Journal of Ionic Liquids最新文献

{"title":"Design and synthesis of phosphonium ionic liquids exhibiting strong fluorescence in various solvents and liquid or glassy state","authors":"David King ,&nbsp;Yan P. Arnaiz ,&nbsp;Hari D. Mandal ,&nbsp;Haesook Han ,&nbsp;Pradip K. Bhowmik","doi":"10.1016/j.jil.2025.100156","DOIUrl":"10.1016/j.jil.2025.100156","url":null,"abstract":"<div><div>Liquid fluorescent ILs (LFILs) are rare materials that exhibit strong photoluminescent properties in the pure liquid state without the need for a solvent. While ILs are known for their optical properties in solution, fluorescence in the pure liquid state is typically weak or absent due to quenching phenomena. LFILs are extremely scarce in the literature, and only a few have been reported with absolute quantum yield (AQY) values to assess their fluorescence efficiency in the pure liquid state. A series of phosphonium ILs (PILs), containing fluorescent 5-(dimethylamino)-1-naphthalenesulfonate (DNS^-) and 9,10-anthraquinone-2-sulfonate (AQS^-), were synthesized as potential soft photoluminescent materials in solution and neat liquid state in very good to excellent yields. Additionally, mono and diphosphonium chloride ILs were prepared via an improved workup process to afford ILs with high purity (&gt;99 %) compared to traditional methods. All fluorescent PILs possessed high thermal stabilities (<em>T</em>_d = 332–383 °C) as determined by thermogravimetric analysis (TGA). The differential scanning calorimetry (DSC) thermograms for the PILs-DNS and PILs-AQS revealed that all of them were ILs, with most being RTILs and the triphenylphosphonium containing PILs existing as glassy ILs (<em>T</em>_g = 21.13 and 30.13 °C) at room temperature. Their photoluminescent properties in the solution state were studied in various organic solvents, with the PILs-DNS possessing AQY values upwards of 0.95 in solution and [P_666,10]DNS exhibited an impressively high AQY of 0.35 in the liquid state. The PILs-AQS did not possess strong photoluminescent properties in solution and no fluorescence in the liquid or glassy state. The PILs-DNS and PILs-AQS demonstrated excellent photostability, exhibiting no significant photobleaching. Study of these novel PILs containing anionic fluorophores is necessary to contribute towards the scarcity of LFILs and offer prospects in a wide range of fields, including chemical/physical sensing, optoelectronics, and biological imaging.</div></div>","PeriodicalId":100794,"journal":{"name":"Journal of Ionic Liquids","volume":"5 1","pages":"Article 100156"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the ionic liquid cholinium L-alaninate as a promising biofilm control in clinically relevant bacteria","authors":"AF Chávez-Almanza ,&nbsp;CA Díaz-Quiroz ,&nbsp;G Ulloa-Mercado ,&nbsp;AA Verdugo-Fuentes ,&nbsp;JF Hernández-Chávez ,&nbsp;J López-Cervantes ,&nbsp;CB Vega-Millán ,&nbsp;P Gortáres-Moroyoqui ,&nbsp;C García-Gómez ,&nbsp;MS Álvarez-Álvarez ,&nbsp;J Rojas-Padilla ,&nbsp;FJ Rivera-Romero","doi":"10.1016/j.jil.2025.100154","DOIUrl":"10.1016/j.jil.2025.100154","url":null,"abstract":"<div><div>Pathogenic biofilms pose a significant clinical challenge owing to their extreme antibiotic resistance. Multiple strategies, including ionic liquids (ILs), have been explored to inhibit or eradicate biofilms. Among them, choline and amino acid based ionic liquids are of interest due to their biocompatibility and low cytotoxicity. This study assessed the antimicrobial efficacy of the ionic liquid cholinium alaninate against planktonic cultures and biofilms of <em>Escherichia coli, Staphylococcus aureus</em>, and <em>Pseudomonas aeruginosa</em>. We determined the minimum inhibitory concentration (MIC) for planktonic cells using growth curve analysis. The inhibition and eradication of biofilm were assessed in microplates through stains to quantify total and viable cells. Treatments with different concentrations of ionic liquid were compared to controls. Results were analyzed using ANOVA and multiple comparison tests. A minimum inhibitory concentration of 1.3 % w/v cholinium alaninate was determined, with inhibition in the order <em>E. coli</em> &lt;<em>P. aeruginosa</em> &lt;<em>S. aureus</em>. For biofilms, a 0.9 % w/v treatment inhibited &gt;95 % of biofilm growth. The sub-inhibitory treatment of 1.3 % w/v resulted in the removal of ≈92 % of biomass for all Gram-negative strains, while ≈85 % eradication was achieved for <em>S. aureus</em>. Approximately 3 % of Gram-negative bacteria and 5 % of <em>S. aureus</em> were metabolically active. Significant differences were observed for all treatments on biofilm (<em>p</em> &lt; 0.05), with the greatest effects on Gram-negative bacteria. The IL cholinium ʟ-alaninate ([Cho][Ala]) effectively prevented biofilm formation and eradicated preformed biofilms. We recommend investigating multidrug resistant pathogens and surfaces that exhibit enhanced adherence.</div></div>","PeriodicalId":100794,"journal":{"name":"Journal of Ionic Liquids","volume":"5 1","pages":"Article 100154"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benzyl triphenyl phosphonium bromide as a corrosion inhibitor: A multifaceted study on aluminium protection in acidic environment","authors":"Mansi Y. Chaudhary ,&nbsp;Meenakshi Gupta ,&nbsp;Yudhvir Singh Sharma ,&nbsp;Prerna Bansal ,&nbsp;Shikha Kaushik ,&nbsp;Rajni Kanojia ,&nbsp;Manish Kumar Gautam ,&nbsp;Shramila Yadav","doi":"10.1016/j.jil.2025.100152","DOIUrl":"10.1016/j.jil.2025.100152","url":null,"abstract":"<div><div>Corrosion, a globally recognized issue, leads to reduced efficiency, significant economic losses, and the depletion of natural resources. Ionic liquids, particularly phosphonium-based compounds, are considered environmentally benign and sustainable alternatives. In this study, the use of Benzyl Triphenyl Phosphonium Bromide (BTPB) as a novel and efficient corrosion inhibitor for 6106 aluminum alloy in hydrochloric acid was investigated through electrochemical and surface analysis techniques. Potentiodynamic polarization, electrochemical impedance spectroscopy (EIS), and weight loss measurements were employed to evaluate its inhibition performance. BTPB exhibited an exceptional maximum inhibition efficiency of 95.95 % at 308 K, with efficiency improving with increasing concentration. Adsorption studies indicated that BTPB follows the Langmuir adsorption isotherm, while thermodynamic analysis provided deeper insights into the adsorption mechanism. Furthermore, surface characterization by scanning electron microscopy (SEM), atomic force microscopy (AFM), and density functional theory (DFT) calculations supported the experimental findings, confirming strong interactions between BTPB molecules and the aluminum surface. The outstanding inhibition efficiency, combined with the green and environmentally friendly nature of BTPB, underscores its potential as an advanced corrosion inhibitor for aluminum alloys in acidic environments.</div></div>","PeriodicalId":100794,"journal":{"name":"Journal of Ionic Liquids","volume":"5 1","pages":"Article 100152"},"PeriodicalIF":0.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermodynamic and computational studies of Promethazine hydrochloride drug in aqueous and aqueous Choline-based deep eutectic solutions","authors":"Ankita S. Chandak ,&nbsp;Ritesh Motghare ,&nbsp;Ratiram G. Chaudhary ,&nbsp;Sangesh P. Zodape","doi":"10.1016/j.jil.2025.100153","DOIUrl":"10.1016/j.jil.2025.100153","url":null,"abstract":"&lt;div&gt;&lt;div&gt;This study explores deep eutectic solvents (DESs) as environmentally friendly green solvents with potential applications in the formulation of drug delivery systems (DDSs). By focusing on the important aspect of optimizing molecular interactions between drugs and DESs, this work offers thermodynamic and molecular interaction insights that facilitate the strategic selection of suitable solvents for advanced medicinal applications. In this regard, the density(&lt;span&gt;&lt;math&gt;&lt;mi&gt;ρ&lt;/mi&gt;&lt;/math&gt;&lt;/span&gt;) and sound velocity (&lt;span&gt;&lt;math&gt;&lt;mi&gt;u&lt;/mi&gt;&lt;/math&gt;&lt;/span&gt;) of the drug Promethazine hydrochloride (P.HCl) in aqueous and aqueous 0.5/ 1.0 mol.kg&lt;sup&gt;−1&lt;/sup&gt; DES (ChCl:U) solutions were measured across various temperatures (288.18–318.15 at 5 K interval). The thermodynamic and compressibility properties such as apparent molar volume of solute &lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt;&lt;msub&gt;&lt;mi&gt;V&lt;/mi&gt;&lt;mi&gt;ϕ&lt;/mi&gt;&lt;/msub&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;, limiting apparent molar volume of solute &lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt;&lt;msubsup&gt;&lt;mi&gt;V&lt;/mi&gt;&lt;mrow&gt;&lt;mi&gt;ϕ&lt;/mi&gt;&lt;/mrow&gt;&lt;mn&gt;0&lt;/mn&gt;&lt;/msubsup&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt; apparent molar compressibility of solute &lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt;&lt;msub&gt;&lt;mi&gt;K&lt;/mi&gt;&lt;mrow&gt;&lt;mi&gt;S&lt;/mi&gt;&lt;mo&gt;,&lt;/mo&gt;&lt;mi&gt;ϕ&lt;/mi&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;, limiting apparent molar compressibility of solute &lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt;&lt;msubsup&gt;&lt;mi&gt;K&lt;/mi&gt;&lt;mrow&gt;&lt;mi&gt;S&lt;/mi&gt;&lt;mo&gt;,&lt;/mo&gt;&lt;mi&gt;ϕ&lt;/mi&gt;&lt;/mrow&gt;&lt;mn&gt;0&lt;/mn&gt;&lt;/msubsup&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;, isentropic compressibility of solution &lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt;&lt;msub&gt;&lt;mi&gt;κ&lt;/mi&gt;&lt;mi&gt;S&lt;/mi&gt;&lt;/msub&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;, thermal expansion coefficient &lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt;&lt;mi&gt;α&lt;/mi&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;, apparent molar expansivity of solute &lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt;&lt;msub&gt;&lt;mi&gt;E&lt;/mi&gt;&lt;mi&gt;ϕ&lt;/mi&gt;&lt;/msub&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt; and limiting apparent molar expansivity of solute &lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt;&lt;msubsup&gt;&lt;mi&gt;E&lt;/mi&gt;&lt;mi&gt;ϕ&lt;/mi&gt;&lt;mn&gt;0&lt;/mn&gt;&lt;/msubsup&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt; were computed from the experimental results. Additionally, the positive values of transfer parameters (&lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;msub&gt;&lt;mstyle&gt;&lt;mi&gt;Δ&lt;/mi&gt;&lt;/mstyle&gt;&lt;mrow&gt;&lt;mi&gt;t&lt;/mi&gt;&lt;mi&gt;r&lt;/mi&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;msubsup&gt;&lt;mi&gt;V&lt;/mi&gt;&lt;mi&gt;ϕ&lt;/mi&gt;&lt;mn&gt;0&lt;/mn&gt;&lt;/msubsup&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;) and (&lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;msub&gt;&lt;mstyle&gt;&lt;mi&gt;Δ&lt;/mi&gt;&lt;/mstyle&gt;&lt;mrow&gt;&lt;mi&gt;t&lt;/mi&gt;&lt;mi&gt;r&lt;/mi&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;msubsup&gt;&lt;mrow&gt;&lt;msub&gt;&lt;mi&gt;K&lt;/mi&gt;&lt;mi&gt;s&lt;/mi&gt;&lt;/msub&gt;&lt;/mrow&gt;&lt;mi&gt;ϕ&lt;/mi&gt;&lt;mn&gt;0&lt;/mn&gt;&lt;/msubsup&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;) suggested the dominance of ionic-hydrophilic interactions. Further, positive Hepler's constant &lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt;&lt;mrow&gt;&lt;msup&gt;&lt;mrow&gt;&lt;mi&gt;∂&lt;/mi&gt;&lt;/mrow&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;/msup&gt;&lt;msubsup&gt;&lt;mi&gt;V&lt;/mi&gt;&lt;mi&gt;ϕ&lt;/mi&gt;&lt;mn&gt;0&lt;/mn&gt;&lt;/msubsup&gt;&lt;mo&gt;/&lt;/mo&gt;&lt;mi&gt;∂&lt;/mi&gt;&lt;msup&gt;&lt;mrow&gt;&lt;mi&gt;T&lt;/mi&gt;&lt;/mrow&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;/msup&gt;&lt;/mrow&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt; values represent structure-making ability of drug P.HCl in all the investigated systems. Also, DFT analysis by using Gaussian 09 at B3LYP/6–311+&lt;em&gt;G&lt;/em&gt;(d,p) was used for geometry optimization, reactive s","PeriodicalId":100794,"journal":{"name":"Journal of Ionic Liquids","volume":"5 1","pages":"Article 100153"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143917478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hexavalent chromium removal using chitin microspheres modified by an ionic liquid cation tricaprylmethylammonium chloride (Aliquat 336)","authors":"Salima Benniche ,&nbsp;Ounissa Senhadji-Kebiche ,&nbsp;Ariana Pintor ,&nbsp;Claudia Fontas","doi":"10.1016/j.jil.2025.100151","DOIUrl":"10.1016/j.jil.2025.100151","url":null,"abstract":"<div><div>A novel sorbent was successfully developed by immobilizing the ionic liquid tricaprylylmethylammonium chloride (Aliquat 336) into chitin, a natural and renewable polysaccharide. The sorbent was comprehensively characterized using SEM, BET, TGA, FTIR and DRX techniques, and its performance was evaluated for the removal of Cr(VI) from aqueous solutions. The effects of key physicochemical parameters—including pH, stirring time, initial Cr(VI) concentration, and sorbent dosage—were systematically investigated. The sorbent demonstrated high selectivity performance and efficiency for Cr(VI) removal, highlighting a maximum adsorption capacity of 35 mg/g, which is 20 times greater than that of native chitin, at an optimum pH of 2. Interference studies with coexisting ions confirmed the robustness of the sorbent to remove Cr(VI) under competitive conditions. Effective desorption was achieved with a 0.1 M NaOH solution, allowing for 80 % metal recovery within 1 hour of contact. Additionally, the sorbent exhibited remarkable stability over five cycles, maintaining its high adsorption capacity without significant loss in performance.</div><div>This study underscores the potential of the new sorbent as a sustainable and efficient material for Cr(VI) remediation, combining high adsorption capacity, reusability, and eco-friendly design.</div></div>","PeriodicalId":100794,"journal":{"name":"Journal of Ionic Liquids","volume":"5 1","pages":"Article 100151"},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ammonium based dicationic ionic liquids: An interaction with CRABP I deciphered with biophysical perspective","authors":"Pratyush Ranjan Hota ,&nbsp;Devi Prasanna Behera ,&nbsp;Harekrushna Sahoo","doi":"10.1016/j.jil.2025.100150","DOIUrl":"10.1016/j.jil.2025.100150","url":null,"abstract":"<div><div>The present article examined the impact of ammonium-based dicationic ionic liquids (ILs) as co-solvent on the biophysical behaviour of CRABP I protein using various spectroscopic techniques along with molecular docking to support the experimental outcomes. Fluorescence study revealed significant alternations in the microenvironments of aromatic fluorescent amino acid residues. Fluorescence intensity indicated a decline upon increase in concentration of co-solvents, with a red shift. A similar trend also observed with the synchronous study. Stern-Volmer parameters revealed the static quenching behaviour whereas, existence of electrostatic interaction between protein and ILs is revealed from binding study using temperature-dependent fluorescence measurements. Conformational and structural changes of the protein were analysed using Circular Dichroism spectrometer. Molecular docking study supported the spectroscopic outcomes at the molecular level.</div></div>","PeriodicalId":100794,"journal":{"name":"Journal of Ionic Liquids","volume":"5 1","pages":"Article 100150"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ionic liquid-assisted approaches in the synthesis of nitrogen-containing heterocycles: A focus on 3- to 6-membered rings","authors":"Pravas Maity ,&nbsp;Amrit Krishna Mitra","doi":"10.1016/j.jil.2025.100146","DOIUrl":"10.1016/j.jil.2025.100146","url":null,"abstract":"<div><div>Nitrogen-containing heterocyclic compounds represent one of the most significant groups in traditional organic chemistry. Many pharmaceuticals, designed to replicate the bioactivity of natural compounds, contain these nitrogen-based heterocyclic compounds. Organic chemists have invested substantial effort into creating these compounds, focusing on innovative and efficient synthetic methods. Ionic liquids (ILs) are highly valued in organic synthesis due to their unique characteristics, such as a wide liquid range, superior solvating properties, low vapour pressure, non-flammability, eco-friendliness, and high thermal stability. They also enhance reaction rates and are easily recyclable. Their dual role as both catalysts and reaction media has drawn significant attention from chemists. With about 4000 research papers published annually, ILs continue to be a major focus of scientific exploration, particularly in the synthesis of nitrogen-containing heterocyclic compounds. This review aims to portray the synthesis of nitrogen-containing heterocyclic compounds (3-membered to 6-membered) assisted by ionic liquids.</div></div>","PeriodicalId":100794,"journal":{"name":"Journal of Ionic Liquids","volume":"5 1","pages":"Article 100146"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decomposition of ionic liquids with chloride anions: A combined study of the gas-phase dissociation of the isolated cations and pyrolysis of the bulk","authors":"Taofiq Abdulraheem,&nbsp;Amanda L. Patrick","doi":"10.1016/j.jil.2025.100149","DOIUrl":"10.1016/j.jil.2025.100149","url":null,"abstract":"<div><div>As the synthesis of diverse ionic liquids (ILs) proliferates and as (proposed) applications increase, there is growing concern about the possibility of finding IL components and degradation products in the environment, possibly as persistent and/or hazardous contaminants. Understanding IL stability and understanding what decomposition products arise when ILs do degrade will help us better understand potential environmental threats. While stability raises concern in terms of persistent environmental pollution, it is also one of the major strengths of ILs toward their many applications. From understanding degradation mechanisms that could be at play during use under extreme conditions to understanding the products that may form during incomplete incineration, a molecular-level understanding of IL thermal transformations is also desirable beyond the environmental concern. Ideally, such a molecular-level understanding could eventually lead to better predictions of thermal stability as a function of structure prior to synthesis and experimental characterization. In this work, the pyrolysis products of nine ILs, each with the chloride anion and various N-heterocyclic cations, were studied by gas chromatography-mass spectrometry and these results were compared to the unimolecular gas-phase dissociation behavior of the respective isolated cations. By comparing these two experimental approaches, differences between unimolecular decomposition pathways and bimolecular decomposition or transformation pathways could be explored. Further, these comparisons shed light on whether gas-phase dissociation of the isolated cation, which is a very straightforward experiment, could be used to provide any insights into bulk pyrolysis pathways. Overall trends, class-based trends, and behaviors specific to only certain species are identified and discussed. This work provides new molecular insights into the pyrolysis of ILs by studying an array of cations, including those with functionalized R-groups, and by integrating results from bulk pyrolysis with those from collision-induced dissociation of the isolated cation.</div></div>","PeriodicalId":100794,"journal":{"name":"Journal of Ionic Liquids","volume":"5 1","pages":"Article 100149"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory and anti-diabetic activity of N1-(4-substitutedbenzyl)/Butyl-2-methyl-4-nitro-3-imidazolium (E)-3-(4-hydroxy-3-methoxyphenyl)acrylates","authors":"Dhurairaj Satheesh ,&nbsp;Annamalai Rajendran ,&nbsp;Chandrasekran Geetha ,&nbsp;Krishnan Parthipan ,&nbsp;Ayyandurai Thirunavukkarasu ,&nbsp;Karunanithi Suganya","doi":"10.1016/j.jil.2025.100148","DOIUrl":"10.1016/j.jil.2025.100148","url":null,"abstract":"<div><div>A series of nine <em>N¹</em>-(4-substitutedbenzyl/butyl)-2-methyl-4-nitro-1<em>H</em>-imidazoles (<strong>3a-i</strong>) and their <em>N</em>¹-(4-substitutedbenzyl)/Butyl-2-methyl-4-nitro-3-imidazolium (<em>E</em>)-3-(4-hydroxy-3-methoxyphenyl)acrylates (<strong>IMS-19, 21-27</strong>) were screened for their anti-inflammatory and anti-diabetic activity in different concentrations (<strong>20, 40, 80, 200 &amp; 400 μg/mL</strong>). The <em>Diclofenac sodium</em> and <em>Acarbose</em> were used as standard drugs for anti-inflammatory and anti-diabetic activities respectively. The 4-nitro-1<em>H</em>-imidazoles <strong>(3a-i)</strong> and their protic imidazolium salts with (<em>E</em>)-3-(4-hydroxy-3-methoxyphenyl)acrylate as an organic anion (<strong>IMS-19, 21-27</strong>) are showed very good to remarkable anti-inflammatory and good to excellent anti-diabetic activities compared to their corresponding standard drug.</div></div>","PeriodicalId":100794,"journal":{"name":"Journal of Ionic Liquids","volume":"5 1","pages":"Article 100148"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143860523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile synthesis of tetraaryl phosphonium ionic liquids","authors":"Stephanie C. Jones ,&nbsp;Devin J. Schwaibold ,&nbsp;Grant Meadows ,&nbsp;Brennan Shuler ,&nbsp;Richard Sykora ,&nbsp;Frank R. Fronczek ,&nbsp;James H. Davis Jr ,&nbsp;Benjamin F. Wicker","doi":"10.1016/j.jil.2025.100147","DOIUrl":"10.1016/j.jil.2025.100147","url":null,"abstract":"<div><div>The syntheses of triphenyl-2-pyridylphosphonium salts, [Mopyphos]A, where A^- = BF₄^-, B(C₆H₅)₄^-, (CF₃SO₂)₂N^-, Sac^-, and Ace^-. (Sac^- = saccharinate, Ace^- = acesulfamate) are described. These salts can be synthesized on a multi-gram scale with good yields and have been characterized by NMR, single crystal XRD, and HRMS. Thermal analyses indicate that the bistriflimide (Tf₂N^- = (CF₃SO₂)₂N^-) salts are especially amenable towards high-temperature ionic liquid (IL) applications with decomposition temperatures above 450°C. The synthetic methods described herein can be utilized to generate several phosphonium bistriflimide ILs of the general formula [(C₆H₅)₃P-Ar]Tf₂N, where Ar = N-heteroaryl).</div></div>","PeriodicalId":100794,"journal":{"name":"Journal of Ionic Liquids","volume":"5 1","pages":"Article 100147"},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}