International Medical Review on Down Syndrome最新文献_第9页

Responding to the pain experiences of people with a learning difficulty and dementia 对有学习困难和痴呆的人的痛苦经历做出反应

International Medical Review on Down Syndrome Pub Date : 2011-03-01 DOI: 10.1016/S2171-9748(11)70002-2

D. Kerr, C. Cunningham, H. Wilkinson

{"title":"Responding to the pain experiences of people with a learning difficulty and dementia","authors":"D. Kerr, C. Cunningham, H. Wilkinson","doi":"10.1016/S2171-9748(11)70002-2","DOIUrl":"10.1016/S2171-9748(11)70002-2","url":null,"abstract":"<div><p>People with a learning disability are living longer. This increased longevity brings with it the conditions of older age including dementia. Amongst people in the general population who have dementia there is inadequate pain recognition and treatment<sup>1–4</sup>. Limited research has been undertaken on the pain management needs of people with a learning disability who have dementia, yet they will experience high levels of physical health needs that will, as a consequence, result in pain<sup>5,6</sup>.</p><p>The research study ‘Responding to the Pain needs of People with a Learning Disability and Dementia’<sup>7</sup> explored the detection, management and understanding of pain amongst a range of professional groups involved in supporting people with a learning disability who have dementia. The study also recorded the experiences and views of some people with a learning disability who had dementia.</p><p>The dilemmas and obstacles to effective pain management were explored. It was found that the pain experiences and management of people with a learning disability who have dementia mirrored findings in the general population. The research did, however, identify extra and compounding issues in relation to people with a learning disability. Drawing on this research this article outlines recommendations for practitioners and service providers and discusses the key lessons for responding more effectively to pain in people with Down's syndrome and dementia.</p></div>","PeriodicalId":100720,"journal":{"name":"International Medical Review on Down Syndrome","volume":"15 1","pages":"Pages 2-7"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S2171-9748(11)70002-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"112939876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Pediatrics, Down's syndrome and allergic disease 儿科，唐氏综合症和过敏性疾病

International Medical Review on Down Syndrome Pub Date : 2011-03-01 DOI: 10.1016/S2171-9748(11)70003-4

F. Muñoz-López

{"title":"Pediatrics, Down's syndrome and allergic disease","authors":"F. Muñoz-López","doi":"10.1016/S2171-9748(11)70003-4","DOIUrl":"10.1016/S2171-9748(11)70003-4","url":null,"abstract":"<div><p>Allergic diseases have a genetic basis (atopy), meaning that inheritance is a determining factor in the development of these processes. Respiratory pathologies are the most common, although reactions to foods and drugs also occur. The most common clinical manifestations occur in the skin and digestive tract, and generalised reactions (anaphylaxis) can often occur that can be severe or even fatal. The increase in respiratory pathologies in recent years has been linked to a reduction in infectious diseases in developed countries. The activity of Th1/Th2 lymphocytes has become imbalanced, leaning towards the Th2 that are responsible for producing antibodies against allergens (“hygiene hypothesis”). In spite of this, children with trisomy 21, with the wide gamut of altered genes responsible for many of the processes associated with this syndrome, rarely suffer from allergic diseases. This is reflected in the small number of publications on this field. In contrast, immune response to pathogens is constantly affected (greater incidence of infections requiring the production of specific antibodies produced by Th1 lymphocyte activity) along with other processes (auto-immune, leukaemia) related to patient immunity, and this could be the cause of the reduced possibility for allergic reactions.</p></div>","PeriodicalId":100720,"journal":{"name":"International Medical Review on Down Syndrome","volume":"15 1","pages":"Pages 8-13"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S2171-9748(11)70003-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83018542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

A new era: one year on 一个新时代:一年过去了

International Medical Review on Down Syndrome Pub Date : 2011-03-01 DOI: 10.1016/S2171-9748(11)70001-0

J.A. Mena , J.M. Corretger

引用次数: 0

Full citizens 完整的公民

International Medical Review on Down Syndrome Pub Date : 2010-11-01 DOI: 10.1016/S2171-9748(10)70010-6

P. Ruf , K. Trias i Trueta

引用次数: 0

Sexuality and Down syndrome 性与唐氏综合症

International Medical Review on Down Syndrome Pub Date : 2010-11-01 DOI: 10.1016/S2171-9748(10)70012-X

B. Garvía Peñuelas

引用次数: 2

Acute lymphoblastic leukemia in children and Down syndrome: Analysis of SHOP/ALL-’99 and ‘05 Protocols 儿童急性淋巴细胞白血病和唐氏综合征:SHOP/ALL- 1999和2005协议的分析

International Medical Review on Down Syndrome Pub Date : 2010-11-01 DOI: 10.1016/S2171-9748(10)70011-8

M. García-Bernal , R. Cilveti , M. Villa , J. Molina , R. Fernández-Delgado , I. Badell

{"title":"Acute lymphoblastic leukemia in children and Down syndrome: Analysis of SHOP/ALL-’99 and ‘05 Protocols","authors":"M. García-Bernal , R. Cilveti , M. Villa , J. Molina , R. Fernández-Delgado , I. Badell","doi":"10.1016/S2171-9748(10)70011-8","DOIUrl":"https://doi.org/10.1016/S2171-9748(10)70011-8","url":null,"abstract":"<div><h3>Introduction and objective</h3><p><em>Down</em> syndrome bears a known predisposition to childhood leukemia. In regards to acute lymphoblastic leukemia (ALL), most international groups show poorer results when compared to non-Down patients.</p></div><div><h3>Patients and methods</h3><p>With this study we analyze the results obtained with Down syndrome patients and ALL younger than 18 years who were treated with SHOP (Spanish Pediatric Hematology Society) protocols for the past decade.</p></div><div><h3>Results</h3><p>Current data obtained from 1000 patients out of 32 centers confirm several aspects: those are related to acute leukemia showing clinical and biological low risk treats, thereof they may be categorized in low risk groups hence receive scheduled chemotherapy of moderate intensity. However, the number of infectious and toxic complications is greater than those for non-Down patients, therefore both overall survival (OS) and event free survival (EFS) are markedly affected.</p></div><div><h3>Conclusions</h3><p>The future aim is to optimize the knowledge on biological aspects of these leukemia, in order to determine those features to be acted upon to improve their outcome.</p></div>","PeriodicalId":100720,"journal":{"name":"International Medical Review on Down Syndrome","volume":"14 3","pages":"Pages 36-46"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S2171-9748(10)70011-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91688052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Sexuality and Down syndrome 性与唐氏综合症

International Medical Review on Down Syndrome Pub Date : 2010-11-01 DOI: 10.1016/S2171-9748(10)70012-X

B. G. Peñuelas

引用次数: 2

Acute lymphoblastic leukemia in children and Down syndrome: Analysis of SHOP/ALL-'99 and '05 Protocols * 儿童急性淋巴细胞白血病和唐氏综合征:SHOP/ALL- 1999和2005协议的分析*

International Medical Review on Down Syndrome Pub Date : 2010-11-01 DOI: 10.1016/S2171-9748(10)70011-8

M. Garcia-Bernal, R. Cilveti, M. Villa, J. Molina, R. Fernández‐Delgado, I. Badell

引用次数: 1

Can bioethics help towards a better respect? 生命伦理学能帮助我们更好地尊重人类吗?

International Medical Review on Down Syndrome Pub Date : 2010-07-01 DOI: 10.1016/S2171-9748(10)70006-4

M.A. Broggi

{"title":"Can bioethics help towards a better respect?","authors":"M.A. Broggi","doi":"10.1016/S2171-9748(10)70006-4","DOIUrl":"10.1016/S2171-9748(10)70006-4","url":null,"abstract":"<div><p>The conquering of dignity is the consideration which all human beings deserve simply for what we are in each and every one of the particularities and differences which define us; applicable to persons with disabilities as much as the rest. In addition, respect dignifies those who feel and show it.</p><p>Bioethics would like to put within our reach a habit of critical thinking and reasoned analysis of our behaviour, to identify the values on which we base our actions. The ethics sustaining it by no means correspond to moralism, rather a rational consideration of what and why we do something. It is a question of acquiring greater awareness in order to be able to progress and help with this. Progress and health as concepts are closely linked to the idea of personal emancipation. To consider this self-construction, it is a question of seeing it as an effort, always admirable, to take advantage of the opportunity to live.</p><p>This effort deserves to enjoy entitlement to general protection, i.e., lack of-discrimination, privacy and confidentiality: an expression of autonomy taking the form it takes and having limitations.</p><p>The help which everyone needs must be a companion sensitive to personal and changing needs. Accompanying does not mean walking in somebody else's place, nor overtaking them, but knowing how to be with someone and walk “by their side”. If we take seriously human rights of all humans whatever their characteristics, then we will see that the questions we should ask ourselves are numerous, daily and requiring courage.</p></div>","PeriodicalId":100720,"journal":{"name":"International Medical Review on Down Syndrome","volume":"14 2","pages":"Pages 19-24"},"PeriodicalIF":0.0,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S2171-9748(10)70006-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81880290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

More than just words 不仅仅是说说而已

International Medical Review on Down Syndrome Pub Date : 2010-07-01 DOI: 10.1016/S2171-9748(10)70005-2

J.J. López Burniol

引用次数: 6