Obesity Pillars最新文献

{"title":"The relationship between obesity and serum calcium level in a sample of Syrian people a cross sectional study","authors":"Ola Faleh,&nbsp;Zaynab Alourfi","doi":"10.1016/j.obpill.2025.100208","DOIUrl":"10.1016/j.obpill.2025.100208","url":null,"abstract":"<div><h3>Introduction</h3><div>Calcium is one of the most important elements in the human body playing a crucial role in various physiological functions. Its serum levels might be influenced by multiple factors. Obesity is a prevalent disease worldwide, and many studies have explored the relationship between obesity and serum calcium levels. This study aimed to investigate the association between Body Mass Index (BMI) and serum calcium.</div></div><div><h3>Material and method</h3><div>This cross-sectional study conducted at the National University Hospital between 2023 and 2024 involved 206 participants. Serum calcium levels were measured. A fasting morning blood sample was collected from each subject, and all tests were performed at The National University Hospital.</div></div><div><h3>Result</h3><div>The analysis showed no significant association between BMI and serum calcium levels, nor between age and serum calcium. However, after adjusting for age, the relationship between BMI and serum calcium strengthened and reached statistical significance, revealing an inverse correlation. This suggests that age acted as a partial confounding variable in the initial assessment.</div></div><div><h3>Conclusion</h3><div>While the initial findings of this cross-sectional study initially revealed no significant relationship between body mass index (BMI) and serum calcium, after adjusting for age, an inverse relationship was found between BMI and serum calcium, with higher BMI associated with lower serum calcium levels.</div></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"16 ","pages":"Article 100208"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare professionals’ perspectives on the current state of obesity management training: A mix methods study","authors":"Francisca Contreras,&nbsp;Tak Ying Louise Ko,&nbsp;Carel W. le Roux,&nbsp;Werd Al-Najim","doi":"10.1016/j.obpill.2025.100202","DOIUrl":"10.1016/j.obpill.2025.100202","url":null,"abstract":"<div><h3>Introduction</h3><div>Obesity is a disease that represents a major global health problem, affecting over a quarter of European adults and straining healthcare systems. Despite its multifactorial causes, many healthcare professionals lack adequate training and confidence in delivering effective, person-centered obesity care. Weight stigma and misconceptions further impair outcomes. Thus, improved education and interprofessional training are essential to support healthcare professionals in delivering optimal obesity care. The aim of this study is to explore the current state of obesity management training among healthcare professionals working in obesity management services by identifying perceived training gaps, confidence levels and impact on clinical practice.</div></div><div><h3>Methodology</h3><div>This study employed a mixed-methods design by combining a cross-sectional survey of 100 healthcare professionals with semi-structured interviews of 20 professionals who work in obesity management. Survey data were analyzed descriptively, and interview transcripts underwent thematic analysis using Braun and Clarke's framework.</div></div><div><h3>Results</h3><div>Of the 100 healthcare professionals surveyed, 88 % reported actively working in obesity management and completed the full survey. Undergraduate training in obesity care was limited, with only 44 % receiving any, and only 12 % rated it as good or excellent. Postgraduate training was pursued by 51 %, with only 6 % completing formal advanced education. Participant perceptions of obesity training were organized in 5 domains: a) Current state of obesity management training, b) Confidence level, c) Gaps in training, d) Impact on clinical practice and d) Recommendation for obesity training curriculum.</div></div><div><h3>Conclusion</h3><div>Healthcare professionals report significant gaps in obesity management training that impact their confidence and clinical practice. The key recommendations made by participants in this study reflect both the perceived deficits and a clear demand for more structured and comprehensive training in obesity management. Integrating structured, evidence-based obesity education into healthcare training programs is essential to reduce stigma, build competence, and improve obesity care.</div></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"16 ","pages":"Article 100202"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of disordered eating and eating behavior on weight loss after sleeve gastrectomy in Egyptian adolescents","authors":"Mohey Elbanna ,&nbsp;Amany Falah ,&nbsp;Ahmed Magdy Hafez","doi":"10.1016/j.obpill.2025.100207","DOIUrl":"10.1016/j.obpill.2025.100207","url":null,"abstract":"<div><h3>Background</h3><div>Bariatric surgery is the most effective treatment for obesity in Adolescents. However, disordered eating is frequent in this population. Several studies found that disordered eating affects weight loss after bariatric surgery. The aim of this study was to find out the impact of disordered eating on weight loss in Egyptian adolescents two years after sleeve gastrectomy.</div></div><div><h3>Methods</h3><div>This is a retrospective cohort study conducted at Ain Shams University Hospitals from March 2020 to March 2024. It included 47 adolescents with obesity who underwent laparoscopic sleeve gastrectomy (LSG) two years before. Their age was 16.2 ± 0.67 years (range 14.5 – 17.8 years old). Their body mass indices were above 99th percentile for age and sex with or without comorbidities. They had a mean BMI of 39.9 kg/m² (range: 36.9 – 54.3 kg/m²). Patients with psychiatric illnesses and eating disorders were excluded. Patients were recruited after completion of two years of follow up for weight loss. Weight loss was evaluated by total weight loss % (TWL%). Disordered eating was detected by the Arabic version of EDE-Q v.6.0, and a global score of &gt; 2.5 was considered positive. TWL% was correlated with EDE-Q score.</div></div><div><h3>Results</h3><div>After two years, the mean TWL% was 27.5% ± 7.7%. Nineteen patients (40.4%) had EDE-Q score more than 2.5. The EDE-Q positive patients had a mean %TWL of 25.7% ± 4.8%, while EDE-Q negative patients had a mean %TWL of 30.5% ± 6.2%. The difference is statistically significant.</div></div><div><h3>Conclusion</h3><div>We conclude that the outcome of sleeve gastrectomy in adolescents is affected by their eating behavior as soon as the restrictive effect of the operations subsides.</div></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"16 ","pages":"Article 100207"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145105018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect and safety of a physical exercise-based intervention on body composition and cardiometabolic health of adolescents with severe obesity. Secondary analysis from the PAC-MAnO trial","authors":"Antonio Videira-Silva ,&nbsp;Fábio de Freitas ,&nbsp;Luis B. Sardinha ,&nbsp;Helena Fonseca","doi":"10.1016/j.obpill.2025.100190","DOIUrl":"10.1016/j.obpill.2025.100190","url":null,"abstract":"<div><h3>Background</h3><div>Severe obesity (SOb) treatment in adolescents has been focused on surgery and pharmacological treatment, in part due to difficulty in implementing lifestyle behavioral changes, such as physical exercise. However, the potential long-term consequences and costs of these options prompt new effective and sustainable treatment options. This study aimed to investigate the effect and safety of a 6-month high-intensity physical exercise-based intervention on body composition and cardiometabolic health in adolescents with SOb (BMI z-score ≥3), compared to those without SOb and SOb controls (without intervention).</div></div><div><h3>Methods</h3><div>Data from 46 adolescents (50 % girls), including 20 with SOb (43.5 %), exposed to two exercise sessions/week for 6 months, and 16 controls were analyzed.</div></div><div><h3>Results</h3><div>Adolescents with SOb showed a higher decrease and increase in central fat mass (<em>β=</em>-2.3, 95 %CI: 4.8, 0.1) and fat-and-bone-free mass (<em>β</em> = 1.70, 95 %CI: 3.25, 0.15) and a higher rate of insulin resistance normalization (58.3 vs. 12.5 %) after the intervention, compared to those without SOb, with no differences in adverse effects. Adolescents with SOb exposed to intervention also showed improvements in BMI, compared to an impairment in controls (95 %CI: 2.64, 0.16).</div></div><div><h3>Conclusion</h3><div>High-intensity physical exercise-based interventions should be considered as an obesity treatment option in adolescents with SOb. Higher exercise volume and/or frequency may further improve health-related outcomes and should become a first-line strategy alongside other lifestyle changes.</div></div><div><h3>Trail registration</h3><div>Clinicaltrials.gov NCT02941770.</div></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"16 ","pages":"Article 100190"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions, attitudes, and practices influencing management of obesity in Ireland–The Awareness, Care and Treatment in Obesity maNagement, (ACTION) Ireland study","authors":"Fiona Curran ,&nbsp;Leona Ryan ,&nbsp;Susan Birney ,&nbsp;Karen Gaynor ,&nbsp;Maura Murphy ,&nbsp;Jean O’ Connell ,&nbsp;Gráinne O'Donoghue","doi":"10.1016/j.obpill.2025.100231","DOIUrl":"10.1016/j.obpill.2025.100231","url":null,"abstract":"<div><h3>Background</h3><div>Data is lacking comparing perceptions of people living with obesity (PWO) and health care professionals (HCPs) towards obesity management in Ireland, where 30 % of the population live with obesity. The ACTION-Ireland study aimed to explore perceptions, attitudes, practices, and barriers to effective obesity management in Ireland, using data from PWO and HCPs comparable to international data sets.</div></div><div><h3>Methods</h3><div>This was a cross-sectional online survey conducted among adults living with BMI ≥30 kg/m² and HCPs managing PWO.</div></div><div><h3>Results</h3><div>A total of 504 PWO and 159 HCPs completed the survey (August–December 2024). Most PWO (75 %) and almost all HCPs (98 %) believe obesity is a chronic disease. While 86 % of HCPs believe they have responsibility to support PWO, 82 % of PWO believe they are completely responsible for weight management.</div><div>PWO waited on average eight years (SD 9.7) from first weight concern to first weight discussion with their HCP. HCPs most initiated obesity conversations when the patient had (70 %) or were at risk of (63 %) obesity complications. Lifestyle interventions were most frequently discussed and recommended by HCPs (physical activity 72 %, diet 67 %), while fewer recommended prescription medication (34 %), referral to obesity specialists (23 %) or for bariatric surgery (24 %). Although 88 % of PWO had attempted weight loss, only 10 % used prescription medication, 4 % visited an obesity specialist, and 2–4 % had bariatric surgery.</div><div>Many HCPs expressed concern about obesity medication; side effects (60 %), long term safety (48 %), lack of knowledge (46 %), cost (79 %), and preference for lifestyle changes (35 %). Importantly, 81 % of HCPs believe society and the healthcare system are not meeting PWO needs.</div></div><div><h3>Conclusions</h3><div>Despite strong consensus that obesity is a disease, disparities remain regarding treatment of and responsibility for obesity management. This dataset highlights opportunities to improve education, management and system level support while identifying inequities and barriers in obesity care.</div></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"16 ","pages":"Article 100231"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145579028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resolution of chronic idiopathic urticaria with setmelanotide in a patient with Bardet-Biedl Syndrome: A case report","authors":"Kate Haggerty ,&nbsp;Jennifer Black ,&nbsp;Ruth Abeles","doi":"10.1016/j.obpill.2025.100221","DOIUrl":"10.1016/j.obpill.2025.100221","url":null,"abstract":"<div><h3>Introduction</h3><div>This case describes the resolution of refractory chronic idiopathic urticaria (CIU) with setmelanotide in a patient with Bardet-Biedl Syndrome (BBS). While setmelanotide is approved for syndromic obesity, this report highlights a novel anti-inflammatory effect potentially mediated by melanocortin-4 receptor (MC4R) agonism, expanding current understanding of its immunomodulatory role in mast cell–mediated disease.</div></div><div><h3>Main symptoms and clinical findings</h3><div>The patient presented with lifelong hyperphagia and class III obesity beginning in childhood, along with multiple features fulfilling BBS clinical criteria: visual impairment with night vision difficulties, renal abnormalities with proteinuria, irregular menses with polycystic ovaries, and neurodevelopmental delay. She also reported refractory CIU with pruritic hives occurring several times weekly despite dual antihistamine therapy. On examination, BMI was 40.5 kg/m², and dermatologic evaluation confirmed recurrent hives unresponsive to standard treatment.</div></div><div><h3>Diagnosis</h3><div>Genetic testing revealed a heterozygous pathogenic <em>BBS9</em> variant (c.1120C &gt; T; p. Arg374∗), supporting a BBS diagnosis. Secondary causes of urticaria were excluded. Setmelanotide was initiated at 2 mg daily and titrated to 3 mg, leading to complete urticaria resolution within three weeks and cessation of antihistamines. Symptoms recurred during a brief treatment pause and resolved upon reinitiation, demonstrating a temporal association. Hyperphagia scores improved from 20 to 0, with significant quality-of-life gains. Adjunct phentermine 18.75 mg daily was later added to optimize appetite control. After ten months, urticaria remained in sustained remission, with only one isolated cold-induced episode.</div></div><div><h3>Conclusion</h3><div>Setmelanotide produced durable remission of refractory CIU in a patient with BBS, suggesting MC4R agonism may exert immunomodulatory effects beyond weight regulation. This finding underscores the broader potential of precision therapies for rare obesity syndromes to reveal new mechanisms of inflammation control.</div></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"16 ","pages":"Article 100221"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145579027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity Medicine Association statement regarding online pharmacologic management of obesity","authors":"Leslie Golden,&nbsp;Harold Edward Bays","doi":"10.1016/j.obpill.2025.100200","DOIUrl":"10.1016/j.obpill.2025.100200","url":null,"abstract":"","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"16 ","pages":"Article 100200"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of nutrition interventions with GLP-1 based therapies: A narrative review of the challenges and solutions","authors":"Angela Fitch ,&nbsp;Linda Gigliotti ,&nbsp;Harold Edward Bays","doi":"10.1016/j.obpill.2025.100205","DOIUrl":"10.1016/j.obpill.2025.100205","url":null,"abstract":"<div><h3>Background</h3><div>Obesity is a heterogeneous systemic chronic disease associated with excess adiposity and a complex etiology and is increasing in prevalence worldwide. Initially used to treat type 2 diabetes mellitus, glucagon-like peptide-1 (GLP-1) based therapies are now widely prescribed for individuals with overweight and obesity as an adjunct to a reduced-calorie diet and increased physical activity. However, despite their impressive weight reduction capabilities, many patients on GLP-1 based therapies do not receive appropriate nutrition advice and struggle to maintain their weight reduction.</div></div><div><h3>Methods</h3><div>This narrative review explores and summarizes existing literature on the challenges associated with nutrition intake in people with obesity taking GLP-1 based therapies and practical applications of nutrition and lifestyle interventions for the management of these individuals to ensure their best long-term health outcomes.</div></div><div><h3>Results</h3><div>Delivering optimal nutrition management to people with obesity treated with GLP-1 based therapies presents healthcare providers with many challenges including addressing the impact of obesity and weight reduction on body composition (particularly muscle mass loss and risk of sarcopenic obesity), and poor nutrition. Physicians should work with dietitians and other healthcare providers to deliver comprehensive lifestyle counselling that is patient-centered, aligning with the needs and preferences of the individual. This should include advice on: timely and appropriate nutrition that centers on adequate macronutrient, micronutrient and fluid intake, particularly increased protein intake alongside resistance training for the preservation of muscle mass; mental health; sleep hygiene, physical activity; and medication adherence and persistence. Evidence-based nutrition guidelines can also provide an important framework for healthcare professionals, helping to ensure nutrition advice is consistent and based on rigorous scientific research.</div></div><div><h3>Conclusions</h3><div>Our findings underscore the importance of ensuring that patients treated with GLP-1 based therapies are closely monitored and provided with comprehensive nutrition and lifestyle support to ensure they achieve the best long-term health outcomes.</div></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"16 ","pages":"Article 100205"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145105016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world effects of incretin-based Obesity medications on body composition","authors":"Rahila Bhatti ,&nbsp;Amena Sadiya ,&nbsp;Bashair M. Mussa ,&nbsp;Rawoof Khan ,&nbsp;Salah Abusnana","doi":"10.1016/j.obpill.2025.100229","DOIUrl":"10.1016/j.obpill.2025.100229","url":null,"abstract":"<div><h3>Background</h3><div>This study evaluated the real-world impact of incretin-based obesity medications Semaglutide and Tirzepatide on body composition in people with obesity. The primary outcomes included changes in weight, waist circumference, skeletal muscle mass, fat mass, and visceral fat over 12 months.</div></div><div><h3>Methods</h3><div>A retrospective observational study was conducted at Genesis Healthcare Centre, Dubai, UAE, from October 2022 to September 2024. A total of 269 adults (BMI ≥30 kg/m² or ≥27 kg/m² with obesity-related complications) who were prescribed Semaglutide or Tirzepatide as part of a comprehensive, multidisciplinary weight management program were included. Body composition was assessed using the InBody 370S analyzer. Data were extracted from the health information system. A repeated measures ANOVA was used to determine significance (p &lt; 0.05) in the statistical analyses, which were conducted using SPSS v29.</div></div><div><h3>Results</h3><div>Both medications significantly reduced weight, BMI, waist circumference, waist-to-height ratio, fat mass, and visceral fat (p &lt; 0.001). At 6 months, weight loss was similar (−9.09 % vs −10.7 %), but by 12 months, Tirzepatide achieved greater reduction (22.02 % vs 11.59 %). Both improved glycemic control and liver function. Females exhibited greater weight loss. Lifestyle interventions supported skeletal muscle mass preservation.</div></div><div><h3>Conclusion</h3><div>Semaglutide and Tirzepatide, significantly improved body composition, weight loss, and metabolic parameters in people with obesity. Tirzepatide demonstrated greater long-term efficacy.</div></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"16 ","pages":"Article 100229"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145527906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmasking heterogeneity in metabolic syndrome in a national sample of disaggregated Asian American subgroups","authors":"Lin Zhu ,&nbsp;Wei Jenny Yang ,&nbsp;Crystal Tse ,&nbsp;Grace X. Ma","doi":"10.1016/j.obpill.2025.100230","DOIUrl":"10.1016/j.obpill.2025.100230","url":null,"abstract":"<div><h3>Background</h3><div>Our previous research has shown that Asian Americans with a body mass index (BMI) above 23 have a higher risk of metabolic syndrome (MetS) than non-Hispanic whites of the same BMI. This exploratory study aimed to characterize patterns of metabolic syndrome heterogeneity across Asian American subgroups.</div></div><div><h3>Method</h3><div>This is a cross-sectional epidemiological study. Using data from the National Health and Nutrition Examination Survey, we computed age-adjusted, gender-specific prevalence for MetS and its individual components for three BMI categories among five major Asian American ethnic groups: Chinese (652), Filipino (262), Asian Indian (409), Vietnamese (243), and Korean (215).</div></div><div><h3>Results</h3><div>High MetS prevalence was observed in Asian Americans with a BMI above 23 (overweight or obesity). There were notable variations in MetS prevalence rates across Asian subgroups. Among the five Asian subgroups, excessive MetS risks were observed in Asian Indians, Filipinos, Vietnamese, and Koreans in one or more sex/BMI level categories. In particular, among men who had overweight (BMI 23–27.4), Asian Indians had statistically higher rates of MetS than their Vietnamese counterparts (50.80 % vs. 22.66 %). We also found elevated MetS risks in Asian Indian women who had overweight and Korean women who had obesity (BMI ≥27.5).</div></div><div><h3>Conclusion</h3><div>Our findings highlight an urgent need for further research on cardiometabolic risks and mechanisms driving these risks among disaggregated Asian ethnic groups. Greater understanding of these factors is essential for the development of culturally tailored intervention efforts to reduce MetS disparities among diverse Asian ethnic populations in the United States.</div></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"16 ","pages":"Article 100230"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145579029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}