The preliminary biocharacteristic study of a potential dopamine D_3 receptor imaging agent, ~(125) I-7-OH-PIPAT

Abstract

Objective To study the biocharacteristics of a potential dopamine D 3 receptor imaging agent, 125 I 7 hydroxy 2 [ N propyl N (3′ iodo 2′ propenyl) amino]tetralin (7 OH PIPAT) which was synthesized in this lab. Methods 125 I 7 OH PIPAT was used as a radioactive tracer to study the biodistribution of 125 I 7 OH PIPAT in rats and in particular, in the brain regions, and autoradiography was used to study the binding sites of 125 I 7 OH PIPAT in rat brain slices. Results The uptake of 125 I 7 OH PIPAT in the whole brain reached to 1%, and autoradiography showed that 125 I 7 OH PIPAT was accumulated at olfactory tubercle and limbic regions of rat brain. Conclusions 125 I 7 OH PIPAT is able to penetrate the brain blood barrier, and has the affinity to dopamine D 3 receptors. It has the potential activity to be a dopamine D 3 receptor imaging agent.