Pain ForumPub Date : 1998-12-01DOI: 10.1016/S1082-3174(98)70002-9
Andrew C.N. Chen , Lars Arendt-Nielsen , Leon Plaghki
{"title":"Laser-evoked potentials in human pain","authors":"Andrew C.N. Chen , Lars Arendt-Nielsen , Leon Plaghki","doi":"10.1016/S1082-3174(98)70002-9","DOIUrl":"10.1016/S1082-3174(98)70002-9","url":null,"abstract":"<div><p>In Part II, the dynamic topography of laser-evoked brain potentials (LEPs) in human pain is reviewed. The cerebral generators of LEPs, SI, Sil, and midline deep generators, are then systematically examined, and the results of LEPs and positron-emission tomography (PET)/functional magnetic resonance imaging (fMRI) in pain studies are compared. The theoretical ground of functional segregation and integration of pain processing in the brain can be delineated. Four contending issues are raised: (1) which to use: electroencephalography or magnetoencephalography?, (2) what are the reliability and validity of source localization in LEPs?, (3) can neural generators of LEPs contribute to PET/fMRI of human pain?, and (4) is there a “holy grail” of pain in the brain? Future directions needed for developing comprehensive neurophysiology of pain mechanisms using dynamic topography/source modeling of LEPs with PET/fMRI neuroimaging are discussed. It is concluded that full understanding of the cerebral genesis of LEPs requires empirical identification of their cortical/subcortical substrates, as well as theoretical modeling of their modular function during sequential and parallel stages of human pain processing in the brain.</p></div>","PeriodicalId":101001,"journal":{"name":"Pain Forum","volume":"7 4","pages":"Pages 201-211"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1082-3174(98)70002-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86253955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain ForumPub Date : 1998-12-01DOI: 10.1016/S1082-3174(98)80006-8
Andrew C.N. Chen , Lars Arendt-Nielsen , Leon Plaghki
{"title":"Understanding of human pain in the brain through topographic mapping and quantification of laser-evoked potentials","authors":"Andrew C.N. Chen , Lars Arendt-Nielsen , Leon Plaghki","doi":"10.1016/S1082-3174(98)80006-8","DOIUrl":"10.1016/S1082-3174(98)80006-8","url":null,"abstract":"","PeriodicalId":101001,"journal":{"name":"Pain Forum","volume":"7 4","pages":"Pages 196-200"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1082-3174(98)80006-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75187189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain ForumPub Date : 1998-12-01DOI: 10.1016/S1082-3174(98)80001-9
{"title":"Response to Dr. J. Loeser's letter on back pain in the workplace","authors":"","doi":"10.1016/S1082-3174(98)80001-9","DOIUrl":"https://doi.org/10.1016/S1082-3174(98)80001-9","url":null,"abstract":"","PeriodicalId":101001,"journal":{"name":"Pain Forum","volume":"7 4","pages":"Pages 169-171"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1082-3174(98)80001-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137110425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain ForumPub Date : 1998-09-01DOI: 10.1016/S1082-3174(98)70008-X
Peggy Mason, Keming Gao
{"title":"Raphe magnus serotonergic neurons tonically modulate nociceptive transmission","authors":"Peggy Mason, Keming Gao","doi":"10.1016/S1082-3174(98)70008-X","DOIUrl":"10.1016/S1082-3174(98)70008-X","url":null,"abstract":"<div><p>Serotonin-containing neurons in the medullary raphe magnus (RM) have long been thought to be important mediators of descending nociceptive inhibition. Although pharmacologic and behavioral studies support this idea, recent physiologic evidence demonstrates that RM serotonergic cells do not respond to antinociceptive stimulation in the periaqueductal gray or analgesic doses of morphine with a change in discharge rate. Instead, serotonergic cell discharge is likely to influence the outcome of modulatory circuits by tonically modulating the effects of other synaptic connections in the dorsal horn. Because serotonergic cells discharge in relation to sleep and wake cycles, RM serotonergic cells are hypothesized to subserve the relative decrease in nociceptive responsiveness observed during waking compared to slow-wave sleep.</p></div>","PeriodicalId":101001,"journal":{"name":"Pain Forum","volume":"7 3","pages":"Pages 143-150"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1082-3174(98)70008-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73599872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain ForumPub Date : 1998-09-01DOI: 10.1016/S1082-3174(98)80043-3
Fernando Cervero
{"title":"From Aristotle to AI haig via an interactive continuum","authors":"Fernando Cervero","doi":"10.1016/S1082-3174(98)80043-3","DOIUrl":"https://doi.org/10.1016/S1082-3174(98)80043-3","url":null,"abstract":"","PeriodicalId":101001,"journal":{"name":"Pain Forum","volume":"7 3","pages":"Pages 135-136"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1082-3174(98)80043-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91777022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain ForumPub Date : 1998-09-01DOI: 10.1016/S1082-3174(98)80041-X
A. Vania Apkarian, Johannes Brüggemann
{"title":"Visceral and somatic pain: The gift that nobody wants and everybody needs","authors":"A. Vania Apkarian, Johannes Brüggemann","doi":"10.1016/S1082-3174(98)80041-X","DOIUrl":"10.1016/S1082-3174(98)80041-X","url":null,"abstract":"","PeriodicalId":101001,"journal":{"name":"Pain Forum","volume":"7 3","pages":"Pages 126-128"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1082-3174(98)80041-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90585880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain ForumPub Date : 1998-09-01DOI: 10.1016/S1082-3174(98)80043-3
F. Cerveró
{"title":"From Aristotle to AI Haig via an Interactive Continuum","authors":"F. Cerveró","doi":"10.1016/S1082-3174(98)80043-3","DOIUrl":"https://doi.org/10.1016/S1082-3174(98)80043-3","url":null,"abstract":"","PeriodicalId":101001,"journal":{"name":"Pain Forum","volume":"87 1","pages":"135-136"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84212174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}