Obesity Pillars最新文献

{"title":"Frequently asked questions to the 2023 obesity medicine association position statement on compounded peptides: A call for action","authors":"Harold Edward Bays ,&nbsp;Angela Fitch ,&nbsp;Carolynn Francavilla Brown ,&nbsp;Courtney Younglove ,&nbsp;Sandra M. Christensen ,&nbsp;Lydia C. Alexander","doi":"10.1016/j.obpill.2024.100122","DOIUrl":"10.1016/j.obpill.2024.100122","url":null,"abstract":"<div><h3>Background</h3><p>In 2023, the Obesity Medicine Association (OMA) published “Compounded peptides: An Obesity Medicine Association Position Statement.” Since this publication, the use of compounded peptides for the treatment of obesity has continued to evolve, leading to additional confusion and questions from obesity medicine clinicians and their patients.</p></div><div><h3>Methods</h3><p>This frequently asked questions (FAQ) document and “Call for Action” commentary is based upon the existing evidence and practical clinical experiences of the authors.</p></div><div><h3>Results</h3><p>This FAQ is intended to provide insights beyond the original 2023 OMA Position Statement regarding the use of “compounded peptides” for treating obesity. Three obstacles impair patient access to highly effective peptide anti-obesity medications: insufficient production especially during times of high demand, high costs, and lack of clarity surrounding the role of compounded peptides. Solutions to enhance patient access to these medications lie within the existing legal and regulatory framework and Food and Drug Administration policies. Implementing these solutions necessitates dispelling misinformation and providing clear guidance on the appropriate prescribing and administration of compounded peptides, particularly during times of acknowledged shortage.</p></div><div><h3>Conclusion</h3><p>Among stakeholders with aligned priorities, challenges can often be overcome by collaboration and communication. Towards the goal of providing patient-centered care, the OMA calls on applicable stakeholders (e.g., pharmaceutical companies, compounding pharmacy organizations, health insurance companies, and the Food and Drug Administration) to work collaboratively to achieve a consensus that improves patient access to safe anti-obesity medications. The purpose of this “Call to Action” is to ask stakeholders to provide clinicians and their patients clarity regarding the role of compounded peptide anti-obesity medications during times of FDA-acknowledged shortages. Finally, this FAQ review provides clinicians with a simple and practical checklist respective to the potential use of compounded peptides.</p></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"11 ","pages":"Article 100122"},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266736812400024X/pdfft?md5=036beb61961b280a3f8c36446a81b826&pid=1-s2.0-S266736812400024X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141963458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary intake by patients taking GLP-1 and dual GIP/GLP-1 receptor agonists: A narrative review and discussion of research needs","authors":"Sandra Christensen ,&nbsp;Katie Robinson ,&nbsp;Sara Thomas ,&nbsp;Dominique R. Williams","doi":"10.1016/j.obpill.2024.100121","DOIUrl":"10.1016/j.obpill.2024.100121","url":null,"abstract":"<div><h3>Background</h3><p>Obesity and type 2 diabetes mellitus (T2DM) are increasingly common in the United States and worldwide. Because both conditions are associated with serious health consequences, weight reduction is recommended by professional medical and nutrition societies to improve outcomes. Due to the striking efficacy of glucagon-like peptide receptor agonists (GLP-1RAs) and dual mechanism glucose-dependent insulinotropic polypeptide/glucagon-like peptide receptor agonists (GIP/GLP-1RAs) for weight reduction and glycemic control, there is increased utilization for patients with obesity and/or T2DM. Yet, the impact of these medications on dietary intake is less understood.</p></div><div><h3>Methods</h3><p>This narrative literature review summarizes clinical studies quantifying and characterizing dietary intake in people with obesity and/or T2DM using GLP-1 or GIP/GLP-1 RAs.</p></div><div><h3>Results</h3><p>Though data from these studies reveal that total caloric intake was reduced by 16–39 %, few studies evaluated the actual composition of the diet.</p></div><div><h3>Conclusions</h3><p>Further research is needed to understand the unique nutritional needs of adults on GLP-1 or dual GIP/GLP-1RAs and to support the development of nutritional guidelines for these individuals.</p></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"11 ","pages":"Article 100121"},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667368124000238/pdfft?md5=059828a6485610b59b26e92bdff236ac&pid=1-s2.0-S2667368124000238-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating coverage: A qualitative study exploring the perceived impact of an insurance company policy to discontinue coverage of antiobesity medication","authors":"Treah Haggerty ,&nbsp;Patricia Dekeseredy ,&nbsp;Joanna Bailey ,&nbsp;Abigail Cowher ,&nbsp;Adam Baus ,&nbsp;Laura Davisson","doi":"10.1016/j.obpill.2024.100120","DOIUrl":"10.1016/j.obpill.2024.100120","url":null,"abstract":"<div><h3>Introduction</h3><p>Obesity rates continue to rise in the United States. Treatment includes modification of diet, exercise, behavioral modification and medical consideration including anti-obesity medications. However, multiple highly effective anti-obesity medications are expensive and with that we see insurers opting out of coverage of these medications. This has led to patients having to abruptly stop treatment with these medications. The purpose of this study is to explore the impact of non-medical discontinuance of obesity medication among patients in medical weight management programs.</p></div><div><h3>Methods</h3><p>This is a qualitative descriptive study. Semistructured interviews were completed with participants in an academic medical weight management clinic. Interviews were recorded and transcribed. Themes were identified by members of the study team through qualitative content analysis. Participants were on or about to start anti-obesity medications and were from a single insurance company which cut coverage to all anti-obesity medications.</p></div><div><h3>Results</h3><p>Twenty-two insured patients from across the state either currently taking or intending to take anti-obesity medications, participated. All participants were female. Few participants said they could afford the cost of the medication. Four main themes emerged: 1) Feelings of hope replaced by hopelessness upon loss of medication coverage, 2) Anger regarding the perceived injustice of anti-obesity medication coverage termination, 3) Perceptions of past and present stigma within the healthcare system and insurance company, 4) Generational influences on obesity treatment.</p></div><div><h3>Conclusion</h3><p>Patients perceive the discontinuation of anti-obesity medication coverage as stigmatizing and unjust, leading to feelings of hopelessness and fear. With more insurance companies denying coverage for these costly medications more information is needed to identify best ways to address the loss of coverage with patients. Clinical management of these patients should incorporate evidence-based obesity treatments while navigating insurance constraints.</p></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"11 ","pages":"Article 100120"},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667368124000226/pdfft?md5=145938bf3166d5bc104c7c7b18584130&pid=1-s2.0-S2667368124000226-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141845379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and advocacy: A joint clinical perspective and expert review from the obesity medicine association and the obesity action coalition - 2024","authors":"Carolynn Francavilla Brown ,&nbsp;Tracy Zvenyach ,&nbsp;Elizabeth Paul ,&nbsp;Leslie Golden ,&nbsp;Catherine Varney ,&nbsp;Harold Edward Bays","doi":"10.1016/j.obpill.2024.100119","DOIUrl":"10.1016/j.obpill.2024.100119","url":null,"abstract":"<div><h3>Background</h3><p>This joint clinical perspective by the Obesity Medicine Association (OMA) and Obesity Action Coalition (OAC) provides clinicians an overview of the role of advocacy in improving the lives of patients living with the disease of obesity, as well as describes opportunities how to engage in advocacy.</p></div><div><h3>Methods</h3><p>This joint clinical perspective is based upon scientific evidence, clinical experiences of the authors, and peer review by the OMA leadership. The Obesity Medicine Association is the largest organization of physicians, nurse practitioners, physician associates, and other clinical experts (i.e., over 5000 members at time of print) who are engaged in improving the lives of patients affected by the disease of obesity. The OAC is a national nonprofit organization of more than 80,000 members who are dedicated to serving the needs of individuals living with obesity.</p></div><div><h3>Results</h3><p>Advocacy involves educational and public policy initiatives that through relationships, networks, and targeted strategies and tactics (e.g., traditional media, social media, petitions, and direct communication with policy makers), promote public awareness and establish public policies that help mitigate bias, stigma, and discrimination, and generally improve the lives of patients living with the disease of obesity.</p></div><div><h3>Conclusions</h3><p>An objective of advocacy is to foster collective involvement and community engagement, leading to collaborations that help empower patients living with obesity and their clinicians to seek and achieve changes in policy, environment, and societal attitudes. Advocacy may also serve to enhance public awareness, promote prevention, advance clinical research, develop safe and effective evidenced-based therapeutic interventions, and facilitate patient access to comprehensive and compassionate treatment of the complex disease of obesity.</p></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"11 ","pages":"Article 100119"},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667368124000214/pdfft?md5=9a83b5950b320b432dd4f869fd486889&pid=1-s2.0-S2667368124000214-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141845571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of weight and waist gain in US South Asians: Findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study","authors":"Sujatha Seetharaman ,&nbsp;Isabel Elaine Allen ,&nbsp;Meghana Gadgil ,&nbsp;Shylaja Srinivasan ,&nbsp;Lisa Swartz Topor ,&nbsp;Alka M. Kanaya","doi":"10.1016/j.obpill.2024.100118","DOIUrl":"10.1016/j.obpill.2024.100118","url":null,"abstract":"<div><h3>Background</h3><p>Weight and waist gain are significant concerns in adulthood. Both weight and waist gain are particularly important among South Asians, known to have an increased risk of developing chronic cardiometabolic complications at any body mass index compared to other racial and ethnic groups. The aim of this study was to investigate factors predicting weight and waist gain in a longitudinal cohort of South Asians living in the US (United States).</p></div><div><h3>Methods</h3><p>This was a prospective analysis using data from exam 1 (2010–2013) and exam 2 (2015–2018) of the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study, a prospective cohort study of South Asians (recruited from San Francisco and Chicago), with a mean 4.8 years of follow-up.</p></div><div><h3>Results</h3><p>Of 634 participants studied (42.7 % women, mean age 55 years, BMI 25.7 kg/m2, weight 70.4 kg at exam 1), 34.7 % had gained ≥5 % weight and 32.3 % gained ≥5 % waist at exam 2. In the adjusted models, older age, higher number of years of US residence, and having diabetes were associated with lower odds of weight gain; being female and having higher adiponectin were associated with higher odds of weight gain. Being female and being employed full/part time or being retired predicted lower likelihood of waist gain. Being single, separated/divorced, having a higher leptin and a higher C-reactive protein level predicted higher likelihood of waist gain.</p></div><div><h3>Conclusions</h3><p>The current study identified several social, demographic, and clinical factors that can serve as targets for obesity interventions among US South Asians. In addition, this study also raises hypotheses about associations of adipokine levels with weight and waist gain.</p></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"11 ","pages":"Article 100118"},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667368124000202/pdfft?md5=a7f7371cf5672a3fbfadd79e77798418&pid=1-s2.0-S2667368124000202-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141960401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal delivery of bitter hop extract reduces appetite and food cravings in healthy adult women undergoing acute fasting","authors":"Edward Walker ,&nbsp;Kim Lo ,&nbsp;Pramod Gopal","doi":"10.1016/j.obpill.2024.100117","DOIUrl":"https://doi.org/10.1016/j.obpill.2024.100117","url":null,"abstract":"<div><h3>Background</h3><p>Dietary restrictions or reductions such as fasting for weight loss are often difficult to adhere to due to increased appetite and food cravings. Recently, gastrointestinal delivery of bitter hops has been shown to be effective at reducing appetite in men. Our aim was to determine the effect of a bitter hop extract on appetite and cravings in women, using a 24 h, water-only fast.</p></div><div><h3>Methods</h3><p>This was a randomized, double-blind, cross-over treatment study. Thirty adult women were recruited and required to fast for 24 h from 1800 h to 1800 h on three occasions and given an <em>ad libitum</em> meal to break each fast. Treatments of either a placebo or one of two doses (high dose; HD: 250 mg or low dose; LD: 125 mg) of a bitter hop-based appetite suppressant (Amarasate®) were given twice per day at 16 and 20 h into the fast.</p></div><div><h3>Results</h3><p>The HD and LD treatment groups exhibited a significant (<em>p</em> &lt; 0.05) reduction in appetite and cravings for food when compared to the placebo control. Two participants reported loose stools and one reported heartburn while on the HD treatment, and one participant reported loose stools while on the LD treatment.</p></div><div><h3>Conclusion</h3><p>These data suggest that appetite suppressant co-therapy may be useful in reducing hunger during fasting in women and shows that gastrointestinal delivery of bitter compounds may also be an effective method of reducing cravings for food.</p><p>This trial received ethical approval from the Northen B New Zealand Human Disability and Ethics committee (Northern B Health and Disability Ethics Committee (2022 EXP 10995) and was prospectively registered with the Australian New Zealand Clinical Trial Registry (ACTRN12622000107729).</p></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"11 ","pages":"Article 100117"},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667368124000196/pdfft?md5=b69372a9d79b2d1f5be5c39ba35b2aa5&pid=1-s2.0-S2667368124000196-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141543786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropathy of Diabetes Following Initiation of a Low-Carbohydrate Diet: Case Report","authors":"Mark Jamal Sahyouni,&nbsp;Luis Anthony Acevedo,&nbsp;Sofia Cristina Rodriguez,&nbsp;Justin Armond Chiles,&nbsp;Nicholas Joseph Pennings","doi":"10.1016/j.obpill.2024.100115","DOIUrl":"10.1016/j.obpill.2024.100115","url":null,"abstract":"<div><h3>Introduction</h3><p>This case study portrays an unusual case of treatment-induced neuropathy of diabetes (TIND) in a patient with uncontrolled type 2 diabetes (T2D) who achieved rapid improvement in glucose control primarily with dietary intervention. Initial presentation was 50-year-old white male with a long-standing history of obesity and a family history of T2D with a screening glucose level &gt;500mg/dL by glucometer, HbA1c of 14.9%, and initial weight 213lbs.</p></div><div><h3>Methods</h3><p>The initial intervention included a low-carbohydrate diet, metformin, and a continuous glucose monitor (CGM). Semaglutide was added after seven days.</p></div><div><h3>Results</h3><p>His glycemia was within the target range within three weeks. Four weeks after initiation of therapy, he developed TIND symptoms consisting of burning, tightness, and numbness of bilateral feet along with 10/10 pain. At three months, his HbA1c dropped to 6.9% and his weight to 195lbs. Treatment of his TIND reduced his pain from 10/10 to 2/10.</p></div><div><h3>Conclusion</h3><p>Whereas TIND is commonly associated with the use of insulin or sulfonylureas, this study adds evidence to the paucity of literature regarding TIND precipitated by dietary intervention.</p></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"11 ","pages":"Article 100115"},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667368124000172/pdfft?md5=5264353f4fd41999bd887942c0829d18&pid=1-s2.0-S2667368124000172-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141402815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-hospital outcomes in metabolically healthy and unhealthy individuals over 65 years of age with obesity undergoing percutaneous intervention for acute coronary syndrome: A nationwide propensity-matched analysis (2016–2020)","authors":"Rupak Desai ,&nbsp;Aobo Li ,&nbsp;Avilash Mondal ,&nbsp;Sashwat Srikanth ,&nbsp;Alka Farmer ,&nbsp;Lin Zheng","doi":"10.1016/j.obpill.2024.100114","DOIUrl":"https://doi.org/10.1016/j.obpill.2024.100114","url":null,"abstract":"<div><h3>Background</h3><p>The obesity paradox in patients with coronary artery disease is well established, but the role of the metabolic syndrome associated with obesity is not well studied. Our study aims to evaluate the in-hospital outcomes of percutaneous coronary intervention (PCI) in metabolically healthy individuals with obesity (MHO) and metabolically unhealthy (MUHO) individuals with obesity over 65 years of age with acute coronary syndrome (ACS) between 2016 and 2020.</p></div><div><h3>Methods</h3><p>This was a retrospective and observational study. Patients were identified through utilizing the National Inpatient Sample (NIS) Database (2016–2020) and ICD-10 codes. By employing a <em>t</em>-test and Pearson's Chi-square test, we assessed and contrasted the initial attributes, concurrent conditions, and results pertaining to all-cause mortality (ACM), cardiogenic shock (CS), length of stay (LOS), and hospitalization expense. Moreover, propensity score matching was conducted in a 1:1 ratio with respect to age, gender, and race. We also utilized multivariable logistic regression to compare MHO and MUHO in terms of the impact on all-cause mortality.</p></div><div><h3>Results</h3><p>Out of a total of 135,395 patients identified, 2995 patients with MUHO were matched with 2995 MHO patients. Patients in the MUHO group had a higher prevalence of chronic pulmonary disease (24.9 % vs. 19.5 %), peripheral vascular disease (9.3 % vs. 6.7 %), hypothyroidism (16 % vs. 11.5 %), prior myocardial infarction (15.9 % vs. 6.2 %), and prior stroke (7.5 % vs. 2.8 %). Patients in the MHO group had a higher ACM (12.4 % vs. 2.8 %, p &lt; 0.001), CS (18.55 % vs. 7 %, p &lt; 0.001), stroke (2.2 % vs. 1 %, p &lt; 0.001), ventricular assist device insertions (5.2 % vs. 2.7 %, p &lt; 0.001), and IABP insertions (8.8 % vs. 3.8 %) compared to the MUHO cohort.</p></div><div><h3>Conclusion</h3><p>Our study revealed an obesity paradox in individuals over 65 years of age undergoing PCI demonstrating worse outcomes, including higher in-hospital mortality, CS, stroke, Ventricular assist device and IABP insertion in MHO patients compared to the MUHO cohort.</p></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"11 ","pages":"Article 100114"},"PeriodicalIF":0.0,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667368124000160/pdfft?md5=0226893a08510e717f417b4649aaba52&pid=1-s2.0-S2667368124000160-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141164049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Special considerations for the child with obesity: An Obesity Medicine Association (OMA) clinical practice statement (CPS) 2024","authors":"Suzanne Cuda,&nbsp;Marisa Censani,&nbsp;Valerie O'Hara,&nbsp;Jennifer Paisley,&nbsp;Roohi Kharofa,&nbsp;Rushika Conroy,&nbsp;Brooke Sweeney,&nbsp;Cristina Fernandez,&nbsp;Meredith L. Dreyer Gillette,&nbsp;Nancy T. Browne","doi":"10.1016/j.obpill.2024.100113","DOIUrl":"10.1016/j.obpill.2024.100113","url":null,"abstract":"<div><h3>Background</h3><p>This Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) details assessment and management of the child with overweight or obesity. The term “child” is defined as the child between 2 and 12 years of age. Because children are in a continual state of development during this age range, we will specify when our discussion applies to subsets within this age range. For the purposes of this CPS, we will use the following definitions: overweight in the child is a body mass index (BMI) ≥ 85th and &lt;95th percentile, obesity in the child is a BMI ≥95th percentile, and severe obesity is a BMI ≥120% of the 95th percentile.</p></div><div><h3>Methods</h3><p>The information and clinical guidance in this <span>OMA</span> Clinical Practice Statement are based on scientific evidence, supported by medical literature, and derived from the clinical perspectives of the authors.</p></div><div><h3>Results</h3><p>This OMA Clinical Practice Statement provides an overview of prevalence of disease in this population, reviews precocious puberty in the child with obesity, discusses the current and evolving landscape of the use of anti-obesity medications in children in this age range, discusses the child with obesity and special health care needs, and reviews hypothalamic obesity in the child.</p></div><div><h3>Conclusions</h3><p>This OMA Clinical Practice Statement on the child with obesity is an evidence based review of the literature and an overview of current recommendations. This CPS is intended to provide a roadmap to the improvement of the health of children with obesity, especially those with metabolic, physiological, psychological complications and/or special healthcare needs. This CPS addresses treatment recommendations and is designed to help the clinician with clinical decision making.</p></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"11 ","pages":"Article 100113"},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667368124000159/pdfft?md5=084fe606099e8a1bea3be311f1cde0e6&pid=1-s2.0-S2667368124000159-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141137374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of concomitant antiobesity medication use with endoscopic sleeve gastroplasty in clinical US settings","authors":"Khushboo Gala ,&nbsp;Wissam Ghusn ,&nbsp;Vitor Brunaldi ,&nbsp;Christopher McGowan ,&nbsp;Reem Z. Sharaiha ,&nbsp;Daniel Maselli ,&nbsp;Brandon Vanderwel ,&nbsp;Prashant Kedia ,&nbsp;Michael Ujiki ,&nbsp;Eric Wilson ,&nbsp;Eric J. Vargas ,&nbsp;Andrew C. Storm ,&nbsp;Barham K. Abu Dayyeh","doi":"10.1016/j.obpill.2024.100112","DOIUrl":"10.1016/j.obpill.2024.100112","url":null,"abstract":"<div><h3>Background</h3><p>To evaluate the weight loss outcomes of the large US cohort of patients undergoing endoscopic sleeve gastroplasty (ESG) with or without concomitant anti-obesity (AOM) use.</p></div><div><h3>Methods</h3><p>We performed a retrospective analysis of adult patients who underwent ESG from seven different sites, from January 1, 2020 to November 30, 2022. Percent total body weight loss (%TBWL) and %excess weight loss (%EWL) were calculated based on baseline weight at the procedure. Medication use was considered if the subject received a prescribed AOM during the study period. SPSS (version 29.0) was used for statistical analyses.</p></div><div><h3>Results</h3><p>A total of 1506 patients were included (1359 (90.2 %) no AOM use and 147 (9.8 %) AOM use). Patients who were on an active AOM at the time of the procedure had a significantly lower TBWL% as compared to patients not on AOMs at 6 months. At the 24-month visit, patients who were prescribed AOMs after the 12-month visit had a significantly higher TBWL% and EWL% as compared to patients who were on active AOM at the time of the procedure. There was no significant difference between classes of medications at any time point, however, patients on a GLP-1RA had a trend towards improved weight loss at 18 and 24 months.</p></div><div><h3>Conclusion</h3><p>In this large, real-world cohort of patients from the United States, data signal that with the use of pharmacotherapy at the appropriate time, patients can achieve optimal results.</p></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"11 ","pages":"Article 100112"},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667368124000147/pdfft?md5=ae8e9cd8ce4d7e051f284d376bfc6c29&pid=1-s2.0-S2667368124000147-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141043930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}