Pediatric Hematology Oncology Journal最新文献

{"title":"COVID-19 associated life-threatening immune-mediated thrombotic thrombocytopenic purpura in an adolescent girl","authors":"Stalin Ramprakash ,&nbsp;C.P. Raghuram ,&nbsp;Anoop P ,&nbsp;Veerabhadra Gupta ,&nbsp;Sujatha Thyagarajan","doi":"10.1016/j.phoj.2024.01.003","DOIUrl":"https://doi.org/10.1016/j.phoj.2024.01.003","url":null,"abstract":"<div><p>Acute COVID-19 infection typically results in mild disease in children, but can lead to several immune manifestations. One such severe manifestation is immune-mediated thrombotic thrombocytopenia (iTTP). It is exceedingly rare in children, and only a few cases have been reported worldwide. We report a case of severe iTTP in a 17-year-old girl. She was positive for COVID-19 infection by reverse-transcription polymerase chain reaction at presentation and had received a Covaxin injection two weeks earlier. She responded to therapeutic plasma exchange, corticosteroids, and rituximab. Early recognition of this complication and prompt initiation of therapeutic plasma exchange and corticosteroids is paramount to achieving a good outcome in this rare, life-threatening complication.</p></div>","PeriodicalId":101004,"journal":{"name":"Pediatric Hematology Oncology Journal","volume":"9 1","pages":"Pages 24-27"},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468124524000032/pdfft?md5=4fea6eb28a6f74808e6767561c1fc1f0&pid=1-s2.0-S2468124524000032-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139434027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of afibrinogenemia: Bleeding to thrombosis- retrospective analysis of five patients","authors":"Sneha Waghela,&nbsp;Sujata Sharma,&nbsp;Nikita Shah,&nbsp;Harshada Uchil,&nbsp;Radha Ghildiyal","doi":"10.1016/j.phoj.2023.12.007","DOIUrl":"10.1016/j.phoj.2023.12.007","url":null,"abstract":"<div><h3>Background</h3><p>Afibrinogenemia is a rare disorder, with autosomal recessive inheritance, most often associated with consanguinity. To date, very few cases have been reported from India. The aim was to study the clinical heterogenicity of patients with afibrinogenemia.</p></div><div><h3>Case series</h3><p>We present a retrospective study of five patients with afibrinogenemia diagnosed at our institute. All five patients had bleeding as a primary symptom. The median age for the first episode of bleeding was 150 days (range: 2 days - 18 months). Four were born of third degree consanguineous couple. The male to female ratio was 0.66. One patient had thrombosis along with bleeding. All patients had normal platelet count with deranged prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time, and low to nil fibrinogen levels. All had at least one episode of deep bleeding. The sites of bleeding included: a) intracranial (n = 3), b) intramuscular (n = 1), and, c) hemarthrosis (n = 1).</p></div><div><h3>Conclusion</h3><p>Afibrinogenemia should be considered as a differential diagnosis in patients with bleeding from any site with prolongation of PT and APTT. Paradoxical arterial and venous thrombosis may be a manifestation, but is rare. Thrombotic phenotype requires management with fibrinogen infusion along with anti-coagulants.</p></div>","PeriodicalId":101004,"journal":{"name":"Pediatric Hematology Oncology Journal","volume":"9 1","pages":"Pages 15-17"},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468124523003546/pdfft?md5=346a5d411575c00f70c2bacd906b8f60&pid=1-s2.0-S2468124523003546-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139394062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Withholding and withdrawal of life-sustaining therapy in terminally ill children with cancer: A position statement by the PHO chapter of the Indian Academy of Pediatrics","authors":"Vikramjit S. Kanwar ,&nbsp;Poonam Bagai ,&nbsp;Anupama Borker ,&nbsp;Veronique Dinand ,&nbsp;Roop Gursahani ,&nbsp;Krutika Kurhade ,&nbsp;Manas Kalra ,&nbsp;Smriti Khanna ,&nbsp;Manjusha Nair ,&nbsp;Amita Mahajan ,&nbsp;Gayatri Palat ,&nbsp;Raghwesh Ranjan ,&nbsp;Santanu Sen ,&nbsp;Lakshmi Shobhavat","doi":"10.1016/j.phoj.2024.01.002","DOIUrl":"10.1016/j.phoj.2024.01.002","url":null,"abstract":"<div><p>In the last four decades, survival in childhood cancer in India has improved significantly, however we increasingly face the question that has challenged providers in high-income countries: when care becomes futile and merely prolongs suffering, how should that be addressed? This position statement was prepared by a panel in the Pediatric Hematology-Oncology chapter of the Indian Academy of Pediatrics (IAP-PHO), with external experts, using a process endorsed by the Executive Committee of IAP-PHO. The panel consisted of providers and stakeholders who were committed to improving end-of-life care (EOLC) in children with cancer. Three case scenarios of terminally ill children with cancer were presented, and the various challenges of EOLC in each situation were brought up, including families who wanted everything possible done for their child and the fear of medicolegal issues by physicians. We emphasize the importance of involving palliative care services early in the process to ensure that families receive a consistent message about their child's outcome. With the recent Supreme Court of India decision, there is now a viable EOLC pathway to withdraw life-sustaining therapy (LST) from children who are terminally ill. We outline it and discuss the various barriers to the withdrawal of LST. Increased access to palliative medicine services, which currently exist sporadically across India, is a core necessity. IAP-PHO hopes to actively work with organizations representing colleagues in palliative care and intensive care, to see how we can improve EOLC in childhood cancer.</p></div>","PeriodicalId":101004,"journal":{"name":"Pediatric Hematology Oncology Journal","volume":"9 1","pages":"Pages 18-23"},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468124524000020/pdfft?md5=29e27c6a765aa9e53e4d25facf26f4fb&pid=1-s2.0-S2468124524000020-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139395720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary hemophagocytic lymphohistiocytosis in a child with Sickle Cell Anemia and Hepatitis A and Hepatitis E co-infection: A case report","authors":"Govind Choudhary,&nbsp;Nida Mirza,&nbsp;Swati Patel","doi":"10.1016/j.phoj.2024.01.001","DOIUrl":"10.1016/j.phoj.2024.01.001","url":null,"abstract":"<div><h3>Background</h3><p>Secondary hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal condition commonly triggered by infections. HLH secondary to hepatitis E or hepatitis A and E coinfection has been scarcely reported. Diagnosing HLH in sickle cell anemia can be tricky.</p></div><div><h3>Case report</h3><p>We present a 10-year-old boy, a known case of sickle cell anemia, who presented with acute viral hepatitis (HAV and HEV IgM positive). He initially improved with supportive management. However, on the fifth day of illness, he developed fever, tachypnea, and pancytopenia. Inflammatory markers, including serum ferritin, triglycerides, and D-dimer were raised. Bone marrow examination revealed hemophagocytosis. A diagnosis of sickle cell disease with HAV and HEV coinfection with secondary HLH was made. The patient responded to steroids and was well on follow-up after 3 months.</p></div><div><h3>Conclusion</h3><p>HAV and HEV coinfection with a background of sickle cell anemia with secondary HLH is very rare. Diagnosis of HLH in sickle cell anemia is challenging. Timely diagnosis and management of secondary HLH are vital for a favorable outcome.</p></div>","PeriodicalId":101004,"journal":{"name":"Pediatric Hematology Oncology Journal","volume":"9 1","pages":"Pages 28-31"},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468124524000019/pdfft?md5=2c3d67761a2946829f395b8cd7baac31&pid=1-s2.0-S2468124524000019-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139455168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-transplant host status determines the outcomes in non-malignant disorders","authors":"Darshan Kataria,&nbsp;Sanaa Khan,&nbsp;Ambreen Pandrowala,&nbsp;Prashant Hiwarkar","doi":"10.1016/j.phoj.2024.11.091","DOIUrl":"10.1016/j.phoj.2024.11.091","url":null,"abstract":"","PeriodicalId":101004,"journal":{"name":"Pediatric Hematology Oncology Journal","volume":"9 4","pages":"Page S5"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treosulfan associated knock knees in children post hematopoietic stem cell transplantation - Report from a 15 year follow study","authors":"Anupama Nair,&nbsp;Vijayshree Muthukumar,&nbsp;Nithya Seshadri,&nbsp;Minakshi Lalchand Balwani,&nbsp;Anuraag Reddy Nalla,&nbsp;Ramya Uppuluri,&nbsp;Revathi Raj","doi":"10.1016/j.phoj.2024.10.060","DOIUrl":"10.1016/j.phoj.2024.10.060","url":null,"abstract":"","PeriodicalId":101004,"journal":{"name":"Pediatric Hematology Oncology Journal","volume":"9 4","pages":"Page S29"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinico haematological profile in malnourished children","authors":"Kritika Arora,&nbsp;Ravinder k gupta","doi":"10.1016/j.phoj.2024.10.006","DOIUrl":"10.1016/j.phoj.2024.10.006","url":null,"abstract":"","PeriodicalId":101004,"journal":{"name":"Pediatric Hematology Oncology Journal","volume":"9 4","pages":"Page S45"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copy number alterations in Pb acute lymphoblastic leukaemia (Pb-all) and proposal for a new integrated risk stratification system","authors":"Ajmeera Azeez,&nbsp;Amita Trehan,&nbsp;Prateek Bhatia,&nbsp;Minu Singh","doi":"10.1016/j.phoj.2024.11.114","DOIUrl":"10.1016/j.phoj.2024.11.114","url":null,"abstract":"","PeriodicalId":101004,"journal":{"name":"Pediatric Hematology Oncology Journal","volume":"9 4","pages":"Pages S3-S4"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of alternate day versus twice daily oral iron therapy in children with iron deficiency anemia – A randomized control trial","authors":"Pranati Grover,&nbsp;Abhilasha Sampagar","doi":"10.1016/j.phoj.2024.11.095","DOIUrl":"10.1016/j.phoj.2024.11.095","url":null,"abstract":"","PeriodicalId":101004,"journal":{"name":"Pediatric Hematology Oncology Journal","volume":"9 4","pages":"Page S7"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world outcomes of children treated for high-risk neuroblastoma and the challenge in identifying the ultra-high-risk","authors":"Aditi Dwivedi,&nbsp;Venkata Rama Mohan Gollamudi,&nbsp;Sneha Shah,&nbsp;Maya Prasad,&nbsp;Badira Cheriyalinkal Parambil,&nbsp;Sajid Qureshi,&nbsp;Siddhartha Laskar,&nbsp;Nehal Khanna,&nbsp;Vasundara Patel,&nbsp;Akshay Baheti,&nbsp;Akanksha Chichra,&nbsp;Mamta Manglani,&nbsp;Ratna Sharma,&nbsp;Rajesh Patil,&nbsp;Ruchira Misra,&nbsp;Ambreen Pandrowala,&nbsp;Pranoti Kini,&nbsp;Purna Kurkure,&nbsp;Girish Chinnaswamy","doi":"10.1016/j.phoj.2024.11.117","DOIUrl":"10.1016/j.phoj.2024.11.117","url":null,"abstract":"","PeriodicalId":101004,"journal":{"name":"Pediatric Hematology Oncology Journal","volume":"9 4","pages":"Page S4"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}