory Medicine: COPD Update Pub Date : 2009-02-01 Epub Date: 2009-03-11 DOI: 10.1016/j.rmedu.2009.02.005
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引用次数: 0
Inhaled Corticosteroids and Mortality in COPD COPD患者吸入皮质类固醇与死亡率
Respiratory Medicine: COPD Update Pub Date : 2009-02-01 Epub Date: 2009-03-11 DOI: 10.1016/j.rmedu.2009.02.008
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引用次数: 10
Salmeterol with fluticasone and tiotropium is better at improving lung function in moderate to severe COPD than any one or two elements of the combination 沙美特罗与氟替卡松和噻托溴铵联合使用在改善中重度COPD患者肺功能方面优于任何一种或两种组合
Respiratory Medicine: COPD Update Pub Date : 2008-11-01 Epub Date: 2008-09-19 DOI: 10.1016/j.rmedu.2008.08.008
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引用次数: 0
ATS 2008 Conference Report: Much PROgress ATS 2008年会议报告:取得很大进展
Respiratory Medicine: COPD Update Pub Date : 2008-11-01 DOI: 10.1016/J.RMEDU.2008.08.002
J. Quint, J. Hurst
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引用次数: 0
Events and grants 活动及资助
Respiratory Medicine: COPD Update Pub Date : 2008-11-01 Epub Date: 2008-09-18 DOI: 10.1016/j.rmedu.2008.08.016
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引用次数: 0
Are shorter courses of antibiotics adequate in exacerbations of COPD? 较短疗程的抗生素是否足以治疗COPD加重?
Respiratory Medicine: COPD Update Pub Date : 2008-11-01 Epub Date: 2008-09-19 DOI: 10.1016/j.rmedu.2008.08.014
{"title":"Are shorter courses of antibiotics adequate in exacerbations of COPD?","authors":"","doi":"10.1016/j.rmedu.2008.08.014","DOIUrl":"https://doi.org/10.1016/j.rmedu.2008.08.014","url":null,"abstract":"<div><h3>Background</h3><p>A study was undertaken to determine whether a short course of antibiotic treatment (&lt; or=5 days) is as effective as the conventional longer treatment in acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease (COPD).</p></div><div><h3>Methods</h3><p>MEDLINE, EMBASE and the Cochrane central register of controlled trials were searched to July 2006. Studies considered eligible were double-blind randomised clinical trials including adult patients &gt; or=18 years of age with a clinical diagnosis of exacerbation of COPD or chronic bronchitis, no antimicrobial therapy at the time of diagnosis and random assignment to antibiotic treatment for&lt;or=5 days versus &gt;5 days. The primary outcome measure was clinical cure at early follow-up on an intention-to-treat basis.</p></div><div><h3>Results</h3><p>Twenty-one studies with a total of 10,698 patients were included. The average quality of the studies was high: the mean (SD) Jadad score was 3.9 (0.9). At early follow-up (&lt; 25 days), the summary odds ratio (OR) for clinical cure with short treatment versus conventional treatment was 0.99 (95% CI 0.90–1.08). At late follow-up the summary OR was 1.0 (95% CI 0.91–1.10) and the summary OR for bacteriological cure was 1.05 (95% CI 0.87–1.26). Similar summary ORs were observed for early cure in trials with the same antibiotic in both arms and in studies grouped by the antibiotic class used in the short-course arm.</p></div><div><h3>Conclusions</h3><p>A short course of antibiotic treatment is as effective as the traditional longer treatment in patients with mild to moderate exacerbations of chronic bronchitis and COPD.</p><p>Reproduced with permission from the BMJ Publishing Group.</p></div>","PeriodicalId":101083,"journal":{"name":"Respiratory Medicine: COPD Update","volume":"4 4","pages":"Page 140"},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmedu.2008.08.014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90015197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new prognostic index for health outcomes in COPD COPD健康结局的新预后指标
Respiratory Medicine: COPD Update Pub Date : 2008-11-01 Epub Date: 2008-09-19 DOI: 10.1016/j.rmedu.2008.08.011
{"title":"A new prognostic index for health outcomes in COPD","authors":"","doi":"10.1016/j.rmedu.2008.08.011","DOIUrl":"https://doi.org/10.1016/j.rmedu.2008.08.011","url":null,"abstract":"<div><h3>Background</h3><p>Chronic obstructive pulmonary disease (COPD) is a debilitating and progressive disease. The severity of the condition has typically been characterized by a single physiological measurement: forced expiratory volume in 1<!--> <!-->second, which has been shown to be prognostic for mortality.</p></div><div><h3>Methods</h3><p>To develop a prognostic tool for COPD that is sensitive not only to mortality but also to other important drivers of health status and cost, data were obtained from a pooled analysis of 12 randomized controlled trials and 3 main outcomes were chosen: mortality, hospitalization, and number of exacerbations. Cox models were employed for the time-to-event data (death or hospitalization), and a negative binomial model was used for calculating the count data (exacerbations). From these models, 3 specific indexes were developed on a 100-point scale, and 1 composite index was obtained as a mean of the specific indexes. One-third of the data was reserved for validation purposes.</p></div><div><h3>Results</h3><p>All indexes provided good discrimination among tertiles in the training and validation samples. The composite index had a performance very similar to that of the specific index in both the training and validation samples: the overall C statistic was estimated as 0.71 for both mortality and hospitalization. Each 10-point change in the composite index corresponds to an increase of 54% in the hazard ratio of death, 57% in the hazard ratio of hospitalization, and 21% in the incidence rate of exacerbations.</p></div><div><h3>Conclusions</h3><p>A composite index for COPD prognosis (the COPD Prognostic Index) has been validated in data not used in its development and is capable of predicting not only mortality, but also hospitalizations and exacerbations. All factors included in the index are straightforward to obtain, which should make the index suitable for use in primary as well as secondary care settings.<br>Reproduced with permission from the American Medical Association</p></div>","PeriodicalId":101083,"journal":{"name":"Respiratory Medicine: COPD Update","volume":"4 4","pages":"Pages 136-137"},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmedu.2008.08.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137086983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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