Z. Tulassay, A. Kryszewski, P. Dítě, D. Kleczkowski, J. Rudzinski, Z. Bartuzi, G. Hasselgren, A. Larko
{"title":"The preliminary biocharacteristic study of a potential dopamine D_3 receptor imaging agent, ~(125) I-7-OH-PIPAT","authors":"Z. Tulassay, A. Kryszewski, P. Dítě, D. Kleczkowski, J. Rudzinski, Z. Bartuzi, G. Hasselgren, A. Larko","doi":"10.3760/CMA.J.ISSN.0253-9780.2003.02.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0253-9780.2003.02.014","url":null,"abstract":"Objective To study the biocharacteristics of a potential dopamine D 3 receptor imaging agent, 125 I 7 hydroxy 2 [ N propyl N (3′ iodo 2′ propenyl) amino]tetralin (7 OH PIPAT) which was synthesized in this lab. Methods 125 I 7 OH PIPAT was used as a radioactive tracer to study the biodistribution of 125 I 7 OH PIPAT in rats and in particular, in the brain regions, and autoradiography was used to study the binding sites of 125 I 7 OH PIPAT in rat brain slices. Results The uptake of 125 I 7 OH PIPAT in the whole brain reached to 1%, and autoradiography showed that 125 I 7 OH PIPAT was accumulated at olfactory tubercle and limbic regions of rat brain. Conclusions 125 I 7 OH PIPAT is able to penetrate the brain blood barrier, and has the affinity to dopamine D 3 receptors. It has the potential activity to be a dopamine D 3 receptor imaging agent.","PeriodicalId":10073,"journal":{"name":"Chinese Journal of Nuclear Medicine","volume":"43 1","pages":"107-109"},"PeriodicalIF":0.0,"publicationDate":"2003-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88043476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"13C-octanoic acid breath test for measurement of solid gastric emptying: reproducibility in normal subjects and patients with diabetes mellitus","authors":"F. Bo, D. Ziegler","doi":"10.3760/CMA.J.ISSN.0253-9780.2001.02.021","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0253-9780.2001.02.021","url":null,"abstract":"Objective To examine the intraindividual reproducibility of the octanoic acid breath test in normal subjects and diabetics and to investigate whether cardiovascular autonomic neuropathy and delayed gastric emptying influence the intraindividual reproducibility.Methods Nine normal subjects (six men, three women,mean age 38 years) and 15 diabetics with insulin treatment [nine men, six women; mean age 47 years; six had cardiovascular autonomic diabetic neuropathy (CADN) and/or delayed gastric emptying time] were, after a nocturnal fasting period, given a standard test meal (labeled with 13C-octanoic acid, 1 046 kJ). Breath samples were taken at ten minute intervals over first one hour and at fifteen minute intervals over the following three hours and examined for 13CO 2 by isotope ratio infrared spectrometry. Using a regression method gastric emptying half times (t 1/2) and lag phase (t lag) were determined.Results There was not a significant difference of t 1/2 and t lag between two measurements in normal subjects and diabetics. The coefficients of variation of day-to-day reproducibility were 11.7% for t 1/2, 19.4% for t lag in normal subjects and 17.8% for t 1/2, 28.2% for t lag in diabetics, but there was not significant difference between normal subjects and diabetics. There was not significant difference of intraindividual coefficient of variation of t 1/2 and t lag between diabetics with/without CADN and between diabetics with normal gastric emptying time and diabetics with delayed gastric emptying time.Conclusions The 13C-octanoic acid breath test has a high intraindividual reproducibility which is not affected by the cardiovascular autonomic neuropathy and delayed gastric emptying. It can be recommended as a non-invasive test for assessing gastric emptying time after a solid test meal in diabetics.","PeriodicalId":10073,"journal":{"name":"Chinese Journal of Nuclear Medicine","volume":"10 1","pages":"107-108"},"PeriodicalIF":0.0,"publicationDate":"2001-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84180342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}